Overexpression of HIF-2α in pancreatic β cells does not alter glucose homeostasis.

abstract：:In a variety of mammalian species, small islets secrete more insulin per volume than large islets. This difference may be due to diffusional limitations of large islets, or inherent differences in the insulin production pathways. The purpose of this study was to identify possible differences in the early phase of gluc...

journal_title：Islets

authors： Huang HH,Stehno-Bittel L

更新日期：2015-01-01 00:00:00

abstract：:The ability of the β-cells to control blood glucose levels depends on their function and mass. In both, type 1 and type 2 diabetes mellitus the main processes leading to β-cell failure are apoptosis and loss of function. Many studies demonstrate how cytokines and chemokines have an active role in triggering the immune...

journal_title：Islets

authors： Paroni F,Domsgen E,Maedler K

更新日期：2009-11-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) are pluripotent and capable of generating new β-cells, but current in vitro differentiation protocols generally fail to produce mature, glucose-responsive, unihormonal β-cells. Instead, these methods tend to produce immature polyhormonal endocrine cells which mature in vivo into gluc...

journal_title：Islets

authors： Gage BK,Baker RK,Kieffer TJ

更新日期：2014-01-01 00:00:00

abstract：:Histopathology based studies of the pancreas obtained from organ donors are increasing our awareness of islet phenotypic heterogeneity during development and aging, as well as in settings of type 1 diabetes, type 2 diabetes, monogenic diabetes or other forms of this metabolic disease. Islet amyloidosis represents a hi...

journal_title：Islets

authors： Beery ML,Jacobsen LM,Atkinson MA,Butler AE,Campbell-Thompson M

更新日期：2019-01-01 00:00:00

abstract：:BACKGROUND: Embolic occlusion of the portal vein due to islet transplantation is one of the major reasons for reduced survival of transplanted islets. In this study, we examined the location of islets as well as the correlation between islet and portal vein size after intraportal islet transplantation and evaluated li...

journal_title：Islets

authors： Sakata N,Obenaus A,Chan N,Mace J,Chinnock R,Hathout E

更新日期：2009-07-01 00:00:00

abstract：:Clinical islet transplantation has routinely been demonstrated to be an efficacious means of restoring glycemic control in select patients with autoimmune diabetes. Notwithstanding marked progress and improvements, the broad-spectrum application of this treatment option is restricted by the complications associated wi...

journal_title：Islets

authors： Pepper AR,Bruni A,Pawlick RL,Gala-Lopez B,Rafiei Y,Wink J,Kin T,Shapiro AM

更新日期：2016-11-01 00:00:00

abstract：:The islets of Langerhans, ranging in size from clusters of a few cells to several thousand cells, are scattered near large blood vessels. While the β-cell mass in mammals is proportional to body weight, the size ranges of islets are similar between species with different body sizes, possibly reflecting an optimal func...

journal_title：Islets

authors： Jo J,Hara M,Ahlgren U,Sorenson R,Periwal V

更新日期：2012-01-01 00:00:00

abstract：:Pancreatic islet transplantation is being extensively researched as an alternative treatment for type 1 diabetic patients. This treatment is currently limited by temporal mismatch, between the availability of pancreas and isolated islets from deceased organ donor, and the recipient's need for freshly isolated islets. ...

journal_title：Islets

authors： Kojayan GG,Alexander M,Imagawa DK,Lakey JRT

更新日期：2018-01-02 00:00:00

abstract：:Zinc transporter 8 (ZnT8) has been identified as a β-cell-specific Zinc transporter expressed in insulin-secretory granules. Recent genome wide association studies indicated that Arg325Trp polymorphism of Slc30a8 encoding ZnT8 is associated with susceptibility to type 2 diabetes. As a first step towards understanding ...

journal_title：Islets

authors： Tamaki M,Fujitani Y,Uchida T,Hirose T,Kawamori R,Watada H

更新日期：2009-09-01 00:00:00

abstract：:We recently reported that human blood outgrowth endothelial cells (BOEC) are supportive to reverse hyperglycemia in marginal islet mass-transplanted diabetic mice. In this report, we investigated whether the observed effect was evoked by islet packing in a blood clot prior to transplantation or could be mimicked by an...

journal_title：Islets

authors： Coppens V,Heremans Y,Leuckx G,Suenens K,Jacobs-Tulleneers-Thevissen D,Verdonck K,Luttun A,Heimberg H,De Leu N

更新日期：2013-09-01 00:00:00

abstract：:The endocrine pancreas expands markedly in the first postnatal days and the insulin producing β-cells initiate a functional maturation preceded by a morphological change of the islets of Langerhans. Trefoil factor 3 (TFF3) is a secreted peptide expressed in intestinal epithelia, where it promotes migration, but its ro...

journal_title：Islets

authors： Winkel L,Bagge A,Larsen L,Haase TN,Rasmussen M,Lykke J,Holmgaard DB,Thim L,Nielsen JH,Dalgaard LT

更新日期：2018-05-04 00:00:00

abstract：:Directed differentiation of stem cells offers a scalable solution to the need for human cell models recapitulating islet biology and T2D pathogenesis. We profiled mRNA expression at 6 stages of an induced pluripotent stem cell (iPSC) model of endocrine pancreas development from 2 donors, and characterized the distinct...

journal_title：Islets

authors： van de Bunt M,Lako M,Barrett A,Gloyn AL,Hansson M,McCarthy MI,Beer NL,Honoré C

更新日期：2016-04-18 00:00:00

abstract：:Several lines of recent evidence provided compelling evidence to suggest increased generation of reactive oxygen species (ROS) as causal for mitochondrial dysregulation and apoptosis in islet β-cells exposed to noxious stimuli including high glucose, lipids and proinflammatory cytokines. Studies along these lines are ...

journal_title：Islets

authors： Mohammed AM,Kowluru A

更新日期：2013-05-01 00:00:00

abstract：:Diabetes (T1DM and T2DM) is characterized by a deficit in β-cell mass. A broader understanding of human β-cell replication mechanism is thus important to increase β-cell proliferation for future therapeutic interventions. Here, we show that p27 (Kip1), a CDK inhibitor, is expressed abundantly in isolated adult human i...

journal_title：Islets

authors： Stein J,Milewski WM,Hara M,Steiner DF,Dey A

更新日期：2011-01-01 00:00:00

abstract：:The Reg3 peptides INGAP-PP and human Reg3α/β (HIP) have been hypothesized to stimulate β-cell neogenesis in the pancreas. Administration of INGAP-PP has been shown to cause an increase in β-cell mass in multiple animal models, reverse streptozotocin (STZ) induced diabetes in mice and reduces HbA1c levels in type 2 dia...

journal_title：Islets

authors： Kapur R,Højfeldt TW,Højfeldt TW,Rønn SG,Karlsen AE,Heller RS

更新日期：2012-01-01 00:00:00

abstract：:The transcription factor Pancreatic and Duodenal Homeobox-1 (PDX-1) plays a major role in the development and function of pancreatic β-cells and its mutation results in diabetes. In adult β-cells, glucose stimulates transcription of the insulin gene in part by regulating PDX-1 expression, stability and activity. Gluco...

journal_title：Islets

authors： Semache M,Ghislain J,Zarrouki B,Tremblay C,Poitout V

更新日期：2014-01-01 00:00:00

abstract：:We have previously identified two genes, encoding lactate dehydrogenase (Ldha) and the monocarboxylate carrier, MCT1 (Slc16a1) whose expression is remarkably low in pancreatic β-cells and islets. We sought here to determine whether these may be part of a larger family of genes selectively repressed ("disallowed") in t...

journal_title：Islets

authors： Pullen TJ,Khan AM,Barton G,Butcher SA,Sun G,Rutter GA

更新日期：2010-03-01 00:00:00

abstract：:Assessing the response of pancreatic islet cells to glucose stimulation is important for understanding β-cell function. Zebrafish are a promising model for studies of metabolism in general, including stimulus-secretion coupling in the pancreas. We used transgenic zebrafish embryos expressing a genetically-encoded Ca2+...

journal_title：Islets

authors： Lorincz R,Emfinger CH,Walcher A,Giolai M,Krautgasser C,Remedi MS,Nichols CG,Meyer D

更新日期：2018-01-01 00:00:00

abstract：:This commentary discusses the concept of β-cell dedifferentiation in diabetes, which is important but not well defined. A broad interpretation is that a state of differentiation has been lost, which means changes in gene expression as well as in structural and functional elements. Thus, a fully mature healthy β cell w...

journal_title：Islets

authors： Weir GC,Aguayo-Mazzucato C,Bonner-Weir S

更新日期：2013-09-01 00:00:00

abstract：AIM:To study the protective effect of a fibrin scaffold toward embedded young porcine endocrine pancreatic islets from hydrogen peroxide within the context of islet encapsulation in transplantation. METHODS:After isolation and in vitro maturation, groups of 200 young porcine islet equivalents (IEQ) were embedded in a ...

journal_title：Islets

authors： Kuehn C,Lakey JR,Lamb MW,Vermette P

更新日期：2013-09-01 00:00:00

abstract：:A 39-y-old man, who had an episode of pancreatic bleeding due to chronic pancreatitis, received total pancreatectomy with islet autotransplantation (TP with IAT). Intraoperative ultrasound (US) examination was done to detect transplanted islets and evaluate the quality of US imaging. Islet isolation from the resecte...

journal_title：Islets

authors： Sakata N,Goto M,Gumpei Y,Mizuma M,Motoi F,Satomi S,Unno M

更新日期：2012-09-01 00:00:00

abstract：:The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3, Neurog3) is critical for the development of the endocrine cells of the islets. Either disrupted or forced expression of Ngn3 early in mouse pancreas development abrogates the formation of islets. The successive waves of Ngn3 expression that occur duri...

journal_title：Islets

authors： Rukstalis JM,Habener JF

更新日期：2009-11-01 00:00:00

abstract：:Islet replacement is a promising approach for type-1 diabetes treatment, but the shortage of organ donors demands new sources of β-cells. The use of stem/precursor cells may represent an attractive alternative. Islet-derived stem/precursor cells (hIPC) have been isolated from human islet preparations, but neither thei...

journal_title：Islets

authors： Carlotti F,Zaldumbide A,Loomans CJ,van Rossenberg E,Engelse M,de Koning EJ,Hoeben RC

更新日期：2010-05-01 00:00:00

abstract：:Metabolic syndrome (MS) can be defined as a group of signs that increases the risk of developing type 2 diabetes mellitus (DM2). These signs include obesity, hyperinsulinemia and insulin resistance. We are interested in the mechanisms that trigger hyperinsulinemia as a step to understand how β cells fail in DM2. Pancr...

journal_title：Islets

authors： Velasco M,Larqué C,Gutiérrez-Reyes G,Arredondo R,Sanchez-Soto C,Hiriart M

更新日期：2012-07-01 00:00:00

abstract：:Since the report of the Edmonton protocol in 2000, islet transplantation has been implemented worldwide, and xenotransplantation using porcine islets has also been reported. In addition, many basic experiments using pancreatic islets and exocrine tissue after isolation have been reported. Recently, exocrine cells have...

journal_title：Islets

authors： Nakashima Y,Miyagi-Shiohira C,Kobayashi N,Saitoh I,Watanabe M,Noguchi H

更新日期：2018-05-04 00:00:00

abstract：:A potentiating effect of medium-chain triglycerides on glucose-stimulated insulin secretion (GSIS) has been observed since the 1960s. Subsequent observations identified octanoic acid (OA), the main component of medium-chain triglyceride, as the potentiator of GSIS, but the mechanism was unclear. We used wild-type (WT)...

journal_title：Islets

authors： Zhang T,Chen P,Stanley CA,Hoshi T,Li C

更新日期：2019-01-01 00:00:00

abstract：:The purification process is one of the most difficult procedures in pancreatic islet isolation. It was demonstrated that the standard purification method using a COBE 2991 cell processor with Ficoll density gradient solution harmed islets mechanically by high shear force. We reported that purification using large bott...

journal_title：Islets

authors： Shimoda M,Itoh T,Iwahashi S,Takita M,Sugimoto K,Kanak MA,Chujo D,Naziruddin B,Levy MF,Grayburn PA,Matsumoto S

更新日期：2012-11-01 00:00:00

abstract：:Worldwide efforts are underway to replace or repair lost or dysfunctional pancreatic β-cells to cure diabetes. However, it is unclear what the final product of these efforts should be, as β-cells are thought to be heterogeneous. To enable the analysis of β-cell heterogeneity in an unbiased and quantitative way, we dev...

journal_title：Islets

authors： Wills QF,Boothe T,Asadi A,Ao Z,Warnock GL,Kieffer TJ,Johnson JD

更新日期：2016-03-03 00:00:00

abstract：:The total mass of pancreatic islet cells is a critical factor in glucose metabolic control. The aim of the present study was to investigate whether in the Munich Wistar Frömter (MWF) rat, beside a reduction in the number of nephrons, there are also alterations in the number of pancreatic islets and of β cell mass. We ...

journal_title：Islets

authors： Figliuzzi M,Bonandrini B,Cattaneo I,Remuzzi G,Remuzzi A

更新日期：2010-09-01 00:00:00

abstract：UNLABELLED:AIMS/ HYPOTHESIS: Caspase-3 is a main effector caspase of the apoptotic cascade. Involvement of caspase-3 has been implicated in a β cell cloned cell line from type 1 diabetic subjects and in isolated islets from type 2 diabetic subjects. RESULTS:The control islets revealed cleaved caspase-3 positive cells ...

journal_title：Islets

authors： Tomita T

更新日期：2010-01-01 00:00:00