Abstract:
:We report on three new patients with spondyloocular syndrome (SOS) in a consanguineous Pakistani family. All three patients present progressive generalized osteoporosis, short stature, recurrent fractures, hearing loss and visual impairments. WES revealed a novel homozygous frameshift variant in exon 11 of XYLT2 (NG 012175.1, NP_071450.2) resulting in loss of evolutionary conserved amino acid sequences (840 - 865/865) at C-terminus p.R840fs∗115. Sanger Sequencing confirmed the presence of the novel homozygous mutation in all three patients while the parents were heterozygous carriers of the mutation, in accordance with an autosomal recessive inheritance pattern. Only nine variants worldwide have previously been reported in XYLT2 in patients with SOS phenotype. These three patients with novel homozygous variant extend the genotypic and phenotypic spectrum of SOS.
journal_name
Front Genetjournal_title
Frontiers in geneticsauthors
Kausar M,Chew EGY,Ullah H,Anees M,Khor CC,Foo JN,Makitie O,Siddiqi Sdoi
10.3389/fgene.2019.00144subject
Has Abstractpub_date
2019-03-05 00:00:00pages
144issn
1664-8021journal_volume
10pub_type
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