Effect of Intensive Periodontal Therapy on Blood Pressure and Endothelial Microparticles in Patients With Prehypertension and Periodontitis: A Randomized Controlled Trial.

Abstract:

BACKGROUND:Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore, the present clinical trial explores whether intensive periodontal therapy would lower BP levels and EMPs of patients with prehypertension with periodontitis. METHODS:From a total 107 patients, 95 underwent randomization (47 assigned to control-treatment [CT] group and 48 assigned to intensive-treatment [IT] group) and completed the trial. Patients received intervention for 4 consecutive weeks and were followed for 6 months. Levels of BP and EMPs were evaluated at baseline and 1, 3, and 6 months after intervention. RESULTS:Periodontal conditions were significantly improved (P <0.05) 6 months after intensive periodontal treatment. In parallel, the primary outcomes including systolic and diastolic BP and EMPs were markedly reduced in the IT group compared with the CT group (absolute difference: 12.57 and 9.65 mm Hg and 581.59/μL, respectively; 95% confidence intervals: 10.45 to 14.69, 7.06 to 12.24, and 348.12 to 815.06, respectively; P <0.05). Reduction in BP levels and EMPs was related to improvement in probing depth (r = 0.358, 0.363, and 0.676, respectively, by the Pearson product-moment correlation; P = 0.009, 0.008, and P <0.001, respectively). CONCLUSION:To the best knowledge of the authors, the present study demonstrates for the first time that intensive periodontal intervention without any antihypertensive medication therapy may be an effective means to lower levels of BP and EMPs in patients with prehypertension with periodontitis.

journal_name

J Periodontol

authors

Zhou QB,Xia WH,Ren J,Yu BB,Tong XZ,Chen YB,Chen S,Feng L,Dai J,Tao J,Yang JY

doi

10.1902/jop.2017.160447

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

711-722

issue

8

eissn

0022-3492

issn

1943-3670

journal_volume

88

pub_type

杂志文章,随机对照试验
  • Oral food consumption and subgingival microorganisms: subgingival microbiota of gastrostomy tube-fed children and healthy controls.

    abstract::This study examined the effect of oral food consumption on the prevalence and levels of subgingival bacteria and yeasts in 20 gastrostomy tube-fed children and 24 healthy controls. Microbial identification was carried out using anaerobic culture and 16S rRNA-based PCR identification methods. Streptococcal and Actinomy...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1997.68.12.1163

    authors: Chen C,Ashimoto A,Sangsurasak S,Flynn MJ,Slots J

    更新日期:1997-12-01 00:00:00

  • Parameter on "Refractory" Periodontitis.

    abstract::The American Academy of Periodontology has developed the following parameter on the treatment of "refractory" periodontitis. Patients should be informed of the disease process, therapeutic alternatives, potential complications, expected results, and their responsibility in treatment. Consequences of no treatment shoul...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.5-S.859

    authors:

    更新日期:2000-05-01 00:00:00

  • Effective periodontal treatment in a patient with type IIA von Willebrand's disease: report of a case.

    abstract::von Willebrand's disease (vWD) is one of the most common hereditary hemorrhagic disorders. A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding. In this case report, the periodontal treatment of a patient with vWD is described. A 45-year-old woman with...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.5.548

    authors: Izumi Y,Taniguchi T,Maruyama Y,Sueda T

    更新日期:1999-05-01 00:00:00

  • Histochemical and immunocytochemical localization of dipeptidyl peptidases II and IV in human gingiva.

    abstract::Dipeptidyl peptidase (DPP) II and IV activities were demonstrated in unfixed cryostat sections of gingival tissue from chronic periodontitis patients using histochemistry with 2-methoxy-4-naphthylamine (MNA) substrates. In the case of DPP IV, enzyme localization was confirmed by immunocytochemistry with mouse monoclon...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.9.846

    authors: Kennett CN,Cox SW,Eley BM

    更新日期:1996-09-01 00:00:00

  • Subgingival microflora of advanced periodontitis in the Dominican Republic.

    abstract::A study of the predominant subgingival microflora was carried out in 24 periodontitis patients, 18 to 60 years of age, in Santo Domingo, Dominican Republic. Paper point sampling, transport in VMGA III, and conventional microbiological techniques were utilized. Direct microscopic examination revealed that cocci and non...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1991.62.9.543

    authors: Slots J,Rams TE,Feik D,Taveras HD,Gillespie GM

    更新日期:1991-09-01 00:00:00

  • Effects of sodium meclofenamate on postoperative pain following periodontal surgery.

    abstract::The analgesic activity of single doses of meclofenamate (100 mg) was compared to aspirin (500 mg) and to placebo on 99 outpatients with moderate to severe pain following periodontal surgery under double-blind conditions. Pain intensity differences scores (PID) at the first, second, and third hour after the ingestion o...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1992.63.3.166

    authors: Gallardo F,Rossi E

    更新日期:1992-03-01 00:00:00

  • Effect of Periodontal Therapy With Amoxicillin-Metronidazole on Pharyngeal Carriage of Penicillin- and Erythromycin-Resistant Viridans Streptococci.

    abstract:BACKGROUND:Previous studies have focused on antibiotic resistance of Gram-negative bacteria before and after periodontal therapy. The purpose of this analysis is to assess changes in resistance patterns of the commensal Gram-positive microbiota. The viridans group streptococci (VGS) have been suggested to serve as rese...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2015.150494

    authors: Mombelli A,Cionca N,Almaghlouth A,Cherkaoui A,Schrenzel J,Giannopoulou C

    更新日期:2016-05-01 00:00:00

  • Clinical evaluation of demineralized-unicortical-ilium-strips for guided tissue regeneration.

    abstract::This study compared demineralized-unicortical-ilium-strips (DUIS) and an expanded polytetrafluoroethylene (ePTFE) physical barrier in combination with decalcified freeze-dried bone allograft (DFDBA) for treatment of Class II mandibular furcations. Twenty patients with adult periodontitis and at least 2 furcation invas...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.8.803

    authors: Yamaoka SB,Mellonig JT,Meffert RM,Arnold RM,Nummikoski PV,Mealey BL

    更新日期:1996-08-01 00:00:00

  • Collagen formation at the tooth-cell interface: comparative ultrastructural study on the effect of partial demineralization of cementum with dentin.

    abstract::In order to compare the effect of partial demineralization with root planing and partial demineralization of cementum with that of dentin on healing, the ultrastructural morphology of the interface between the layer of human periodontal ligament-derived, fibroblast-like cells (HPF) and the treated root surface was stu...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1995.66.4.267

    authors: Higashi T,Onzuka T,Satoh G,Yoshino H,Okamoto H

    更新日期:1995-04-01 00:00:00

  • Is platelet concentrate advantageous for the surgical treatment of periodontal diseases? A systematic review and meta-analysis.

    abstract:BACKGROUND:The aim of the present review is to systematically evaluate the effects of autogenous platelet concentrates on clinical outcomes of the surgical treatment of periodontal diseases. METHODS:MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched using a combination of specific se...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1902/jop.2010.100605

    authors: Del Fabbro M,Bortolin M,Taschieri S,Weinstein R

    更新日期:2011-08-01 00:00:00

  • Short-term effects of rhBMP-2-enhanced bone augmentation beyond the skeletal envelope within a titanium cap in rabbit calvarium.

    abstract:BACKGROUND:Recombinant human bone morphogenetic protein (rhBMP)-2 in a bioabsorbable collagen sponge (ACS) carrier supports significant bone formation. However, histomorphometric data on the augmentation of bone formation beyond the skeletal envelope are insufficient. Our objective was to evaluate the short-term effect...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2008.070305

    authors: Hasegawa Y,Sato S,Takayama T,Murai M,Suzuki N,Ito K

    更新日期:2008-02-01 00:00:00

  • RANKL upregulation associated with periodontitis and Porphyromonas gingivalis.

    abstract:BACKGROUND:Receptor activator of nuclear factor-kappa B (NF-kappaB) ligand (RANKL) and osteoprotegerin (OPG) are critical for homeostatic control of osteoclast activity, suggesting their vital roles in the progression of bone loss in periodontitis. In this study, the expression of RANKL and OPG mRNA and the relationshi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.060398

    authors: Wara-aswapati N,Surarit R,Chayasadom A,Boch JA,Pitiphat W

    更新日期:2007-06-01 00:00:00

  • Using a Delphi panel to survey criteria for successful periodontal therapy in anterior teeth.

    abstract:BACKGROUND:Valuable decision making for periodontal treatment success in situations where there is ambiguous or conflicting information was previously reported using a consensus building method, the Delphi survey, for posterior teeth with chronic periodontitis. This study focuses on outcome measures relevant in assessi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.9.1508

    authors: Lightfoot WS,Hefti A,Mariotti A

    更新日期:2005-09-01 00:00:00

  • Relationship between metabolic syndrome and periodontal disease in Japanese adults.

    abstract:BACKGROUND:Metabolic syndrome is becoming a common disorder worldwide. Studies have shown a relationship between metabolic syndrome and periodontal disease, although information on the relationship is limited. METHODS:We analyzed 1,070 Japanese people aged 40, 50, 60, and 70 years who participated in health and period...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.090218

    authors: Kushiyama M,Shimazaki Y,Yamashita Y

    更新日期:2009-10-01 00:00:00

  • Aspartate aminotransferase (AST) levels in human periodontium-derived cells.

    abstract::The ability to objectively assess periodontal disease activity can significantly affect periodontal therapy. Aspartate aminotransferase (AST) is released extracellularly upon tissue destruction which suggests its potential as a key index in a quantitative assay for evaluating periodontal disease activity. The purpose ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.8.733

    authors: Mizuho F,Mori H,Deguchi S,Ogawa Y,Hori T

    更新日期:1996-08-01 00:00:00

  • Protease-active extracellular protein preparations from Porphyromonas gingivalis W83 induce N-cadherin proteolysis, loss of cell adhesion, and apoptosis in human epithelial cells.

    abstract:BACKGROUND:The protease-induced cytotoxicity of P. gingivalis may partly result from alteration of the extracellular matrix and/or surface receptors that mediate interaction between the host cells and their matrix. While P. gingivalis-induced degradation of E-cadherin has been documented, there is no information on the...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.5.641

    authors: Chen Z,Casiano CA,Fletcher HM

    更新日期:2001-05-01 00:00:00

  • The laser gingivectomy. The use of the CO2 laser for the removal of phenytoin hyperplasia.

    abstract::A new technique for the removal of phenytoin hyperplasia using the carbon dioxide (CO2) surgical laser is presented as well as a review of laser physics and the current uses of the CO2 laser in dentistry. Twelve cases of phenytoin hyperplasia removed surgically by the CO2 laser are presented; hence a laser gingivectom...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1985.56.8.492

    authors: Pick RM,Pecaro BC,Silberman CJ

    更新日期:1985-08-01 00:00:00

  • The effect of a supragingival plaque-control regimen on the subgingival microbiota in smokers and never-smokers: evaluation by real-time polymerase chain reaction.

    abstract:BACKGROUND:The aim of the present study was to evaluate the effect of strict supragingival plaque control on the subgingival microbiota in smokers and never-smokers. Research into the impact of supragingival plaque control on the number of subgingival bacteria has resulted in contradictory findings. Real-time polymeras...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.2008.070558

    authors: Gomes SC,Nonnenmacher C,Susin C,Oppermann RV,Mutters R,Marcantonio RA

    更新日期:2008-12-01 00:00:00

  • The influence of β-tricalcium phosphate blocks containing extracellular matrix on osteogenic differentiation of rat bone marrow stromal cells.

    abstract:BACKGROUND:The aim of the present study is to assess the osteogenic differentiation of rat bone marrow stromal cells (RBMCs) in β-tricalcium phosphate (β-TCP) blocks containing extracellular matrix (ECM) produced by human alveolar bone periosteal cells (HABPCs). METHODS:HABPCs were cultured in β-TCP blocks for 1 week ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.120490

    authors: Iwasaki K,Munemasa N,Tago K,Nemoto K,Tsujigami H,Sugaya A,Deguchi S

    更新日期:2013-10-01 00:00:00

  • The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.

    abstract::A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximate...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1986.57.8.472

    authors: Vogel RI,Lamster IB,Wechsler SA,Macedo B,Hartley LJ,Macedo JA

    更新日期:1986-08-01 00:00:00

  • Reliability of attachment level measurements using the cementoenamel junction and a plastic stent.

    abstract::Repeated measurements of attachment level appear to be important assessments in periodontal clinical trials, yet the lack of reliability for this assessment creates measurement error which in turn demands increased sample sizes or reduces the power of the test. A plastic occlusal stent has been developed as a fixed re...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.2.115

    authors: Clark DC,Chin Quee T,Bergeron MJ,Chan EC,Lautar-Lemay C,de Gruchy K

    更新日期:1987-02-01 00:00:00

  • Removal of an amalgam tattoo using a subepithelial connective tissue graft and laser deepithelialization.

    abstract:BACKGROUND:A 56-year-old female presented for periodontal treatment with a large amalgam tattoo located in alveolar mucosa on the facial aspect of her maxillary central incisors. The lesion had been present for 42 years since having endodontic surgery at teeth #8 and #9 after a traumatic childhood incident. METHODS:A ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.080613

    authors: Campbell CM,Deas DE

    更新日期:2009-05-01 00:00:00

  • Aggregatibacter actinomycetemcomitans-Induced AIM2 Inflammasome Activation Is Suppressed by Xylitol in Differentiated THP-1 Macrophages.

    abstract:BACKGROUND:Aggressive periodontitis is characterized by rapid destruction of periodontal tissue caused by Aggregatibacter actinomycetemcomitans. Interleukin (IL)-1β is a proinflammatory cytokine, and its production is tightly regulated by inflammasome activation. Xylitol, an anticaries agent, is anti-inflammatory, but ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.150477

    authors: Kim S,Park MH,Song YR,Na HS,Chung J

    更新日期:2016-06-01 00:00:00

  • Absence of histologic signs of chronic inflammation following closed subgingival scaling and root planing using the dental endoscope: human biopsies - a pilot study.

    abstract:BACKGROUND:The primary goal of periodontal therapy is the reduction or elimination of inflammation. Traditionally, this is accomplished through removal of subgingival tooth-borne accretions using non-surgical and/or surgical treatment modalities. Numerous studies indicated the difficulty in removing these accretions to...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2008.080190

    authors: Wilson TG Jr,Carnio J,Schenk R,Myers G

    更新日期:2008-11-01 00:00:00

  • Current understanding of the role of microscopic monitoring, baking soda, and hydrogen peroxide in the treatment of periodontal disease. Committee on Research, Science and Therapy. The American Academy of Periodontology.

    abstract::The Keyes technique came to national attention following a reference in The New York Times in the late 1970s. Several lay press articles and discussions on national television served to further focus the interest of patients, general dentists, and periodontists on this potential approach to periodontal therapy. Early ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,收录出版

    doi:

    authors:

    更新日期:1998-08-01 00:00:00

  • The interaction between serum amyloid A and Toll-like receptor 2 pathway regulates inflammatory cytokine secretion in human gingival fibroblasts.

    abstract:BACKGROUND:Serum amyloid A (SAA) has been identified to trigger inflammation response, and play a crucial role in chronic inflammatory diseases. However, the regulatory mechanism of SAA still remains unclear during the development of periodontitis METHODS: SAA mRNA and protein expression were detected in healthy and in...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.19-0050

    authors: Song LT,Lai W,Li JS,Mu YZ,Li CY,Jiang SY

    更新日期:2020-01-01 00:00:00

  • The effects of platelet-derived growth factor-BB on periodontal cells in an in vitro wound model.

    abstract:BACKGROUND:Platelet-derived growth factor (PDGF-BB) has been shown to enhance periodontal regeneration. Principles of guided tissue regeneration dictate that one of the goals of therapy is to modulate the wound healing processes to favor repopulation of the wound with cells derived from the periodontal ligament rather ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.3.331

    authors: Mumford JH,Carnes DL,Cochran DL,Oates TW

    更新日期:2001-03-01 00:00:00

  • Effect of carrageenan-induced inflammation on the binucleate keratinocytes of guinea pig palatal mucosa.

    abstract::A 1% carrageenan solution was injected into the palatal mucosa of male guinea pigs between the two first molars. Biopsy specimens were taken 1, 3, 6, 12 and 24 hours after the injection. Control specimens with healthy mucosa and tyrode injected mucosa were used in order to evaluate the carrageenan-induced inflammation...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1979.50.3.114

    authors: Daniel A,Fournier B

    更新日期:1979-03-01 00:00:00

  • The use of blade implants in a selected population of partially edentulous adults. A five-year report.

    abstract::Based on the findings observed after the insertion of 33 blade implants in 23 patients, ages 31 to 74, for periods up to 60 months, the following conclusions can be made: (1) The blade implant is a technically feasible procedure which can be maintained in the mouth for period up to 5 years, although some degree of bon...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1976.47.1.19

    authors: Smithloff M,Fritz ME

    更新日期:1976-01-01 00:00:00

  • Clinical and microbiologic effects of local tetracycline irrigation on periodontitis.

    abstract::This investigation was conducted on seven individuals referred for treatment of moderate adult periodontitis. Twenty-eight sites with an average probing depth of 5.6 +/- 0.9 mm were evaluated. One tooth per jaw quadrant was randomly assigned to receive one of the following treatments: (I) no treatment, i.e., control; ...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.1988.59.5.301

    authors: Silverstein L,Bissada N,Manouchehr-Pour M,Greenwell H

    更新日期:1988-05-01 00:00:00