Abstract:
BACKGROUND AND OBJECTIVES:Immunoglobulin A vasculitis (IgAV) might develop after vaccination. However, this potential relationship is essentially based on case reports, and robust pharmaco-epidemiologic data are scarce. We aimed to investigate the effect of vaccination on short-term risk of IgAV in children. METHODS:We enrolled children <18 years old with IgAV seen in 5 pediatric departments from 2011 to 2016. Data on vaccinations administered during the year preceding IgAV onset were collected from immunization records. With a case-crossover method and by using conditional logistic-regression analyses, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by comparing vaccine exposure during the 3-month "index period" immediately preceding IgAV onset to that during 3 consecutive 3-month "control" periods immediately before the index period. Stratifications by season, year of onset, infection history, age, sex, type, or number of vaccines were performed. Sensitivity analyses used 1-, 1.5-, or 2-month index and control periods. RESULTS:Among 167 children (mean age: 6.7 years) enrolled, 42 (25%) received ≥1 vaccine during the year before IgAV onset. Fifteen (9%) children were vaccinated during the 3-month index period as compared with 4% to 7% during the 3 control periods. The OR for IgAV occurring within the 3 months after vaccination was 1.6 (95% CI: 0.8-3.0). Analyses of IgAV risk within 1, 1.5, or 2 months of vaccination yielded ORs of 1.4 (95% CI: 0.5-3.5), 1.4 (95% CI: 0.6-3.2), and 1.3 (95% CI: 0.6-2.6), respectively. Stratifications revealed no significant association. CONCLUSIONS:Vaccination may not be a major etiological factor of childhood IgAV.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Piram M,Gonzalez Chiappe S,Madhi F,Ulinski T,Mahr Adoi
10.1542/peds.2018-0841subject
Has Abstractpub_date
2018-11-01 00:00:00issue
5eissn
0031-4005issn
1098-4275pii
peds.2018-0841journal_volume
142pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVES:To examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) to changes in body composition in older adolescents. METHODS:Medically healthy 15- to 20-year-olds who were unmedicated or within 1 month of sta...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-3943
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:The prevalence and identification of hypertriglyceridemia in youths will likely will increase in the future as a consequence of childhood obesity and increased screening for dyslipidemias. We sought to review our clinical experience with hypertriglyceridemia, evaluate factors associated with increased trigly...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-0367
更新日期:2009-02-01 00:00:00
abstract::An organization of clinical faculty has been formed at Rainbow Babies and Childrens Hospital, Cleveland, Ohio, to help coordinate the mutual goals but sometimes conflicting needs of practicing pediatricians and a teaching hospital. The organization has been active in developing and conducting educational experiences f...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1975-08-01 00:00:00
abstract::Pulmonary interstitial emphysema is a condition that has become a significant problem chiefly as a complication of mechanical ventilation of the newborn. In its severe forms, it may compromise ventilation and restrict pulmonary blood flow to the degree that it becomes a significant cause of mortality. When its occurre...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-10-01 00:00:00
abstract:OBJECTIVE:We examined the association between type of child care, participation in different types of child care in the year before kindergarten and the likelihood of obesity at the start of kindergarten. METHODS:Using a nationally representative sample of 15 691 first-time kindergartners from the Early Childhood Long...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-2233
更新日期:2008-08-01 00:00:00
abstract::Hyperammonemia with coma, tachypnea, and respiratory alkalosis developed in a 3-year-old boy with prune"-belly syndrome during a urinary tract infection with Proteus mirabilis. Hyperammonemia is thought to have resulted from the production within the massively dilated urinary tract of excessive amounts of ammonia due ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1980-02-01 00:00:00
abstract::Trismus refers to any condition inducing limited mouth opening and may present as a result of acquired or congenital pathology. We present the case of a newborn who presented with severe, congenital trismus due to brainstem dysgenesis. We describe the course of his investigations, and a multidisciplinary approach to t...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2015-4605
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Improvement in survival of extremely premature infants over the past several decades has resulted in an increase in the number of infants with chronic lung disease (CLD). Historical neonatal exposures associated with CLD now less frequently precede the disease. There is now increasing interest in exposures an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-3249
更新日期:2009-09-01 00:00:00
abstract::Measles is readily spread to susceptible individuals, but is no longer endemic in the United States. In March 2011, measles was confirmed in a Minnesota child without travel abroad. This was the first identified case-patient of an outbreak. An investigation was initiated to determine the source, prevent transmission, ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-4260
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Many individuals with autism spectrum disorders (ASDs) are approaching adolescence and young adulthood; interventions to assist these individuals with vocational skills are not well understood. This study systematically reviewed evidence regarding vocational interventions for individuals with A...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2012-0682
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:Sedation sometimes is necessary to perform an electroencephalogram (EEG) on a child. A dramatic decline in the need to use conscious sedation in our EEG laboratory prompted this review of our sedation experience. The purpose of this review was to determine the incidence of adverse sedation effects and to dete...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.1.163
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:The aim of this article was to describe how providers in an Indian NICU reach life-or-death treatment decisions. METHODS:Qualitative in-depth interviews, field observations, and document analysis were conducted at an Indian nonprofit private tertiary institution that provided advanced neonatal care under con...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-3227
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Two of the most prevalent problems facing youth in the United States are injury and obesity. Obesity increases the risk of injury, prolongs recovery time, and increases morbidity among injured children. OBJECTIVE:The purpose of this study was to compare characteristics of injuries between obese and nonobese...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-2367
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:To analyze, in extremely low birth weight infants, associations between peak bilirubin concentration and evidence of brain damage, and between peak bilirubin concentration and blindness attributable to retinopathy of prematurity. METHODS:Retrospective study of 128 infants of =800 g birth weight and =27 ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.6.1426
更新日期:1998-12-01 00:00:00
abstract::CO2 chemoreceptor function was assessed during natural sleep and following the administration of 100 mg/kg of chloral hydrate to 26 puppies. With chloral hydrate-induced sleep, there were no significant changes in ventilation or in CO2 chemoreceptor response. The ventilation and CO2 chemoreceptor response of a group o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::The bilirubin titration point--the lowest bilirubin concentration at which loosely bound bilirubin could be demonstrated by Sephadex gel filtration--was determined in samples collected before, during, and on completion of 17 exchange transfusions as well as in the discarded and donor blood. The bilirubin titration poi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::Today clinical information is used for a multitude of purposes beyond patient care documentation including quality review and improvement processes, allocation of resources, budgetary and long-term planning, productivity measurement, and justification to payers for services provided. Providers in perinatal medicine ar...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::In February 1981, a measles outbreak occurred in a pediatric practice in DeKalb County, GA. The source case, a 12-year-old boy vaccinated against measles at 11 1/2 months of age, was in the office for one hour on the second day of rash, primarily in a single examining room. On examination, he was noted to be coughing ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::An overview is presented of the major methods of contraception available to the sexually active adolescent. Emphasis is given to the combined birth control pill, while the literature describing absolute and relative contraindications to oral contraception is reviewed. It is noted that adolescents with chronic illness ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Sleep deprivation and sleepiness are associated with poorer school performance, impaired neurobehavioral functioning, and behavioral problems. OBJECTIVE:To determine if adolescents with high levels of sleepiness or short sleep duration have impaired executive functioning. METHODS:Ours was a cross-sectional...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-1182
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:International efforts have been focused on identifying children at low risk of clinically important traumatic brain injury in whom computed tomography (CT) neuroimaging can be avoided. We sought to determine if CT use for pediatric head trauma has decreased among US emergency departments (EDs)...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-0814
更新日期:2018-10-01 00:00:00
abstract::Recently, a 7-month-old, terminally ill Gypsy infant was admitted to a pediatric intensive care unit. Treating this child and her extended family was a challenging experience during which numerous culture-related problems were encountered. The Gypsy approach to acute medical care consisted of the presence of a large e...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract:OBJECTIVE:Hepatitis B vaccine is recommended for all infants, and the series may be started during the delivery admission. For infants who are born either to women who are positive for hepatitis B surface antigen (HBsAg) or to women whose HBsAg status is unknown, vaccination should be started within 12 hours of birth t...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.111.6.e645
更新日期:2003-06-01 00:00:00
abstract::We have examined the suppression of urinary pregnanetriol and 17-ketosteroids during treatment with cortisol, cortisone, prednisone, and dexamethasone in eight patients with congenital adrenal hyperplasia. A large individual variation in response to each agent was observed. In some individuals, cortisone is less effec...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1976-06-01 00:00:00
abstract:BACKGROUND:The possible link between immunization and atopic diseases has been under intense debate in the last decade. OBJECTIVE:The aim of this study was to systematically review the available evidence on the association of whole-cell pertussis and BCG vaccination with the risk of asthma in childhood and adolescence...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.2006-3569
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Chagas disease is caused by infection with Trypanosoma cruzi. In adults, treatment with benznidazole is associated with a high incidence of adverse drug reactions (ADRs). However, in infants and children, treatment with benznidazole seems associated with a lower incidence and decreased severity of ADRs, but ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-1172
更新日期:2011-01-01 00:00:00
abstract::Two immunochemical methods were used to identify Haemophilus influenzae and Streptococcus pneumoniae capsular antigens in the urine and serum of 162 children with acute lower respiratory tract infection. These methods were compared with standard bacterial blood culture. Viral and mycoplasma cultures of respiratory sec...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::Sudden infant death syndrome (SIDS) victims were regarded as normal as a matter of definition (Beckwith 1970) until 1952 when Kinney and colleagues argued for elimination of the clause, "unexpected by history." They argued that "not all SIDS victims were normal," and referred to their hypothesis that SIDS results from...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.110.5.e64
更新日期:2002-11-01 00:00:00
abstract::A child with a poorly differentiated lymphoma developed varicella while being treated with maintenance chemotherapeutic agents. He received a transfusion of nonirradiated leukocytes from 1 unit of whole blood donated by a healthy volunteer who had recently recovered from varicella. The clinical course of varicella was...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
abstract::A 5-year-old boy with chronic granulomatous disease (CGD) received four granulocyte transfusions from unrelated HLA-matched donors as part of therapy for a hepatic abscess. Survival studies of transfused granulocytes using the endotoxin-stimulated nitroblue tetrazolium (NBT) test on two occasions demonstrated 19.6% an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00