Evaluation of long-term cultured endothelial cells as a model system for studying vascular ageing.

abstract：:In this study, we showed that in flies kept for 2 weeks at 1 (terrestrial gravity), 3 or 5 x g (hypergravity, HG) before transfer to 1 x g, resistance to heat remained higher in HG flies for several weeks after the transfer. The measurement of heat shock protein 70 (hsp70) indicated no induction of the protein in HG, ...

journal_title：Mechanisms of ageing and development

authors： Minois N,Guinaudy MJ,Payre F,Le Bourg E

更新日期：1999-06-01 00:00:00

abstract：:It is generally accepted that free-radical induced blood lipid peroxidation and especially peroxidized LDL play a central role in the pathogenesis of atherosclerosis and related cardiovascular disease. Moreover, recent research highlights the key contribution of apolipoprotein B (apo B) to atherogenesis as the main in...

journal_title：Mechanisms of ageing and development

authors： Ramírez-Boscá A,Soler A,Carrión MA,Díaz-Alperi J,Bernd A,Quintanilla C,Quintanilla Almagro E,Miquel J

更新日期：2000-10-20 00:00:00

abstract：:Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites. This reaction is catalysed by GSH S-transferase (GST) and play a major role in modulation of AFB1 adduct formation to nuclear DNA. Changes recorded in hepatic GST activity during development of rats ca...

journal_title：Mechanisms of ageing and development

authors： Allameh A,Farahani M,Zarghi A

更新日期：2000-05-18 00:00:00

abstract：:The previous observation (Eur. J. Biochem., 82 (1978) 563--567) that age-dependent accumulation of lipid peroxides follows as a consequence of increased radical formation in mitochondria has prompted an examination of the response of a set of protective enzymes to the above situation. Levels of mitochondrial catalase ...

journal_title：Mechanisms of ageing and development

authors： Nohl H,Hegner D,Summer KH

更新日期：1979-10-01 00:00:00

abstract：:This paper is part of a series aimed to investigate the mechanism of the action of Folcysteine, a substance that has the capacity to release in the body active -SH groups and has been proved to be effective in the control of menopausal troubles. As an experimental model the ovariectomized rat, rather similar, from the...

journal_title：Mechanisms of ageing and development

authors： Moldoveanu E,Klein R,Bartoc R,Bruhis S,Oeriu I

更新日期：1975-09-01 00:00:00

abstract：:As measured by X-ray microanalysis of frozen-dried cryosections, physiological concentrations of phosphorus, Na+, K+ and Mg2+ show a biphasic age dependence in some compartments of rat hepatocytes, especially in the regions of condensed chromatin associated with the actively transcribed genes. This could be consistent...

journal_title：Mechanisms of ageing and development

authors： von Zglinicki T,Bimmler M

更新日期：1987-04-01 00:00:00

abstract：:Elevated reactive oxygen species (ROS) levels have been observed in mammals during aging, implying an important role of ROS in the aging process. Most bird species are known to live longer and to contain lower ROS levels than mammals of the same body weight. The influence of ROS on the aging process of birds has been ...

journal_title：Mechanisms of ageing and development

authors： Strecker V,Mai S,Muster B,Beneke S,Bürkle A,Bereiter-Hahn J,Jendrach M

更新日期：2010-01-01 00:00:00

abstract：:In this paper, I attempt to address the problem of how to model the survival curve in the early lifespan years; the neonatal years. I present a general model for a two group population in which the first group represents early stage failure and the second group represents the classical Gompertzian failure. After calcu...

journal_title：Mechanisms of ageing and development

authors： Witten M

更新日期：1986-01-01 00:00:00

abstract：:The purpose of this study was to test the hypothesis that regular exercise training in elderly people affects the type 1/type 2 balance. Nine elderly women who train by walking (mean+/-S.E.M., age 63+/-1 years, VO2 peak 32.2+/-1.0 ml kg(-1) min(-1)), 12 age-matched untrained women (63+/-1 years, 27.8+/-0.9 ml kg(-1) m...

journal_title：Mechanisms of ageing and development

authors： Ogawa K,Oka J,Yamakawa J,Higuchi M

更新日期：2003-08-01 00:00:00

abstract：:Werner syndrome (WS) is a premature aging and cancer-prone disease caused by loss of the RecQ helicase WRN protein. Cultured WS fibroblasts display high genomic instability and senesce prematurely. Epigenetic inactivation of the WRN gene occurs in numerous tumor types, in which WRN demonstrates tumor suppressor-like a...

journal_title：Mechanisms of ageing and development

authors： Opresko PL,Calvo JP,von Kobbe C

更新日期：2007-07-01 00:00:00

abstract：:Possible alterations in the population of poly(A)(+)mRNA during ageing were investigated by translation in vitro of poly(A)(+)mRNA from the liver, kidney and brain of male ddY mice of different ages. [35S]Methionine-labeled translation products were analysed by two-dimensional polyacrylamide gel electrophoresis follow...

journal_title：Mechanisms of ageing and development

authors： Anzai K,Imazato C,Goto S

更新日期：1983-10-01 00:00:00

abstract：:Alteration of T cell surface marker expression with a decrease of CD3 positive cells relative to the number of CD4 and CD8 positive cells, diminished in vitro proliferative response to mitogenic stimuli like PHA and antibodies to the CD3/Ti complex, and increase in serum IL-2 receptor levels, are among the changes in ...

journal_title：Mechanisms of ageing and development

authors： Hallgren HM,Bergh N,Rodysill KJ,O'Leary JJ

更新日期：1988-05-01 00:00:00

abstract：:The B cell responsiveness mediated by T cells has been evaluated in 50 aged donors by using a Pokeweed mitogen (PWM)-driven differentiation system. Peripheral blood mononuclear cells (PBMC) from aged donors exhibited a lower plaque-forming cell (PFC) generation in comparison with young donors. Similar results were obt...

journal_title：Mechanisms of ageing and development

authors： Antonaci S,Jirillo E,Gallitelli M,Garofalo AR,Bonomo L

更新日期：1987-11-01 00:00:00

abstract：:The cerebellum is exquisitely sensitive to deficiencies in the cellular response to specific DNA lesions. Genetic disorders caused by such deficiencies involve relentless, progressive cerebellar atrophy with striking loss of Purkinje and granule neurons. The reason for the extreme sensitivity of these cells to defecti...

journal_title：Mechanisms of ageing and development

authors： Tzur-Gilat A,Ziv Y,Mittelman L,Barzilai A,Shiloh Y

更新日期：2013-10-01 00:00:00

abstract：:We tested the hypothesis that Ca(2+)-activated myosin ATPase activity is lower in muscles of aged rats relative to muscles of young rats, independent of changes in myosin isoform expression. Myofibrils were prepared from permeabilized fibers of soleus, plantaris, and semimembranosus muscles of young (8-12 months) and ...

journal_title：Mechanisms of ageing and development

authors： Lowe DA,Husom AD,Ferrington DA,Thompson LV

更新日期：2004-09-01 00:00:00

abstract：:In mammals, proliferation is rapid in many tissues during early postnatal life, causing rapid somatic growth. This robust proliferation is then suppressed as the animal approaches adult size, bringing many tissues to a quiescent state where proliferation occurs only as needed to replace dying cells. Recent evidence su...

journal_title：Mechanisms of ageing and development

authors： Lui JC,Chen W,Barnes KM,Baron J

更新日期：2010-10-01 00:00:00

abstract：:There is now strong evidence implicating the generation of reactive oxygen species (ROS) and the corresponding response to oxidative stress as key factors in the pathogenesis of several human diseases including cancer, atherosclerosis, and neurodegenerative disorders, and in ageing. The carcinogenicity of oxidative st...

journal_title：Mechanisms of ageing and development

authors： Lee KW,Lee HJ

更新日期：2006-05-01 00:00:00

abstract：:The ascidian Ciona intestinalis has a short life span and powerful regeneration capacities. The regeneration of the oral siphon (OS) involves wound healing, blastema formation, cell proliferation, and replacement of 8 oral pigment organs (OPO), the latter via differentiation and migration of stem/precursor cells from ...

journal_title：Mechanisms of ageing and development

authors： Jeffery WR

更新日期：2012-09-01 00:00:00

abstract：:Long-Evans female rats three weeks, three months and 13-14 months of age were placed on tryptophan-deficient diets for periods ranging from a few months to nearly two years. Growth was interupted during the period of tryptophan-deficiency, but when the animals were returned to a complete diet, they gained weight and g...

journal_title：Mechanisms of ageing and development

authors： Segall PE,Timiras PS

更新日期：1976-03-01 00:00:00

abstract：:Morphometric comparison of freeze-fractured mitochondria in flight muscles of adult (37-day-old) and old (68-day-old) houseflies revealed a 28% decrease of cristae in the old flies. The major membrane change with age was an increase in the 90-120-A particles in the inner membrane external face concomitant with a loss ...

journal_title：Mechanisms of ageing and development

authors： Turturro A,Shafiq SA

更新日期：1981-06-01 00:00:00

abstract：:The synthesis of sulfated proteoglycans in late fetal (19th to 22nd day of intrauterine life), early postnatal, and adult liver tissue as well as in hepatocytes and their distribution in plasma membranes were studied. Overall proteoglycan production is enhanced two-fold in fetal as compared with adult liver tissue. In...

journal_title：Mechanisms of ageing and development

authors： Gressner AM,Vasel A

更新日期：1985-09-01 00:00:00

abstract：:The endothelin-1 (ET-1) concentrations were measured by RIA in the media of confluent monolayer cultures of rat articular chondrocyte (RAC) exposed to fetal calf serum (FCS) and several growth factors and cytokines. The cells were obtained from 1- and 18-month-old rats. First passage cells were starved in Dulbecco's m...

journal_title：Mechanisms of ageing and development

authors： Messai H,Khatib AM,Lebrun G,Aubin P,Florina M,Jean F,Mitrovic DR

更新日期：2000-02-22 00:00:00

abstract：:In order to gain a better understanding of tissue plasticity with aging, we investigated the adaptive responses of young and adult animals to both 7 and 28 days of hypobaric hypoxia. Senescence is associated with a decreased tolerance to hypoxia that may be related to an age-associated decline in glucose transporter s...

journal_title：Mechanisms of ageing and development

authors： Dill RP,Chadan SG,Li C,Parkhouse WS

更新日期：2001-05-15 00:00:00

abstract：:In a longitudinal design in which each animal was examined repeatedly throughout its life, we used flow cytometry to determine the numbers or proportions of a variety of T lymphocyte subsets in the peripheral blood of mice aged 8-20 months. Half of the 128 mice were given a low calorie diet which is known to extend li...

journal_title：Mechanisms of ageing and development

authors： Miller RA

更新日期：1997-06-01 00:00:00

abstract：:Cellular and organismal decline is, in part, believed to be a consequence of oxygen and nitrogen-based reactants which persistently damage macromolecules throughout a lifetime. The resulting accumulation of damaged molecules eventually seriously compromises essential functions of cells leading to their death. Excessiv...

journal_title：Mechanisms of ageing and development

authors： Reiter RJ,Tan DX,Burkhardt S

更新日期：2002-04-30 00:00:00

abstract：:Adult Wistar NIN (WNIN) rats (6 months old) of both sexes were orally fed Amalakirasayana at a dose of 4.5 g per kg body weight, five days in a week. The Amalakirasayana was prepared by Arya Vaidya Sala, Kottakkal, Kerala, India, which is considered as gold standard. After 3, 9 and 15 months of such therapeutic regime...

journal_title：Mechanisms of ageing and development

authors： Swain U,Sindhu KK,Boda U,Pothani S,Giridharan NV,Raghunath M,Rao KS

更新日期：2012-04-01 00:00:00

abstract：:This study aimed to assess platelets as a possible model for screening the accumulation of mitochondrial DNA mutations, particularly during normal ageing. For this purpose we isolated platelets from young and old donors selected by lack of systemic and haematological diseases. We studied the accumulation of a particul...

journal_title：Mechanisms of ageing and development

authors： Biagini G,Pallotti F,Carraro S,Sgarbi G,Pich MM,Lenaz G,Anzivino F,Gualandi G,Xin D

更新日期：1998-04-01 00:00:00

abstract：:Both vascular relaxation and cAMP accumulation mediated by beta adrenergic agonists declines with increasing age. We have developed a method to measure the biologically relevant cAMP bound to the regulatory subunits of cAMP-dependent protein kinase in rat aorta. In homogenates of rat aorta, binding of [3H]cAMP was sat...

journal_title：Mechanisms of ageing and development

authors： Chin JH,Hoffman BB

更新日期：1990-04-09 00:00:00

abstract：:Aging is known to affect adversely the corticosterone status and the brain function including cognition. Calorie restricted (CR) diet has been found to improve brain aging. The objective of the present investigation is to study the effect of short-term CR diet without any food deprivation on aging-induced impairment o...

journal_title：Mechanisms of ageing and development

authors： Chakraborty A,Banerjee S,Mukherjee B,Poddar MK

更新日期：2020-07-01 00:00:00

abstract：:The present work explores the application of information theoretical measures, such as entropy and normalized mutual information, for research of biomarkers of aging. The use of information theory affords unique methodological advantages for the study of aging processes, as it allows evaluating non-linear relations be...

journal_title：Mechanisms of ageing and development

authors： Blokh D,Stambler I

更新日期：2017-04-01 00:00:00