Abstract：
OBJECTIVE:Glioblastoma multiforme (GBM) is an aggressive primary brain tumor with dismal survival. This study aims to examine the prognostic value of primary tumor sites and race on survival outcomes. METHODS:Patient data obtained from the Scott and White Hospital Brain Tumor Registry (1976-2013) were stratified according to sex, age, race, primary tumor site, vital status, and survival. RESULTS:Of the 645 patients, 580 (89.9%) were diagnosed with GBM not otherwise specified (GBM NOS), 57 (8.8%) with GBM, and 8 (1.2%) with giant-cell GBM. Most were male (53.5%), aged 50 years or older (78.7%). The white population had the highest GBM prevalence (87.1%) and the lowest overall survival versus all other race groups (6.6% vs. 30.1%; P < 0.01). The black population had a relatively low prevalence of GBM (5.9%) and the greatest overall survival versus all others (47.4% vs. 7.3%; P < 0.01). Primary tumor sites located in the temporal (25.8% vs. 20.2%; P = 0.03), occipital (8.1% vs. 2.9%; P = 0.05), and parietal lobes (24.2% vs. 20.8%; P = 0.05) had a greater occurrence in surviving individuals. The overall survival for men versus women was (62.9% vs. 37.1%; P = 0.12). CONCLUSIONS:Black racial background and temporal, occipital, or parietal primary tumor sites are suggestive of positive survival outcomes. Conversely, white racial background with primary tumor sites in the brain overlapping and NOS areas seem to be associated with negative outcomes and decreased survival. Thus, racial background and primary tumor site may be useful prognostic factors in patients with GBM.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Nizamutdinov D,Stock EM,Dandashi JA,Vasquez EA,Mao Y,Dayawansa S,Zhang J,Wu E,Fonkem E,Huang JHdoi
10.1016/j.wneu.2017.09.104subject
Has Abstractpub_date
2018-01-01 00:00:00pages
e67-e74eissn
1878-8750issn
1878-8769pii
S1878-8750(17)31611-Xjournal_volume
109pub_type
杂志文章abstract：INTRODUCTION:Intradural spinal arachnoid cysts (SACs) are among many etiologies for syringomyelia. Consequentially, neurologic symptoms arise such as pain, gait disturbance, and bladder dysfunction. Identification of SAC on magnetic resonance imaging (MRI) can be challenging, as SACs can be fenestrated or in the form o...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.11.004
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Spontaneous resolution of acute subdural hematomas (SDHs), occurring as the result of a traumatic injury, is well reported in the literature and rapidly resolving SDHs have been reported as well. Although the mechanism behind the rapid resolution of a SDH has not been well understood, there are postulated me...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.029
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Cyclooxygenase 2 (COX-2) is a key enzyme in the synthesis of prostaglandins. Recent studies have shown that overexpression of COX-2 can reduce the antitumor effect of the immune system by inhibiting the proliferation of B and T lymphocytes. Programmed cell death ligand 1 (PD-L1) was the first functionally ch...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.09.031
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:A possible risk factor for premature facet joint degeneration or adjacent segment degeneration after surgical treatment of spine fractures is facet joint violation (FV) during insertion of pedicle screws. The aim of this study was to determine risk factors for FV in the thoracic and lumbar spine after minimal...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.01.138
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Various complications after C1 lateral mass and C2 pedicle screw fusion surgery (C1LM-C2PSFS) have been reported. However, to our knowledge, this is the first report of contusional cerebellar hemorrhage caused by placement in the protrusion (chin-out) position after C1LM-2PSFS. CASE DESCRIPTION:An 81-year-o...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.01.092
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND AND IMPORTANCE:Lesions located lateral to the lower brainstem, such as proximal posterior inferior cerebellar artery (PICA) aneurysms, are surgically challenging. We report a case of a patient with a left proximal PICA aneurysm that was successfully clipped via a so-called "extended" suboccipital subtonsilla...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.06.019
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:Work hour restrictions and current quality, financial, and legal concerns have reduced resident operative volume and autonomy. Although laboratory (cadaveric or animal) dissection has a rich history in neurosurgery, its current role in resident training is unclear. Recent literature suggests educators have lo...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2014.05.028
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Incomplete penetration of a burr hole sometimes occurs when performing a craniotomy in elderly patients due to osteoporosis. Completion of the burr hole takes more time and may sometimes cause tearing of the dura mater. We have introduced a small bone piece method that can easily and reliably recover an inco...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.06.080
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Plaque characteristics play pivotal roles in ischemic events, but stenosis severity does not accurately reflect carotid plaque volume due to expansive remodeling in some patients with low-grade stenosis (LGS). This study aimed to assess the safety, efficacy, and durability of carotid endarterectomy (CEA) for...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.11.208
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:A critical step in the far lateral approach (FLA) is exposure of the V3 segment of the vertebral artery, located deep in the suboccipital triangle (SOT). Safe exposure of the SOT is achieved by means of a plane-by-plane dissection, which carries the risk of devascularization. A suitable alternative is to lif...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.02.090
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:To evaluate effect of obesity on 12-month functional outcomes after surgery for lumbar stenosis in adult patients. METHODS:Data were collected on patients treated with lumbar laminectomy for symptomatic lumbar spinal stenosis as part of an observational registry and analyzed using a retrospective cohort stud...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.06.072
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:There is an increasing trend toward skull base (SB) approaches and retractorless surgery to minimize brain manipulation during surgery. We evaluated the radiographic changes over time after surgical resection of anterior cranial fossa meningiomas with and without both SB approaches and/or fixed retractor syst...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.01.069
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:To avoid surgical site infections (SSIs) by identifying patients at high risk for infectious complications, a better understanding of relevant risk factors is required. This manuscript describes a matched case-control study of patients undergoing cranial neurosurgery with postoperative surgical site infectio...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2016.07.093
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:We sought to (1) describe psychological, physical, and cognitive functions in patients 10 years after intracranial aneurysm rupture and (2) identify any differences in outcome variables between age groups, gender or aneurysm locations. METHODS:A consecutive sample of patients (n=217) treated for intracranial...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2012.03.032
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Neoplasms located in the Meckel cave account for 0.2%-0.5% of all intracranial tumors. This area is the site of many types of pathologic lesions, most often trigeminal nerve schwannomas and meningiomas. Melanin-containing tumors are rare in this area. These tumor types can be suspected if the magnetic resona...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.04.153
更新日期：2018-08-01 00:00:00
abstract：:Recent advances in neuroimaging demonstrated many markedly improved images hitherto unavailable, specifically the areas that lie deep in the brain. The anatomic images of the deep brain structure taken in vivo using 7.0 T magnetic resonance imaging (MRI) and the molecular images using high resolution research tomograp...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2012.10.020
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:In the pediatric population, awake craniotomy began to be used for the resection of brain tumor located close to eloquent areas. Some specificities must be taken into account to adapt this method to children. OBJECTIVE:The aim of this clinical study is to not only confirm the feasibility of awake craniotomy...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.06.073
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Primary leptomeningeal melanomatosis (PLM) is a rare and aggressive form of nonmetastatic invasion of leptomeninges by malignant melanocytic cells. Clinical presentation includes nonspecific meningism with various forms of cerebrospinal fluid circulation or absorption disorders leading to hydrocephalus. CAS...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.06.039
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:Treatment of giant intracranial arteriovenous malformations (gAVMs) is a formidable challenge for neurosurgeons and carries significant morbidity and mortality rates for patients compared with smaller AVMs. In this study, we reviewed the treatments, angiographic results, and clinical outcomes in 64 patients w...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.07.051
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:Meningeal melanocytomas of the central nervous system are extremely rare, with an incidence of 1 per 10 million individuals. Cases of primary cerebellopontine angle melanocytoma (PCPAM) have only been described in single case reports. The goal of the present study was to analyze the surgical management of PCP...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.05.004
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:This study sought to describe a patient with a slowly progressive cauda equina syndrome (CES) who had imaging findings of the CES that occurs as a rare complication of ankylosing spondylitis (AS), but whose spinal fusion was due to thoracolumbosacral instrumentation, not spondyloarthropathy. METHODS:A 53-ye...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2011.12.014
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Imaging of the craniocervical junction (CCJ) after trauma is crucial for injury detection and description. Of all the anatomic measurements of the CCJ, the normal value of atlanto-occipital interval (AOI) is not yet well established in adults. The aim of our study is to determine the normal values of the AOI...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.023
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:To describe the technical details of 3-piece orbitozygomatic (OZ) craniotomy using a diamond threadwire saw as an alternative to cutting the orbital rim and zygoma. METHODS:The details of this procedure are presented by cadaver dissection and a surgical case. RESULTS:Three-piece OZ craniotomy consists of 3 ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.235
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Brainstem tethering is a rare disease. CASE DESCRIPTION:We report and discuss a 20-year-old patient who experienced paroxysmal apnea (a symptom of Ondine's curse) during sleeping, causing him to wake up and control his breathing consciously. A magnetic resonance imaging study revealed that his medulla oblon...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2011.03.020
更新日期：2011-12-01 00:00:00
abstract：:The degree of primary resection of malignant brain gliomas (MBGs) has correlated positively with progression-free and overall survival. The indications for surgery and reoperation in MBG relapse remain controversial. Surgery will not be curative and should be followed by adjuvant treatment. We reviewed the reported st...
journal_title：World neurosurgery
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.wneu.2019.09.037
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:Medical complications severely impair recovery of neurosurgical patients after craniotomy. The purpose of this study was to identify patients at risk of peri- and postoperative medical complications. Therefore, we present a large population of patients with different medical complications after elective crani...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.03.087
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:There is sparse literature that investigates the adverse effects of postoperative pulmonary complication (PPCs) specifically in postcraniotomy tumor patients. In this study, we describe the rate of PPCs, determine predictive factors, and delineate associations with adverse outcomes. METHODS:The National Surg...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.058
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:Dorsal longitudinal T-myelotomy is a long-established operation to treat severe spastic paraplegia. The present study aimed to report this surgical technique and investigate the efficacy of T-myelotomy for spasticity relief. METHODS:All cases undergoing T-myelotomy for treatment of intractable spastic parapl...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.05.008
更新日期：2018-08-01 00:00:00
abstract：:Most neurovascular innovations have been introduced by using case series followed by observational studies. A better approach would be a pragmatic randomized trial. Two important aspects of trial design, patient selection and randomized allocation, remain poorly understood. We discuss the role trial methodology can pl...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.06.127
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND AND IMPORTANCE:Aneurysms of the anterior choroidal artery are uncommon, and distal anterior choroidal artery aneurysms are even rarer, with only 34 cases reported in the medical literature. These lesions have been most commonly reported in association with moyamoya disease or arteriovenous malformations. Mos...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.05.176
更新日期：2017-09-01 00:00:00
