The impact of anti-inflammatory cytokines on the pancreatic β-cell.

Abstract:

:Considerable efforts have been invested to understand the mechanisms by which pro-inflammatory cytokines mediate the demise of β-cells in type 1 diabetes but much less attention has been paid to the role of anti-inflammatory cytokines as potential cytoprotective agents in these cells. Despite this, there is increasing evidence that anti-inflammatory molecules such as interleukin (IL)-4, IL-10 and IL-13 can exert a direct influence of β-cell function and viability and that the circulating levels of these cytokines may be reduced in type 1 diabetes. Thus, it seems possible that targeting of anti-inflammatory pathways might offer therapeutic potential in this disease. In the present review, we consider the evidence implicating IL-4, IL-10 and IL-13 as cytoprotective agents in the β-cell and discuss the receptor components and downstream signaling pathways that mediate these effects.

journal_name

Islets

journal_title

Islets

authors

Russell MA,Morgan NG

doi

10.4161/19382014.2014.950547

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

e950547

issue

3

eissn

1938-2014

issn

1938-2022

pii

950547

journal_volume

6

pub_type

杂志文章,评审

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