Tolerance to amoxapine antidepressant effects.

abstract：PURPOSE:In critical burn patients, the pharmacokinetic parameters (absorption, distribution, metabolism, and excretion) of many classes of drugs, including antibiotics, are altered. The aim of this study was to compare 2 groups of burn patients undergoing treatment for health care-associated infections with and without...

journal_title：Clinical therapeutics

authors： Machado AS,Oliveira MS,Sanches C,Silva Junior CVD,Gomez DS,Gemperli R,Santos SRCJ,Levin AS

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Enzyme replacement therapy (ERT) with imiglucerase is a well-established, effective treatment for Gaucher disease. However, there have been no published reports regarding the excretion of imiglucerase into human breast milk and its effects on the nursing infant. OBJECTIVE:This letter reports on the successf...

journal_title：Clinical therapeutics

authors： Sekijima Y,Ohashi T,Ohira S,Kosho T,Fukushima Y

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Opiates, acetaminophen, nonselective nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase-2-selective inhibitors such as rofecoxib are used in the treatment of acute pain because of their anti-inflammatory and/or analgesic properties. Rofecoxib has demonstrated an improved gastrointestinal safet...

journal_title：Clinical therapeutics

authors： Korn S,Vassil TC,Kotey PN,Fricke JR Jr

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Plasma concentrations of cloxacillin have been found to vary as much as 20-fold among individuals receiving the same oral dose. There is evidence that cloxacillin may be a substrate for P-glycoprotein, suggesting that polymorphisms in the ABCB1 gene may be a contributing factor to the observed variability in...

journal_title：Clinical therapeutics

authors： Yin OQ,Tomlinson B,Chow MS

更新日期：2009-05-01 00:00:00

abstract：:The efficacy, acceptability, and tolerability of tioconazole solution (1%) in a pump spray were evaluated in an open-label trial in 26 patients with dermatophytosis, superficial candidiasis, and tinea versicolor. Medication was applied twice daily for 30 consecutive days. Eighteen patients had dermatophyte lesions: fo...

journal_title：Clinical therapeutics

authors： del Palacio Hernanz A,Lopez Gomez S,Iglesias Diez L

更新日期：1987-01-01 00:00:00

abstract：:Six hundred forty-eight patients (50.5% men; 49.5% women) with diabetes mellitus on animal-source insulin therapy for at least five years were studied. In this patient population, approximately 68.7% had Type I insulin-dependent diabetes mellitus and 31.3% had Type II noninsulin-dependent diabetes mellitus, nonetheles...

journal_title：Clinical therapeutics

authors： Garber AJ,Davidson JA,Krosnick A,Beaser RS,Anderson JH Jr

更新日期：1991-09-01 00:00:00

abstract：:Patients with seasonal or allergic bronchial asthma experience an immediate allergic response caused by allergen-specific immunoglobulin E-mediated histamine release. The release of histamine and other chemical mediators may trigger airway hyperresponsiveness and exaggerated bronchoconstriction, characteristic feature...

journal_title：Clinical therapeutics

authors： Menardo JL,Horak F,Danzig MR,Czarlewski W

更新日期：1997-11-01 00:00:00

abstract：:Since the introduction of angiotensin converting enzyme (ACE) inhibitors into clinical use, much information has been accumulated in animal models and man regarding their effects on renal function in different disease states. Enalapril, the first nonsulfhydryl ACE inhibitor approved for general use in the United State...

journal_title：Clinical therapeutics

authors： Weir MR

更新日期：1989-09-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate the impact of a listed penicillin allergy on the time to first dose of antibiotic in a Veterans Affairs hospital. Additional clinical outcomes of patients with penicillin allergies were compared with those of patients without a penicillin allergy. METHODS:A retrospec...

journal_title：Clinical therapeutics

authors： Conway EL,Lin K,Sellick JA,Kurtzhalts K,Carbo J,Ott MC,Mergenhagen KA

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Geriatric patients are more sensitive to the anesthetic effects of propofol and its adverse effects, such as hypotension, than is the general population; thus, a reduced dose (1-1.5 mg/kg) is recommended for the induction of anesthesia. The extent to which clinicians follow established dosing guidelines has not...

journal_title：Clinical therapeutics

authors： Phillips AT,Deiner S,Mo Lin H,Andreopoulos E,Silverstein J,Levin MA

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Numerous studies have explored dietary-management strategies for decreasing leukotriene synthesis by inflammatory cells through supplementation with polyunsaturated fatty acids such as gamma-linolenic acid (GLA) and eicosapentaenoic acid (EPA). OBJECTIVES:This study sought to determine the optimal daily int...

journal_title：Clinical therapeutics

authors： Surette ME,Koumenis IL,Edens MB,Tramposch KM,Chilton FH

更新日期：2003-03-01 00:00:00

abstract：:The optimal antibiotic therapy for patients with acute bacterial exacerbations of chronic bronchitis (ABECB) who have failed to respond to previous oral antimicrobial therapy is not known; however, newer macrolide and fluoroquinolone antibiotics may be appropriate. This multicenter, randomized, double-masked, double-d...

journal_title：Clinical therapeutics

authors： Lipsky BA,Unowsky J,Zhang H,Townsend L,Talbot GH

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Gastrointestinal (GI) symptoms and high dosing frequency have been cited as reasons for inadequate adherence to daily or weekly oral bisphosphonate therapy. Inadequate adherence may lead to poor therapeutic outcomes. OBJECTIVE:The PRIOR study evaluated adherence to and GI tolerability of monthly therapy wit...

journal_title：Clinical therapeutics

authors： Lewiecki EM,Babbitt AM,Piziak VK,Ozturk ZE,Bone HG

更新日期：2008-04-01 00:00:00

abstract：:This pilot study was conducted to compare both the clinical effectiveness and the treatment costs of newer (atypical) antipsychotic medications (clozapine and risperidone) with those of older (classic) neuroleptic medications (chlorpromazine and haloperidol) for psychosis in a community mental health care setting. The...

journal_title：Clinical therapeutics

authors： Galvin PM,Knezek LD,Rush AJ,Toprac MG,Johnson B

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:Long-acting insulin analogues were developed to facilitate consistent glycemic control without excessive hypoglycemia. However, structural modifications of the insulin molecule can alter biological responses and binding characteristics with specific receptors. The aim of this study was to estimate the risk of s...

journal_title：Clinical therapeutics

authors： Lin JC,Shau WY,Lai MS

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:Improvement in health behaviors following cancer diagnosis may contribute to better prognosis and well-being. This study examines the prevalence of health behaviors in cervical cancer survivors who have completed treatment, and associations between health behaviors and quality of life (QOL). METHODS:We recruit...

journal_title：Clinical therapeutics

authors： Iyer NS,Osann K,Hsieh S,Tucker JA,Monk BJ,Nelson EL,Wenzel L

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the bioavailability of hydroxyprogesterone caproate (HPC) administered as a subcutaneous injection in the back of the upper arm using a prefilled autoinjector syringe with a 27-gauge needle compared with standard intramuscular injection in the gluteus maximus using a 21...

journal_title：Clinical therapeutics

authors： Krop J,Kramer WG

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Although annual per-person health care costs for patients with end-stage renal disease (ESRD) on in-center hemodialysis greatly exceed those for patients on peritoneal dialysis (PD), which is a home dialysis therapy, current use of PD remains low. In April 2008, the Centers for Medicare & Medicaid Services i...

journal_title：Clinical therapeutics

authors： Neil N,Guest S,Wong L,Inglese G,Bhattacharyya SK,Gehr T,Walker DR,Golper T

更新日期：2009-04-01 00:00:00

abstract：:The purpose of this study was to estimate the impact of the introduction of propentofylline, a glial-cell modulator with neuroprotective properties, on the costs of dementia care in Sweden. To estimate the clinical effects of propentofylline treatment on dementia, we conducted a meta-analysis of four double-masked, pl...

journal_title：Clinical therapeutics

authors： Wimo A,Witthaus E,Rother M,Winblad B

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Idiopathic thrombocytopenic purpura (ITP) is a relatively rare acquired autoimmune disease characterized by either decreased platelet production or increased platelet destruction leading to reduced platelet counts and increased risk of bleeding. Immune modulators have been used in treatment; however, a novel...

journal_title：Clinical therapeutics

authors： Zhang Y,Kolesar JM

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Patients newly diagnosed with type 2 diabetes mellitus generally initiate therapy with either metformin [Met] or a sulfonylurea [SU] drug, followed by the addition of a second agent (Met, an SU drug, or a thiazolidinedione [TZD] drug) if the diabetes is not well controlled. If necessary, the usual third line...

journal_title：Clinical therapeutics

authors： Rascati KL,Richards KM,Lopez D,Cheng LI,Wilson JP

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:Glucosamine is widely used by patients with osteoarthritis (OA) to provide symptomatic relief and to delay disease progression. However, clinical studies have reported inconsistent clinical outcomes. The current study hypothesized that the reported inconsistent clinical results could be, in part, due to variabl...

journal_title：Clinical therapeutics

authors： Asthana C,Peterson GM,Shastri MD,Jones G,Patel RP

更新日期：2020-08-01 00:00:00

abstract：:Oral rehydration therapy (ORT) has had a dramatic global impact. The worldwide consequences of this therapy are discussed in four categories: (1) adoption of ORT as the primary therapy for acute dehydrating diarrhea; (2) establishment of national ORT programs; (3) scientific knowledge gained from studies into intestin...

journal_title：Clinical therapeutics

authors： Banwell JG

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the pharmacokinetic (PK) and pharmacodynamic (PD) properties and safety of single and multiple doses of cinacalcet in Chinese healthy volunteers (HVs) for the purposes of a New Drug Application package for the Chinese Food and Drug Administration. METHODS:In this randomized,...

journal_title：Clinical therapeutics

authors： Liu H,Wang H,Liu T,Jiang J,Chen X,Gao F,Hu P

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Valproic acid has been associated with a highly variable intersubject absorptive phase; therefore, magnesium salt (magnesium valproate [MgV]) was developed to diminish variation during enteric absorption. OBJECTIVES:The aims of this study were to assess the pharmacokinetics of single oral doses of MgV 500-m...

journal_title：Clinical therapeutics

authors： Marcelín-Jiménez G,Angeles-Moreno AP,Contreras-Zavala L,Morales-Martínez M,Rivera-Espinosa L

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Preclinical studies have reported that the relative bioavailability of dalcetrapib, a modulator of cholesteryl ester transfer protein (CETP) inhibitor activity, was ∼60% higher when administered in the fed state compared with the fasting state. OBJECTIVE:This article reports on 3 studies conducted to assess...

journal_title：Clinical therapeutics

authors： Derks M,Kawamura H,Abt M,Meneses-Lorente G,Phelan M,Ishikawa T

更新日期：2011-06-01 00:00:00

abstract：:This study categorizes the types of inappropriate intravenous prescriptions in hospitalized patients in China. Prescription data from 2016 were retrospectively analyzed based on predefined categories of inappropriateness. Of the 123,521 patients included, 89.2% received intravenous medications, contributing to 80% of ...

journal_title：Clinical therapeutics

authors： Zeng S,Wang D,Yan Y,Zhu M,Liu W,Gong Z,Wang L,Sun S

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:Although recent reports suggest an association between saxagliptin and an increased risk of admissions for heart failure, it is not clear whether dipeptidyl peptidase IV (DPP-IV) inhibition contributes to heart failure in high-risk patients. The purpose of this research is to understand heart failure risk among...

journal_title：Clinical therapeutics

authors： Clifton P

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Migraine is a common, chronic, often disabling neurologic condition that is underdiagnosed and undertreated. OBJECTIVE:We undertook this questionnaire-based study as a substudy of a multicenter trial of rizatriptan effectiveness. Our goal was to assess the history of acute migraine medication use and the re...

journal_title：Clinical therapeutics

authors： Ceballos Hernansanz MA,Sanchez Roy R,Cano Orgaz A,López-Gil A,START 10 Study Group.

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Cobalamin (vitamin B12) deficiency, the most common cause of megaloblastic anemia, is treated with intramuscular (IM) cobalamin. It has been suggested by some investigators that oral (p.o.) cobalamin treatment may be as effective in the treatment of this condition, with the advantages of ease of administrati...

journal_title：Clinical therapeutics

authors： Bolaman Z,Kadikoylu G,Yukselen V,Yavasoglu I,Barutca S,Senturk T

更新日期：2003-12-01 00:00:00