Review on chemogenomic approaches towards hepatitis C viral targets.

abstract：:Labeled oligonucleotide analogues for antisense imaging of messenger RNA (mRNA) have great potential for detection of endogenous gene expression in vivo. Successful antisense imaging may be useful for detecting cellular gene expression patterns and early molecular changes in disease. Conclusive demonstration of this t...

journal_title：Journal of cellular biochemistry

authors： Lewis MR,Jia F

更新日期：2003-10-15 00:00:00

abstract：:Induced pluripotent stem cells (iPSC) hold tremendous potential for personalized cell-based repair strategies to treat musculoskeletal disorders. To establish human iPSCs as a potential source of viable chondroprogenitors for articular cartilage repair, we assessed the in vitro chondrogenic potential of the pluripoten...

journal_title：Journal of cellular biochemistry

authors： Guzzo RM,Gibson J,Xu RH,Lee FY,Drissi H

更新日期：2013-02-01 00:00:00

abstract：:Garlic is known as a potent spice and a medicine with broad therapeutic properties ranging from antibacterial to anticancer, antidiabetic, and anticoagulant. Two major proteins of 40 KD and 14 KD constituting approximately 96% of total garlic proteins have been recently purified at our Institute. This immunocytochemic...

journal_title：Journal of cellular biochemistry

authors： Wen GY,Mato A,Wisniewski HM,Malik MN,Jenkins EC,Sheikh AM,Kim KS

更新日期：1995-08-01 00:00:00

abstract：:Panax notoginseng saponin (PNS) constitutes the major effective components of Panax notoginseng, which is widely used to treat microcirculatory disturbance associated diseases. In this study, we designed to investigate the effect of PNS on the treatment of pulmonary fibrosis (PF) and further explored its mechanism. A ...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Li Q,Shao Q,Song J,Zhou B,Shu P

更新日期：2018-11-01 00:00:00

abstract：:Previously we have reported the production of a monoclonal antibody (Mab 1.2) which recognizes a cytoplasmic protein, terminin, in three different molecular weights: 90 (Tp90), 60 (Tp60), and 30 kDa (Tp30) forms. Further characterization shows that Tp90 is found in young growing and nongrowing quiescent fibroblasts, w...

journal_title：Journal of cellular biochemistry

authors： Wang E,Liu D

更新日期：1996-01-01 00:00:00

abstract：:To find the key factors that were involved in the survival and vascular endothelial differentiation of chick blatodisc induced by fibroblast growth factor 2 (FGF-2), we built a chick vasculogenesis model in vitro. Subsequently, the activities of phosphatidylcholine-specific phospholipase C (PC-PLC), including Ca(2+)-d...

journal_title：Journal of cellular biochemistry

authors： Zhao J,Zhao B,Wang W,Huang B,Zhang S,Miao J

更新日期：2007-10-01 00:00:00

abstract：:Endometrial carcinoma (EC) is one of the main gynecologic malignancies affecting women, but effective treatments are currently lacking. In the present study, we investigated the effect of sorafenib, a general kinase inhibitor, on several EC cell lines (HEC1A, HEC1B, and RL95-2). Sorafenib induced cell death in EC cell...

journal_title：Journal of cellular biochemistry

authors： Sun NK,Huang SL,Chang TC,Chao CC

更新日期：2013-08-01 00:00:00

abstract：:Chondrosarcoma (CHS) is a common malignant bone sarcoma and its occurrence increases with age. microRNAs (miRNAs) are a class of noncoding RNAs that participate in various biological processes and disease pathogenesis by targeting functional messenger RNA (mRNA). However, the modulation of miRNAs in CHS remains largel...

journal_title：Journal of cellular biochemistry

authors： Sui J,Liu Q,Zhang H,Kong Y

更新日期：2019-06-01 00:00:00

abstract：:Secreted phosphoprotein 24 kD (spp24) is a bone matrix protein isolated during attempts to identify osteogenic proteins. It is not osteogenic but performs other important roles in the regulation of bone metabolism, at least in part, by binding to and affecting the activity of members of the BMP/TGF-β family of cytokin...

journal_title：Journal of cellular biochemistry

authors： Tian H,Li CS,Zhao KW,Wang JC,Duarte ME,David CL,Phan K,Atti E,Brochmann EJ,Murray SS

更新日期：2015-04-01 00:00:00

abstract：:Pancreatic stellate cells (PSCs) secrete various factors, which can influence the β-cell function. The identification of stellate cell infiltration into the islets in pancreatic diseases suggests possible existence of cross-talk between these cells. To elucidate the influence of PSCs on β-cell function, mouse PSCs wer...

journal_title：Journal of cellular biochemistry

authors： Bynigeri RR,Mitnala S,Talukdar R,Singh SS,Duvvuru NR

更新日期：2020-01-01 00:00:00

abstract：:Circular RNAs (circRNA) are endogenous noncoding RNAs and play important roles in cancer; however, the roles of circRNAs in colon cancer are far from clear. The circRNA expression profile in colon cancer tissues was analyzed by microarray. The data from microarray showed that there were 198 upregulated and 136 downreg...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Liu H,Zhao P,Zhou H,Mao T

更新日期：2019-03-01 00:00:00

abstract：:Molecular mechanisms responsible for tumor resistance to apoptosis often involve the Fas/FasL pathway. While squamous cell carcinomas of the head and neck (SCCHN) express both Fas and FasL, their resistance to self-induced apoptosis or apoptosis mediated by Fas agonistic antibody (CH-11Ab) was independent of the level...

journal_title：Journal of cellular biochemistry

authors： Wieckowski E,Atarashi Y,Stanson J,Sato TA,Whiteside TL

更新日期：2007-01-01 00:00:00

abstract：:Cisplatin (DDP)-based chemotherapy is a standard strategy for ovarian cancer (OC), while chemoresistance remains a major therapeutic challenge. Transcription factor SOX9 has been reported to be associated with tumor cell proliferation, metastasis, and chemoresistance. In the current study, we observed a higher SOX9 ex...

journal_title：Journal of cellular biochemistry

authors： Xiao S,Li Y,Pan Q,Ye M,He S,Tian Q,Xue M

更新日期：2019-03-01 00:00:00

abstract：:Several independent assay procedures were used to estimate the activities of the enzyme constituents of the phosphoenolpyruvate-sugar phosphotransferase system (PTS) in osmotically shocked bacterial membrane vesicles. The soluble enzymes of the system were found to be in association with the membrane by several criter...

journal_title：Journal of cellular biochemistry

authors： Saier MH Jr,Cox DF,Feucht BU,Novotny MJ

更新日期：1982-01-01 00:00:00

abstract：:NELL-1 (Nel-like molecule-1) is a secreted osteogenic growth factor first identified in human craniosynostosis (CS) patients. NELL-1 protein has been observed to promote bone and cartilage differentiation and to suppress adipogenesis in both in vitro and in vivo models. Despite these findings, the cell surface recepto...

journal_title：Journal of cellular biochemistry

authors： Shen J,James AW,Chung J,Lee K,Zhang JB,Ho S,Lee KS,Kim TM,Niimi T,Kuroda S,Ting K,Soo C

更新日期：2012-12-01 00:00:00

abstract：:The conversion of expandable liver progenitor cells into pancreatic beta cells would provide a renewable cell source for diabetes cell therapy. Previously, we reported the establishment of liver epithelial progenitor cells (LEPCs). In this work, LEPCs were modified into EGFP/Pdx-1 LEPCs, cells with stable expression o...

journal_title：Journal of cellular biochemistry

authors： Jin CX,Li WL,Xu F,Geng ZH,He ZY,Su J,Tao XR,Ding XY,Wang X,Hu YP

更新日期：2008-05-01 00:00:00

abstract：:Protein phosphatase 2A (PP2A) is an important enzyme within various signal transduction pathways. The present study was investigated PP2A mediates JS-K-induced apoptosis by affecting Bcl-2 family protein. JS-K showed diverse inhibitory effects in five HCC cell lines, especially HepG2 cells. JS-K caused a dose- and tim...

journal_title：Journal of cellular biochemistry

authors： Liu L,Huang Z,Chen J,Wang J,Wang S

更新日期：2018-08-01 00:00:00

abstract：:A gene coding for the (pro)phospholipase A2 (PLA2) from bovine pancreas has been designed, synthesized, and expressed in Escherichia coli. The gene was designed with a variety of restriction sites that will facilitate future mutagenesis studies. Codons occurring frequently in prokaryotic systems were chosen whenever p...

journal_title：Journal of cellular biochemistry

authors： Noel JP,Tsai MD

更新日期：1989-07-01 00:00:00

abstract：:A23187 stimulates the metabolism of endogenous as well as exogenous arachidonic acid (AA) and eicosapentaenolc acid (EPA) to their corresponding leukotrienes in human neutrophils. In contrast, conflicting results have been obtained concerning the effect of FMLP on the metabolism of these fatty acids. In the present st...

journal_title：Journal of cellular biochemistry

authors： Mahadevappa VG,Powell WS

更新日期：1989-07-01 00:00:00

abstract：:Selenoprotein P (SePP) is involved in the protection against diseases. The present study is the first investigation of the effect of selenium supplementation on plasma selenium and expression of SEPP1 in mRNA and protein levels based on metabolic syndrome (MetS), in individuals suffering from coronary artery diseases....

journal_title：Journal of cellular biochemistry

authors： Gharipour M,Ouguerram K,Nazih EH,Salehi M,Behmanesh M,Roohafza H,Hosseini SM,Nezafati P,Dianatkhah M,Gharipour A,Haghjoo S,Sarrafzadegan N,Sadeghi M

更新日期：2018-11-01 00:00:00

abstract：:Extracellular nucleotides and nucleosides have emerged as important elements regulating tissue homeostasis. Acting through specific receptors, have the ability to control gene expression patterns to direct cellular fate. We observed that SKOV-3 cells express the ectonucleotidases: ectonucleotide pyrophosphatase 1 (ENP...

journal_title：Journal of cellular biochemistry

authors： Martínez-Ramírez AS,Díaz-Muñoz M,Battastini AM,Campos-Contreras A,Olvera A,Bergamin L,Glaser T,Jacintho Moritz CE,Ulrich H,Vázquez-Cuevas FG

更新日期：2017-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been used in therapies for bone tissue healing. The aim of this study was to investigate the effect of cell source and osteoblast differentiation on gene expression profiles of MSCs from bone marrow (BM-MSCs) or adipose tissue (AT-MSCs) to contribute for selecting a suitable cell pop...

journal_title：Journal of cellular biochemistry

authors： Fideles SOM,Ortiz AC,Assis AF,Duarte MJ,Oliveira FS,Passos GA,Beloti MM,Rosa AL

更新日期：2019-02-11 00:00:00

abstract：:We investigated the early effects of the anti-idiotypic antibody (clone 1D5), which recognized the estrogen receptor (ER), on cytosolic free calcium concentration ([Ca2+]i) and its long term effects on creatine kinase (CK) specific activity in female human and rat osteoblasts. These actions were compared to the known ...

journal_title：Journal of cellular biochemistry

authors： Sömjen D,Kohen F,Lieberherr M

更新日期：1997-04-01 00:00:00

abstract：:Sterol 14α-Demethylase Cytochrome P450 (CYP51) protein involved in ergosterol biosynthesis pathways turn out to be a crucial target for the fungicidal compound. However, the recognition mechanism and dynamic behavior of CYP51 in wheat leaf rust pathogen, Puccinia triticina, is still obscure. Previously, a mutation at ...

journal_title：Journal of cellular biochemistry

authors： Pandey B,Sharma P

更新日期：2018-03-01 00:00:00

abstract：:Growth and differentiation factor 7(GDF7), also later called as bone morphogenetic protein (BMP)12, is a new member of the BMP superfamily, which induces formation of tendon-like tissue formation in the ectopic implantation experiments. We examined the effect of BMP12 on proliferation and expression of phenotype-relat...

journal_title：Journal of cellular biochemistry

authors： Furuya K,Nifuji A,Rosen V,Noda M

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:Current study focused on the influence of miR-200b-3p on cardiocyte apoptosis of diabetic cardiomyopathy (DCM) by regulating CD36 and peroxisome proliferator-activated receptor γ (PPAR-γ) signaling pathway. METHODS:Bioinformatic analysis was used to analyze differentially expressed microRNA (miRNAs), messeng...

journal_title：Journal of cellular biochemistry

authors： Xu L,Chen W,Ma M,Chen A,Tang C,Zhang C,Cai L

更新日期：2019-04-01 00:00:00

abstract：:Elevation of free fatty acids (FFAs) is known to affect microvascular function and contribute to obesity-associated insulin resistance, hypertension, and microangiopathy. Proliferative and synthetic vascular smooth muscle cells (VSMCs) increase intimal thickness and destabilize atheromatous plaques. This study aimed t...

journal_title：Journal of cellular biochemistry

authors： Cheng CI,Lee YH,Chen PH,Lin YC,Chou MH,Kao YH

更新日期：2017-05-01 00:00:00

abstract：:The aim of this study was to investigate the role of NYD-SP15 in the growth and oxidative-stress responses of ARPE-19 cells. ARPE-19 cell lines overexpressing wild type or RNA interference against NYD-SP15 were established via lentivirus transfection. Cell growth and proliferation, migration, apoptosis, and cell cycle...

journal_title：Journal of cellular biochemistry

authors： Xu Y,Wang L,Cao L,Chen L,Liu Q

更新日期：2018-10-28 00:00:00

abstract：:The role of insulin-like growth factor-I (IGF-I) in regulating estrogen receptor-alpha (ER-alpha) gene expression and activity was investigated in the human breast cancer cell line MCF-7. Treatment of cells with 40 ng/ml IGF-I resulted in a 60% decrease in ER-alpha protein concentration by 3 h, and the amount of ER-al...

journal_title：Journal of cellular biochemistry

authors： Stoica A,Saceda M,Fakhro A,Joyner M,Martin MB

更新日期：2000-01-01 00:00:00

abstract：:Antioxidants may prevent apoptosis of cancer cells via inhibiting reactive oxygen species (ROS). However, to date no study has been carried out to elucidate the effects of strong antioxidant N-acetylcysteine (NAC) on Bleomycin induced apoptosis in human testicular cancer (NTERA-2, NT2) cells. For this reason, we studi...

journal_title：Journal of cellular biochemistry

authors： Kucuksayan E,Cort A,Timur M,Ozdemir E,Yucel SG,Ozben T

更新日期：2013-07-01 00:00:00