Spleen size and chromosome analysis as prognostic factors in chronic myelogenous leukemia.

Abstract:

:Of 72 patients with chronic myelogenous leukemia (CML), 37 were Ph1 positive, eight were negative, and 27 were not evaluated for the Ph1 chromosome. Of the 37 patients positive for Ph1, 31 had adequate evaluation. These 31 patients were reviewed for survival with reference to spleen size. Seventeen patients with spleens 3 cm or less below the left costal margin had a 50% survival of 75 months, with a mean survival of 53.9 months. Fourteen patients with spleens greater than 3 cm below the left costal margin had a 50% survival of 21 months, with a mean survival of 19 months (P = .0014). It is concluded that small splenic size in CML is associated with longer survival. It may be that this observation should be taken into consideration when considering splenectomy in the management of patients with CML.

journal_name

South Med J

journal_title

Southern medical journal

authors

Collins RK,Jackson JF,Morrison FS,Meydrech EF

doi

10.1097/00007611-197906000-00003

subject

Has Abstract

pub_date

1979-06-01 00:00:00

pages

642-4, 651

issue

6

eissn

0038-4348

issn

1541-8243

journal_volume

72

pub_type

杂志文章
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  • Prevalence and Clinical Impact of Atrial Fibrillation in Patients with Pulmonary Embolism.

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    更新日期:1992-04-01 00:00:00

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    更新日期:1992-08-01 00:00:00

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    authors: Tobin HM,Hiratzka LF,Vargish T

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    更新日期:1991-02-01 00:00:00

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    更新日期:1985-08-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1992-07-01 00:00:00

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    pub_type: 杂志文章

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  • Bilateral renal loss resulting from intravesical formalin instillation.

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    pub_type: 杂志文章

    doi:10.1097/00007611-197809000-00029

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    更新日期:1978-09-01 00:00:00

  • Unusual presentation of pheochromocytoma with ischemic sigmoid colitis and stenosis.

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    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181b571e6

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    doi:

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    更新日期:1979-03-01 00:00:00