Abstract:
:Low concentrations of arsenic (As) contamination in aquatic environment is a worldwide issue, which is of great concern. To evaluate the impact of low concentrations of As on zebrafish, we measured the growth, antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT), oxidative damage (malondialdehyde, MDA) and apoptosis-related genes (nrf2, p53 and c-jun) of adult zebrafish after exposing to different AsIII concentrations (0, 10, 50, 100 or 150 μg L-1) for 28 d. Results indicated that exposure to low AsIII concentrations decreased the zebrafish weight by 14%, increased the activities of SOD and CAT by 23-41% and 31-59%, decreased the contents of MDA by 29-54%, and modulated transcription of apoptosis related genes. Our study showed that chronic exposure to AsIII concentrations <150 μg L-1 generated oxidative stress and damage on zebrafish, and altered apoptosis-related genes in zebrafish.
journal_name
Chemospherejournal_title
Chemosphereauthors
Dong WQ,Sun HJ,Zhang Y,Lin HJ,Chen JR,Hong HCdoi
10.1016/j.chemosphere.2018.08.010subject
Has Abstractpub_date
2018-11-01 00:00:00pages
648-652eissn
0045-6535issn
1879-1298pii
S0045-6535(18)31478-4journal_volume
211pub_type
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