Altered Expression of Imprinted Genes in Squamous Cell Carcinoma of the Head and Neck.

abstract：UNLABELLED:BACKGROND/AIM: Recent evidence indicates that inflammation is a hallmark of cancer. Tumor-associated neutrophils (TANs) contribute to tumor invasion. However, whether TANs and lymph node metastasis are related is unknown. Intranodal lymphatic vessel density (LVD) is significantly correlated with tumor progre...

journal_title：Anticancer research

authors： Tokumoto M,Tanaka H,Ohira M,Go Y,Okita Y,Sakurai K,Toyokawa T,Kubo N,Muguruma K,Maeda K,Sawada T,Hirakawa K

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:The aim of this study was to examine the interobserver variance in delineating the contour of unresectable pancreatic cancer for chemoradiotherapy. PATIENTS AND METHODS:CT images of two cases of unresectable pancreatic tumors (head and body cancer) were sent to eight radiation therapy facilities in a CD-ROM...

journal_title：Anticancer research

authors： Yamazaki H,Nishiyama K,Tanaka E,Koiwai K,Shikama N,Ito Y,Arahira S,Tamamoto T,Shibata T,Tamaki Y,Kodaira T,Oguchi M

更新日期：2007-07-01 00:00:00

abstract：AIM:To investigate the possibility of enhancing an anti-metastatic effect of 5-fluorouracil (5-FU) on colorectal cancer (CRC) cells by combining it with continuous calcium supplementation. MATERIALS AND METHODS:Optimal doses of 5-FU with/without lactate salt (CaLa) were determined via clonogenicity and 3-(4,5-dimethyl...

journal_title：Anticancer research

authors： Park M,Sundaramoorthy P,Sim JJ,Jeong KY,Kim HM

更新日期：2017-01-01 00:00:00

abstract：:Chronic lymphocytic leukaemia remains the most common adult leukaemia in Western countries. In this review we tried to give an overview of the important prognostic markers and the developments in this field. We also reflected about the accumulative character of the disease and the influence of the micro-environment on...

journal_title：Anticancer research

authors： Boelens J,Lust S,Vanhoecke B,Offner F

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Chagas disease patients with longstanding megaesophagus have a significantly increased risk for esophageal carcinoma. MATERIALS AND METHODS:PCR-SSCP analysis and DNA sequencing of esophageal mucosa from Chagas disease patients (with or without megaesophagus) in the exons of the TP53, CDKN2A and FHIT genes w...

journal_title：Anticancer research

authors： DA Silva Manoel-Caetano F,Silveira AF,Silva AE

更新日期：2009-04-01 00:00:00

abstract：:An in vitro pilot study was conducted of the possible utility of combining low doses of cytosine arabinoside (araC) and GM-CSF to stimulate leukemic cell differentiation. Cytosine arabinoside induced macrophage differentiation in some cultures but only when the drug produced substantial cytostatic effects. GM-CSF, whe...

journal_title：Anticancer research

authors： Gao XZ,Yin MY,Preisler HD

更新日期：1989-07-01 00:00:00

abstract：AIM:To describe the feasibility, safety, and oncological outcomes of a modified triple-incision total radical vulvectomy and inguino-femoral lymphadenectomy in patients with locally advanced squamous vulvar cancer. PATIENTS AND METHODS:A modified triple-incision technique performed by two surgical teams operating simu...

journal_title：Anticancer research

authors： Fambrini M,Sorbi F,Sisti G,Checcucci V,Cariti G,Scotti V,Tinacci E,Turrini I,Micaglio M,De Magnis A

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND/AIM:Bone metastases are associated with increased morbidity and poor prognosis in a variety of cancers. The present study investigated the effects of targeted radionuclide therapy with α-emitting, bone-seeking radium-224 (224Ra) on osteolytic bone metastasis of MDA-MB-231(SA)-GFP human breast cancer cells in...

journal_title：Anticancer research

authors： Juzeniene A,Bernoulli J,Suominen M,Halleen J,Larsen RH

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Although p21 is an important component that regulates cell-cycle progression, no consensus has been reached about its clinicopathological significance in esophageal squamous cell carcinoma (ESCC). In the present study, we investigated its prognostic significance and correlation with cyclin-D1 (CCND1) express...

journal_title：Anticancer research

authors： Shiozaki A,Nakashima S,Ichikawa D,Fujiwara H,Konishi H,Komatsu S,Kubota T,Okamoto K,Iitaka D,Shimizu H,Nako Y,Takemoto K,Kishimoto M,Otsuji E

更新日期：2013-10-01 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (CDDP) is the most active anticancer agent. It has been reported that intracellular accumulation of CDDP is an important step as a determinant for resistance to CDDP, which may be modulated by Na+, K(+)-ATPase activity. In this study, the significance of membrane Na+, K(+)-ATPase activ...

journal_title：Anticancer research

authors： Bando T,Fujimura M,Kasahara K,Matsuda T

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS:We examined the expression pattern of SHH and its signal proteins in clin...

journal_title：Anticancer research

authors： Kuroda H,Kurio N,Shimo T,Matsumoto K,Masui M,Takabatake K,Okui T,Ibaragi S,Kunisada Y,Obata K,Yoshioka N,Kishimoto K,Nagatsuka H,Sasaki A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Shortened, constitutively active androgen receptor (AR) isoforms have been characterized and linked to tumor progression and chemoresistance in prostate cancer (PCa). We examined the regulation of shortened AR isoforms by a newly-identified AR regulatory signaling pathway involving heat-shock protein HSPB1 a...

journal_title：Anticancer research

authors： Stope MB,Bradl J,Peters S,Streitbörger A,Weiss M,Zimmermann U,Walther R,Lillig CH,Burchardt M

更新日期：2013-11-01 00:00:00

abstract：:The antitumor effects of the somatostatin structural derivative TT-232 in different rodent and xenograft tumor models are summarized in this report. TT-232 had previously been shown to inhibit the proliferation of a large number of cancer cell lines in vitro and reduce the size of different tumors in animal models in ...

journal_title：Anticancer research

authors： Tejeda M,Gaál D,Hullán L,Hegymegi-Barakonyi B,Kéri G

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:SagA1 and SagA2 molecules produced from beta-hemolytic Streptococcus anginosus subsp. anginosus are composed of a leader peptide and a propeptide, and their mature form has hemolytic activity as a well-known Streptococcal peptide toxin, streptolysin. The function of these SagA molecules is thought to be depe...

journal_title：Anticancer research

authors： Kawaguchi Y,Tabata A,Nagamune H,Ohkura K

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Breast cancer cells frequently metastasize to the skeleton and produce and secrete proteinases, such as matrix metalloproteinase-13 (MMP-13), which promote destruction of the bone matrix. However, the mechanism of MMP-13 expression induced in areas of bone metastasis is unknown. Here, the interaction between...

journal_title：Anticancer research

authors： Ibaragi S,Shimo T,Hassan NM,Isowa S,Kurio N,Mandai H,Kodama S,Sasaki A

更新日期：2011-04-01 00:00:00

abstract：UNLABELLED:The quantity and quality of circulating DNA fragments was analyzed by quantitative real-time polymerase chain reactions (qPCR) in plasma from patients with esophageal carcinomas, in order to assess their diagnostic value. PATIENTS AND METHODS:Plasma was collected preoperatively from 24 patients with esophag...

journal_title：Anticancer research

authors： Tomita H,Ichikawa D,Ikoma D,Sai S,Tani N,Ikoma H,Fujiwara H,Kikuchi S,Okamoto K,Ochiai T,Otsuji E

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Preclinical studies have indicated that BRCA1 functions differentially to modulate the chemosensitivity of cancer cells. PATIENTS AND METHODS:To clarify these findings, BRCA1 expression in primary tumors was evaluated by immunohistochemistry in 50 patients with metastatic breast cancer. RESULTS:BRCA1 expre...

journal_title：Anticancer research

authors： Kurebayashi J,Yamamoto Y,Kurosumi M,Okubo S,Nomura T,Tanaka K,Sonoo H

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Embryonic stem cell expressed Ras (ERas) oncogene is associated with the tumorigenicity of embryonic stem cells. The aim of this study was to clarify the significance of ERas expression in clinical samples of gastric carcinomas. MATERIALS AND METHODS:Three hundred and few tissues from gastric cancer patient...

journal_title：Anticancer research

authors： Kaizaki R,Yashiro M,Shinto O,Yasuda K,Matsuzaki T,Sawada T,Hirakawa K

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND/AIM:Although insulin-like growth factor-1 (IGF-1) is well-implicated in cancer biology, the potential roles of IGF-1 variants in different types of cancer are largely unknown. The aim of the present study was to in vitro characterize several human cancers for their IGF-1 variant expression patterns. MATERIA...

journal_title：Anticancer research

authors： Christopoulos PF,Philippou A,Koutsilieris M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Alterations of mitochondrial DNA (mtDNA) have been found in cancer patients, therefore informative mtDNA mutations could serve as biomarkers for the disease. MATERIALS AND METHODS:The two hypervariable regions HVR1 and HVR2 in the D-Loop region were sequenced in ten paired tissue and plasma samples from bre...

journal_title：Anticancer research

authors： Cai FF,Kohler C,Zhang B,Chen WJ,Barekati Z,Garritsen HS,Lenner P,Toniolo P,Zhang JJ,Zhong XY

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND/AIM:To investigate whether high-dose-rate (HDR) intracavitary brachytherapy (IBT) dose ratios can predict treatment outcomes in patients with stage IIB cervical cancer. PATIENTS AND METHODS:Ninety-three patients treated with weekly cisplatin-based concurrent chemoradiotherapy and HDR IBT were analyzed. Pote...

journal_title：Anticancer research

authors： Cho O,Noh OK,Oh YT,Chang SJ,Chun M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) are ubiquitous environment-contaminating synthetic chemicals that have been associated with increased risk of hepatic cancer, melanoma, non-Hodgkin lymphoma and cancer of many other body organs. Structural binding analyses of PCB 77 and PCB 118 with peroxisome proliferator-ac...

journal_title：Anticancer research

authors： Sheikh IA,Khweek AA,Beg MA

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:In germ cell testicular tumors (GCTT) mdm-2 gene was analyzed for amplification and transcripts but not for protein. The purpose of this study is to determine whether mdm-2 protein level is aberrant in GCTT and if so, what is the relationship between mdm-2 overexpression and other disease parameters includin...

journal_title：Anticancer research

authors： Eid H,Institoris E,Géczi L,Bodrogi I,Bak M

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Although in vitro and clinical studies indicate that overexpression of P-glycoprotein (Pgp), p53, or metallothionein (MT) is involved in modulating drug resistance/sensitivity of cancer cells, the clinical relevance of the overexpression remains to be elucidated. MATERIALS AND METHODS:In this paper the expr...

journal_title：Anticancer research

authors： Eid H,Géczi L,Mágori A,Bodrogi I,Institoris E,Bak M

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND/AIM:NME/NM23 nucleoside diphosphate kinase 1 (NME1) is a metastasis suppressor gene, exhibiting reduced expression in metastatic cancers and the ability to suppress metastatic activity of cancer cells. We previously identified NME1-regulated genes with prognostic value in human melanoma. This study was condu...

journal_title：Anticancer research

authors： Pamidimukkala NV,Leonard MK,Snyder D,McCorkle JR,Kaetzel DM

更新日期：2018-11-01 00:00:00

abstract：:We have previously shown that transfection of NIH 3T3 cells with the T24 H-ras oncogene converts the cells to a tumorigenic and metastatic phenotype, in proportion to levels of ras expression. We hypothesize that ras-induced increases in malignancy occur via altered expression of various genes. We have identified OPN ...

journal_title：Anticancer research

authors： Chambers AF,Behrend EI,Wilson SM,Denhardt DT

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain-containing 7 (NLRP7) (pyrin-containing apoptotic protease activating factor-1-like protein 3; PYPAF3, NACHT domain-, leucine-rich repeat, and pyrin domain-containing 7; NALP7) has been thought to contribute to innate immunity a...

journal_title：Anticancer research

authors： Ohno S,Kinoshita T,Ohno Y,Minamoto T,Suzuki N,Inoue M,Suda T

更新日期：2008-07-01 00:00:00

abstract：:Two human herpesviruses, HHV-6 and HHV-7, recently identified and closely related, were studied for their influence on cellular apoptosis and proliferation. Infection was monitored by viral DNA--and antigen expression. Apoptosis and cell proliferation were determined by immunocytological techniques and the markers p53...

journal_title：Anticancer research

authors： Kirn E,Krueger E,Boehmer S,Klussmann JP,Krueger GR

更新日期：1997-11-01 00:00:00

abstract：:K-ras-NIH3T3 cells were more invasive than NIH3T3 cells in a chemotactic invasion assay. Conophylline, a new vinca alkaloid isolated as a ras function inhibitor, inhibited the invasion of K-ras-NIH3T3 cells, while it showed no effect on NIH3T3 cells. Conophylline did not increase expression of fibronectin but induced ...

journal_title：Anticancer research

authors： Amino N,Ohse T,Koyano T,Umezawa K

更新日期：1996-01-01 00:00:00

abstract：:The purpose of this analysis was to study the association between the quantity of free circulating DNA and clinical variables in 99 advanced non-small cell lung cancer patients (NSCLC). The quantification in the serum of the gene of the catalytic fraction of telomerase (hTERT) by RT-PCR was used as a reference of the ...

journal_title：Anticancer research

authors： Camps C,Sirera R,Bremnes RM,Ródenas V,Blasco A,Safont MJ,Garde J,Juarez A,Caballero C,Sanchez JJ,Taron M,Rosell R

更新日期：2006-11-01 00:00:00