Islet amyloidosis in a child with type 1 diabetes.

abstract：BACKGROUND:Many studies have evaluated whether there are characteristics related to pancreas donors and the islet isolation process that can influence pancreatic islet yield. However, this analysis has not yet been performed in Brazil, one of the world leaders in whole pancreas organ transplantation (WOPT), where pancr...

journal_title：Islets

authors： Sá GP,Sogayar MC,Eliaschewitz FG,Genzini T,Letrinta R,Onari ES,Mantovani M,Labriola L,Matos D,Lopes-Filho GJ,Gonzalez AM,Mares-Guia TR

更新日期：2011-11-01 00:00:00

abstract：:Pancreatic islet dysfunction is a key element in the development of type 2 diabetes. Determining possible early warning signs of dysfunction is thus important to determining the underlying causes of diabetes. We describe an improved fluorescent imaging approach to detect potential islet dysfunction. Using Cell Tracker...

journal_title：Islets

authors： Corbin KL,Hall TE,Haile R,Nunemaker CS

更新日期：2011-01-01 00:00:00

abstract：:Insulin is secreted from the pancreatic β-cells in response to elevated glucose. In intact islets the capacity for insulin release is determined by a complex interplay between different cell types. This has made it difficult to specifically assess the role of β-cell defects to the insulin secretory impairment in type ...

journal_title：Islets

authors： Reinbothe TM,Safi F,Axelsson AS,Mollet IG,Rosengren AH

更新日期：2014-01-01 00:00:00

abstract：:Several lines of recent evidence provided compelling evidence to suggest increased generation of reactive oxygen species (ROS) as causal for mitochondrial dysregulation and apoptosis in islet β-cells exposed to noxious stimuli including high glucose, lipids and proinflammatory cytokines. Studies along these lines are ...

journal_title：Islets

authors： Mohammed AM,Kowluru A

更新日期：2013-05-01 00:00:00

abstract：:The purification process is one of the most difficult procedures in pancreatic islet isolation. It was demonstrated that the standard purification method using a COBE 2991 cell processor with Ficoll density gradient solution harmed islets mechanically by high shear force. We reported that purification using large bott...

journal_title：Islets

authors： Shimoda M,Itoh T,Iwahashi S,Takita M,Sugimoto K,Kanak MA,Chujo D,Naziruddin B,Levy MF,Grayburn PA,Matsumoto S

更新日期：2012-11-01 00:00:00

abstract：:BACKGROUND: Embolic occlusion of the portal vein due to islet transplantation is one of the major reasons for reduced survival of transplanted islets. In this study, we examined the location of islets as well as the correlation between islet and portal vein size after intraportal islet transplantation and evaluated li...

journal_title：Islets

authors： Sakata N,Obenaus A,Chan N,Mace J,Chinnock R,Hathout E

更新日期：2009-07-01 00:00:00

abstract：:This commentary discusses the concept of β-cell dedifferentiation in diabetes, which is important but not well defined. A broad interpretation is that a state of differentiation has been lost, which means changes in gene expression as well as in structural and functional elements. Thus, a fully mature healthy β cell w...

journal_title：Islets

authors： Weir GC,Aguayo-Mazzucato C,Bonner-Weir S

更新日期：2013-09-01 00:00:00

abstract：:We have previously identified two genes, encoding lactate dehydrogenase (Ldha) and the monocarboxylate carrier, MCT1 (Slc16a1) whose expression is remarkably low in pancreatic β-cells and islets. We sought here to determine whether these may be part of a larger family of genes selectively repressed ("disallowed") in t...

journal_title：Islets

authors： Pullen TJ,Khan AM,Barton G,Butcher SA,Sun G,Rutter GA

更新日期：2010-03-01 00:00:00

abstract：:The islets of Langerhans, ranging in size from clusters of a few cells to several thousand cells, are scattered near large blood vessels. While the β-cell mass in mammals is proportional to body weight, the size ranges of islets are similar between species with different body sizes, possibly reflecting an optimal func...

journal_title：Islets

authors： Jo J,Hara M,Ahlgren U,Sorenson R,Periwal V

更新日期：2012-01-01 00:00:00

abstract：:Inactivation of the gene encoding the aristaless-related homeodomain transcription factor Alx3 results in islet cell apoptosis and impaired glucose homeostasis that worsens with age due to the appearance of insulin resistance. Alx3-deficient mice also show extrapancreatic developmental defects with variable penetrance...

journal_title：Islets

authors： Vallejo M

更新日期：2011-03-01 00:00:00

abstract：:The endocrine pancreas expands markedly in the first postnatal days and the insulin producing β-cells initiate a functional maturation preceded by a morphological change of the islets of Langerhans. Trefoil factor 3 (TFF3) is a secreted peptide expressed in intestinal epithelia, where it promotes migration, but its ro...

journal_title：Islets

authors： Winkel L,Bagge A,Larsen L,Haase TN,Rasmussen M,Lykke J,Holmgaard DB,Thim L,Nielsen JH,Dalgaard LT

更新日期：2018-05-04 00:00:00

abstract：:Both type 1 and type 2 diabetes are associated with insufficient functional β-cell mass. Understanding intracellular signaling pathways associated with this decline is important in broadening our understanding of the disease and potential therapeutic strategies. The hypoxia inducible factor pathway (HIF) plays a criti...

journal_title：Islets

authors： Brunt JJ,Shi SY,Schroer SA,Sivasubramaniyam T,Cai EP,Woo M

更新日期：2014-01-01 00:00:00

abstract：:Worldwide efforts are underway to replace or repair lost or dysfunctional pancreatic β-cells to cure diabetes. However, it is unclear what the final product of these efforts should be, as β-cells are thought to be heterogeneous. To enable the analysis of β-cell heterogeneity in an unbiased and quantitative way, we dev...

journal_title：Islets

authors： Wills QF,Boothe T,Asadi A,Ao Z,Warnock GL,Kieffer TJ,Johnson JD

更新日期：2016-03-03 00:00:00

abstract：:The sophistication of intracellular Ca ( 2+) signalling reflects the necessity for the many different types of cells to fine tuning their specific activities. This can, at least in part, be explained by the molecular complexity of the Ca ( 2+) signalling machinery, consisting of different intracellular Ca ( 2+) releas...

journal_title：Islets

authors： Rossi D,Sorrentino V

更新日期：2010-11-01 00:00:00

abstract：:The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3, Neurog3) is critical for the development of the endocrine cells of the islets. Either disrupted or forced expression of Ngn3 early in mouse pancreas development abrogates the formation of islets. The successive waves of Ngn3 expression that occur duri...

journal_title：Islets

authors： Rukstalis JM,Habener JF

更新日期：2009-11-01 00:00:00

abstract：:Considerable efforts have been invested to understand the mechanisms by which pro-inflammatory cytokines mediate the demise of β-cells in type 1 diabetes but much less attention has been paid to the role of anti-inflammatory cytokines as potential cytoprotective agents in these cells. Despite this, there is increasing...

journal_title：Islets

authors： Russell MA,Morgan NG

更新日期：2014-01-01 00:00:00

abstract：:Assessing the response of pancreatic islet cells to glucose stimulation is important for understanding β-cell function. Zebrafish are a promising model for studies of metabolism in general, including stimulus-secretion coupling in the pancreas. We used transgenic zebrafish embryos expressing a genetically-encoded Ca2+...

journal_title：Islets

authors： Lorincz R,Emfinger CH,Walcher A,Giolai M,Krautgasser C,Remedi MS,Nichols CG,Meyer D

更新日期：2018-01-01 00:00:00

abstract：:The total mass of pancreatic islet cells is a critical factor in glucose metabolic control. The aim of the present study was to investigate whether in the Munich Wistar Frömter (MWF) rat, beside a reduction in the number of nephrons, there are also alterations in the number of pancreatic islets and of β cell mass. We ...

journal_title：Islets

authors： Figliuzzi M,Bonandrini B,Cattaneo I,Remuzzi G,Remuzzi A

更新日期：2010-09-01 00:00:00

abstract：:Islet replacement is a promising approach for type-1 diabetes treatment, but the shortage of organ donors demands new sources of β-cells. The use of stem/precursor cells may represent an attractive alternative. Islet-derived stem/precursor cells (hIPC) have been isolated from human islet preparations, but neither thei...

journal_title：Islets

authors： Carlotti F,Zaldumbide A,Loomans CJ,van Rossenberg E,Engelse M,de Koning EJ,Hoeben RC

更新日期：2010-05-01 00:00:00

abstract：:Recent studies extend the concept of developmental and adaptive plasticity to include a paternal role in the programming of metabolic disease, including diabetes. Parents greatly influence the development and health of their offspring. Although genetic imprinting plays a major role in determining offspring health outc...

journal_title：Islets

authors： Cerf ME

更新日期：2011-05-01 00:00:00

abstract：:A growing body of evidence implicates essential roles for small molecular weight G-proteins (e.g., Cdc42, Rac1, Arf6 and Rab3A and Rab27A) in islet β-cell function including glucose-stimulated insulin secretion (GSIS). One of the known mechanisms for optimal activation of small G-proteins involves post-translational p...

journal_title：Islets

authors： Arora DK,Syed I,Machhadieh B,McKenna CE,Kowluru A

更新日期：2012-09-01 00:00:00

abstract：:Costimulation blockade is an effective way to prevent allograft rejection. In this study, we tested the efficacy of two negative co-signaling molecules in protecting islet allograft function. We used local expression of B7-H4 by adenoviral transduction of islets (Ad-B7-H4) and systemic administration of CTLA-4.Ig to i...

journal_title：Islets

authors： Wang X,Hao J,Metzger DL,Mui A,Lee IF,Akhoundsadegh N,Chen CL,Ou D,Ao Z,Verchere CB,Warnock GL

更新日期：2012-07-01 00:00:00

abstract：:Directed differentiation of stem cells offers a scalable solution to the need for human cell models recapitulating islet biology and T2D pathogenesis. We profiled mRNA expression at 6 stages of an induced pluripotent stem cell (iPSC) model of endocrine pancreas development from 2 donors, and characterized the distinct...

journal_title：Islets

authors： van de Bunt M,Lako M,Barrett A,Gloyn AL,Hansson M,McCarthy MI,Beer NL,Honoré C

更新日期：2016-04-18 00:00:00

abstract：:The transcription factor Pancreatic and Duodenal Homeobox-1 (PDX-1) plays a major role in the development and function of pancreatic β-cells and its mutation results in diabetes. In adult β-cells, glucose stimulates transcription of the insulin gene in part by regulating PDX-1 expression, stability and activity. Gluco...

journal_title：Islets

authors： Semache M,Ghislain J,Zarrouki B,Tremblay C,Poitout V

更新日期：2014-01-01 00:00:00

abstract：:A 39-y-old man, who had an episode of pancreatic bleeding due to chronic pancreatitis, received total pancreatectomy with islet autotransplantation (TP with IAT). Intraoperative ultrasound (US) examination was done to detect transplanted islets and evaluate the quality of US imaging. Islet isolation from the resecte...

journal_title：Islets

authors： Sakata N,Goto M,Gumpei Y,Mizuma M,Motoi F,Satomi S,Unno M

更新日期：2012-09-01 00:00:00

abstract：:The ability of the β-cells to control blood glucose levels depends on their function and mass. In both, type 1 and type 2 diabetes mellitus the main processes leading to β-cell failure are apoptosis and loss of function. Many studies demonstrate how cytokines and chemokines have an active role in triggering the immune...

journal_title：Islets

authors： Paroni F,Domsgen E,Maedler K

更新日期：2009-11-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) are pluripotent and capable of generating new β-cells, but current in vitro differentiation protocols generally fail to produce mature, glucose-responsive, unihormonal β-cells. Instead, these methods tend to produce immature polyhormonal endocrine cells which mature in vivo into gluc...

journal_title：Islets

authors： Gage BK,Baker RK,Kieffer TJ

更新日期：2014-01-01 00:00:00

abstract：:NeuroD (BETA2), a bHLH transcription factor is known to be involved in early pancreatic endocrine as well as neuronal differentiation. NeuroD is known to regulate distinct sets of molecules that are important for survival and differentiation of pancreatic cells. We assessed whether forced expression of NeuroD, can ind...

journal_title：Islets

authors： Appavoo M,Tuch B

更新日期：2009-07-01 00:00:00

abstract：:Type 1 and type 2 diabetes are ultimately characterized by depleted β-cell mass. Characterization of the molecular pathways that control β-cell proliferation could be harnessed to restore these cells. The homeobox β-cell transcription factor Nkx6.1 induces β-cell proliferation by activating the orphan nuclear receptor...

journal_title：Islets

authors： Hobson A,Draney C,Stratford A,Becker TC,Lu D,Arlotto M,Tessem JS

更新日期：2015-01-01 00:00:00

abstract：:A potentiating effect of medium-chain triglycerides on glucose-stimulated insulin secretion (GSIS) has been observed since the 1960s. Subsequent observations identified octanoic acid (OA), the main component of medium-chain triglyceride, as the potentiator of GSIS, but the mechanism was unclear. We used wild-type (WT)...

journal_title：Islets

authors： Zhang T,Chen P,Stanley CA,Hoshi T,Li C

更新日期：2019-01-01 00:00:00