Abstract：
:Phytol (PYT) is a diterpenoid having important biological activity. However, it is a water non-soluble compound. This study aims to prepare PYT nanoemulsion (PNE) and evaluation of toxic, cytotoxic and genotoxic activities of PYT and PNE. For this, the PNE was prepared by the phase inversion method. The cytotoxicity test was performed in Artemia salina, while toxicity, cytotoxicity and genotoxicity in Allium cepa at concentrations of 2, 4, 8 and 16 mM. Potassium dichromate and copper sulfate were used as positive controls for the tests of A. salina and A. cepa, respectively. In addition, an adaptation response was detected in A. cepa by using the comet assay. The results suggest that both PYT and PNE exhibited toxic and cytotoxic effects at 4-16 mM in either test system, while genotoxicity at 2-16 mM in A. cepa. PNE exhibited more toxic, cytotoxic and genotoxic effects at 8 and 16 mM than the PYT. However, both PYT and PNE at 2 and 4 mM decreased the index and frequency of damage in A. cepa after 48 and 72 h, suggesting a possible adaptation response or DNA damage preventing capacity. Nanoemulsified PYT (PNE) may readily cross the biological membranes with an increase in bioavailability and produce more toxic, cytotoxic and genotoxic effects in the used test systems.
journal_name
Chemospherejournal_title
Chemosphereauthors
Islam MT,Streck L,de Alencar MV,Cardoso Silva SW,da Conceição Machado K,da Conceição Machado K,Gomes Júnior AL,Paz MF,da Mata AM,de Castro E Sousa JM,da Costa Junior JS,Lins Rolim HM,da Silva-Junior AA,de Carvalho Melo-Cavalcandoi
10.1016/j.chemosphere.2017.02.145subject
Has Abstractpub_date
2017-06-01 00:00:00pages
93-101eissn
0045-6535issn
1879-1298pii
S0045-6535(17)30334-Xjournal_volume
177pub_type
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