Abstract:
:Connexin 43 (Cx43) is the major connexin protein in ventricular cardiomyocytes. Six Cx43 proteins assemble into so-called hemichannels at the sarcolemma and opposing hemichannels form gap junctions, which allow the passage of small molecules and electrical current flow between adjacent cells. Apart from its localization at the plasma membrane, Cx43 is also present in cardiomyocyte mitochondria, where it is important for mitochondrial function in terms of oxygen consumption and potassium fluxes. The expression of gap junctional and mitochondrial Cx43 is altered under several pathophysiological conditions among them are hypertension, hypertrophy, hypercholesterolemia, ischemia/reperfusion injury, post-infarction remodeling, and heart failure. The present review will focus on the role of Cx43 in cardiovascular diseases and will highlight the importance of mitochondrial Cx43 in cardioprotection.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Boengler K,Schulz Rdoi
10.1007/978-3-319-55330-6_12subject
Has Abstractpub_date
2017-01-01 00:00:00pages
227-246eissn
0065-2598issn
2214-8019journal_volume
982pub_type
杂志文章,评审abstract::Porphyrins form extremely stable chelates with Cu2+. Two copper radionuclides, 67Cu and 64Cu, have attractive nuclear decay properties for use in nuclear medicine applications. We have investigated the use of radiocopper-labeled porphyrins for localization in inflamed tissue and for attachment to antibodies for tumor ...
journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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doi:
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