当前位置： SCI文献检索 > World Neurosurgery期刊下所有文献 > Magnetic Resonance Imaging Reveals a Pronounced Treatment Response of a Isocitrate Dehydrogenase- and B-Raf Proto-Oncogene-Wildtype Epithelioid Glioblastoma.

Magnetic Resonance Imaging Reveals a Pronounced Treatment Response of a Isocitrate Dehydrogenase- and B-Raf Proto-Oncogene-Wildtype Epithelioid Glioblastoma.

Abstract：

:We here report findings on magnetic resonance imaging from a 60-year-old patient with an epithelioid glioblastoma of the corpus callosum treated with radiotherapy in combination with concomitant and adjuvant temozolomide. Neuropathology revealed a highly aggressive molecular subtype of the epithelioid glioblastoma without an isocitrate dehydrogenase and B-Raf proto-oncogene mutation or a O6-methylguanine-DNA-methyltransferase promoter hypermethylation. This subtype is typically associated with an unfavorable clinical course and poor overall survival. Unexpectedly, the first follow-up magnetic resonance imaging 10 weeks after chemoradiation completion revealed an early and almost complete treatment response.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Werner JM,Brunn A,Fink GR,Galldiks N

doi

10.1016/j.wneu.2019.04.025

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

213-215

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(19)31017-4

journal_volume

127

pub_type

杂志文章

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