Heat Waves, Drugs with Anticholinergic Effects, and Outcomes in Older Hospitalized Adults.


OBJECTIVES:To determine whether heat waves (HWs) affect exposure to drugs with anticholinergic effects (DACEs) on admission and the effect of such on length of stay (LOS) and in-hospital mortality in older adults. DESIGN:Retrospective. SETTING:Metropolitan teaching hospital. PARTICIPANTS:Individuals aged 65 and older with at least one chronic condition (n = 307) admitted to a medical ward during five consecutive HWs (≥5 consecutive days of a maximum temperature of ≥35 °C or ≥3 consecutive days of a maximum temperature of ≥40 °C) recorded between 2007 and 2009. Individuals admitted before or after each HW, matched for HW period, age, and day of the week admitted, served as controls (n = 1,114). MEASUREMENTS:Data on clinical and demographic characteristics, Charlson Comorbidity Index (CCI), total medication and DACE exposure on admission (any DACE, number of DACEs, or Anticholinergic Risk Scale (ARS) score), LOS, and in-hospital mortality were collected using electronic medical data. RESULTS:No significant differences in total medications, DACE exposure, CCI, number of daily admissions, LOS, or in-hospital mortality were observed between the HW and control groups. DACE exposure (ARS) predicted longer LOS during non-HW (β = 0.70, standard error (SE) = 0.27, P = .01) but not HW (β = 0.02, SE = 0.46, P = .96) periods. ARS did not predict mortality during non-HW (odds ratio (OR) = 1.02, SE = 0.12, P = .87) or HW (OR = 1.21, SE = 0.23, P = .31) periods. CONCLUSION:The effect of DACE exposure on LOS, but not mortality, is different between HW and non-HW periods in older hospitalized adults. This should be considered when assessing the effect of DACEs in pharmacoepidemiological studies.


J Am Geriatr Soc


Mangoni AA,Kim S,Hakendorf P,Mayner L,Woodman RJ




Has Abstract


2016-05-01 00:00:00












  • Assessing environmentally determined mobility disability: self-report versus observed community mobility.

    abstract:OBJECTIVES:To examine the test-retest reliability and concurrent validity of a new self-report measure of mobility function by comparing it with observed mobility, self-reported activity of daily living (ADL) function, and performance-based measures of gait and balance. DESIGN:Cross-sectional study involving two group...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究


    authors: Shumway-Cook A,Patla A,Stewart AL,Ferrucci L,Ciol MA,Guralnik JM

    更新日期:2005-04-01 00:00:00

  • Is there an association between metabolic syndrome and cognitive function in very old adults? The Newcastle 85+ Study.

    abstract:OBJECTIVES:To determine, using data from the Newcastle 85+ Study, whether there is an association between modern diagnostic criteria for metabolic syndrome (MetS) and cognitive function in very old adults (≥85) and whether inflammation, physical activity, or diabetes mellitus status affects this association. DESIGN:Lo...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Harrison SL,Stephan BC,Siervo M,Granic A,Davies K,Wesnes KA,Kirkwood TB,Robinson L,Jagger C

    更新日期:2015-04-01 00:00:00

  • A Hospital Partnership with a Nursing Home Experiencing a COVID-19 Outbreak: Description of a Multiphase Emergency Response in Toronto, Canada.

    abstract::Nursing homes have become "ground zero" for the coronavirus disease 2019 (COVID-19) epidemic in North America, with homes experiencing widespread outbreaks, resulting in severe morbidity and mortality among their residents. This article describes a 371-bed acute-care hospital's emergency response to a 126-bed nursing ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Stall NM,Farquharson C,Fan-Lun C,Wiesenfeld L,Loftus CA,Kain D,Johnstone J,McCreight L,Goldman RD,Mahtani R

    更新日期:2020-07-01 00:00:00

  • The frailty identity crisis.

    abstract::Frailty is a common and central problem of old age. Recent research has defined frailty as an accumulation of deficits or as a distinct clinical syndrome involving specific comorbid physical disorders and functional impairment, but the psychological aspects of frailty have received little attention. It is proposed tha...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Fillit H,Butler RN

    更新日期:2009-02-01 00:00:00

  • Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort.

    abstract:OBJECTIVES:To apply diagnostic criteria for mild cognitive impairment (MCI) to a geographically representative sample, to estimate the prevalence of MCI, and to estimate 10-year trajectories of incident disability for cognitively intact participants and subgroups with MCI. DESIGN:Prospective cohort; 10 years of follow...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Purser JL,Fillenbaum GG,Pieper CF,Wallace RB

    更新日期:2005-11-01 00:00:00

  • Asymptomatic bacteriuria, urinary antibody, and survival in the institutionalized elderly.

    abstract:OBJECTIVE:To compare clinical status of elderly institutionalized subjects with asymptomatic bacteriuria and normal urinary antibody to those with elevated urinary antibody to the major outer membrane of Escherichia coli. DESIGN:Retrospective review. SETTING:Long term facility for the elderly. PARTICIPANTS:Convenien...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Nicolle LE,Brunka J,McIntyre M,Murray D,Harding GK

    更新日期:1992-06-01 00:00:00

  • Effect of aging on serum albumin.

    abstract::Some studies have shown a negative association between age and serum albumin. Several of these studies included older people with known disease. Disease may reduce albumin in any age group. Other studies have shown no association between age and albumin. To investigate the association of age and albumin, albumin level...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Cooper JK,Gardner C

    更新日期:1989-11-01 00:00:00

  • Immunologic response to a single dose of tetanus toxoid in older people.

    abstract:OBJECTIVES:Several studies have demonstrated that a large percentage of older people are inadequately immunized against tetanus. The aim of this study was to assess the immunity against tetanus in a group of individuals aged 69 and older and to examine the immune response to a single dose of tetanus toxoid. DESIGN:A c...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Shohat T,Marva E,Sivan Y,Lerman I,Mates A,Cohen A

    更新日期:2000-08-01 00:00:00

  • Doxorubicin (adriamycin) therapy of uterine sarcoma without surgery in an elderly patient.

    abstract::A case is presented of primary endolymphatic stromal sarcoma of the uterus in a debilitated elderly patient. Surgical intervention was contraindicated. Radium therapy was unsuccessful. A 4-month course of treatment with doxorubicin (Adriamycin) resulted in disappearance of the tumor. The patient is living 19 months af...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Adducci JE

    更新日期:1976-10-01 00:00:00

  • Use of self-report to predict ability to walk 400 meters in mobility-limited older adults.

    abstract:OBJECTIVES:To determine whether the ability to walk 400 m could be predicted from self-reported walking habits and abilities in older adults and to develop an accurate self-report measure appropriate for observational trials of mobility when functional measures are impractical to collect. DESIGN:Cross-sectional. SETT...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Sayers SP,Brach JS,Newman AB,Heeren TC,Guralnik JM,Fielding RA

    更新日期:2004-12-01 00:00:00

  • Compression injury of the sciatic nerve during a prolonged surgical procedure in a diabetic patient.

    abstract::Patients with diabetes mellitus and an underlying mixed axonal and demyelinating polyneuropathy are particularly prone to compression neuropathies with consequent axonal degeneration and a poor prognosis for recovery. This hazard should be taken into account whenever a prolonged surgical procedure is contemplated. An ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Massey EW,Pleet AB

    更新日期:1980-04-01 00:00:00

  • Long-term systemic inflammation and cognitive impairment in a population-based cohort.

    abstract:OBJECTIVES:Evidence suggests inflammation is associated with cognitive impairment, but previous epidemiological studies have reported conflicting results. DESIGN:Prospective population-based cohort. SETTING:Epidemiology of Hearing Loss Study participants. PARTICIPANTS:Individuals without cognitive impairment in 1998...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Wichmann MA,Cruickshanks KJ,Carlsson CM,Chappell R,Fischer ME,Klein BE,Klein R,Tsai MY,Schubert CR

    更新日期:2014-09-01 00:00:00

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    abstract::In reviewing the literature on treatment approaches with the psychiatric elderly, a large number of studies were found which espouse comprehensive rehabilitation programs that usually require supplementation of existing personnel and expansion of facilities. Although some agencies and institutions are fortunate in sec...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Goga JA,Hambacher WO

    更新日期:1977-07-01 00:00:00

  • Apathy: Risk Factor for Mortality in Nursing Home Patients.

    abstract:OBJECTIVES:To determine the prognostic value of apathy for mortality in patients of somatic (SC) and dementia special care (DSC) nursing home (NH) units. DESIGN:Longitudinal design, secondary analyses of a 2-year, cluster-randomized trial with six measurements, approximately 4 months in between. SETTING:SC and DSC-un...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Nijsten JMH,Leontjevas R,Pat-El R,Smalbrugge M,Koopmans RTCM,Gerritsen DL

    更新日期:2017-10-01 00:00:00

  • The relationship between age and process of care and patient tolerance of bronchoscopy.

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Hehn BT,Haponik E,Rubin HR,Lechtzin N,Diette GB

    更新日期:2003-07-01 00:00:00

  • Use of Electronic Health Records by Older Adults, 85 Years and Older, and Their Caregivers.

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Ramirez-Zohfeld V,Seltzer A,Xiong L,Morse L,Lindquist LA

    更新日期:2020-05-01 00:00:00

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Verreault R,Semba RD,Volpato S,Ferrucci L,Fried LP,Guralnik JM

    更新日期:2002-05-01 00:00:00

  • Reduced incidence of endometrial cancer among postmenopausal women treated with progestogens.

    abstract::Because of adverse publicity regarding increased risk of endometrial cancer in women receiving estrogen therapy, a 2-year prospective study was conducted in 1976 to determine the incidence of endometrial cancer in postmenopausal women. A retrospective study for the year 1975 was also added. A postmenopausal survey c...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Gambrell RD Jr,Massey FM,Castaneda TA,Ugenas AJ,Ricci CA

    更新日期:1979-09-01 00:00:00

  • Adiponectin isoforms in elderly patients with or without coronary artery disease.

    abstract:OBJECTIVES:To study the distribution of adiponectin isoforms in a group of very old patients. DESIGN:Cross-sectional. SETTING:Geriatric ambulatory clinic of the Department of Medicine at Policlinico "Tor Vergata." PARTICIPANTS:One hundred eight elderly adults (mean age 85.0+/-3.2) with or without a history of a prev...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Rizza S,Gigli F,Galli A,Micchelini B,Lauro D,Lauro R,Federici M

    更新日期:2010-04-01 00:00:00

  • Accelerometer-Measured Hospital Physical Activity and Hospital-Acquired Disability in Older Adults.

    abstract:BACKGROUND:Hospital-acquired disability (HAD) is common and often related to low physical activity while in the hospital. OBJECTIVE:To examine whether wearable hospital activity trackers can be used to predict HAD. DESIGN:A prospective observational study between January 2016 and March 2017. SETTING:An academic medi...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Pavon JM,Sloane RJ,Pieper CF,Colón-Emeric CS,Cohen HJ,Gallagher D,Hall KS,Morey MC,McCarty M,Hastings SN

    更新日期:2020-02-01 00:00:00

  • A behavior management program to increase social responses in psychogeriatric patients.

    abstract::Although increased numbers of psychogeriatric patients have been placed in proprietary nursing homes in recent years, many facilities have not been able to accommodate the behavioral problems involved. This study summarizes the results of a behavior management program for improving the social functioning and social be...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Nigl AJ,Jackson B

    更新日期:1981-02-01 00:00:00

  • Correlation Between Use of Zopiclone and Risk of Hip Fracture in Elderly Adults: A Case-Control Study in Taiwan.

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Lai SW,Lin CL,Chen WC,Liao KF

    更新日期:2015-12-01 00:00:00

  • Lower body functioning prevalence and correlates in older American Indians in a southeastern tribe: the Native Elder Care Study.

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Goins RT,Innes K,Dong L

    更新日期:2012-03-01 00:00:00

  • Europe-wide survey of teaching in geriatric medicine.

    abstract::By 2050, the European population of 720 million will include 187 million (one quarter) octogenarians. Although living longer is a true privilege, care for the graying population suffering from chronic and disabling diseases will raise enormous challenges to healthcare systems and geriatric education. Are European coun...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Michel JP,Huber P,Cruz-Jentoft AJ

    更新日期:2008-08-01 00:00:00

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Lindquist LA,Ramirez-Zohfeld V

    更新日期:2019-06-01 00:00:00

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Russo-Magno P,O'Brien A,Panciera T,Rounds S

    更新日期:2001-09-01 00:00:00

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Andresen EM,Patrick DL,Carter WB,Malmgren JA

    更新日期:1995-09-01 00:00:00

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Cole M,McCusker J,Dendukuri N,Han L

    更新日期:2003-06-01 00:00:00

  • Sarcopenia Definition & Outcomes Consortium Defined Low Grip Strength in Two Cross-Sectional, Population-Based Cohorts.

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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


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    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验


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    更新日期:2008-10-01 00:00:00