Abstract:
:The CRISPR/Cas9 system has emerged as a powerful tool to edit the genome. Among many applications, the system generates the exciting possibility of engineering small and large portions of chromosomes to induce a variety of structural alterations such as deletions, inversions, insertions and inter-chromosomal translocations. Furthermore, the availability of viral vectors that express Cas9 has been critical to deliver the CRISPR/Cas9 system directly in vivo to induce chromosomal rearrangements. This review provides an overview of the state-of-the-art CRISPR/Cas9 technology to model a variety of rearrangements in vivo in animal models.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Cheong TC,Blasco RB,Chiarle Rdoi
10.1007/978-981-13-0593-1_4subject
Has Abstractpub_date
2018-01-01 00:00:00pages
39-48eissn
0065-2598issn
2214-8019journal_volume
1044pub_type
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journal_title:Advances in experimental medicine and biology
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