Abstract:
:This study has compared the effect on heart rate control of the addition of pindolol 15 mg bd or verapamil 40 mg tds to maintenance digoxin therapy in 12 patients with chronic atrial fibrillation. The study was performed in a randomized cross-over fashion. Treatment effects were assessed by 24-h ambulatory electrocardiography and symptomatic improvement by symptom scores. The results show that the combination of pindolol and digoxin provides better control of atrial fibrillation. With an attenuation of daytime tachycardia, prevention of nocturnal bradycardia and reduction in the length of nocturnal pauses in rhythm. Overall heart rate variability was significantly less with digoxin and pindolol (523 beats min-1 h-1) than with digoxin and verapamil (745 beats min-1 h-1). We conclude that, in the dosages employed, combined digoxin and pindolol therapy is superior to either digoxin and verapamil in combination or digoxin alone for the treatment of atrial fibrillation.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
James MA,Channer KS,Papouchado M,Rees JRdoi
10.1093/oxfordjournals.eurheartj.a059386subject
Has Abstractpub_date
1989-01-01 00:00:00pages
83-90issue
1eissn
0195-668Xissn
1522-9645journal_volume
10pub_type
临床试验,杂志文章,随机对照试验abstract:AIMS:Induced pluripotent stem cells (iPSCs) provide a unique opportunity for the generation of patient-specific cells for use in disease modelling, drug screening, and regenerative medicine. The aim of this study was to compare human-induced pluripotent stem cells (hiPSCs) derived from different somatic cell sources re...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehs203
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Patients with univentricular hearts have decreased exercise tolerance and may demonstrate exertional dyspnoea. It is not known if chronic hypoxaemia exacerbates exercise intolerance and contributes to symptomatic limitation. The extent to which surgical correction of a right-to-left shunt by a Fontan-type pr...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a015449
更新日期:1997-08-01 00:00:00
abstract::After years of stagnant finances for research, moves are under way to increase research funds in Europe. ...
journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Sixteen cases of sudden unexpected cardiac death, 15 males and one female, are known to have occurred among young Swedish orienteers from 1979 to 1992, of which seven cases occurred between 1989 and 1992. This is considered to be indicative of an increased death rate. RESULTS:Histopathological evaluation sh...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a014972
更新日期:1996-06-01 00:00:00
abstract:AIMS:Targeting interleukin-1 (IL-1) represents a novel therapeutic approach to atherosclerosis. CANTOS demonstrated the benefits of IL-1β neutralization in patients post-myocardial infarction with residual inflammatory risk. Yet, some mouse data have shown a prominent role of IL-1α rather than IL-1β in atherosclerosis,...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehz008
更新日期:2019-08-07 00:00:00
abstract::At the moment, the most reliable method for diagnosing right ventricular dysplasia is considered to be angiography. Morphological alterations such as the presence of akinetic/dyskinetic areas, aneurysmatic dilatations and deep anteroapical fissuring, not necessarily associated with an increase in ventricular volume, a...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/10.suppl_d.42
更新日期:1989-09-01 00:00:00
abstract:AIMS:Sirolimus- and paclitaxel-eluting stents effectively reduce restenosis in small coronary vessels. The relative efficacy of these drug-eluting stents in this high-risk subset is not known. METHODS AND RESULTS:A total of 360 patients undergoing percutaneous coronary intervention for de novo lesions in native corona...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehi721
更新日期:2006-02-01 00:00:00
abstract:AIMS:we investigated the relationship between sublingual perfused capillary density (PCD) as a measure of tissue perfusion and outcome (i.e. occurrence of organ failure and mortality) in patients with cardiogenic shock from acute myocardial infarction. METHODS AND RESULTS:we performed a prospective study in 68 patient...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehq324
更新日期:2010-12-01 00:00:00
abstract::During the long-term follow-up of patients with hypertrophic cardiomyopathy (HCM), some patients develop left ventricular (LV) wall motion abnormalities in the absence of fixed coronary artery disease. The purpose of this study is to clarify which clinical features in patients with HCM seem to influence gradual develo...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.12.1629
更新日期:1993-12-01 00:00:00
abstract:AIMS:Coronary artery calcium (CAC) scoring has emerged as a tool for risk stratification and potentially for monitoring response to risk factor modification. Therefore, repeat measurements should provide robust results and low inter-scanner variability for allowing meaningful comparison. The purpose of this study was t...
journal_title:European heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurheartj/ehr157
更新日期:2011-08-01 00:00:00
abstract:AIMS:Left ventricular (LV) hypertrophy and abnormal non-invasive measures of LV diastolic function are common in patients with severe aortic stenosis (AS) but their prognostic importance is uncertain. This study aimed to determine whether tissue Doppler measures of LV systolic and/or diastolic function or echocardiogra...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehq159
更新日期:2010-09-01 00:00:00
abstract:AIMS:Little research exists on exercise performance and training in patients with an implemented cardioverter defibrillator (ICD) and only in a limited number of patients. This study aims to investigate the effect of exercise training in ICD patients in comparison to the effects in other cardiac patients without an ICD...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ehj.2004.04.034
更新日期:2004-07-01 00:00:00
abstract:AIMS:To assess compliance to guidelines in the management of patients with atrial fibrillation. METHODS AND RESULTS:A total of 728 questionnaires were mailed to physicians with the intention of studying 'theoretical' compliance to practice guidelines. A retrospective evaluation of 200 records from consecutive patients...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2000.2300
更新日期:2001-10-01 00:00:00
abstract:AIMS:The aim of this study is to simultaneously evaluate the incremental prognostic value of multiple cardiac biomarkers reflecting different underlying pathophysiological processes in a well-characterized population of patients with non-ST-segment acute coronary syndrome (NSTE-ACS). METHODS AND RESULTS:We measured ca...
journal_title:European heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurheartj/ehq468
更新日期:2011-03-01 00:00:00
abstract::The effects of dexamethasone on cultured rat beating heart cells experimentally infected with coxsackievirus B2 were investigated at an early stage (1-3 days) post challenge. Changes in the release of the cardiac enzyme, aspartate amino-transferase (AST), beating %, cytopathic effect (CPE), virus titre, ultrastructure...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/12.suppl_d.39
更新日期:1991-08-01 00:00:00
abstract::The endothelium may play a role as a target and mediator of hypertension. Due to its anatomical position, it is very exposed to mechanical forces; as a source of vasoactive material it may participate in increasing peripheral vascular resistance and in promoting local ischaemia in the heart and brain. Morphological an...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/13.suppl_d.50
更新日期:1992-09-01 00:00:00
abstract::Advanced coronary artery disease (CAD), impaired left ventricular function and prolongation of the QT-interval are considered risk factors for sudden cardiac death in CAD-patients. So far, however, there are no studies investigating in detail whether there is a correlation between the QT-interval and changes in corona...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061951
更新日期:1986-01-01 00:00:00
abstract:AIM:The purpose of our study was to evaluate the relative impact of bivalirudin on bleeding outcomes associated with trans-radial interventions (TRI) in real world practice. METHODS AND RESULTS:Data for patients undergoing percutaneous coronary intervention (PCI) between January 2010 and March 2014 at the 47 hospitals...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehv434
更新日期:2016-06-21 00:00:00
abstract::Valvular heart disease is a significant, global cause of morbidity and mortality. In the ageing population of industrialized nations, degenerative aortic stenosis has become the most common native valve disorder. Although surgical aortic valve replacement is associated with excellent clinical outcomes, a large number ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehp260
更新日期:2009-09-01 00:00:00
abstract::Thrombolytic treatment efficacy is greater when the delay between onset of pain and treatment is short. One way to shorten this delay is to give treatment at home, but one cannot recommend this technique if it has not been demonstrated first, that pre-hospital thrombolysis is feasible and safe, and second, that it is ...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/11.suppl_f.43
更新日期:1990-08-01 00:00:00
abstract::Stephan Achenbach reviews the history of coronary computer tomography angiography and discusses its further evolution. ...
journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:2016-02-21 00:00:00
abstract::The present review discusses the prognostic significance of post-infarction angina pectoris, and the significance of post-infarction intervention with verapamil on the prevalence of post-infarction ischaemia and prognosis. Angina pectoris during the first month after acute myocardial infarction (AMI) was found to be a...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/16.suppl_h.13
更新日期:1995-08-01 00:00:00
abstract:AIMS:Cardiomyopathies are a heterogeneous group of disorders associated with premature death due to ventricular arrhythmia or heart failure. The purpose of this study was to examine the characteristics of patients enrolled in the pilot phase of the EURObservational Research Programme (EORP) cardiomyopathy registry. ME...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehv497
更新日期:2016-01-07 00:00:00
abstract::Pulmonary arterial hypertension (PAH) can be a rapidly progressive disorder and is associated with high rate of mortality, despite medical intervention. With the availability of effective therapy, early disease detection is an important strategic objective to improve treatment outcomes. Resting echocardiography is cur...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/ehr160
更新日期:2011-10-01 00:00:00
abstract:AIMS:Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The objective of this study was to describe the natural course of focal and diffuse coronary atherosclerosis over time. METHO...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/oxfordjournals.eurheartj.a015401
更新日期:1997-07-01 00:00:00
abstract::Plasma neuropeptide Y-like immunoreactivity (NPY-LI) is elevated in patients with acute myocardial ischaemia and congestive heart failure (CHF) owing to increased activity of the sympathetic nervous system. The prognostic value of plasma NPY-LI with regard to mortality was studied in 324 random patients admitted to a ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060526
更新日期:1994-04-01 00:00:00
abstract:AIMS:The object of this study is to analyse the trends in coronary events in Finland during 1993-2002, correcting for the effect of troponins. METHODS AND RESULTS:A population-based myocardial infarction register recorded all coronary events (n=14 782) in four geographical areas of Finland during 1993-2002. Correction...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehl120
更新日期:2006-10-01 00:00:00
abstract::The first marathon run as an athletic event took place in the context of the Olympic Games in 1896 in Athens, Greece. Today, participation in a 'marathon run' has become a global phenomenon attracting young professional athletes as well as millions of mainly middle-aged amateur athletes worldwide each year. One of the...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/eht502
更新日期:2014-11-21 00:00:00
abstract::To assess the prevalence of asymmetric septal hypertrophy (ASH) in hypertensive patients, 613 echocardiographic examinations performed over a period of one year were reviewed. Asymmetric septal hypertrophy (defined by an echocardiographic interventricular septum to left ventricular free wall thickness ratio of greater...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/4.suppl_g.1
更新日期:1983-11-01 00:00:00
abstract::Opiate agonists were administered into the cisterna magna of normotensive urethane-anaesthetized artificially-ventilated rats. Increases in blood pressure and heart rate were produced by fentanyl (0.3-3.0 nmol). [D-ala]2-met-enkephalinamide (17 nmol), and beta-endorphin (2.9 nmol). On the contrary, ethylketocyclazocin...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/4.suppl_g.61
更新日期:1983-11-01 00:00:00