Experimental Evolution as a High-Throughput Screen for Genetic Adaptations.


:Experimental evolution is a method in which populations of organisms, often microbes, are founded by one or more ancestors of known genotype and then propagated under controlled conditions to study the evolutionary process. These evolving populations are influenced by all population genetic forces, including selection, mutation, drift, and recombination, and the relative contributions of these forces may be seen as mysterious. Here, I describe why the outcomes of experimental evolution should be viewed with greater certainty because the force of selection typically dominates. Importantly, any mutant rising rapidly to high frequency in large populations must have acquired adaptive traits in the selective environment. Sequencing the genomes of these mutants can identify genes or pathways that contribute to an adaptation. I review the logic and simple mathematics why this evolve-and-resequence approach is a powerful way to find the mutations or mutation combinations that best increase fitness in any new environment.






Cooper VS




Has Abstract


2018-05-09 00:00:00












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    authors: Amich J

    更新日期:2019-08-21 00:00:00

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    authors: O'Flaherty S,Briner Crawley A,Theriot CM,Barrangou R

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    更新日期:2019-02-06 00:00:00

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    authors: Bravo-Santano N,Ellis JK,Mateos LM,Calle Y,Keun HC,Behrends V,Letek M

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  • Evidence that the Plasmodium falciparum Protein Sortilin Potentially Acts as an Escorter for the Trafficking of the Rhoptry-Associated Membrane Antigen to the Rhoptries.

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    更新日期:2020-02-19 00:00:00

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    更新日期:2019-06-05 00:00:00

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    authors: Krishnananthasivam S,Sathkumara HD,Corea E,Natesan M,De Silva AD

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    authors: Altamirano S,Fang D,Simmons C,Sridhar S,Wu P,Sanyal K,Kozubowski L

    更新日期:2017-06-14 00:00:00

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    authors: Arkhipova IR

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    pub_type: 杂志文章


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    authors: Valotteau C,Prystopiuk V,Cormack BP,Dufrêne YF

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    pub_type: 杂志文章


    authors: Tomkovich S,Stough JMA,Bishop L,Schloss PD

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    pub_type: 杂志文章


    authors: Dodds D,Bose JL,Deng MD,Dubé GR,Grossman TH,Kaiser A,Kulkarni K,Leger R,Mootien-Boyd S,Munivar A,Oh J,Pestrak M,Rajpura K,Tikhonov AP,Turecek T,Whitfill T

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    pub_type: 杂志文章


    authors: Yu J,Hika B,Liu R,Sheng Z,Hause BM,Li F,Wang D

    更新日期:2017-08-09 00:00:00

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    pub_type: 杂志文章


    authors: Wangsanut T,Tobin JM,Rolfes RJ

    更新日期:2018-10-24 00:00:00

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    pub_type: 杂志文章


    authors: Reis FCG,Borges BS,Jozefowicz LJ,Sena BAG,Garcia AWA,Medeiros LC,Martins ST,Honorato L,Schrank A,Vainstein MH,Kmetzsch L,Nimrichter L,Alves LR,Staats CC,Rodrigues ML

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    pub_type: 杂志文章


    authors: Russo TA,MacDonald U

    更新日期:2020-01-08 00:00:00

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    pub_type: 杂志文章


    authors: Franklin-Murray AL,Mallya S,Jankeel A,Sureshchandra S,Messaoudi I,Lodoen MB

    更新日期:2020-01-29 00:00:00

  • In Silico Identification of Three Types of Integrative and Conjugative Elements in Elizabethkingia anophelis Strains Isolated from around the World.

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    pub_type: 杂志文章


    authors: Xu J,Pei D,Nicholson A,Lan Y,Xia Q

    更新日期:2019-04-03 00:00:00

  • Deletion of a Single LeishIF4E-3 Allele by the CRISPR-Cas9 System Alters Cell Morphology and Infectivity of Leishmania.

    abstract::The genomes of Leishmania and trypanosomes encode six paralogs of the eIF4E cap-binding protein, known in other eukaryotes to anchor the translation initiation complex. In line with the heteroxenous nature of these parasites, the different LeishIF4E paralogs vary in their biophysical features and their biological beha...


    pub_type: 杂志文章


    authors: Shrivastava R,Tupperwar N,Drory-Retwitzer M,Shapira M

    更新日期:2019-09-04 00:00:00