Abstract：
:An ovulated egg of vertebrates is surrounded by unique extracellular matrix, the egg coat or zona pellucida, playing important roles in fertilization and early development. The vertebrate egg coat is composed of two to six zona pellucida (ZP) glycoproteins that are characterized by the evolutionarily conserved ZP-domain module and classified into six subfamilies based on phylogenetic analyses. Interestingly, investigations of biochemical and functional features of the ZP glycoproteins show that the roles of each ZP-glycoprotein family member in the egg-coat formation and the egg-sperm interactions seemingly vary across vertebrates. This might be one reason why comprehensive understandings of the molecular basis of either architecture or physiological functions of egg coat still remain elusive despite more than 3 decades of intensive investigations. In this chapter, an overview of avian egg focusing on the oogenesis are provided in the first section, and unique features of avian egg coat, i.e., perivitelline layer, including the morphology, biogenesis pathway, and physiological functions are discussed mainly on chicken and quail in terms of the characteristics of ZP glycoproteins in the following sections. In addition, these features of avian egg coat are compared to mammalian zona pellucida, from the viewpoint that the structural and functional varieties of ZP glycoproteins might be associated with the evolutionary adaptation to their reproductive strategies. By comparing the egg coat of birds and mammals whose reproductive strategies are largely different, new insights into the molecular mechanisms of vertebrate egg-sperm interactions might be provided.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Okumura Hdoi
10.1007/978-981-10-3975-1_5subject
Has Abstractpub_date
2017-01-01 00:00:00pages
75-90eissn
0065-2598issn
2214-8019journal_volume
1001pub_type
杂志文章abstract：:Zebrafish are increasingly being used to study cancer. Almost all tumor types have been found in zebrafish. However, tumor incidence is relatively low and tumors develop late in life. Functional inactivation of tumor suppressors is a crucial step in cancer progression and more and more tumor suppressor genes are being...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/0-306-46838-7_40
更新日期：2000-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-40204-4_3
更新日期：2020-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 历史文章,杂志文章,评审
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更新日期：2010-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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更新日期：2019-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/978-3-030-15950-4_2
更新日期：2019-01-01 00:00:00
