Abstract:
:Ninety-three consecutive outpatients receiving tricyclic antidepressants for at least one month were asked about medication side effects, including excessive appetite and craving for sweets. Prevalence of these side effects and their relationship (Pearson r) to type of medication, dosage, patient characteristics, diagnoses, weight gain, and clinical improvement were examined. More than one-third (38%) reported excessive appetite, 34% had a craving for sweets, and about one-half (48%) had either one or the other of these reactions. These adverse side effects were related significantly to weight gain (P less than .001) and a higher dose of medication, but not to clinical improvement. Clinical improvement was in the moderate-to-good range but was not related to medication dose. Because increasing degrees of overweight can pose serious health risks, especially for the elderly, it is critical for future research to examine ways of maintaining therapeutic benefit while minimizing food craving side effects. Methods of dealing with these issues clinically are suggested.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Stein EM,Stein S,Linn MWdoi
10.1111/j.1532-5415.1985.tb01777.xsubject
Has Abstractpub_date
1985-10-01 00:00:00pages
687-92issue
10eissn
0002-8614issn
1532-5415journal_volume
33pub_type
杂志文章abstract::This study was designed to determine which elements professionals consider important for evaluation of decision-making capacity. Survey with a vignette case report of an individual with mild dementia was mailed to four groups of individuals: 1. members of the Academy of Psychosomatic Medicine, 2. chairs of Veterans Af...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2003.51412.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To identify presenting characteristics of older patients with subdural hematoma who are unlikely to survive hospitalization. DESIGN:A retrospective cohort. PATIENTS:All patients > or = 65 years of age hospitalized at a tertiary care center from 1985-1990 with the primary diagnosis of subdural hematoma. MEA...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1995.tb07329.x
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVES:To examine the relationship between cognitive function and self-reported oral health-related quality of life (HRQoL) in community-dwelling older adults. DESIGN:Cross-sectional. SETTING:Community in West Virginia. PARTICIPANTS:Two hundred twenty-six community-dwelling older adults. MEASUREMENTS:Oral HRQoL...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12402
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:To characterize rehabilitation services use of older adults according to fall-risk classification based on screening guidelines. DESIGN:Cross-sectional analysis of 2015 National Health and Aging Trends Study. SETTING:Study participants' homes. PARTICIPANTS:National sample of 7,440 community-dwelling Medic...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15625
更新日期:2019-01-01 00:00:00
abstract::As nursing homes become increasingly important sites for biomedical and behavioral research, researchers must address the ethical problems of increased vulnerability and the high prevalence of mental and physical disorders in the nursing home population. Obtaining valid informed consent is but one of the many difficul...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.1993.tb07470.x
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVES:To examine the neuropsychological and clinical profile of help-seekers in an early-detection community dementia program and to explore any relationship between profiles and time to seek help. DESIGN:Cross-sectional. SETTING:Early-detection community dementia program. PARTICIPANTS:Help-seekers (N = 1,005) ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.13938
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine physical activity and the predictors of physical activity and exercise among nursing home residents. DESIGN:Population study. PARTICIPANTS:The sample (n = 190) was obtained by selecting every man and every second women from the entire nursing home population (n = 346...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1994.tb06593.x
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVES:To understand the natural history of frailty after an aggressive surgical intervention, kidney transplantation (KT). DESIGN:Prospective cohort study (December 2008-March 2014). SETTING:Baltimore, Maryland. PARTICIPANTS:Kidney transplantation recipients (N = 349). MEASUREMENTS:The Fried frailty score was ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.13657
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:To develop and validate a picture-based memory impairment screen (PMIS) for the detection of dementia. DESIGN:Cross-sectional. SETTING:Outpatient clinics, Baby Memorial Hospital, Kozhikode city in the southern Indian state of Kerala. PARTICIPANTS:Three hundred four community-residing adults aged 55 to 94 ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2012.04191.x
更新日期:2012-11-01 00:00:00
abstract::Thirty-two demented, elderly residents of a nursing home were admitted to a specially designed dementia unit. Each patient was assessed three times: prior to admission, and at four and 12 months after admission to the unit. Patients were evaluated using a modified version of a previously published assessment scale as ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1987.tb04638.x
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVES:To examine the effects of dehydroepiandrosterone (DHEA) supplementation on cognitive function and quality of life in healthy older adults. DESIGN:Double-blind, randomized, controlled clinical trial. SETTING:Clinical research facility. PARTICIPANTS:One hundred ten men and 115 women aged 55 to 85 (mean +/- ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1532-5415.2008.01768.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:To describe the features of community-acquired pneumonia (CAP) requiring hospitalization in subjects receiving home care. DESIGN:Prospective study from November 15, 2000, to November 14, 2002. SETTING:Six hospitals in the Edmonton, Canada, area. PARTICIPANTS:Two thousand four hundred sixty-four subjects a...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2005.53264.x
更新日期:2005-05-01 00:00:00
abstract::Thyroid disease in the aged, both hypothyroidism and hyperthyroidism, may be subtle or may be present with no clinical symptoms and signs, and is therefore difficult to diagnose on the basis of clinical evaluation. The help of the laboratory is essential in making the diagnosis of disease of the thyroid. Therapeutic s...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.1993.tb06488.x
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVES:To assess the effect of a Screening Tool of Older Persons potentially inappropriate Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) medication intervention on clinical and economic outcomes. DESIGN:Parallel-group randomized trial. SETTING:Chronic care geriatric facility. PAR...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,随机对照试验
doi:10.1111/jgs.12993
更新日期:2014-09-01 00:00:00
abstract::It has been reported that postural hypotension in the elderly is common. However, these studies included institutionalized and more or less disabled persons. Furthermore, postural hypotension may be related to baseline blood pressure. In this study, the influence of age and blood pressure on the hemodynamic and plasma...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1989.tb05684.x
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the skeletal health, calcium, and vitamin D homeostasis of patients upon their entry to a long-term-care facility. Factors that could contribute to the risk of future osteoporotic fractures were also evaluated. DESIGN:Cross-sectional study. PATIENTS:Two hundred eighty-seven consecutive admission...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1993.tb06452.x
更新日期:1993-10-01 00:00:00
abstract::Prescription drugs are not always taken as directed. When there is a discrepancy between the use of a drug and the prescription directions, the drug-taking behavior is considered "nonadherent." To determine the extent of prescription non adherence by old persons and the reasons for nonadherence, an in-home survey was ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1982.tb05623.x
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVES:To determine whether a distance coaching course on improving nursing home incontinence care could be replicated and brought to scale with a larger group of nursing homes without sacrificing outcomes. DESIGN:The study collected descriptive and comparative data. SETTING:Fourteen nursing homes in the original...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2012.03939.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of psychotropic medication withdrawal and a home-based exercise program in reducing falls in older people. DESIGN:A randomized controlled trial with a two by two factorial design. SETTING:Seventeen general practices in Dunedin, New Zealand. PARTICIPANTS:Women and men aged 65 yea...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1532-5415.1999.tb03843.x
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVES:To estimate the incidence of chronic activities of daily living (ADL) disability and to analyze the sociodemographic, health status, adverse lifestyle, and leisure-time physical activity predictors for chronic ADL disability. DESIGN:We recruited a cohort of community-dwelling older people in Taipei, Taiwan,...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1999.tb05231.x
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:Older people approaching end of life are commonly prescribed multiple medications, many of which may be inappropriate or futile. Our objective was to examine the effect of applying the STOPPFrail, a recently developed deprescribing tool, to the medication regimens of older patients with advanced frailty. DE...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16278
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:To investigate the effects of the changes in serum bioavailable and total testosterone (TT) levels with aging on visceral body fat distribution and muscle strength in Chinese men. DESIGN:Cross-sectional study. SETTING:Ambulatory care. PARTICIPANTS:Four hundred seventy-five healthy ambulatory Chinese men (...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2008.01746.x
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:The serum concentration of interleukin 6 (IL-6), a cytokine that plays a central role in inflammation, increases with age. Because inflammation is a component of many age-associated chronic diseases, which often cause disability, high circulating levels of IL-6 may contribute to functional decline in old age...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1999.tb01583.x
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To compare clinical status of elderly institutionalized subjects with asymptomatic bacteriuria and normal urinary antibody to those with elevated urinary antibody to the major outer membrane of Escherichia coli. DESIGN:Retrospective review. SETTING:Long term facility for the elderly. PARTICIPANTS:Convenien...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1992.tb02112.x
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVES:To determine whether cognitive test scores and cognitive decline predict incidence of first diagnosed stroke. DESIGN:Stroke-free Health and Retirement Study participants were followed on average 7.6 years for self- or proxy-reported first stroke (1,483 events). Predictors included baseline performance on a ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2008.02132.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:To review the epidemiology, pathophysiology, and etiology of congestive heart failure (CHF) in older adults. METHODS:Published reports relevant to the epidemiology, pathophysiology, and etiology of CHF were systematically reviewed. Studies involving older adults and more recent studies were emphasized. RES...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.1997.tb02968.x
更新日期:1997-08-01 00:00:00
abstract:PURPOSE:To determine whether the management of heart failure by specialized multidisciplinary heart failure disease-management programs was associated with improved outcomes. BACKGROUND:The advent of angiotensin-converting enzyme inhibitors, beta-blockers, and spironolactone has revolutionized the management of heart ...
journal_title:Journal of the American Geriatrics Society
pub_type: 评论,杂志文章
doi:10.1046/j.1532-5415.2002.50418.x
更新日期:2002-09-01 00:00:00
abstract::Japan implemented a mandatory social long-term care insurance (LTCI) system in 2000, making long-term care services a universal entitlement for every senior. Although this system has grown rapidly, reflecting its popularity among seniors and their families, it faces several challenges, including skyrocketing costs. Th...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.2007.01281.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:To elucidate the relationship between stroke and depressive symptoms and to determine whether disability or cerebrovascular risk factors mediate that relationship. DESIGN:A prospective longitudinal epidemiological survey. SETTING:The mid-Monongahela Valley, a rural, nonfarm, low-socioeconomic-status commun...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2004.52217.x
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVES:To determine the proportion of untreated women who reported receiving treatment after incident fracture and to identify factors that predict treatment across an international spectrum of individuals. DESIGN:Prospective observational study. Self-administered questionnaires were mailed at baseline and 1 year....
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1532-5415.2011.03854.x
更新日期:2012-03-01 00:00:00