Abstract:
:Pesticides have become an essential tool for pest kill, weed control and microbiome inhibition for both agricultural and domestic use. However, with the massive use, pesticides can exist in soil, air and water, and sometimes even accumulate in the human or other mammals through food chains. Lots of researches have proven that pesticides possess toxicity to mammals on endocrine, neural and immune systems. Autophagy, as a conservative intracellular process, which is activated by stress-related signals, plays a pivotal role, either "angle" or "demon", in regulation of cell fate and function. Recent evidences in researches elucidated a strong link between the autophagy and the toxicity of pesticides. In this review, we summarized the previous researches which focus on the autophagy regulation in the pesticides-induced toxicity, and hope that this work can help us to discover a potential strategy for the treatment of the disease caused by pesticides.
journal_name
Chemospherejournal_title
Chemosphereauthors
He B,Wang X,Yang C,Zhu J,Jin Y,Fu Zdoi
10.1016/j.chemosphere.2019.125138subject
Has Abstractpub_date
2020-03-01 00:00:00pages
125138eissn
0045-6535issn
1879-1298pii
S0045-6535(19)32377-Xjournal_volume
242pub_type
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