Effect of oral penicillin on pneumococcal carriage in elderly men with chronic bronchitis.

abstract：BACKGROUND:Meclofenoxate hydrochloride is a psychostimulant in the nootropic agent group available in capsule and tablet formulations approved for traumatic cataphora, alcoholic poisoning, anoxia neonatorum, and children's enuresis in China. Although these 2 generic formulations are marketed in China, information regar...

journal_title：Clinical therapeutics

authors： Zou JJ,Ji HJ,Wu DW,Yao J,Hu Q,Xiao DW,Wang GJ

更新日期：2008-09-01 00:00:00

abstract：:This study compared the cost-effectiveness of donepezil, a new cholinesterase inhibitor indicated for the treatment of mild-to-moderate probable Alzheimer's disease (AD), with no treatment. A Markov state transition model was employed to simulate treatment costs based on Swedish epidemiologic data. The Markov states u...

journal_title：Clinical therapeutics

authors： Jönsson L,Lindgren P,Wimo A,Jönsson B,Winblad B

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Huoxue-Tongluo lyophilized powder for injection (HTLPI), a traditional Chinese medicine preparation, is a compound of Persicae semen and Paeoniae Radix Rubra that is used mainly for treating blood-stasis obstruction syndrome in the acute stage of cerebral ischemic stroke. Amygdalin (AD) and paeoniflorin (PF) ar...

journal_title：Clinical therapeutics

authors： Li X,Shi F,Zhang R,Sun C,Gong C,Jian L,Ding L

更新日期：2016-02-01 00:00:00

abstract：:Absorption of the antiarrhythmic agent mexiletine from conventional capsules (200 mg) and two sustained-release formulations (360 and 432 mg) was studied in four healthy volunteer subjects, and use of the 360-mg preparation was studied in nine patients who had been using conventional capsules. In the four volunteers, ...

journal_title：Clinical therapeutics

authors： Holt DW,Chadwick DE,Campbell RW

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the pharmacokinetic (PK) and pharmacodynamic (PD) properties and safety of single and multiple doses of cinacalcet in Chinese healthy volunteers (HVs) for the purposes of a New Drug Application package for the Chinese Food and Drug Administration. METHODS:In this randomized,...

journal_title：Clinical therapeutics

authors： Liu H,Wang H,Liu T,Jiang J,Chen X,Gao F,Hu P

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Outcomes in patients with type 2 diabetes mellitus (DM) can differ based on the antidiabetic medication that is used. Thiazolidinediones (TZDs) are a newer class of agents used for the treatment of type 2 DM. No previous study has compared health care utilization associated with the 2 TZDs on the market. OB...

journal_title：Clinical therapeutics

authors： Balkrishnan R,Arondekar BV,Camacho FT,Shenolikar RA,Horblyuk R,Anderson RT

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Recent developments in pharmacologic and device therapy, as well as initiatives to increase the use of standard orders and promote in-hospital communication, have improved the care of patients with myocardial infarction (MI). The increased presence of hospitalists, physicians who provide in-hospital care as ...

journal_title：Clinical therapeutics

authors： Amin A

更新日期：2006-10-01 00:00:00

abstract：:The effect of leuprorelin acetate depot on the endocrine system and on lipid metabolism was evaluated in a multicentre, noncomparative study. During the first month of treatment, suppression of serum oestradiol levels to below 20 pg/ml was achieved and luteinising hormone and follicle-stimulating hormone levels were r...

journal_title：Clinical therapeutics

authors： Bühler K,Winkler U,Schindler AE

更新日期：1992-01-01 00:00:00

abstract：:Exposure of the eye to airborne particles in patients predisposed to allergy often results in the signs and symptoms of allergic conjunctivitis such as red, itchy eyes and ocular discharge. The mediators of these allergic symptoms include histamine, inflammatory substances such as prostaglandins, and other products of...

journal_title：Clinical therapeutics

authors： Raizman MB

更新日期：1995-09-01 00:00:00

abstract：:The pharmacokinetics of cimetidine were studied in three newborn infants with reflux esophagitis or stress ulcer. One infant was given 5 mg/kg intravenously (IV), one was given 10 mg/kg IV, and one was given 10 mg orally. Serum concentrations 30 minutes after administration were 1.2 micrograms/ml, 5 micrograms/ml, and...

journal_title：Clinical therapeutics

authors： Stile IL,Simon R,Hiatt IM,Hegyi T

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate the efficacy and tolerability of a triple combination of amlodipine/losartan/rosuvastatin in patients with hypertension and hypercholesterolemia. METHODS:A randomized, multicenter, double-blind, placebo-controlled study was conducted. Eligible patients with hypertens...

journal_title：Clinical therapeutics

authors： Lee HY,Kim SY,Choi KJ,Yoo BS,Cha DH,Jung HO,Ryu DR,Choi JH,Lee KJ,Park TH,Oh JH,Kim SM,Choi JY,Kim KH,Shim J,Kim WS,Choi SW,Park DG,Song PS,Hong TJ,Rhee MY,Rha SW,Park SW

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Immune thrombocytopenic purpura (ITP) is characterized by platelet deficiency due to platelet destruction and/or inadequate production. Initial therapy consists of corticosteroids or intravenous immunoglobulin (IVIg). Patients with chronic refractory disease might undergo splenectomy. Although there is no tr...

journal_title：Clinical therapeutics

authors： Cersosimo RJ

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Clarithromycin is a semisynthetic macrolide that exhibits broad-spectrum activity against gram-positive, gram-negative, and atypical respiratory tract and skin/skin structure pathogens, Mycobacterium species, and Helicobacter pylori. It is indicated for the treatment of a wide variety of respiratory and derm...

journal_title：Clinical therapeutics

authors： Guay DR,Gustavson LE,Devcich KJ,Zhang J,Cao G,Olson CA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:Long-acting insulin analogues were developed to facilitate consistent glycemic control without excessive hypoglycemia. However, structural modifications of the insulin molecule can alter biological responses and binding characteristics with specific receptors. The aim of this study was to estimate the risk of s...

journal_title：Clinical therapeutics

authors： Lin JC,Shau WY,Lai MS

更新日期：2014-09-01 00:00:00

abstract：:Health care provision in the United States is driven by the fact that most health insurance is commercial and private. This leads to the tendency to view patients as units that will produce a future cash yield. The quality of life (QOL) movement in the United States is in some ways a response to this view and has a ro...

journal_title：Clinical therapeutics

authors： Leppik IE

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate prescription patterns of antiasthmatic medications in ambulatory care, guideline adherence by physician specialties and medical institutions, and the rate of hospitalization and emergency department visits due to asthma exacerbation. METHODS:The ambulatory visits between 2...

journal_title：Clinical therapeutics

authors： Chou CL,Perng DW,Lin TL,Lin AM,Chen TJ,Wu MS,Chou YC

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Due to the emergence of community-associated strains, the prevalence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections has increased substantially in pediatric patients. A vancomycin AUC(0-24)/MIC index >400 best predicts treatment outcomes for invasive MRSA infection in adults. Data ...

journal_title：Clinical therapeutics

authors： Frymoyer A,Hersh AL,Coralic Z,Benet LZ,Joseph Guglielmo B

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:The goal of this multicenter, double-blind, randomized, parallel-group study was to compare the effects of losartan potassium (hereafter referred to as losartan), candesartan cilexitil (hereafter referred to as candesartan), and losartan/hydrochlorothiazide (HCTZ) in patients with mild to moderate hypertensio...

journal_title：Clinical therapeutics

authors： Manolis AJ,Grossman E,Jelakovic B,Jacovides A,Bernhardi DC,Cabrera WJ,Watanabe LA,Barragan J,Matadamas N,Mendiola A,Woo KS,Zhu JR,Mejia AD,Bunt T,Dumortier T,Smith RD

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Linezolid is available in an oral as well as an intravenous formulation. It is an oxazolidinone antibiotic and is effective in treating resistant gram-positive organisms such as methicillin-resistant Staphylococcus aureus and multidrug-resistant Streptococcus pneumoniae. OBJECTIVES:The goals of this study w...

journal_title：Clinical therapeutics

authors： Ball AT,Xu Y,Sanchez RJ,Shelbaya A,Deminski MC,Nau DP

更新日期：2010-12-01 00:00:00

abstract：:Inhibitors of platelet glycoprotein (GP) IIb-IIIa have been demonstrated to be effective in controlling acute cardiac complications in patients presenting with acute ischemic coronary syndromes (AICS). Since patients with atherosclerotic coronary vascular disease may present with AICS on multiple occasions, it is impo...

journal_title：Clinical therapeutics

authors： Lorenz TJ,Macdonald F,Kitt MM

更新日期：1999-01-01 00:00:00

abstract：:A meeting of 14 transplant and pharmacokinetic specialists from Europe and North America was convened in November 2001 to evaluate scientific and clinical data regarding the use of different formulations of cyclosporin A (CsA). The following consensus was achieved. (1) CsA is a critical-dose drug with a narrow therape...

journal_title：Clinical therapeutics

authors： Pollard S,Nashan B,Johnston A,Hoyer P,Belitsky P,Keown P,Helderman H,CONSENT: Consensus on Substitution in European Transplantation.

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:The effectiveness of a drug is significantly influenced by a patient's adherence to the required regimen. OBJECTIVE:The goal of this retrospective database analysis was to determine the factors affecting adherence over a 12-month follow-up period in adults with type 2 diabetes mellitus (DM) initiating once-...

journal_title：Clinical therapeutics

authors： Malmenäs M,Bouchard JR,Langer J

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:These studies assessed the comparative efficacy of rofecoxib and valdecoxib in the treatment of acute postoperative dental pain. METHODS:Two randomized, double-blind, placebo-controlled, single-dose studies were conducted in patients undergoing extraction of > or =2 third molars, with > or =1 mandibular impa...

journal_title：Clinical therapeutics

authors： Daniels SE,Desjardins PJ,Bird SR,Smugar SS,Tershakovec AM

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:NSAIDs are associated with risks of gastrointestinal (GI) and cardiovascular (CV) toxicities. It has been reported that the risks of GI and CV events are dose related, resulting in guidance explicitly emphasizing the use of NSAIDs at the lowest effective dose for the shortest duration. To understand the pote...

journal_title：Clinical therapeutics

authors： Odom DM,Mladsi DM,Saag KG,Sherif BN,Miles L,Ronquest N,Wang J

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:The goal of this study is to identify and compare all direct costs of intravenous and subcutaneous rituximab given to patients with diffuse large B-cell lymphoma in the Netherlands. METHODS:Using a prospective, observational, bottom-up microcosting study, we collected primary data on the direct medical costs o...

journal_title：Clinical therapeutics

authors： Mihajlović J,Bax P,van Breugel E,Blommestein HM,Hoogendoorn M,Hospes W,Postma MJ

更新日期：2017-06-01 00:00:00

abstract：:Several patients treated with amoxapine (in dosages ranging from 50 to 300 mg/day) had excellent initial responses followed by relapse unresponsive to dose adjustment, suggesting pharmacological tolerance to its antidepressant effect. ...

journal_title：Clinical therapeutics

authors： Zetin M,Aden G,Moldawsky R

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Nonadherence to treatment is an important determinant of long-term outcomes in women with osteoporosis. OBJECTIVES:This study was conducted to investigate the association between adherence and osteoporotic fracture risk and to identify optimal thresholds for good compliance and persistence. A secondary obje...

journal_title：Clinical therapeutics

authors： Cotté FE,Mercier F,De Pouvourville G

更新日期：2008-12-01 00:00:00

abstract：:In a multicenter, parallel-group, double-masked, randomized study, two questionnaires were administered to a clinical study population to identify which specific symptoms of seasonal allergic rhinitis patients perceived as most important to relieve (personal preferences) and to learn whether any relationship existed b...

journal_title：Clinical therapeutics

authors： Ricard N,Kind P,Christian S,Jensen M,Stewart J

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Dementia is a cerebral disorder resulting in a progressive deterioration of intellectual function that compromises the patient's ability to function. The diagnostic criteria for dementia are primarily clinical and are based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The Hac...

journal_title：Clinical therapeutics

authors： Emeriau JP,Lehert P,Mosnier M

更新日期：2000-07-01 00:00:00

abstract：:A national multicentre trial was organized in order to compare the efficacy and safety of leuprorelin acetate depot and danazol in the treatment of endometriosis. Sixty-seven patients with pelvic endometriosis of different severity at laparoscopy were included in the study and followed during the 24 weeks of treatment...

journal_title：Clinical therapeutics

authors： Crosignani PG,Gastaldi A,Lombardi PL,Montemagno U,Vignali M,Serra GB,Stella C

更新日期：1992-01-01 00:00:00