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Gene-gene and gene-environment interactions on risk of male infertility: Focus on the metabolites.

Abstract：

:Infertility affects about 17% couples, and males contribute to half of the cases. Compared with independent effects of genetic and environmental factors, interactions between them help in the understanding of the susceptibility to male infertility. Thus, we genotyped 25 polymorphisms, measured 16 urinary chemical concentrations and explored interactions between gene-gene and gene-environment in 1039 Han Chinese using metabolomic analysis. We first observed that GSTT1 might interact with GSTM1 (Pinter=6.33×10(-8)). Furthermore, an interaction between GSTM1 and 4-n-octylphenol (4-n-OP) was identified (Pinter=7.00×10(-3)), as well as a 2-order interaction among GSTT1, GSTM1 and 4-n-OP (Pinter=0.04). Subjects with GSTT1-present and GSTM1-null genotypes were susceptible to male infertility when exposed to 4-n-OP (OR=14.05, 95% CI=4.78-60.20, P=2.34×10(-5)). Most metabolites identified were involved in the tricarboxylic acid cycle. In conclusion, it is a novel study of the interaction on male infertility from the aspect of metabolomics.

journal_name

Environ Int

journal_title

Environment international

authors

Hu W,Chen M,Wu W,Lu J,Zhao D,Pan F,Lu C,Xia Y,Hu L,Chen D,Sha J,Wang X

doi

10.1016/j.envint.2016.02.025

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

188-95

eissn

0160-4120

issn

1873-6750

pii

S0160-4120(16)30061-7

journal_volume

91

pub_type

杂志文章

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