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Mechanical Unloading in Heart Failure.

Abstract：

:Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means of preventing or reversing cardiac remodeling. In acute myocardial infarction, cardiac unloading is used to reduce oxygen demand and limit infarct size. Research has demonstrated the benefits of short-term unloading with mechanical circulatory support devices before reperfusion in the context of acute myocardial infarction with cardiogenic shock, and a confirmatory trial is ongoing. In chronic heart failure, ventricular unloading using mechanical circulatory support can reverse many of the cellular and anatomic changes that accompany ventricular remodeling. Ongoing research is evaluating the ability of left ventricular assist devices to promote myocardial recovery and remission from clinical heart failure.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Uriel N,Sayer G,Annamalai S,Kapur NK,Burkhoff D

doi

10.1016/j.jacc.2018.05.038

subject

Has Abstract

pub_date

2018-07-31 00:00:00

pages

569-580

issue

5

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(18)35001-0

journal_volume

72

pub_type

杂志文章,评审

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