Modulation of Lipid Droplet Metabolism-A Potential Target for Therapeutic Intervention in Flaviviridae Infections.

abstract：:Candia tropicalis is an increasingly important human pathogen, causing nosocomial fungemia among patients with neutropenia or malignancy. However, limited research has been published concerning its pathogenicity. Based on the phenotypes of C. tropicalis in our previous study, we selected nine representative strains wi...

journal_title：Frontiers in microbiology

authors： Yu S,Li W,Liu X,Che J,Wu Y,Lu J

更新日期：2016-07-29 00:00:00

abstract：:Oral exposure to the heavy metal lead (Pb) causes various dysfunctions in animals. However, the influence of gut bacteria on Pb absorption, bioaccumulation, and excretion is largely unknown. In this study, we use a mouse model to investigate the relationship between gut microbiota, Pb-intolerant intestinal microbes an...

journal_title：Frontiers in microbiology

authors： Zhai Q,Qu D,Feng S,Yu Y,Yu L,Tian F,Zhao J,Zhang H,Chen W

更新日期：2020-01-22 00:00:00

abstract：:Background: Antimicrobial resistance (AMR) in bacteria is an increasing health concern. The spread of AMR bacteria (AMRB) between animals and humans via the food chain and the exchange of AMR genes requires holistic approaches for risk mitigation. The AMRB exposure of humans via food is currently only poorly understoo...

journal_title：Frontiers in microbiology

authors： Jans C,Sarno E,Collineau L,Meile L,Stärk KDC,Stephan R

更新日期：2018-03-06 00:00:00

abstract：:The pathogenicity of Stenotrophomonas maltophilia is regulated in part by its quorum sensing (QS) system. The main QS signaling molecule in S. maltophilia is known as diffusible signal factor (DSF), and the rpf gene cluster is responsible for its synthesis and perception. Two cluster variants have been previously desc...

journal_title：Frontiers in microbiology

authors： Yero D,Huedo P,Conchillo-Solé O,Martínez-Servat S,Mamat U,Coves X,Llanas F,Roca I,Vila J,Schaible UE,Daura X,Gibert I

更新日期：2020-06-03 00:00:00

abstract：:Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their transcriptional and posttranscriptional machinery as a response. Under conditions that cause growth to slow or stop, bacteria typically stabilize their transcriptomes in what has been shown to be a conserved stress response. In...

journal_title：Frontiers in microbiology

authors： Vargas-Blanco DA,Shell SS

更新日期：2020-09-09 00:00:00

abstract：:The interactions of mitochondria with the endoplasmic reticulum (ER) are crucial for maintaining proper mitochondrial morphology, function and dynamics. This enables cells to utilize their mitochondria optimally for energy production and anabolism, and it further provides for metabolic control over developmental decis...

journal_title：Frontiers in microbiology

authors： Koch B,Tucey TM,Lo TL,Novakovic S,Boag P,Traven A

更新日期：2017-12-20 00:00:00

abstract：:Swine grown under commercial conditions are vulnerable to environmental exposure to several viruses, which may cause infectious diseases and spread easily and rapidly, resulting in significant economic losses in animal husbandry. Previous studies have suggested that probiotics seem to be a new and promising alternativ...

journal_title：Frontiers in microbiology

authors： Chang-Liao WP,Lee A,Chiu YH,Chang HW,Liu JR

更新日期：2020-07-15 00:00:00

abstract：:The response of methanogens to thawing permafrost is an important factor for the global greenhouse gas budget. We tracked methanogenic community structure, activity, and abundance along the degradation of sub-Arctic palsa peatland permafrost. We observed the development of pronounced methane production, release, and a...

journal_title：Frontiers in microbiology

authors： Liebner S,Ganzert L,Kiss A,Yang S,Wagner D,Svenning MM

更新日期：2015-05-12 00:00:00

abstract：:Fungi are prominent components of most terrestrial ecosystems, both in terms of biomass and ecosystem functioning, but the hyper-diverse nature of most communities has obscured the search for unifying principles governing community organization. In particular, unlike plants and animals, observational studies provide l...

journal_title：Frontiers in microbiology

authors： Crowther TW,Maynard DS,Crowther TR,Peccia J,Smith JR,Bradford MA

更新日期：2014-10-31 00:00:00

abstract：:Human rhinovirus (HRV) is a positive sense RNA virus, which, despite replicating in the cytoplasm, has a significant impact on nuclear transport and nuclear localization of host proteins. A number of studies have identified differences between HRV serotypes, with respect to host response, protease activity and replica...

journal_title：Frontiers in microbiology

authors： Walker EJ,Jensen LM,Croft S,Ghildyal R

更新日期：2015-08-24 00:00:00

abstract：:In poultry farming, the spread of bacterial pathogens results in disease outbreaks causing significant economic losses to this industry. Many of these pathogenic bacteria are zoonotic and have a substantial impact on public health. Antimicrobials are essential for the prevention and treatment of these bacterial infect...

journal_title：Frontiers in microbiology

authors： Aranda MIR,Gómez GAT,de Barros M,Dos Santos MH,de Oliveira LL,Pena JL,Moreira MAS

更新日期：2019-03-20 00:00:00

abstract：:Objectives: Sequence type 1193 is emerging as a new, virulent and resistant lineage among fluoroquinolone resistant Escherichia coli (FQrE. coli). In this study, we investigated the prevalence and molecular characteristics of this clone isolated from a Chinese university hospital. Methods: 73 phylogenetic group B2-FQr...

journal_title：Frontiers in microbiology

authors： Wu J,Lan F,Lu Y,He Q,Li B

更新日期：2017-11-21 00:00:00

abstract：:Food contamination by staphylococcal enterotoxins (SEs) is responsible for many food poisoning outbreaks (FPOs) each year, and they represent the third leading cause of FPOs in Europe. SEs constitute a protein family with 27 proteins. However, enzyme immunoassays can only detect directly in food the five classical SEs...

journal_title：Frontiers in microbiology

authors： Merda D,Felten A,Vingadassalon N,Denayer S,Titouche Y,Decastelli L,Hickey B,Kourtis C,Daskalov H,Mistou MY,Hennekinne JA

更新日期：2020-06-30 00:00:00

abstract：:Estuarine sediments are significant repositories of anthropogenic contaminants, and thus knowledge of the impacts of pollution upon microbial communities in these environments is important to understand potential effects on estuaries as a whole. The Lagos lagoon (Nigeria) is one of Africa's largest estuarine ecosystem...

journal_title：Frontiers in microbiology

authors： Obi CC,Adebusoye SA,Ugoji EO,Ilori MO,Amund OO,Hickey WJ

更新日期：2016-08-05 00:00:00

abstract：:To assess the diversity and composition of airborne fungi associated with particulate matters (PMs) in Beijing, China, a total of 81 PM samples were collected, which were derived from PM2.5, PM10 fractions, and total suspended particles during haze and non-haze days. The airborne fungal community in these samples was ...

journal_title：Frontiers in microbiology

authors： Yan D,Zhang T,Su J,Zhao LL,Wang H,Fang XM,Zhang YQ,Liu HY,Yu LY

更新日期：2016-04-14 00:00:00

abstract：:Microorganisms play a significant role in the evolution and functioning of the eukaryotes with which they interact. Much of our understanding of beneficial host-microbe interactions stems from studying already established associations; we often infer the genotypic and environmental conditions that led to the existing ...

journal_title：Frontiers in microbiology

authors： Hoang KL,Morran LT,Gerardo NM

更新日期：2016-09-13 00:00:00

abstract：:Schistosomiasis japonica is a significant health problem that leads to morbidity and mortality of humans. It is characterized by hepatic granulomatous response and fibrosis caused by eggs deposition in the liver. β-actin, a traditional housekeeping gene, is widely used as an internal control to normalize gene and prot...

journal_title：Frontiers in microbiology

authors： Zhang B,Wu X,Liu J,Song L,Song Q,Wang L,Yuan D,Wu Z

更新日期：2019-01-31 00:00:00

abstract：:Initially thought as being non-immunogenic, recombinant AAVs have emerged as efficient vector candidates for treating monogenic diseases. It is now clear however that they induce potent immune responses against transgene products which can lead to destruction of transduced cells. Therefore, developing strategies to ci...

journal_title：Frontiers in microbiology

authors： Adriouch S,Franck E,Drouot L,Bonneau C,Jolinon N,Salvetti A,Boyer O

更新日期：2011-09-29 00:00:00

abstract：:Rare sugars are monosaccharides with limited availability in nature and their biological functions are largely unknown. Among them, tagatose was developed as a low-calorie sweetener and showed beneficial effects on human health. Tagatose is metabolized by only certain microbial taxa and inhibits the growth of importan...

journal_title：Frontiers in microbiology

authors： Chahed A,Nesler A,Navazio L,Baldan B,Busato I,Ait Barka E,Pertot I,Puopolo G,Perazzolli M

更新日期：2020-02-06 00:00:00

abstract：:Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis. To date, these transcriptional responses have been shown to be dependent on the presence of the azoles and/or depletion of ergosterol. Usi...

journal_title：Frontiers in microbiology

authors： Hu C,Zhou M,Wang W,Sun X,Yarden O,Li S

更新日期：2018-01-17 00:00:00

abstract：:Carbon monoxide (CO) is commonly known as a toxic gas, yet both cultivation studies and emerging genome sequences of bacteria and archaea establish that CO is a widely utilized microbial growth substrate. In this study, we determined the prevalence of anaerobic carbon monoxide dehydrogenases ([Ni,Fe]-CODHs) in current...

journal_title：Frontiers in microbiology

authors： Techtmann SM,Lebedinsky AV,Colman AS,Sokolova TG,Woyke T,Goodwin L,Robb FT

更新日期：2012-04-17 00:00:00

abstract：:Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated. The arenavirus Z protein facilitates production of virus-like part...

journal_title：Frontiers in microbiology

authors： Mpingabo PI,Urata S,Yasuda J

更新日期：2020-09-30 00:00:00

abstract：:Toxin/antitoxin (TA) systems are present in most prokaryote genomes. Toxins are almost exclusively proteins that reduce metabolism (but do not cause cell death), and antitoxins are either RNA or proteins that counteract the toxin or the RNA that encodes it. Although TA systems clearly stabilize mobile genetic elements...

journal_title：Frontiers in microbiology

authors： Song S,Wood TK

更新日期：2020-08-13 00:00:00

abstract：:Streptococcus suis serotype 2 (SS2) is an emerging human pathogen worldwide. A large outbreak occurred in the summer of 2005 in China. Serum samples from this outbreak revealed that levels of the main proinflammatory cytokines were significantly higher in patients with streptococcal toxic-shock-like syndrome (STSLS) t...

journal_title：Frontiers in microbiology

authors： Bi L,Pian Y,Chen S,Ren Z,Liu P,Lv Q,Zheng Y,Zhang S,Hao H,Yuan Y,Jiang Y

更新日期：2015-06-26 00:00:00

abstract：:Bacillus cereus is a gram-positive pathogen mainly known to evoke two types of foodborne poisonings. The diarrheal syndrome is caused by enterotoxins produced during growth in the intestine. In contrast, the emetic type is caused by the dodecadepsipeptide cereulide pre-formed in food. Usually, both diseases are self-l...

journal_title：Frontiers in microbiology

authors： Bauer T,Sipos W,Stark TD,Käser T,Knecht C,Brunthaler R,Saalmüller A,Hofmann T,Ehling-Schulz M

更新日期：2018-11-07 00:00:00

abstract：:The intestinal microbiome is essential in humans to maintain physiological balance and nutrition metabolism. Laparoscopic cholecystectomy due to gallstone disease and cholecystitis can cause intestinal microbial dysbiosis, and following bile acid metabolism dysfunction, positions the patient at high risk of colorectal...

journal_title：Frontiers in microbiology

authors： Wang W,Wang J,Li J,Yan P,Jin Y,Zhang R,Yue W,Guo Q,Geng J

更新日期：2018-06-25 00:00:00

abstract：:Mycoparasite Coniothyrium minitans parasitizes specifically the mycelia or sclerotia of Sclerotinia sclerotiorum, a worldwidely spread plant fungal pathogen causing serious diseases on crops. The interaction of C. minitans with S. sclerotiorum remains reciprocal and complex and little is known, especially on the side ...

journal_title：Frontiers in microbiology

authors： Zhao H,Zhou T,Xie J,Cheng J,Jiang D,Fu Y

更新日期：2020-02-11 00:00:00

abstract：:Arguably, microbial physiology started when Leeuwenhoek became fascinated by observing a Vorticella beating its cilia, my point being that almost any observation of microbes has a physiological component. With the advent of modern microbiology in the mid-19th century, the field became recognizably distinctive with suc...

journal_title：Frontiers in microbiology

authors： Schaechter M

更新日期：2015-04-21 00:00:00

abstract：:Microbial decomposition of organic matter is an essential process in the global carbon cycle. The soil bacteria Pseudopedobacter saltans and Flavobacterium johnsoniae are both able to degrade complex organic molecules, but it is not fully known how their membrane structures are adapted to their environmental niche. Th...

journal_title：Frontiers in microbiology

authors： Moore EK,Hopmans EC,Rijpstra WI,Sánchez-Andrea I,Villanueva L,Wienk H,Schoutsen F,Stams AJ,Sinninghe Damsté JS

更新日期：2015-06-29 00:00:00

abstract：:Historically, disease progression in animal models of Q fever has been carried out using PCR to monitor the presence of Coxiella burnetii DNA in the host. However, the colonization and dissemination of other bacterial infections in animal models are tracked using viable counts, enabling an accurate assessment of viabl...

journal_title：Frontiers in microbiology

authors： Hartley MG,Ralph E,Norville IH,Prior JL,Atkins TP

更新日期：2019-07-16 00:00:00