Abstract：
:This retrospective research was conducted in the Department of Obstetrics and Gynaecology of the Dr. Cipto Mangunkusumo Hospital, Jakarta, covering the period between 1977 and 1981. The incidence of hydatidiform mole was 1 in 77 pregnancies. The incidence of malignant trophoblastic disease was 1 in 185 pregnancies. Of the 406 cases of hydatidiform mole, 22.9% became malignant. Patients of 24 years of age or younger had a higher risk of getting hydatidiform mole (P less than 0.05) compared to older patients. The risk of becoming malignant increased with age and became evident after 40 years of age. Parity 1 or less was associated with a higher risk of getting hydatidiform mole (P less than 0.05), but had no influence on hydatidiform mole becoming malignant. The influence of blood group was not so clear, although there was a tendency for moles to occur more frequently in patients with blood groups A or B. By contrast, there was a tendency for the change into malignancy to occur more frequently in women with blood groups B or O. Gestational age had no influence towards the change into malignancy or metastasis. Uterine size (greater than 20 weeks gestation) correlated with the progression of hydatidiform mole into malignancy. However, subsequent metastasis was not influenced by the size of the uterus. It was found that 76.4% of malignant trophoblastic diseases originated from hydatidiform moles, 12.4% from abortions, 9.5% from normal deliveries, and 1.2% from ectopic pregnancies. Non-hydatidiform moles had a slightly greater risk for metastasis, although this was not significant. Hydatidiform mole in histologic stages II or III (Hertig-Mansell classification) had a significantly greater tendency (P less than 0.05) to become malignant than in stage I.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Aziz MF,Kampono N,Moegni EM,Sjamsuddin S,Barnas B,Samil RSdoi
10.1007/978-1-4684-4811-5_9subject
Has Abstractpub_date
1984-01-01 00:00:00pages
165-75eissn
0065-2598issn
2214-8019journal_volume
176pub_type
杂志文章abstract：:We have examined the question of how hormones regulate the biosynthesis of gonadotropins. In particular we have studied the effects of gonadal sex steroid hormones on the regulation of LH subunit gene expression to determine whether they may occur at the pre-translational level. Success in the molecular cloning of cDN...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4684-5209-9_11
更新日期：1986-01-01 00:00:00
abstract：:There has been a continued interest in translational research focused on both natural products and manipulation of functional groups on these compounds to create novel derivatives with higher desired activities. Oleanolic acid, a component of traditional Chinese medicine used in hepatitis therapy, was modified by chem...
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abstract：:Mesenchymal stem cells (MSCs) are pluripotent stem cells with the ability to differentiate into a variety of other connective tissue cells, such as chondral, bony, muscular, and tendon tissue. Bone marrow-derived MSCs are pluripotent cells that can differentiate among others into osteoblasts, adipocytes and chondrocyt...
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abstract：:Many cases of West's syndrome are inoperable, because there is no clear epileptic focus. In some cases, however, there is a structural abnormality which can be surgically removed. Dr. Hoffman discusses his experience with surgery for cortical dysplasia in West's syndrome. ...
journal_title：Advances in experimental medicine and biology
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doi：
更新日期：2002-01-01 00:00:00
abstract：:Three different commercially available melatonin preparations were analyzed by on-line HPLC-electrospray ionization-tandem mass spectrometry. All three samples contained the same impurities at the approximately 0.1-0.5% level of parent melatonin. Based on accurate mass-HPLC-MS and tandem mass spectrometric analyses, t...
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更新日期：1999-01-01 00:00:00
abstract：:The P300 event-related potential (ERP) is associated with attention and memory operations of the brain. P300 is changed in many cognitive disorders such as dementia, Alzheimer, schizophrenia, and major depression disorder. Therefore, investigation on basis of this component can help to improve our understanding of pat...
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更新日期：2011-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-0-387-78225-6_11
更新日期：2008-01-01 00:00:00
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doi：10.1007/978-1-4684-4703-3_82
更新日期：1984-01-01 00:00:00
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更新日期：2008-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:Overhauser enhanced MRI (OMRI) is one of the free radical imaging technologies and has been used in biomedical research such as for partial oxygen measurements in tumor, and redox status in acute oxidative diseases. The external magnetic field of OMRI is frequently in the range of 5-10 mTesla to ensure microwave penet...
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doi：10.1007/978-3-319-55231-6_51
更新日期：2017-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:RNA granules are microscopically visible cellular structures that aggregate by protein-protein and protein-RNA interactions. Using stress granules as an example, we discuss the principles of RNA granule formation, which rely on the multivalency of RNA and multi-domain proteins as well as low-affinity interactions betw...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-3-319-29073-7_11
更新日期：2016-01-01 00:00:00
abstract：:During the last years it has become obvious that the current way of treating epilepsy with antiepeileptic drugs is insufficient concerning the modification of the underlying disesease and provides merely a symptomatic treatment, without clear influence on the course of the disease. There is a pressing need to find alt...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4419-8969-7_6
更新日期：2004-01-01 00:00:00
abstract：:Probiotics are defined as live microorganisms that, when administered in adequate amount, confer a health benefit on the host. Amongst the many benefits associated with the consumption of probiotics, modulation of the immune system has received the most attention. Several animal and human studies have provided unequiv...
journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-0-387-74087-4_17
更新日期：2008-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-4090-1_1
更新日期：2012-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：
更新日期：2008-01-01 00:00:00
abstract：:Recent studies emphasize the role of chronic hypoxia in the kidney as a final common pathway to end-stage renal disease (ESRD). Hypoxia of tubular cells leads to apoptosis or epithelial-mesenchymal transdifferentiation. This in turn exacerbates fibrosis of the kidney with loss of peritubular capillaries and subsequent...
journal_title：Advances in experimental medicine and biology
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更新日期：2007-01-01 00:00:00
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更新日期：2010-01-01 00:00:00
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更新日期：1987-01-01 00:00:00
abstract：:To evaluate interrelationships among the oxygenation, the energy status, and the development of necrosis in tumor microregions, oxygen tensions were measured with microelectrodes, and ATP distributions were determined with a quantitative imaging technique using multicellular spheroids as in vitro tumor models. The res...
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更新日期：1990-01-01 00:00:00
abstract：:Fertility preservation includes all the necessary steps that have to be taken in order to implement a woman's aim for preserving and enhancing her future chances of having her own biological offspring.There are two available choices for patients to maintain their fertility.The first category includes all the preventiv...
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更新日期：2020-01-01 00:00:00
abstract：:The kisspeptin system is considered to be essential for successful mammalian reproduction. In addition to the Kiss1 peptide, Kiss2, the product of kiss2 (the kiss1 paralogue), has also been shown to activate kisspeptin receptor signaling pathways in nonmammalian species. Furthermore, in nonmammalian species, there are...
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更新日期：2013-01-01 00:00:00
abstract：:We describe an investigation into how Massey University's Pollen Classifynder can accelerate the understanding of pollen and its role in nature. The Classifynder is an imaging microscopy system that can locate, image and classify slide based pollen samples. Given the laboriousness of purely manual image acquisition an...
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更新日期：2015-01-01 00:00:00
abstract：:Serologic and structural comparisons of the rabbit IgA-g allotypes revealed that 1) the IgA-g allotypes have multiple allotypic determinant sites, 2) the g74, g76 and g77 allotypic specificities have several allotypic determinants in common whereas g75 molecules do not appear to have allotypic determinants in common w...
journal_title：Advances in experimental medicine and biology
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更新日期：1978-01-01 00:00:00
abstract：:Prostate cancer causes significant morbidity in men and metastatic disease is a major cause of cancer related deaths. Prostate metastasis is controlled by various cellular intrinsic and extrinsic factors, which are often under the regulatory control of various metastasis-associated genes. Given the dynamic nature of m...
journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-3-319-95693-0_5
更新日期：2018-01-01 00:00:00
