Treatment of chronic erosive gastritis: a double-blind trial of pirenzepine and cimetidine.

abstract：BACKGROUND:Pharmacokinetic/pharmacodynamic (PK/PD) optimization of antibiotic therapy has been shown to improve outcomes in several antibiotic classes. Despite the frequent use of beta-lactams, clinical data in humans remain limited. OBJECTIVE:This study evaluated the relationship between serum pharmacokinetics, pharm...

journal_title：Clinical therapeutics

authors： Smith PF,Ballow CH,Booker BM,Forrest A,Schentag JJ

更新日期：2001-08-01 00:00:00

abstract：:Patients with seasonal or allergic bronchial asthma experience an immediate allergic response caused by allergen-specific immunoglobulin E-mediated histamine release. The release of histamine and other chemical mediators may trigger airway hyperresponsiveness and exaggerated bronchoconstriction, characteristic feature...

journal_title：Clinical therapeutics

authors： Menardo JL,Horak F,Danzig MR,Czarlewski W

更新日期：1997-11-01 00:00:00

abstract：:A total of 128 corticosteroid-independent adults with chronic allergic asthma were treated for six weeks with 400 micrograms/day of beclomethasone dipropionate aerosol. Most patients (114 or 89%) had a good to excellent response, characterized by a marked improvement in the signs and symptoms of asthma. Substantial im...

journal_title：Clinical therapeutics

authors： Malfitan VA

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:The primary purpose of this article was to consider the candidate disruptors of the development of a healthy microbiome in patients with autism. The reported abnormalities in the microbiome of individuals with autism are discussed. METHODS:This selected review used data from published articles related to the a...

journal_title：Clinical therapeutics

authors： Buie T

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Insulin therapy may eventually be required to maintain glycemic control in many patients with type 2 diabetes mellitus. Premixed insulin analogues offer relatively physiologic and predictable time-action profiles and are available in more convenient delivery systems with finer needles than in the past. They ...

journal_title：Clinical therapeutics

authors： Rolla AR,Rakel RE

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is estimated to affect up to 11% of those aged > or =65 years in the United States, and the number of patients with AD is predicted to increase over the next few decades as the population ages. The substantial social and economic burden associated with AD is well established, with th...

journal_title：Clinical therapeutics

authors： Migliaccio-Walle K,Getsios D,Caro JJ,Ishak KJ,O'Brien JA,Papadopoulos G,AHEAD Study Group.

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:The comparative efficacy of endocrine-based therapies (ETs) for hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer (mBC) is not well characterized. This network meta-analysis (NMA) synthesized available evidence on progression-free survival (PFS) wit...

journal_title：Clinical therapeutics

authors： Ayyagari R,Tang D,Patterson-Lomba O,Zhou Z,Xie J,Chandiwana D,Dalal AA,Niravath PA

更新日期：2018-04-01 00:00:00

abstract：:Hydroxychloroquine (HCQ), an antimalarial agent used to treat patients with autoimmune diseases, has been shown to suppress human immunodeficiency virus type 1 (HIV-1) replication in T cells and monocytes in vitro by inhibiting posttranscriptional modification of the virus. An initial randomized, placebo-controlled cl...

journal_title：Clinical therapeutics

authors： Sperber K,Chiang G,Chen H,Ross W,Chusid E,Gonchar M,Chow R,Liriano O

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Citalopram and theophylline may be prescribed together to treat patients with depression and asthmatic disease. Because theophylline has a low therapeutic index, small changes in plasma levels may result in therapeutic failure or adverse effects. Both citalopram and theophylline are metabolized by cytochrome...

journal_title：Clinical therapeutics

authors： Møller SE,Larsen F,Pitsiu M,Rolan PE

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:Our aim was to develop and validate the extrapolative performance of a regression model using a limited sampling strategy for accurate estimation of the area under the plasma concentration versus time curve for saroglitazar. METHODS:Healthy subject pharmacokinetic data from a well-powered food-effect study (fa...

journal_title：Clinical therapeutics

authors： Joshi SN,Srinivas NR,Parmar DV

更新日期：2018-03-01 00:00:00

abstract：:This study categorizes the types of inappropriate intravenous prescriptions in hospitalized patients in China. Prescription data from 2016 were retrospectively analyzed based on predefined categories of inappropriateness. Of the 123,521 patients included, 89.2% received intravenous medications, contributing to 80% of ...

journal_title：Clinical therapeutics

authors： Zeng S,Wang D,Yan Y,Zhu M,Liu W,Gong Z,Wang L,Sun S

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Sirolimus, a new immunosuppressive agent, has recently been approved in the United States for use in combination with cyclosporine and corticosteroids in renal allograft transplantation. Therapeutic drug monitoring (TDM) of sirolimus is advocated by the drug's manufacturer in certain patient populations. Giv...

journal_title：Clinical therapeutics

authors： Napoli KL

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:This single-dose, open-label, randomized, 3-period, 3-treatment crossover drug-drug interaction study was conducted to evaluate differences in the pharmacokinetic properties of saxagliptin and dapagliflozin when coadministered. METHODS:Healthy subjects (N = 42) were randomized to receive saxagliptin 5 mg alone...

journal_title：Clinical therapeutics

authors： Vakkalagadda B,Lubin S,Reynolds L,Liang D,Marion AS,LaCreta F,Boulton DW

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the time to onset of pain relief from a single dose of a tablet formulation of paracetamol (acetaminophen) containing sodium bicarbonate (PSC). METHODS:A single oral dose of PSC or placebo was randomly administered to patients with acute sore throat under double-blind c...

journal_title：Clinical therapeutics

authors： Burnett I,Schachtel B,Sanner K,Bey M,Grattan T,Littlejohn S

更新日期：2006-09-01 00:00:00

abstract：:The objective of this study was to compare the lipid-altering efficacy and safety of simvastatin with that of gemfibrozil in hypercholesterolemic patients with non-insulin-dependent diabetes mellitus (NIDDM). The study was a 24-week, double-blind, randomized, multicenter trial conducted at clinics and hospitals in the...

journal_title：Clinical therapeutics

authors： Sweany AE,Shapiro DR,Tate AC,Goldberg RB,Stein EA

更新日期：1995-03-01 00:00:00

abstract：:A double-blind, randomized, placebo-controlled trial was undertaken to evaluate the effect of penicillin on the pneumococcal carrier state of 32 men with chronic bronchitis. Treatment consisted of 250-mg phenoxymethyl penicillin or placebo tablets taken by mouth twice daily for periods of one to three years. Penicilli...

journal_title：Clinical therapeutics

authors： Haas H,Morris JF,Samson S

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Few studies have examined the relative efficacy and tolerability of antihypertensive drug classes in Chinese populations. OBJECTIVE:This study compared the efficacy, tolerability, and duration of antihypertensive effect of amlodipine besylate and enalapril in Chinese patients with hypertension, including el...

journal_title：Clinical therapeutics

authors： Tomlinson B,Woo J,Thomas GN,Chau YM,Critchley JA

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Coronary heart disease is the major cause of mortality in individuals with diabetes mellitus (DM). Given the increasingly aggressive low-density lipoprotein cholesterol (LDL-C) goals for patients with DM set by the National Cholesterol Education Program Adult Treatment Panel III and the American Diabetes Ass...

journal_title：Clinical therapeutics

authors： Lewin AJ,Kipnes MS,Meneghini LF,Plotkin DJ,Perevozskaya IT,Shah S,Maccubbin DL,Mitchel YB,Tobert JA,Simvastatin\/Thiazolidinedione Study Group.

更新日期：2004-03-01 00:00:00

abstract：:The legal right to assert a conscientious objection is reviewed, using as an example the dispensing of abortifacient drugs by pharmacists. The three areas of law that most significantly concern the right to assert a conscientious refusal are employment law, conscience clauses, and religious discrimination law. Each of...

journal_title：Clinical therapeutics

authors： Brushwood DB

更新日期：1993-01-01 00:00:00

abstract：:Immediate complications of trauma and shock include right heart failure, acute respiratory distress syndrome, coagulopathy, brain edema, small bowel dysfunction, renal failure, and immune dysfunction. Nosocomial infections are also common in trauma patients. These infections are the combined result of a compromised ho...

journal_title：Clinical therapeutics

authors： Trunkey DD

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:During amyotrophic lateral sclerosis progression, up to 85% of patients develop dysphagia. Riluzole oral suspension 50 mg/10 mL is bioequivalent to riluzole 50-mg film-coated tablets administered orally under fasting conditions. Here, we compare the bioavailability of a single 50-mg dose of riluzole oral suspen...

journal_title：Clinical therapeutics

authors： Brooks BR,Bettica P,Cazzaniga S

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Prostate cancer is the second most common cancer among men worldwide. In the past 10 years in Iran, prostate cancer has increased and become more common among hormone-related cancers. As the percentage of seniors in the population increases, the economic burden of this cancer will likely increase significantly....

journal_title：Clinical therapeutics

authors： Mojahedian MM,Toroski M,Keshavarz K,Aghili M,Zeyghami S,Nikfar S

更新日期：2019-01-01 00:00:00

abstract：:The effects of long-term aprindine administration on cardiac function were clinically investigated in seven patients with supraventricular or ventricular arrhythmias associated with organic heart disease. Three patients had normal cardiac function and four had various degrees of cardiac dysfunction before treatment wi...

journal_title：Clinical therapeutics

authors： Tsutsui H,Araki H,Nagata Y,Nakamura M

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:A link between the use of alendronate and atypical diaphyseal femoral fracture has been suggested. OBJECTIVE:The goal of this study was to evaluate the benefits of alendronate in preventing rehospitalization due to hip fractures and whether its use increases risk of hospitalization for atypical diaphyseal f...

journal_title：Clinical therapeutics

authors： Hsiao FY,Huang WF,Chen YM,Wen YW,Kao YH,Chen LK,Tsai YW

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to describe the pharmacokinetics of 3 different single doses of fulvestrant-a new estrogen receptor (ER) antagonist that downregulates the ER with no known agonist effects-administered as a prolonged-release IM formulation. METHODS:Pharmacokinetic data were obtained in a randomized,...

journal_title：Clinical therapeutics

authors： Robertson JF,Odling-Smee W,Holcombe C,Kohlhardt SR,Harrison MP

更新日期：2003-05-01 00:00:00

abstract：:Healing rates were examined retrospectively in 124 outpatients with peptic ulcer who had received cimetidine for at least four weeks. Treatment was unsuccessful in 73 patients. A statistical analysis of the factors involved in treatment failure revealed that in patients with duodenal ulcers 60.6% of the treatment succ...

journal_title：Clinical therapeutics

authors： Granelli P,Angelini GP,Celli L

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Concomitant aspirin use is a risk factor for nonsteroidal anti-inflammatory drug (NSAID)-associated upper gastrointestinal toxicity. In high-risk individuals, such as those with a history of NSAID-related gastric ulcer bleeding, gastroprotective therapy with a proton pump inhibitor has been reported to reduc...

journal_title：Clinical therapeutics

authors： Goldstein JL,Huang B,Amer F,Christopoulos NG

更新日期：2004-10-01 00:00:00

abstract：:To determine the cost relative to efficacy and tolerability of two antimicrobial regimens, a prospective, multicenter study compared imipenem-cilastatin (I-C) monotherapy with clindamycin+aminoglycoside (C+A) in the treatment of serious lower respiratory, intra-abdominal, gynecologic, and urinary tract infections. The...

journal_title：Clinical therapeutics

authors： Kreter B

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Postoperative emetic symptoms (nausea, retching, and vomiting) are common following total joint replacement, with an incidence as high as 83% when no prophylactic antiemetic is provided. However, most antiemetics currently used in Japan, such as antihistamines (eg, hydroxyzine), butyrophenones (eg, droperido...

journal_title：Clinical therapeutics

authors： Fujii Y,Nakayama M

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the annhypertensive efficacy and tolerability of the angiotensin-converting enzyme inhibitor imidapril and the angiotensin II type 1 receptor antagonist candesartan in mild to moderate essential hypertension. METHODS:The trial was conducted at 8 centers across Portugal a...

journal_title：Clinical therapeutics

authors： Palma Gámiz JL,Pêgo M,Contreras EM,Anglada MP,Martínez JO,Esquerra EA,Sagastagoitia Gorostiza JD,Iberian Multicenter Imidapril Study on Hypertension.

更新日期：2006-12-01 00:00:00