MicroRNA and Long Non-coding RNA Regulation in Skeletal Muscle From Growth to Old Age Shows Striking Dysregulation of the Callipyge Locus.

abstract：:Most cell functions are carried out by interacting factors, thus underlying the functional importance of genetic interactions between genes, termed epistasis. Epistasis could be under strong selective pressures especially in conditions where the mutation rate of one of the interacting partners notably differs from the...

journal_title：Frontiers in genetics

authors： Levin L,Blumberg A,Barshad G,Mishmar D

更新日期：2014-12-23 00:00:00

abstract：:Homozygous and compound heterozygous mutations in GNB5 gene have been associated with a wide spectrum of clinical presentations, ranging from neurodevelopmental issues with or without cardiac arrhythmia (LADCI) to severe developmental delay with epileptic encephalopathy, retinal dystrophy, and heart rhythm abnormaliti...

journal_title：Frontiers in genetics

authors： Sciacca FL,Ciaccio C,Fontana F,Strano C,Gilardoni F,Pantaleoni C,D'Arrigo S

更新日期：2020-05-13 00:00:00

abstract：:This article reviews research results and ideas presented at a special symposium at the International Association of Gerontology and Geriatrics (IAGG) Congress held in July 2017 in San Francisco. Five researchers presented their results related to infection and Alzheimer's disease (AD). Prof. Itzhaki presented her wor...

journal_title：Frontiers in genetics

authors： Fülöp T,Itzhaki RF,Balin BJ,Miklossy J,Barron AE

更新日期：2018-09-10 00:00:00

abstract：:Different genes have their protein products localized in various subcellular compartments. The diversity in protein localization may serve as a gene characteristic, revealing gene essentiality from a subcellular perspective. To measure this diversity, we introduced a Subcellular Diversity Index (SDI) based on the Gene...

journal_title：Frontiers in genetics

authors： Jia K,Zhou Y,Cui Q

更新日期：2020-01-21 00:00:00

abstract：Background:Lung disease phenotype varies widely even in the F508del (homozygous) genotype. Leukocyte-driven inflammation is important for pulmonary disease pathogenesis in cystic fibrosis (CF). Blood cytokines correlate negatively with pulmonary function in F508del homozygous patients, and gap junction proteins (GJA) m...

journal_title：Frontiers in genetics

authors： Horn T,Ludwig M,Eickmeier O,Neerinex AH,Maitland-van der Zee AH,Smaczny C,Wagner TOF,Schubert R,Zielen S,Majoor C,Bos LD,Schmitt-Grohé S

更新日期：2020-10-28 00:00:00

abstract：:Pathogenic microorganism analysis based on next-generation sequencing technology is an important tool for clinical diagnosis, public health surveillance, and outbreak investigation. However, scientific researchers without the relevant background lack the time, training, or infrastructure to use large data sets or inst...

journal_title：Frontiers in genetics

authors： Han N,Miao J,Zhang T,Qiang Y,Peng X,Li X,Zhang W

更新日期：2020-08-31 00:00:00

abstract：:The uses of breeding programs for the Pacific white shrimp [Penaeus (Litopenaeus) vannamei] based on mixed linear models with pedigreed data are described. The application of these classic breeding methods yielded continuous progress of great value to increase the profitability of the shrimp industry in several countr...

journal_title：Frontiers in genetics

authors： Castillo-Juárez H,Campos-Montes GR,Caballero-Zamora A,Montaldo HH

更新日期：2015-03-24 00:00:00

abstract：:Cotton (Gossypium spp.) is the most important natural fiber crop in the world. The R2R3-MYB gene family is a large gene family involved in many plant functions including cotton fiber development. Although previous studies have reported its phylogenetic relationships, gene structures, and expression patterns in tetrapl...

journal_title：Frontiers in genetics

authors： Wang N,Ma Q,Ma J,Pei W,Liu G,Cui Y,Wu M,Zang X,Zhang J,Yu S,Ma L,Yu J

更新日期：2019-08-15 00:00:00

abstract：:[This corrects the article on p. 23 in vol. 9, PMID: 29456554.]. ...

journal_title：Frontiers in genetics

authors： Yang L,Banerjee S,Cao J,Bai X,Peng Z,Chen H,Huang H,Han P,Feng S,Yi N,Song X,Wu J

更新日期：2018-04-04 00:00:00

abstract：:The study of microorganisms that pervade each and every part of this planet has encountered many challenges through time such as the discovery of unknown organisms and the understanding of how they interact with their environment. The aim of this review is to take the reader along the timeline and major milestones tha...

journal_title：Frontiers in genetics

authors： Escobar-Zepeda A,Vera-Ponce de León A,Sanchez-Flores A

更新日期：2015-12-17 00:00:00

abstract：:Both natural and artificial selection are among the main driving forces shaping genetic variation across the genome of livestock species. Selection typically leaves signatures in the genome, which are often characterized by high genetic differentiation across breeds and/or a strong reduction in genetic diversity in re...

journal_title：Frontiers in genetics

authors： Onzima RB,Upadhyay MR,Doekes HP,Brito LF,Bosse M,Kanis E,Groenen MAM,Crooijmans RPMA

更新日期：2018-08-14 00:00:00

abstract：:Previous efforts to characterize conservation between the human and mouse genomes focused largely on sequence comparisons. These studies are inherently limited because they don't account for gene structure differences, which may exist despite genomic sequence conservation. Recent high-throughput transcriptome studies ...

journal_title：Frontiers in genetics

authors： Wood EJ,Chin-Inmanu K,Jia H,Lipovich L

更新日期：2013-09-26 00:00:00

abstract：:The carbon catabolite repression 4 (CCR4)-negative on TATA-less (NOT) complex serves as one of the major deadenylases of eukaryotes. Although it was originally identified and characterized in yeast, recent studies have revealed that the CCR4-NOT complex also exerts important functions in mammals, -including humans. Ho...

journal_title：Frontiers in genetics

authors： Shirai YT,Suzuki T,Morita M,Takahashi A,Yamamoto T

更新日期：2014-08-21 00:00:00

abstract：:A complete and compelling evolutionary explanation for the origin of human menopause is wanting. Menopause onset is defined clinically as the final menses, confirmed after 1 year without menstruation. The theory proposed herein explains at multiple levels - ultimately genetic but involving (1) behavioral, (2) life his...

journal_title：Frontiers in genetics

authors： Takahashi M,Singh RS,Stone J

更新日期：2017-01-06 00:00:00

abstract：:For datasets of gastric cancer collected by TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) repositories, we applied a bioinformatics approach to obtain expression data for the ISLR (immunoglobulin superfamily containing leucine-rich repeat) gene, which is highly expressed in gastric cancer tissues an...

journal_title：Frontiers in genetics

authors： Li S,Zhao W,Sun M

更新日期：2020-06-16 00:00:00

abstract：:MicroRNAs (miRNAs) are known to be important post-transcriptional regulators that are involved in the etiology of complex psychiatric traits. The present study aimed to incorporate miRNAs information into pathway analysis using a genome-wide association dataset to identify relevant biological pathways for bipolar diso...

journal_title：Frontiers in genetics

authors： Shih WL,Kao CF,Chuang LC,Kuo PH

更新日期：2012-12-18 00:00:00

abstract：:Silversides are fish that inhabit marine coastal waters, coastal lagoons, and estuarine regions in southern South America. The freshwater (FW) silversides have the ability to tolerate salinity variations. Odontesthes humensis have similar habitats and biological characteristics of congeneric O. bonariensis, the most s...

journal_title：Frontiers in genetics

authors： Silveira TLR,Martins GB,Domingues WB,Remião MH,Barreto BF,Lessa IM,Santos L,Pinhal D,Dellagostin OA,Seixas FK,Collares T,Robaldo RB,Campos VF

更新日期：2018-02-06 00:00:00

abstract：:Comparative phylogeography has its roots in classical biogeography and, historically, relies on a pattern-based approach. Here, we present a model-based framework for comparative phylogeography. Our framework was initially developed for statistical phylogeography based on a multi-model inference approach, by coupling ...

journal_title：Frontiers in genetics

authors： Collevatti RG,Terribile LC,Diniz-Filho JA,Lima-Ribeiro MS

更新日期：2015-02-17 00:00:00

abstract：:Recently, cancer has been characterized as a heterogeneous disease composed of many different subtypes. Early diagnosis of cancer subtypes is an important study of cancer research, which can be of tremendous help to patients after treatment. In this paper, we first extract a novel dataset, which contains gene expressi...

journal_title：Frontiers in genetics

authors： Li S,Jiang L,Tang J,Gao N,Guo F

更新日期：2020-09-10 00:00:00

abstract：:Melanoma is the leading cause of cancer-related death among skin tumors, with an increasing incidence worldwide. Few studies have effectively investigated the significance of an immune-related gene (IRG) signature for melanoma prognosis. Here, we constructed an IRGs prognostic signature using bioinformatics methods an...

journal_title：Frontiers in genetics

authors： Liu N,Liu Z,Liu X,Duan X,Huang Y,Jin Z,Niu Y,Zhang L,Chen H

更新日期：2020-08-28 00:00:00

abstract：:There is evidence of a purifying filter acting in the female germline to prevent the expansion of deleterious mutations in the mitochondrial DNA (mtDNA). Given our poor understanding of this filter, here we investigate the competence of the mouse embryo to eliminate dysfunctional mitochondria. Toward that, mitochondri...

journal_title：Frontiers in genetics

authors： Machado TS,Macabelli CH,Collado MD,Meirelles FV,Guimarães FEG,Chiaratti MR

更新日期：2020-07-15 00:00:00

abstract：:The emergence of eusociality ("true sociality") in several insect lineages represents one of the most successful evolutionary adaptations in the animal kingdom in terms of species richness and global biomass. In contrast to solitary insects, eusocial insects evolved a set of unique behavioral and physiological traits ...

journal_title：Frontiers in genetics

authors： Søvik E,Bloch G,Ben-Shahar Y

更新日期：2015-05-27 00:00:00

abstract：:Colitis-associated cancer (CAC) has been linked to microRNA (miRNA) aberrant expression elicited by inflammation. In this study, we used the AOM/DSS-induced CAC mice model to explore the ectopic expression of miRNAs in the precancerous stage of CAC. As a result, we found that miR-31-5p, miR-223-3p, and let-7f-5p were ...

journal_title：Frontiers in genetics

authors： Chen G,Feng Y,Li X,Jiang Z,Bei B,Zhang L,Han Y,Li Y,Li N

更新日期：2019-06-19 00:00:00

abstract：:Ephb6 gene knockout causes hypertension in castrated mice. EPHB6 controls catecholamine secretion by adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent way. Nicotinic acetylcholine receptor (nAChR) is a ligand-gated Ca2+/Na+ channel, and its opening is the first signaling event leading to catecholamine...

journal_title：Frontiers in genetics

authors： Wu T,Wang Y,Shi W,Zhang BQ,Raelson J,Yao YM,Wu HD,Xu ZX,Marois-Blanchet FC,Ledoux J,Blunck R,Sheng JZ,Hu SJ,Luo H,Wu J

更新日期：2020-11-27 00:00:00

abstract：:As one of the hotspot regions for sympatric speciation studies, Evolution Canyon (EC) became an ideal place for its high level of microclimatic divergence interslopes. In this study, to highlight the genetic mechanisms of sympatric speciation, phenotypic variation on flowering time and transcriptomic divergence were i...

journal_title：Frontiers in genetics

authors： Qian C,Yan X,Yin H,Fan X,Yin X,Sun P,Li Z,Nevo E,Ma XF

更新日期：2018-11-14 00:00:00

abstract：:Background:NKX2-1 related disorders (also known as brain-lung-thyroid syndrome or benign hereditary chorea 1) are associated with a wide spectrum of symptoms. The core features are various movement disorders, characteristically chorea, less frequently myoclonus, dystonia, ataxia; thyroid disease; and lung involvement....

journal_title：Frontiers in genetics

authors： Balicza P,Grosz Z,Molnár V,Illés A,Csabán D,Gézsi A,Dézsi L,Zádori D,Vécsei L,Molnár MJ

更新日期：2018-08-22 00:00:00

abstract：:The genetic resources available for the commercially important fish species Yellowtail kingfish (YTK) (Seriola lalandi) are relative sparse. To overcome this, we aimed (1) to develop a linkage map for this species, and (2) to identify markers/variants associated with economically important traits in kingfish (with an ...

journal_title：Frontiers in genetics

authors： Nguyen NH,Rastas PMA,Premachandra HKA,Knibb W

更新日期：2018-04-17 00:00:00

abstract：:Poultry feed constitutes the largest cost in poultry production, estimated to be up to 70% of the total cost. Moreover, there is pressure on the poultry industry to increase production to meet the protein demand of humans and simultaneously reduce emissions to protect the environment. Therefore, improving feed efficie...

journal_title：Frontiers in genetics

authors： Ye S,Chen ZT,Zheng R,Diao S,Teng J,Yuan X,Zhang H,Chen Z,Zhang X,Li J,Zhang Z

更新日期：2020-04-03 00:00:00

abstract：:Germline variants of PIP4K2A impact susceptibility of acute lymphoblastic leukemia (ALL) through inducing its overexpression. Although limited reports suggested the oncogenic role of PIP4K2A in cancers, regulatory network and prognostic effect of this gene remains poorly understood in tumorigenesis and leukemogenesis....

journal_title：Frontiers in genetics

authors： Zhang S,Li Z,Yan X,Bao L,Deng Y,Zeng F,Wang P,Zhu J,Yin D,Liao F,Zhou X,Zhang D,Xia X,Wang H,Yang X,Zhang W,Gao H,Zhang W,Yang L,Hou Q,Xu H,Zhang Y,Shu Y,Wang Y

更新日期：2019-01-15 00:00:00

abstract：:Environmental exposures vary by timing, severity, and frequency and may have a number of deleterious effects throughout the life course. The period of in utero development, for example, is one of the most crucial stages of development during which adverse environmental exposures can both alter the growth and developme...

journal_title：Frontiers in genetics

authors： Maccani MA,Knopik VS

更新日期：2012-04-09 00:00:00