当前位置： SCI文献检索 > ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY期刊下所有文献 > Clinical Symptoms, Neurological Signs, and Electrophysiological Findings in Surviving Residents with Probable Arsenic Exposure in Toroku, Japan.

Clinical Symptoms, Neurological Signs, and Electrophysiological Findings in Surviving Residents with Probable Arsenic Exposure in Toroku, Japan.

Abstract：

:Chronic arsenic intoxication is known to cause multisystem impairment and is still a major threat to public health in many countries. In Toroku, a small village in Japan, arsenic mines operated from 1920 to 1962, and residents suffered serious sequelae of arsenic intoxication. We have performed annual medical examinations of these residents since 1974, allowing us to characterize participants' long-term health following their last exposure to arsenic. The participants could not be described as having "chronic arsenic intoxication," because their blood arsenic levels were not measured. In this study, we defined them as having "probable arsenic intoxication." Symptoms frequently involved the sensory nervous system, skin, and upper respiratory system (89.1-97.8%). In an analysis of neurological findings, sensory neuropathy was common, and more than half of the participants complained of hearing impairment. Longitudinal assessment with neurological examinations and nerve conduction studies revealed that sensory dysfunction gradually worsened, even after exposure cessation. However, we could not conclude that arsenic caused the long-term decline of sensory function due to a lack of comparisons with age-matched healthy controls. This is the first study to characterize the longitudinal sequelae after probable arsenic exposure. Our study will be helpful to assess the prognosis of patients worldwide who still suffer from chronic arsenic intoxication.

journal_name

Arch Environ Contam Toxicol

journal_title

Archives of environmental contamination and toxicology

authors

Ishii N,Mochizuki H,Ebihara Y,Shiomi K,Nakazato M

doi

10.1007/s00244-018-0544-8

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

521-529

issue

4

eissn

0090-4341

issn

1432-0703

pii

10.1007/s00244-018-0544-8

journal_volume

75

pub_type

杂志文章

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