Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis.

abstract：:Numerous studies link arsenic exposure to human cancers in a variety of tissues, including the prostate. Our prior work showed that chronic arsenic exposure of the non-tumorigenic, human prostate epithelial cell line, RWPE-1, to low levels of (5 microM) sodium arsenite for 29 weeks resulted in malignant transformation...

journal_title：Toxicology and applied pharmacology

authors： Benbrahim-Tallaa L,Waterland RA,Styblo M,Achanzar WE,Webber MM,Waalkes MP

更新日期：2005-08-15 00:00:00

abstract：:Marijuana or synthetic cannabinoids and alcohol are often used together, with these combinations causing motor impairments that can subsequently lead to motor vehicle accidents. This study investigated the combined use of both synthetic cannabinoids and ethanol and their effect on motor coordination in mice in additio...

journal_title：Toxicology and applied pharmacology

authors： Funada M,Takebayashi-Ohsawa M,Tomiyama KI

更新日期：2020-12-01 00:00:00

abstract：:1,3-butadiene (BD) has been classified as a human carcinogen, however, the relationship between chromosomal damage and its metabolic polymorphisms is not clear. The present study used the CBMN assay to detect chromosomal damage in the peripheral lymphocytes of 166 exposed workers and 41 non-exposed healthy individuals...

journal_title：Toxicology and applied pharmacology

authors： Tan H,Wang Q,Wang A,Ye Y,Feng N,Feng X,Lu L,Au W,Zheng Y,Xia Z

更新日期：2010-09-15 00:00:00

abstract：:The phenylurea compound EDU (N-[2-(2-oxo-1-imidazolindinyl)ethyl]-N'-phenylurea) has been shown to protect plants from the damaging effects of ozone exposure. Models of rat lung injury, based on acute exposure to 2 ppm ozone for 3 hr and on exposure to 0.85 ppm ozone for 2 days, were used to determine whether EDU pret...

journal_title：Toxicology and applied pharmacology

authors： Bassett DJ,Elbon CL,Reichenbaugh SS,Boswell GA,Stevens TM,McGowan MC,Kerr JS

更新日期：1989-08-01 00:00:00

abstract：:Arsenic trioxide (ATO) has been reported to inhibit the activity of Ten-eleven translocation methylcytosine dioxygenase (TET). TET modulates FOXP3 expression, while dysregulation of FOXP3 expression promotes the malignant progression of leukemia cells. We examined the role of TET-FOXP3 axis in the cytotoxic effects of...

journal_title：Toxicology and applied pharmacology

authors： Chen YJ,Huang CH,Shi YJ,Lee YC,Wang LJ,Chang LS

更新日期：2018-11-01 00:00:00

abstract：:Aconitine (AC) is the primary bioactive/toxic alkaloid in plants of the Aconitum species. Our previous study demonstrated that Mdr1 was involved in efflux of AC. However, the mechanism by which Mdr1 regulates the efficacy/toxicity of AC in vivo remains unclear. The present study aimed to determine the effects of Mdr1a...

journal_title：Toxicology and applied pharmacology

authors： Zhu L,Wu J,Zhao M,Song W,Qi X,Wang Y,Lu L,Liu Z

更新日期：2017-04-01 00:00:00

abstract：:Juvenile rats have been reported to be more sensitive to the acute neurotoxic effects of the pyrethroid deltamethrin than adults. While toxicokinetic differences between juveniles and adults are documented, toxicodynamic differences have not been examined. Voltage-gated sodium channels, the primary targets of pyrethro...

journal_title：Toxicology and applied pharmacology

authors： Meacham CA,Brodfuehrer PD,Watkins JA,Shafer TJ

更新日期：2008-09-15 00:00:00

abstract：:Several neurotoxic compounds cause aggregation of neurofilaments in peripheral axons. This may represent a primary action of these chemicals or a secondary response to other cellular damage. To distinguish between these possibilities, the effects of acrylamide and 2,5-hexanedione (2,5-HD) on vimentin were examined in ...

journal_title：Toxicology and applied pharmacology

authors： Sager PR

更新日期：1989-01-01 00:00:00

abstract：:Exposure of mice to cationic rhodamines, Rh 123 and Rh 6G, has been found to be associated with developmental toxicity, while neutral rhodamines (e.g., Rh B) had no such effect. When mouse embryos from dams given ip injections of Rh 123, Rh 6G (15 mg/kg), or Rh B (30 mg/kg) on gestation Day (GD) 10 were examined, Rh 1...

journal_title：Toxicology and applied pharmacology

authors： Ranganathan S,Churchill PF,Hood RD

更新日期：1989-06-01 00:00:00

abstract：:4-Alkylbicyclophosphates, R1C(CH2O)3P(O), with suitable R1 substituents (e.g., t-butyl, isopropyl, or cyclohexyl) are highly toxic compounds [mouse intraperitoneal (ip) LD50 values 0.036-0.52 mg/kg] and are potent noncompetitive gamma-aminobutyric acid (GABA) antagonists. 4-Alkylmonocyclophosphates of the type R1(HOCH...

journal_title：Toxicology and applied pharmacology

authors： Toia RF,Casida JE

更新日期：1985-10-01 00:00:00

abstract：:Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In parallel, extensive resear...

journal_title：Toxicology and applied pharmacology

authors： Riebeling C,Wiemann M,Schnekenburger J,Kuhlbusch TA,Wohlleben W,Luch A,Haase A

更新日期：2016-05-15 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients harboring EGFR mutation who initially respond to EGFR-TKI will gradually develop acquired resistance. There is still a challenge to treat EGFR-TKI resistant NSCLC patients. Polyphyllin I (PP I), a steroidal saponin isolated from Paris polyphylla., has been exhibited antitumo...

journal_title：Toxicology and applied pharmacology

authors： Yang Q,Chen W,Xu Y,Lv X,Zhang M,Jiang H

更新日期：2018-10-01 00:00:00

abstract：:The benzofurane derivative benzbromarone (BBR) previously has led to liver tumor formation after long-term treatment of rats, but no indications of genotoxicity were detected. The present studies were designed to elucidate the mechanism(s) possibly involved in liver tumor formation by BBR. Female Wistar rats were used...

journal_title：Toxicology and applied pharmacology

authors： Parzefall W,Schuppler J,Barthel G,Meyer-Rogge B,Schulte-Hermann R

更新日期：1990-12-01 00:00:00

abstract：:Drinking water contaminated with arsenic, a human carcinogen, is a worldwide health issue. An understanding of cellular signaling events in response to arsenic exposure and rational designing of strategies to reduce arsenic damages by modulating signaling events are important to fight against arsenic-induced diseases....

journal_title：Toxicology and applied pharmacology

authors： Wang XJ,Sun Z,Chen W,Li Y,Villeneuve NF,Zhang DD

更新日期：2008-08-01 00:00:00

abstract：:Female Sprague-Dawley rats were treated with a single ip dose of aflatoxin B1 (AFB1) (3 or 6 mg/kg). Twenty-four hours later and weekly until killed, some of the rats treated with AFB1 were given ethynylestradiol (EE) by gavage at the dose of 13 mg/kg. One, three, six, and nine months following the beginning of the ex...

journal_title：Toxicology and applied pharmacology

authors： Kamdem L,Magdalou J,Siest G,Ban M,Zissu D

更新日期：1983-01-01 00:00:00

abstract：:Historical studies report that cellular injury and silicosis are related to cytosolic free calcium (Ca2+). Moreover, reactive oxygen species (ROS) have been linked to cellular injury. However, the detail mechanism of the increase in [Ca2+]i and the relationship between [Ca2+]i and ROS production remains unknown. Quart...

journal_title：Toxicology and applied pharmacology

authors： Tian F,Zhu T,Shang Y

更新日期：2010-01-15 00:00:00

abstract：:Chlorinated dibenzo-p-dioxins (CDDs) are a series of mono- to octa-chlorinated homologous chemicals commonly referred to as polychlorinated dioxins. One of the most potent, well-known, and persistent member of this family is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). As part of translational research to make computer...

journal_title：Toxicology and applied pharmacology

authors： Emond C,Ruiz P,Mumtaz M

更新日期：2017-01-15 00:00:00

abstract：:Direct additions to culture media of either acetaminophen (APAP) or 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) resulted in abnormal closure of the anterior neuropores of cultured rat embryos in the absence of an exogenous bioactivation system. Concentrations required to produce a 50% incidence of the defect were appro...

journal_title：Toxicology and applied pharmacology

authors： Harris C,Stark KL,Luchtel DL,Juchau MR

更新日期：1989-12-01 00:00:00

abstract：:Follicle growth culminates in ovulation, which allows for the expulsion of fertilizable oocytes and the formation of corpora lutea. Bisphenol A (BPA) is present in many consumer products, and it has been suggested that BPA impairs ovulation; however, the underlying mechanisms are unknown. Therefore, this study first e...

journal_title：Toxicology and applied pharmacology

authors： Moore-Ambriz TR,Acuña-Hernández DG,Ramos-Robles B,Sánchez-Gutiérrez M,Santacruz-Márquez R,Sierra-Santoyo A,Piña-Guzmán B,Shibayama M,Hernández-Ochoa I

更新日期：2015-12-15 00:00:00

abstract：:The commonly used antidepressants imipramine, amitriptyline, and nortriptyline were found to significantly inhibit human natural killer (NK) cell-mediated cytolysis in vitro and suppress the stimulation of NK cells by IFN-gamma. This is a previously unrecognized biologic property of these drugs with psychotropic activ...

journal_title：Toxicology and applied pharmacology

authors： Xiao L,Eneroth P

更新日期：1996-04-01 00:00:00

abstract：:Prescribing appropriate Tacrolimus (Tac) dosing is still a challenge for clinicians due to the interindividual variability in dose requirement and the narrow therapeutic index. Our objective is to identify potential factors that affects Tac exposure in Tunisian Kidney patients and to develop and validate a Tac dose re...

journal_title：Toxicology and applied pharmacology

authors： Ben-Fredj N,Hannachi I,Chadli Z,Ben-Romdhane H,A Boughattas N,Ben-Fadhel N,Aouam K

更新日期：2020-11-15 00:00:00

abstract：:Differential induction of hepatic cytochromes P450 by 3,4,5,3',4'-pentachlorobiphenyl (PENCB) has been observed in the rat and the guinea pig: (1) in rat and guinea pig, treatment with the chosen dose levels resulted in significant induction of total, carbon monoxide-discernible cytochrome P450 content; the absorption...

journal_title：Toxicology and applied pharmacology

authors： Huang S,Gibson GG

更新日期：1991-03-15 00:00:00

abstract：:The iron chelate, ferric nitrilotriacetate (FeNTA), induces acute proximal tubular necrosis as a consequence of lipid peroxidation and oxidative tissue damage. Chronic exposure of FeNTA leads to a high incidence of renal adenocarcinomas in rodents. NF-E2-related factor 2 (Nrf2) is a transcription factor that is activa...

journal_title：Toxicology and applied pharmacology

authors： Tanaka Y,Aleksunes LM,Goedken MJ,Chen C,Reisman SA,Manautou JE,Klaassen CD

更新日期：2008-09-15 00:00:00

abstract：:Fibrinogen, a soluble 340kDa plasma glycoprotein, is critical in achieving and maintaining hemostasis. Reduced fibrinogen levels are associated with an increased risk of bleeding and recent research has investigated the efficacy of fibrinogen concentrate for controlling perioperative bleeding. European guidelines on t...

journal_title：Toxicology and applied pharmacology

authors： Beyerle A,Nolte MW,Solomon C,Herzog E,Dickneite G

更新日期：2014-10-01 00:00:00

abstract：:Glycyrrhetinic acid (GA), the main active ingredient of licorice, reportedly has anti-inflammatory and hepatoprotective properties, but its molecular mechanisms remain be elusive. In the present study, Balb/c mice were pretreated with GA (10, 30, or 100mg/kg) 1h before lipopolysaccharide (LPS)/d-galactosamine (D-GalN)...

journal_title：Toxicology and applied pharmacology

authors： Yin X,Gong X,Zhang L,Jiang R,Kuang G,Wang B,Chen X,Wan J

更新日期：2017-04-01 00:00:00

abstract：:Diethyl maleate (DEM) pretreatment has previously been shown to result in a transient depletion of lung glutathione and an associated decrease of the time to the onset of rat mortality resulting from exposures to 100% oxygen in vivo. The effects of oxygen exposure on mitochondrial energy metabolism were assessed by me...

journal_title：Toxicology and applied pharmacology

authors： Bassett DJ,Reichenbaugh SS

更新日期：1992-08-01 00:00:00

abstract：:Rodent bioassays indicate that B6C3F1 mice are more sensitive to the carcinogenicity of benzene than are rats. The urinary profile of benzene metabolites is different in rats vs mice. Mice produce higher proportions of hydroquinone conjugates and muconic acid, indicators of metabolism via pathways leading to putative ...

journal_title：Toxicology and applied pharmacology

authors： Sabourin PJ,Muggenburg BA,Couch RC,Lefler D,Lucier G,Birnbaum LS,Henderson RF

更新日期：1992-06-01 00:00:00

abstract：:We have studied the effects of opiates on ATP and acetylcholine (ACh) release from cholinergic nerve terminals isolated from the electric organ of Torpedo marmorata. The release of ATP was inhibited by morphine and this action was reversed by naloxone. Morphine, [D-Met2-Pro5]enkephalinamide and [D-Ala2-Leu5]enkephalin...

journal_title：Toxicology and applied pharmacology

authors： Saltó C,Calvet R,Guitart X,Solsona C,Marsal J

更新日期：1990-10-01 00:00:00

abstract：:Deoxynivalenol (DON) is one of the most common mycotoxins which contaminate cereals and their by-products worldwide. Previous studies have stated toxic effects of DON on liver. Heme oxygenase-1 (HO-1) plays a potential role in protecting liver and maintaining gut microbiota homeostasis. Therefore, a study on the poten...

journal_title：Toxicology and applied pharmacology

authors： Peng Z,Liao Y,Chen L,Liu S,Shan Z,Nüssler AK,Yao P,Yan H,Liu L,Yang W

更新日期：2019-07-01 00:00:00

abstract：:Acute exposure to Cd produces liver injury, whereas chronic exposure results in kidney injury. Tolerance to the hepatotoxicity is observed during chronic exposure to Cd due to the induction of metallothionein (MT). The nephrotoxicity produced by chronic Cd exposure purportedly results from renal uptake of Cd-metalloth...

journal_title：Toxicology and applied pharmacology

authors： Sendelbach LE,Klaassen CD

更新日期：1988-01-01 00:00:00