Genes contributing to genetic variation of muscling in sheep.

abstract：:Pharmacogenomics is the study of how genes affect a person's response to drugs. Thus, understanding the effect of drug at the molecular level can be helpful in both drug discovery and personalized medicine. Over the years, transcriptome data upon drug treatment has been collected and several databases compiled before ...

journal_title：Frontiers in genetics

authors： Oh M,Park S,Lee S,Lee D,Lim S,Jeong D,Jo K,Jung I,Kim S

更新日期：2020-11-12 00:00:00

abstract：:I present here an in-depth, although non-exhaustive, review of two topics in molecular dating. Clock models, which describe the evolution of the rate of evolution, are considered first. Some of the shortcomings of popular approaches-uncorrelated clock models in particular-are presented and discussed. Autocorrelated mo...

journal_title：Frontiers in genetics

authors： Guindon S

更新日期：2020-05-27 00:00:00

abstract：:The megadiversity of the neotropical ichthyofauna has been associated to recent diversification processes, reflecting in subtle or lacking morphological differentiation between species, challenging the classical taxonomic identification. Leporinus friderici occurs in several river basins of South America, and its nomi...

journal_title：Frontiers in genetics

authors： Silva-Santos R,Ramirez JL,Galetti PM Jr,Freitas PD

更新日期：2018-02-15 00:00:00

abstract：:DNA methylation is an indispensable epigenetic modification that dynamically regulates gene expression and genome stability during cell growth and development processes. The target of rapamycin (TOR) has emerged as a central regulator to regulate many fundamental cellular metabolic processes from protein synthesis to ...

journal_title：Frontiers in genetics

authors： Zhu T,Li L,Feng L,Mo H,Ren M

更新日期：2020-03-03 00:00:00

abstract：:Growing evidences have indicated that microRNAs (miRNAs) play a significant role relating to many important bioprocesses; their mutations and disorders will cause the occurrence of various complex diseases. The prediction of miRNAs associated with underlying diseases via computational approaches is beneficial to ident...

journal_title：Frontiers in genetics

authors： Zhang Y,Chen M,Cheng X,Wei H

更新日期：2020-04-30 00:00:00

abstract：:Mutations in CHD7 have been shown to be a major cause of CHARGE syndrome, which presents many symptoms and features common to other syndromes making its diagnosis difficult. Next generation sequencing (NGS) of a panel of intellectual disability related genes was performed in an adult patient without molecular diagnosi...

journal_title：Frontiers in genetics

authors： Villate O,Ibarluzea N,Fraile-Bethencourt E,Valenzuela A,Velasco EA,Grozeva D,Raymond FL,Botella MP,Tejada MI

更新日期：2018-01-26 00:00:00

abstract：:The switch to a modern lifestyle in recent decades has coincided with a rapid increase in prevalence of obesity and other diseases. These shifts in prevalence could be explained by the release of genetic susceptibility for disease in the form of gene-by-environment (GxE) interactions. Yet, the detection of interaction...

journal_title：Frontiers in genetics

authors： Marigorta UM,Gibson G

更新日期：2014-07-21 00:00:00

abstract：:Most proteins are regulated by posttranslational modifications and changes in these modifications contribute to evolutionary changes as well as to human diseases. Phosphorylation of serines, threonines, and tyrosines are the most common modifications identified to date in eukaryotic proteomes. While the mode of action...

journal_title：Frontiers in genetics

authors： Landry CR,Freschi L,Zarin T,Moses AM

更新日期：2014-07-23 00:00:00

abstract：:Fragile X syndrome (FXS) is mostly caused by two distinct events that occur in the FMR1 gene (Xq27.3): an expansion above 200 repeats of a CGG triplet located in the 5'UTR of the gene, and methylation of the cytosines located in the CpG islands upstream of the CGG repeats. Here, we describe two unrelated families with...

journal_title：Frontiers in genetics

authors： Fernández E,Gennaro E,Pirozzi F,Baldo C,Forzano F,Turolla L,Faravelli F,Gastaldo D,Coviello D,Grasso M,Bagni C

更新日期：2018-11-02 00:00:00

abstract：:The study of microorganisms that pervade each and every part of this planet has encountered many challenges through time such as the discovery of unknown organisms and the understanding of how they interact with their environment. The aim of this review is to take the reader along the timeline and major milestones tha...

journal_title：Frontiers in genetics

authors： Escobar-Zepeda A,Vera-Ponce de León A,Sanchez-Flores A

更新日期：2015-12-17 00:00:00

abstract：:Large-scale tumor genome sequencing projects have revealed a complex landscape of genomic mutations in multiple cancer types. A major goal of these projects is to characterize somatic mutations and discover cancer drivers, thereby providing important clues to uncover diagnostic or therapeutic targets for clinical trea...

journal_title：Frontiers in genetics

authors： Chen L,Miao Y,Liu M,Zeng Y,Gao Z,Peng D,Hu B,Li X,Zheng Y,Xue Y,Zuo Z,Xie Y,Ren J

更新日期：2018-07-17 00:00:00

abstract：:Bamboo is one of the fastest-growing non-timber forest plants. Moso bamboo (Phyllostachys edulis) is the most economically valuable bamboo in Asia, especially in China. With the release of the whole-genome sequence of moso bamboo, there are increasing demands for refined annotation of bamboo genes. Recently, large amo...

journal_title：Frontiers in genetics

authors： Ma X,Zhao H,Xu W,You Q,Yan H,Gao Z,Su Z

更新日期：2018-11-27 00:00:00

abstract：:Assortative mating is a universal feature of human societies, and individuals from ethnically diverse populations are known to mate assortatively based on similarities in genetic ancestry. However, little is currently known regarding the exact phenotypic cues, or their underlying genetic architecture, which inform anc...

journal_title：Frontiers in genetics

authors： Norris ET,Rishishwar L,Wang L,Conley AB,Chande AT,Dabrowski AM,Valderrama-Aguirre A,Jordan IK

更新日期：2019-04-24 00:00:00

abstract：:The interaction of miRNA and lncRNA is known to be important for gene regulations. However, the number of known lncRNA-miRNA interactions is still very limited and there are limited computational tools available for predicting new ones. Considering that lncRNAs and miRNAs share internal patterns in the partnership bet...

journal_title：Frontiers in genetics

authors： Huang YA,Huang ZA,You ZH,Zhu Z,Huang WZ,Guo JX,Yu CQ

更新日期：2019-08-29 00:00:00

abstract：:Transcriptomics technologies such as next-generation sequencing and microarray platforms provide exciting opportunities for improving diagnosis and treatment of complex diseases. Transcriptomics studies often share similar hypotheses, but are carried out on different platforms, in different conditions, and with differ...

journal_title：Frontiers in genetics

authors： Wu C,Huang BE,Chen G,Lovenberg TW,Pocalyko DJ,Yao X

更新日期：2019-04-30 00:00:00

abstract：:Autism spectrum disorder (ASD) is mainly reflected in the communication and language barriers, difficulties in social communication, and it is a kind of neurological developmental disorder. Most researches have used the machine learning method to classify patients and normal controls, among which support vector machin...

journal_title：Frontiers in genetics

authors： Bi XA,Wang Y,Shu Q,Sun Q,Xu Q

更新日期：2018-02-06 00:00:00

abstract：:The comet assay is a simple and cost effective technique, commonly used to analyze and quantify DNA damage in individual cells. The versatility of the comet assay allows introduction of various modifications to the basic technique. The difference in the methylation sensitivity of the isoschizomeric restriction enzymes...

journal_title：Frontiers in genetics

authors： Lewies A,Van Dyk E,Wentzel JF,Pretorius PJ

更新日期：2014-07-07 00:00:00

abstract：:Imprinted loci play a critical role in fetal development. Their expression is often regulated by CCCTC-binding factor (CTCF) protein binding at imprinting control regions (ICRs). Prenatal alcohol exposure has been shown to reduce global DNA methylation in the developing mouse fetus. This study explored the effect of p...

journal_title：Frontiers in genetics

authors： Knezovich JG,Ramsay M

更新日期：2012-02-22 00:00:00

abstract：:Variability of the comet assay is a serious issue, whether it occurs from experiment to experiment in the same laboratory, or between different laboratories analysing identical samples. Do we have to live with high variability, just because the comet assay is a biological assay rather than analytical chemistry? Numero...

journal_title：Frontiers in genetics

authors： Collins AR,El Yamani N,Lorenzo Y,Shaposhnikov S,Brunborg G,Azqueta A

更新日期：2014-10-20 00:00:00

abstract：:Beef is an essential food source in the world. Beef quality, especially tenderness, has a significant impact on consumer satisfaction and industry profit. Many types of research to date have focused on the exploration of physiological and developmental mechanisms of beef tenderness. Still, the role and impact of DNA m...

journal_title：Frontiers in genetics

authors： Zhao C,Ji G,Carrillo JA,Li Y,Tian F,Baldwin RL,Zan L,Song J

更新日期：2020-08-26 00:00:00

abstract：:[This corrects the article on p. 102 in vol. 6, PMID: 25852744.]. ...

journal_title：Frontiers in genetics

authors： Brito S,Thompson K,Campistol J,Colomer J,Hardy SA,He L,Fernández-Marmiesse A,Palacios L,Jou C,Jiménez-Mallebrera C,Armstrong J,Montero R,Artuch R,Tischner C,Wenz T,McFarland R,Taylor RW

更新日期：2015-07-28 00:00:00

abstract：:The evolutionary dynamics and tissue specificity of protein-coding genes are well documented in plants. However, the evolutionary consequences of small RNAs (sRNAs) on tissue-specific functions remain poorly understood. Here, we performed integrated analysis of 195 deeply sequenced sRNA libraries of maize B73, represe...

journal_title：Frontiers in genetics

authors： Xu Y,Zhang T,Li Y,Miao Z

更新日期：2020-02-11 00:00:00

abstract：:The prevalence of obesity continues to increase particularly in developed countries. To establish the primary mechanisms involved, relevant animal models which track the developmental pathway to obesity are required. This need is emphasized by the substantial rise in the number of overweight and obese children, of whi...

journal_title：Frontiers in genetics

authors： Symonds ME,Sebert S,Budge H

更新日期：2011-05-31 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental toxicant and endocrine disrupting compound with reproductive and developmental effects in humans and model organisms, including zebrafish. Our previous microarray and histological studies found defects in spermatogenesis and fertility of zebrafis...

journal_title：Frontiers in genetics

authors： Akemann C,Meyer DN,Gurdziel K,Baker TR

更新日期：2019-01-11 00:00:00

abstract：:The sustainable development of aquaculture has been impeded by infectious diseases worldwide. However, the genomic architecture and the genetic basis underlying the disease resistance remain poorly understood, which severely hampers both the understanding of the evolution of fish disease resistance traits and the prev...

journal_title：Frontiers in genetics

authors： Zhou Q,Su Z,Li Y,Liu Y,Wang L,Lu S,Wang S,Gan T,Liu F,Zhou X,Wei M,Liu G,Chen S

更新日期：2019-11-20 00:00:00

abstract：:High-throughput analysis of the transcriptome and proteome individually are used to interrogate complex oncogenic processes in cancer. However, an outstanding challenge is how to combine these complementary, yet partially disparate data sources to accurately identify tumor-specific gene products and clinical biomarker...

journal_title：Frontiers in genetics

authors： Schwartz GW,Petrovic J,Zhou Y,Faryabi RB

更新日期：2018-06-15 00:00:00

abstract：:Improving grain yield in the staple food crop rice has been long sought goal of plant biotechnology. One of the traits with significant impact on rice breeding programs is peduncle elongation at the time of heading failing which leads to significant reduction in grain yield due to incomplete panicle exsertion. To deci...

journal_title：Frontiers in genetics

authors： Kandpal M,Vishwakarma C,Krishnan K,Chinnusamy V,Pareek A,Sharma MK,Sharma R

更新日期：2020-12-03 00:00:00

abstract：:Empirical evidence is limited on whether allopolyploid species combine or merge parental adaptations to broaden habitats. The allopolyploid Arabidopsis kamchatica is a hybrid of the two diploid parents Arabidopsis halleri and Arabidopsis lyrata. A. halleri is a facultative heavy metal hyperaccumulator, and may be foun...

journal_title：Frontiers in genetics

authors： Paape T,Akiyama R,Cereghetti T,Onda Y,Hirao AS,Kenta T,Shimizu KK

更新日期：2020-09-30 00:00:00

abstract：:Human pluripotent stem cells (hPSCs) are increasingly used for cell-based regenerative therapies worldwide, with embryonic and induced pluripotent stem cells as potential treatments for debilitating and chronic conditions, such as age-related macular degeneration, Parkinson's disease, spinal cord injuries, and type 1 ...

journal_title：Frontiers in genetics

authors： Henry MP,Hawkins JR,Boyle J,Bridger JM

更新日期：2019-01-21 00:00:00

abstract：:Beef tenderness, a complex trait affected by many factors, is economically important to beef quality, industry, and consumer's palatability. In this study, RNA-Seq was used in network analysis to better understand the biological processes that lead to differences in beef tenderness. Skeletal muscle transcriptional pro...

journal_title：Frontiers in genetics

authors： Gonçalves TM,de Almeida Regitano LC,Koltes JE,Cesar ASM,da Silva Andrade SC,Mourão GB,Gasparin G,Moreira GCM,Fritz-Waters E,Reecy JM,Coutinho LL

更新日期：2018-10-05 00:00:00