Abstract：
:Cowden's disease (multiple hamartoma syndrome) is a syndrome involving abnormalities of multiple organ systems. Transmitted in an autosomal dominant pattern, it carries a high frequency of mammary carcinoma in early middle age in affected women. The hyperkeratotic cutaneous and gingival markers of the disease are its principal overt manifestations. Prophylactic bilateral total mastectomy with optional immediate reconstruction is recommended for women Cowden's disease. An illustrative family with the disease is presented in which one affected young woman was found to have invasive mammary carcinoma with regional metastasis at the time of prophylactic mastectomy.
journal_name
Surgeryjournal_title
Surgeryauthors
Walton BJ,Morain WD,Baughman RD,Jordan A,Crichlow RWsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
82-6issue
1eissn
0039-6060issn
1532-7361pii
0039-6060(86)90206-0journal_volume
99pub_type
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