Abstract:
:The KIR2DL4 receptor and its ligand HLA-G are considered important for fetal-maternal immune tolerance and successful pregnancy. The absence of a particular variant of KIR2DL4 might be a bad prognostic factor for pregnancy outcome. However, it could be compensated by the presence of the respective LILRB1 allele. Therefore, we investigated the KIR2DL4, LILRB1 and HLA-G polymorphisms in 277 couples with spontaneous abortion and 219 control couples by HRM, PCR-SSP and RFLP methods. We found a protective effect of women's heterozygosity in -716 HLA-G (p = 0.0206) and LILRB1 (p = 0.0131) against spontaneous abortion. Surprisingly, we observed more 9A/10A genotypes of KIR2DL4 gene carriers in the group of male partners from the miscarriage group in comparison to the men from the control group (p = 0.0288). Furthermore, there was no association of women's KIR2DL4 polymorphism with susceptibility to spontaneous abortion. Multivariate analysis indicated that women's -716 HLA-G and LILRB1 and men's KIR2DL4 9A/10A are important in terms of the protection or susceptibility to miscarriage, respectively (p = 0.00968). In conclusion, a woman's heterozygosity in HLA-G and LILRB1 might be an advantage for a success of reproduction, but the partner's heterozygosity in 9A/10A KIR2DL4 alleles might not.
journal_name
Arch Immunol Ther Exp (Warsz)journal_title
Archivum immunologiae et therapiae experimentalisauthors
Nowak I,Malinowski A,Barcz E,Wilczyński JR,Wagner M,Majorczyk E,Motak-Pochrzęst H,Banasik M,Kuśnierczyk Pdoi
10.1007/s00005-016-0389-7subject
Has Abstractpub_date
2016-12-01 00:00:00pages
505-514issue
6eissn
0004-069Xissn
1661-4917pii
10.1007/s00005-016-0389-7journal_volume
64pub_type
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journal_title:Archivum immunologiae et therapiae experimentalis
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journal_title:Archivum immunologiae et therapiae experimentalis
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journal_title:Archivum immunologiae et therapiae experimentalis
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journal_title:Archivum immunologiae et therapiae experimentalis
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journal_title:Archivum immunologiae et therapiae experimentalis
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