Abstract：
OBJECTIVE:To provide insights into the role of multiparametric magnetic resonance imaging (mpMRI) in predicting oncological control following 2 focal ablation (FA) templates for selective cases of prostate cancer. MATERIALS AND METHODS:A total of 59 radical prostatectomies were performed between 2012 and 2016 on cases that fulfilled criteria for FA. The Gleason score (GS), extent of Gleason pattern (GP) 4, maximum linear cross-sectional length (MLCSL), and location of tumor foci were recorded and related to scale on corresponding 3-mm transverse slice prostate maps. Gleason pattern 4 extra-focal disease (GP4EFD) was defined as prostate cancer with any GP 4 not detected by mpMRI and transrectal ultrasound systematic biopsy observed outside a specified ablation zone. The location of these GP4EFD relative to the MRI lesion (MRI-L) (contralateral or ipsilateral) was recorded and used to predict oncological control following a hypothetical margin and ipsilateral hemi-ablation templates. RESULTS:Overall, 15 of 59 (25.4%) of the prostate specimens had at least 1 GP4EFD. Of the total 20 GP4EFD, 7 of 20 (35%) were ipsilateral and 13 of 20 (65%) were contralateral to the MRI-L. Of the GP4EFD, 16 of 20 (80%), 2 of 20 (10%), and 2 of 20 (10%) were GS 3 + 4, GS 4 + 3, and GS 4 + 4, respectively. Of these GP4EFD, 10 of 20 (50%) exhibited an MLCSL <5 mm. Ablating only the MRI-L+10 mm or performing an ipsilateral hemi-ablation would leave residual GP4 in 14 of 59 (23.7%) and 11 of 59 (18.6%) of cases, respectively. CONCLUSION:Because a significant proportion of candidates for FA based on mpMRI and systematic biopsy will have pre-existing GP4EFD outside ablation templates, active surveillance of the untreated prostate is mandatory.
journal_name
Urologyjournal_title
Urologyauthors
Kenigsberg AP,Llukani E,Deng FM,Melamed J,Zhou M,Lepor Hdoi
10.1016/j.urology.2017.10.014subject
Has Abstractpub_date
2018-02-01 00:00:00pages
121-125eissn
0090-4295issn
1527-9995pii
S0090-4295(17)31097-Xjournal_volume
112pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVE:To analyze and compare the etiological uropathogens and the susceptibility profile findings on urine culture between sporadic cases of community-acquired, uncomplicated urinary tract infection (UTI) and recurrent UTI cases in women. MATERIALS AND METHODS:We retrospectively analyzed the clinical data of 1629 ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.05.033
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:To determine whether the additional benefits of improved prostate cancer detection associated with 5α-reductase inhibitors are sufficient to warrant chemoprevention in the case where the degree of prostate cancer risk reduction is deemed inadequate. METHODS:We reanalyzed data from REDUCE, a randomized trial ...
journal_title：Urology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.urology.2014.08.048
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:To present management challenges, surgical technique, and outcome associated with penoscrotal reconstruction in patients with giant scrotal lymphedema in sub-Saharan Africa. METHODS:A prospective study of all patients who had penoscrotal reconstruction for giant scrotal lymphedema at our university teaching ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.09.064
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:To evaluate increased serum soluble interleukin-2 receptor (sIL-2R) levels in patients with renal cell carcinoma (RCC). METHODS:Serum sIL-2R levels were measured in 52 patients with RCC and 10 control subjects by an enzyme-linked immunosorbent assay (ELISA) technique. The correlation between serum sIL-2R le...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(97)00476-7
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:To investigate alterations of DMBT1 in prostate cancer and determine the correlation of its alterations to the clinicopathologic features of prostate cancer. DMBT1 has been proposed as a candidate tumor suppressor gene for epithelial cancer. METHODS:The alterations of DMBT1 expression after treatment with D...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.09.023
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the safety and short-term efficacy of complete sacrocolpopexy mesh excision with concomitant autologous fascia sacrocolpopexy. METHODS:A retrospective cohort study of patients undergoing complete sacrocolpopexy mesh excision and concomitant autologous fascia sacrocolpopexy from March 2013 to Sept...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.04.040
更新日期：2017-08-01 00:00:00
abstract：:The identification of the decapeptide luteinizing hormone-releasing hormone (LHRH) has led to the development of LHRH agonists, which are a new class of drugs for the treatment of advanced prostate cancer. These peptides have a modified amino acid structure that makes them more potent than LHRH. Prolonged administrati...
journal_title：Urology
pub_type： 临床试验,杂志文章,评审
doi：10.1016/0090-4295(89)90105-2
更新日期：1989-05-01 00:00:00
abstract：:Forty-three patients with benign prostatic hypertrophy with marked urinary distress, which I believed warranted surgical treatment, were selected from private practice. These patients were treated with long-term conservative therapy to determine the efficacy of candicidin for this condition. Patients receiving candici...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/0090-4295(74)90113-7
更新日期：1974-07-01 00:00:00
abstract：OBJECTIVES:To determine whether Zuidex using a non-cystoscopy mid-urethral injection technique produces as good a result (i.e. was not inferior) as Contigen injected endoscopically at the bladder neck in the treatment of urinary stress incontinence secondary to intrinsic sphincter deficiency in adult women. METHODS:A ...
journal_title：Urology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.urology.2009.05.034
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy and complications of ileovesicostomy in patients with neurogenic bladder dysfunction. METHODS:Fifteen consecutive neurologically impaired patients (8 from multiple sclerosis, 4 from spinal cord injury, 3 from other causes) with complications of previous bladder management underwent ...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(99)00192-2
更新日期：1999-10-01 00:00:00
abstract：:The pelvic cake kidney in which there is complete fusion of both kidneys into a single renal parenchymal mass has been described as the rarest of renal fusion anomalies. Pelvic cake kidney most commonly drains via 2 separate ureters, with fewer than 10 reports demonstrating a cake kidney drained by a single ureter. We...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.10.015
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:To provide contemporary gestational age-specific recommendations for management, a retrospective series of patients with renal or bladder cancer during pregnancy is reported. METHODS:Obstetric and oncological data of pregnant patients with a diagnosis of renal or bladder cancer were selected from the worldwi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.08.084
更新日期：2020-10-22 00:00:00
abstract：:Carcinoma of the prostate is one of the commonest of cancers occurring in men over the age of fifty years. A small focus of cancer in the prostate can be active biologically and give rise to metastases without producing any symptoms of bladder neck obstruction. In such cases, the attention may be directed away from th...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(82)90208-4
更新日期：1982-04-01 00:00:00
abstract：OBJECTIVES:To assess the feasibility and patient impact of using standardized video presentations concerning alternative treatments for managing localized prostate cancer. METHODS:One hundred eleven men with newly diagnosed localized prostate cancer were shown a video tape concerning the risks and benefits of four tre...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(97)00494-9
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:A highly effective treatment for interstitial cystitis (IC) remains elusive. We determined whether sacral third nerve root (S3) percutaneous neurostimulation (PNS) might be effective in relieving symptoms of IC, as well as in normalizing urinary factors that are specifically altered in IC. METHODS:Six conse...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)00476-3
更新日期：2000-05-01 00:00:00
abstract：OBJECTIVES:To externally review a nomogram developed to predict the 10-year survival probability of men selected for radical prostatectomy. METHODS:A total of 1910 consecutive patients who underwent radical prostatectomy from 1992 to 2004 were studied. The mean age was 64.2 years; the mean follow-up for the surviving ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.09.084
更新日期：2009-03-01 00:00:00
abstract：:Schwannoma of the penis is a rare tumor. We report a case of penile schwannoma in a young man who was accurately diagnosed preoperatively with the help of gray-scale and color flow Doppler ultrasonography, and confirmed by magnetic resonance imaging. The tumor was successfully resected to completion, with preservation...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.05.003
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:To report stricture characteristics, complications, and treatment outcomes among elderly men undergoing urethral reconstruction. MATERIALS AND METHODS:A retrospective review of urethroplasty cases and outcomes by a single surgeon from 2007 to 2014 was performed. Men were stratified by decade of life at time ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.09.029
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVES:To better understand the role of specific macronutrients on the risk of benign prostatic hyperplasia (BPH), we used data from an Italian case-control study. Although BPH is extremely common among the elderly, its etiology-and, particularly, the role of diet and specific macronutrients-is still unclear. METH...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.01.007
更新日期：2006-06-01 00:00:00
abstract：:We diagnosed prostatic adenosquamous carcinoma by prostate core needle biopsy in a 55-year-old man with no history of prostate cancer. The prognosis, DNA analysis, and histogenesis of this extremely rare tumor are controversial. To our knowledge, this is the first case of adenosquamous carcinoma diagnosed by core need...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(98)00418-x
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVE:To increase the diagnostic sensitivity of standard MAG3 diuretic renal scans for ureteropelvic junction obstruction (UPJO) by exploring the utility of an alternative measurement P40, the percentage of maximal tracer counts present at 40 minutes. MATERIALS AND METHODS:Patients with strong clinical and anatomi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.11.049
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:Autologous fat has been used as a bulking implant material for stress urinary incontinence. There is considerable controversy as to the ultimate fate of the grafted fat. This study was conducted to determine the fate of autogenous fat implanted into the bladder of rats. METHODS:Two groups of adult female ra...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(98)00338-0
更新日期：1998-11-01 00:00:00
abstract：OBJECTIVES:To review our experience to better define pediatric renal cell carcinoma (RCC). Pediatric RCC is rare, and recent data suggest it may be a unique disease. METHODS:A retrospective review was conducted of hospital and pathology records from 1965 to 2003. Patients with RCC were identified, and the clinical and...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.06.104
更新日期：2005-12-01 00:00:00
abstract：:A new type of nephrostomy is described with the following main characteristics: it uses a small multiperforated Silastic tube; its crosswise location allows perfect drainage of all of the calyces and the pelvis; it does not become obstructed nor move from its position; and it causes minimum traumatization of the renal...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(77)90305-3
更新日期：1977-06-01 00:00:00
abstract：:A patient with posterior urethral valves presented with unilateral lower leg ecchymosis and edema. He initially had significant renal function impairment. The ecchymosis and edema resolved after appropriate therapy, and his renal function returned to normal. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(91)80015-y
更新日期：1991-07-01 00:00:00
abstract：OBJECTIVES:To investigate the efficacy of pazopanib, both alone and in combination with docetaxel, in bladder cancer cells. Bladder cancer expresses many potential therapeutic targets of biological agents, including the vascular endothelial growth factor receptor (VEGFR). Pazopanib is a small molecule inhibitor of VEGF...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.02.041
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVES:To determine how the implementation of prostate-specific antigen (PSA) testing has affected disease-specific survival and other characteristics of prostate cancer. METHODS:Data were collected on all patients with prostate cancer diagnosed between 1988 and 1998 and registered in the Center for Prostate Disea...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)01960-x
更新日期：2002-11-01 00:00:00
abstract：:Less than 5%-7% of germ cell tumors are extragonadal, with the central nervous system being the most common location in children, followed by retroperitoneum and mediastinum. Only 10% of mediastinal tumors are malignant and one-third of these are pure seminomas (germinomas). We report the case of a 9-year-old boy with...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.08.038
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVES:To evaluate the oncologic outcomes of hand-assisted retroperitoneoscopic nephroureterectomy (HARNU) for upper urinary tract urothelial carcinoma and compare them with the data from conventional open surgery. METHODS:We collected the data from 25 patients who underwent HARNU at our institution from January 1...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/j.urology.2007.01.088
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:To describe epidemiologic patterns, stage at presentation, histology, and treatment differences associated with Hispanic men diagnosed with testicular germ cell tumor (TGCT). Hispanics are the fastest growing demographic in the United States and reports suggest that the incidence of TGCT is rising most rapidl...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.08.059
更新日期：2018-02-01 00:00:00
