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Aerobic capacity explains physical functioning and participation in patients with multiple sclerosis-related fatigue.

Abstract：

OBJECTIVE:To investigate whether aerobic capacity explains the level of self-reported physical activity, physical functioning, and participation and autonomy in daily living in persons with multiple sclerosis-related fatigue. DESIGN:A cross-sectional study. PATIENTS:Sixty-two participants with multiple sclerosis-related fatigue. METHODS:Aerobic capacity was measured with a leg ergometer and was expressed as maximal oxygen uptake (VO2max, in ml/kg/min). Physical activity was measured with the Physical Activity Scale for Individuals with Physical Disabilities (PASIPD), physical functioning with the Short Form 36 - physical functioning (SF36-pf), and participation and autonomy in daily living with the Impact on Participation and Autonomy questionnaire (IPA). Multiple regression analyses were performed, adjusted for potential confounders (gender, age, body mass index, educational level, and employment status). RESULTS:Mean maximal oxygen uptake (VO2max) was 23.9 ml/kg/min (standard deviation (SD) 6.3 ml/kg/min). There was no significant relationship between VO2max and physical activity (PASIPD): β = 0.320, 95% confidence interval (95% CI) = -0.109 to 0.749, R2 = 10.8%. Higher VO2max correlated with better physical functioning (SF36-pf): β = 1.527, 95% CI = 0.820-2.234, R2 = 25.9%, and was significantly related to IPA domains "autonomy indoors" (β = -0.043, 95% CI = -0.067 to -0.020, R2 = 20.6%), "autonomy outdoors" (β = -0.037, 95% CI = -0.062 to -0.012, R2 = 18.2%) and "social life and relationships" (β=-0.033, 95% CI = -0.060 to -0.007, R2 = 21.3%). CONCLUSION:Maximum aerobic capacity was severely reduced in persons with multiple sclerosis-related fatigue. This partly explains the limited physical functioning and restrictions in participation and autonomy indoors, outdoors and in social life and relationships in these persons.

journal_name

J Rehabil Med

journal_title

Journal of rehabilitation medicine

authors

Driehuis ER,van den Akker LE,de Groot V,Beckerman H

doi

10.2340/16501977-2306

subject

Has Abstract

pub_date

2018-02-13 00:00:00

pages

185-192

issue

eissn

1650-1977

issn

1651-2081

journal_volume

pub_type

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Aerobic capacity explains physical functioning and participation in patients with multiple sclerosis-related fatigue.