听力与言语-语言病理学

行为科学

医学伦理学

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  • Mechanisms of octanoic acid potentiation of insulin secretion in isolated islets.

    abstract::A potentiating effect of medium-chain triglycerides on glucose-stimulated insulin secretion (GSIS) has been observed since the 1960s. Subsequent observations identified octanoic acid (OA), the main component of medium-chain triglyceride, as the potentiator of GSIS, but the mechanism was unclear. We used wild-type (WT)...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2019.1566683

    authors: Zhang T,Chen P,Stanley CA,Hoshi T,Li C

    更新日期:2019-01-01 00:00:00

  • Islet amyloidosis in a child with type 1 diabetes.

    abstract::Histopathology based studies of the pancreas obtained from organ donors are increasing our awareness of islet phenotypic heterogeneity during development and aging, as well as in settings of type 1 diabetes, type 2 diabetes, monogenic diabetes or other forms of this metabolic disease. Islet amyloidosis represents a hi...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2019.1599707

    authors: Beery ML,Jacobsen LM,Atkinson MA,Butler AE,Campbell-Thompson M

    更新日期:2019-01-01 00:00:00

  • Adhesion characteristics of porcine pancreatic islets and exocrine tissue to coating materials.

    abstract::Since the report of the Edmonton protocol in 2000, islet transplantation has been implemented worldwide, and xenotransplantation using porcine islets has also been reported. In addition, many basic experiments using pancreatic islets and exocrine tissue after isolation have been reported. Recently, exocrine cells have...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2018.1460294

    authors: Nakashima Y,Miyagi-Shiohira C,Kobayashi N,Saitoh I,Watanabe M,Noguchi H

    更新日期:2018-05-04 00:00:00

  • Trefoil factor 3 in perinatal pancreas is increased by gestational low protein diet and associated with accelerated β-cell maturation.

    abstract::The endocrine pancreas expands markedly in the first postnatal days and the insulin producing β-cells initiate a functional maturation preceded by a morphological change of the islets of Langerhans. Trefoil factor 3 (TFF3) is a secreted peptide expressed in intestinal epithelia, where it promotes migration, but its ro...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2018.1472186

    authors: Winkel L,Bagge A,Larsen L,Haase TN,Rasmussen M,Lykke J,Holmgaard DB,Thim L,Nielsen JH,Dalgaard LT

    更新日期:2018-05-04 00:00:00

  • Systematic review of islet cryopreservation.

    abstract::Pancreatic islet transplantation is being extensively researched as an alternative treatment for type 1 diabetic patients. This treatment is currently limited by temporal mismatch, between the availability of pancreas and isolated islets from deceased organ donor, and the recipient's need for freshly isolated islets. ...

    journal_title:Islets

    pub_type: 历史文章,杂志文章

    doi:10.1080/19382014.2017.1405202

    authors: Kojayan GG,Alexander M,Imagawa DK,Lakey JRT

    更新日期:2018-01-02 00:00:00

  • In vivo monitoring of intracellular Ca2+ dynamics in the pancreatic β-cells of zebrafish embryos.

    abstract::Assessing the response of pancreatic islet cells to glucose stimulation is important for understanding β-cell function. Zebrafish are a promising model for studies of metabolism in general, including stimulus-secretion coupling in the pancreas. We used transgenic zebrafish embryos expressing a genetically-encoded Ca2+...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2018.1540234

    authors: Lorincz R,Emfinger CH,Walcher A,Giolai M,Krautgasser C,Remedi MS,Nichols CG,Meyer D

    更新日期:2018-01-01 00:00:00

  • Long-term function and optimization of mouse and human islet transplantation in the subcutaneous device-less site.

    abstract::Clinical islet transplantation has routinely been demonstrated to be an efficacious means of restoring glycemic control in select patients with autoimmune diabetes. Notwithstanding marked progress and improvements, the broad-spectrum application of this treatment option is restricted by the complications associated wi...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2016.1253652

    authors: Pepper AR,Bruni A,Pawlick RL,Gala-Lopez B,Rafiei Y,Wink J,Kin T,Shapiro AM

    更新日期:2016-11-01 00:00:00

  • Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model.

    abstract::Directed differentiation of stem cells offers a scalable solution to the need for human cell models recapitulating islet biology and T2D pathogenesis. We profiled mRNA expression at 6 stages of an induced pluripotent stem cell (iPSC) model of endocrine pancreas development from 2 donors, and characterized the distinct...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2016.1182276

    authors: van de Bunt M,Lako M,Barrett A,Gloyn AL,Hansson M,McCarthy MI,Beer NL,Honoré C

    更新日期:2016-04-18 00:00:00

  • Statistical approaches and software for clustering islet cell functional heterogeneity.

    abstract::Worldwide efforts are underway to replace or repair lost or dysfunctional pancreatic β-cells to cure diabetes. However, it is unclear what the final product of these efforts should be, as β-cells are thought to be heterogeneous. To enable the analysis of β-cell heterogeneity in an unbiased and quantitative way, we dev...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2016.1150664

    authors: Wills QF,Boothe T,Asadi A,Ao Z,Warnock GL,Kieffer TJ,Johnson JD

    更新日期:2016-03-03 00:00:00

  • Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.

    abstract::Type 1 and type 2 diabetes are ultimately characterized by depleted β-cell mass. Characterization of the molecular pathways that control β-cell proliferation could be harnessed to restore these cells. The homeobox β-cell transcription factor Nkx6.1 induces β-cell proliferation by activating the orphan nuclear receptor...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2015.1027854

    authors: Hobson A,Draney C,Stratford A,Becker TC,Lu D,Arlotto M,Tessem JS

    更新日期:2015-01-01 00:00:00

  • Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretion.

    abstract::In a variety of mammalian species, small islets secrete more insulin per volume than large islets. This difference may be due to diffusional limitations of large islets, or inherent differences in the insulin production pathways. The purpose of this study was to identify possible differences in the early phase of gluc...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2015.1129097

    authors: Huang HH,Stehno-Bittel L

    更新日期:2015-01-01 00:00:00

  • Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines.

    abstract::The transcription factor Pancreatic and Duodenal Homeobox-1 (PDX-1) plays a major role in the development and function of pancreatic β-cells and its mutation results in diabetes. In adult β-cells, glucose stimulates transcription of the insulin gene in part by regulating PDX-1 expression, stability and activity. Gluco...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/19382014.2014.982376

    authors: Semache M,Ghislain J,Zarrouki B,Tremblay C,Poitout V

    更新日期:2014-01-01 00:00:00

  • Overexpression of PAX4 reduces glucagon expression in differentiating hESCs.

    abstract::Human embryonic stem cells (hESCs) are pluripotent and capable of generating new β-cells, but current in vitro differentiation protocols generally fail to produce mature, glucose-responsive, unihormonal β-cells. Instead, these methods tend to produce immature polyhormonal endocrine cells which mature in vivo into gluc...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.29236

    authors: Gage BK,Baker RK,Kieffer TJ

    更新日期:2014-01-01 00:00:00

  • Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2.

    abstract::Insulin is secreted from the pancreatic β-cells in response to elevated glucose. In intact islets the capacity for insulin release is determined by a complex interplay between different cell types. This has made it difficult to specifically assess the role of β-cell defects to the insulin secretory impairment in type ...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.28095

    authors: Reinbothe TM,Safi F,Axelsson AS,Mollet IG,Rosengren AH

    更新日期:2014-01-01 00:00:00

  • The impact of anti-inflammatory cytokines on the pancreatic β-cell.

    abstract::Considerable efforts have been invested to understand the mechanisms by which pro-inflammatory cytokines mediate the demise of β-cells in type 1 diabetes but much less attention has been paid to the role of anti-inflammatory cytokines as potential cytoprotective agents in these cells. Despite this, there is increasing...

    journal_title:Islets

    pub_type: 杂志文章,评审

    doi:10.4161/19382014.2014.950547

    authors: Russell MA,Morgan NG

    更新日期:2014-01-01 00:00:00

  • Overexpression of HIF-2α in pancreatic β cells does not alter glucose homeostasis.

    abstract::Both type 1 and type 2 diabetes are associated with insufficient functional β-cell mass. Understanding intracellular signaling pathways associated with this decline is important in broadening our understanding of the disease and potential therapeutic strategies. The hypoxia inducible factor pathway (HIF) plays a criti...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.1080/19382014.2015.1006075

    authors: Brunt JJ,Shi SY,Schroer SA,Sivasubramaniyam T,Cai EP,Woo M

    更新日期:2014-01-01 00:00:00

  • β-cell dedifferentiation in diabetes is important, but what is it?

    abstract::This commentary discusses the concept of β-cell dedifferentiation in diabetes, which is important but not well defined. A broad interpretation is that a state of differentiation has been lost, which means changes in gene expression as well as in structural and functional elements. Thus, a fully mature healthy β cell w...

    journal_title:Islets

    pub_type: 杂志文章,评审

    doi:10.4161/isl.27494

    authors: Weir GC,Aguayo-Mazzucato C,Bonner-Weir S

    更新日期:2013-09-01 00:00:00

  • Young porcine endocrine pancreatic islets cultured in fibrin show improved resistance toward hydrogen peroxide.

    abstract:AIM:To study the protective effect of a fibrin scaffold toward embedded young porcine endocrine pancreatic islets from hydrogen peroxide within the context of islet encapsulation in transplantation. METHODS:After isolation and in vitro maturation, groups of 200 young porcine islet equivalents (IEQ) were embedded in a ...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.26989

    authors: Kuehn C,Lakey JR,Lamb MW,Vermette P

    更新日期:2013-09-01 00:00:00

  • Bioengineering a highly vascularized matrix for the ectopic transplantation of islets.

    abstract::Islet transplantation is a promising treatment for Type 1 diabetes; however limitations of the intra-portal site and poor revascularization of islets must be overcome. We hypothesize that engineering a highly vascularized collagen-based construct will allow islet graft survival and function in alternative sites. In th...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.27175

    authors: Ellis CE,Vulesevic B,Suuronen E,Yeung T,Seeberger K,Korbutt GS

    更新日期:2013-09-01 00:00:00

  • Reversal of hyperglycemia in diabetic mice by a marginal islet mass together with human blood outgrowth endothelial cells is independent of the delivery technique and blood clot-induced processes.

    abstract::We recently reported that human blood outgrowth endothelial cells (BOEC) are supportive to reverse hyperglycemia in marginal islet mass-transplanted diabetic mice. In this report, we investigated whether the observed effect was evoked by islet packing in a blood clot prior to transplantation or could be mimicked by an...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.26778

    authors: Coppens V,Heremans Y,Leuckx G,Suenens K,Jacobs-Tulleneers-Thevissen D,Verdonck K,Luttun A,Heimberg H,De Leu N

    更新日期:2013-09-01 00:00:00

  • Activation of apocynin-sensitive NADPH oxidase (Nox2) activity in INS-1 832/13 cells under glucotoxic conditions.

    abstract::Several lines of recent evidence provided compelling evidence to suggest increased generation of reactive oxygen species (ROS) as causal for mitochondrial dysregulation and apoptosis in islet β-cells exposed to noxious stimuli including high glucose, lipids and proinflammatory cytokines. Studies along these lines are ...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.25058

    authors: Mohammed AM,Kowluru A

    更新日期:2013-05-01 00:00:00

  • An effective purification method using large bottles for human pancreatic islet isolation.

    abstract::The purification process is one of the most difficult procedures in pancreatic islet isolation. It was demonstrated that the standard purification method using a COBE 2991 cell processor with Ficoll density gradient solution harmed islets mechanically by high shear force. We reported that purification using large bott...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.23008

    authors: Shimoda M,Itoh T,Iwahashi S,Takita M,Sugimoto K,Kanak MA,Chujo D,Naziruddin B,Levy MF,Grayburn PA,Matsumoto S

    更新日期:2012-11-01 00:00:00

  • Intraoperative ultrasound examination is useful for monitoring transplanted islets: a case report.

    abstract::A 39-y-old man, who had an episode of pancreatic bleeding due to chronic pancreatitis, received total pancreatectomy with islet autotransplantation (TP with IAT). Intraoperative ultrasound (US) examination was done to detect transplanted islets and evaluate the quality of US imaging. Islet isolation from the resecte...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.22384

    authors: Sakata N,Goto M,Gumpei Y,Mizuma M,Motoi F,Satomi S,Unno M

    更新日期:2012-09-01 00:00:00

  • Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells.

    abstract::A growing body of evidence implicates essential roles for small molecular weight G-proteins (e.g., Cdc42, Rac1, Arf6 and Rab3A and Rab27A) in islet β-cell function including glucose-stimulated insulin secretion (GSIS). One of the known mechanisms for optimal activation of small G-proteins involves post-translational p...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.22538

    authors: Arora DK,Syed I,Machhadieh B,McKenna CE,Kowluru A

    更新日期:2012-09-01 00:00:00

  • Metabolic syndrome induces changes in KATP-channels and calcium currents in pancreatic β-cells.

    abstract::Metabolic syndrome (MS) can be defined as a group of signs that increases the risk of developing type 2 diabetes mellitus (DM2). These signs include obesity, hyperinsulinemia and insulin resistance. We are interested in the mechanisms that trigger hyperinsulinemia as a step to understand how β cells fail in DM2. Pancr...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.21374

    authors: Velasco M,Larqué C,Gutiérrez-Reyes G,Arredondo R,Sanchez-Soto C,Hiriart M

    更新日期:2012-07-01 00:00:00

  • Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival.

    abstract::Costimulation blockade is an effective way to prevent allograft rejection. In this study, we tested the efficacy of two negative co-signaling molecules in protecting islet allograft function. We used local expression of B7-H4 by adenoviral transduction of islets (Ad-B7-H4) and systemic administration of CTLA-4.Ig to i...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.21239

    authors: Wang X,Hao J,Metzger DL,Mui A,Lee IF,Akhoundsadegh N,Chen CL,Ou D,Ao Z,Verchere CB,Warnock GL

    更新日期:2012-07-01 00:00:00

  • Mathematical models of pancreatic islet size distributions.

    abstract::The islets of Langerhans, ranging in size from clusters of a few cells to several thousand cells, are scattered near large blood vessels. While the β-cell mass in mammals is proportional to body weight, the size ranges of islets are similar between species with different body sizes, possibly reflecting an optimal func...

    journal_title:Islets

    pub_type: 杂志文章,评审

    doi:10.4161/isl.18660

    authors: Jo J,Hara M,Ahlgren U,Sorenson R,Periwal V

    更新日期:2012-01-01 00:00:00

  • Short-term effects of INGAP and Reg family peptides on the appearance of small β-cells clusters in non-diabetic mice.

    abstract::The Reg3 peptides INGAP-PP and human Reg3α/β (HIP) have been hypothesized to stimulate β-cell neogenesis in the pancreas. Administration of INGAP-PP has been shown to cause an increase in β-cell mass in multiple animal models, reverse streptozotocin (STZ) induced diabetes in mice and reduces HbA1c levels in type 2 dia...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.18659

    authors: Kapur R,Højfeldt TW,Højfeldt TW,Rønn SG,Karlsen AE,Heller RS

    更新日期:2012-01-01 00:00:00

  • Differential synthesis and action of TGFß superfamily ligands in mouse and rat islets.

    abstract::Members of the TGFß superfamily, including activins and TGFß, modulate glucose-stimulated insulin secretion (GSIS) in vitro using rat islets while genetic manipulations that reduce TGFß superfamily signaling in vivo in mice produced hypoplastic islets and/or hyperglycemia. Moreover, deletion of Fstl3, an antagonist of...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.3.6.18013

    authors: Brown ML,Kimura F,Bonomi LM,Ungerleider NA,Schneyer AL

    更新日期:2011-11-01 00:00:00

  • Islet versus pancreas transplantation in Brazil: Defining criteria for pancreas allocation decision.

    abstract:BACKGROUND:Many studies have evaluated whether there are characteristics related to pancreas donors and the islet isolation process that can influence pancreatic islet yield. However, this analysis has not yet been performed in Brazil, one of the world leaders in whole pancreas organ transplantation (WOPT), where pancr...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.3.6.17908

    authors: Sá GP,Sogayar MC,Eliaschewitz FG,Genzini T,Letrinta R,Onari ES,Mantovani M,Labriola L,Matos D,Lopes-Filho GJ,Gonzalez AM,Mares-Guia TR

    更新日期:2011-11-01 00:00:00

  • Parental high-fat programming of offspring development, health and β-cells.

    abstract::Recent studies extend the concept of developmental and adaptive plasticity to include a paternal role in the programming of metabolic disease, including diabetes. Parents greatly influence the development and health of their offspring. Although genetic imprinting plays a major role in determining offspring health outc...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.3.3.15420

    authors: Cerf ME

    更新日期:2011-05-01 00:00:00

  • The aristaless-like homeobox protein Alx3 as an etiopathogenic factor for diabetes mellitus.

    abstract::Inactivation of the gene encoding the aristaless-related homeodomain transcription factor Alx3 results in islet cell apoptosis and impaired glucose homeostasis that worsens with age due to the appearance of insulin resistance. Alx3-deficient mice also show extrapancreatic developmental defects with variable penetrance...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.3.2.14658

    authors: Vallejo M

    更新日期:2011-03-01 00:00:00

  • A novel fluorescence imaging approach for comparative measurements of pancreatic islet function in vitro.

    abstract::Pancreatic islet dysfunction is a key element in the development of type 2 diabetes. Determining possible early warning signs of dysfunction is thus important to determining the underlying causes of diabetes. We describe an improved fluorescent imaging approach to detect potential islet dysfunction. Using Cell Tracker...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.3.1.14133

    authors: Corbin KL,Hall TE,Haile R,Nunemaker CS

    更新日期:2011-01-01 00:00:00

  • GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1).

    abstract::Diabetes (T1DM and T2DM) is characterized by a deficit in β-cell mass. A broader understanding of human β-cell replication mechanism is thus important to increase β-cell proliferation for future therapeutic interventions. Here, we show that p27 (Kip1), a CDK inhibitor, is expressed abundantly in isolated adult human i...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.3.1.14435

    authors: Stein J,Milewski WM,Hara M,Steiner DF,Dey A

    更新日期:2011-01-01 00:00:00

  • The multiple alternatives of intracellular calcium signaling: a functionally distinct RyR splicing variant in pancreatic islets.

    abstract::The sophistication of intracellular Ca ( 2+) signalling reflects the necessity for the many different types of cells to fine tuning their specific activities. This can, at least in part, be explained by the molecular complexity of the Ca ( 2+) signalling machinery, consisting of different intracellular Ca ( 2+) releas...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.2.6.13859

    authors: Rossi D,Sorrentino V

    更新日期:2010-11-01 00:00:00

  • Effect of inborn pancreatic islet deficit in the Munich Wister Frömter rat.

    abstract::The total mass of pancreatic islet cells is a critical factor in glucose metabolic control. The aim of the present study was to investigate whether in the Munich Wistar Frömter (MWF) rat, beside a reduction in the number of nephrons, there are also alterations in the number of pancreatic islets and of β cell mass. We ...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.2.5.13178

    authors: Figliuzzi M,Bonandrini B,Cattaneo I,Remuzzi G,Remuzzi A

    更新日期:2010-09-01 00:00:00

  • No non-redundant function of suppressor of cytokine signaling 2 in insulin producing β-cells.

    abstract::The members of the Suppressor of Cytokine Signaling (SOCS) protein family mainly modulate the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. SOCS-1 and SOCS-3 have already been shown to influence growth and apoptosis of pancreatic beta cells. We hypothesized that SOCS-2, which is e...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.2.4.12556

    authors: Puff R,Dames P,Weise M,Göke B,Parhofer K,Lechner A

    更新日期:2010-07-01 00:00:00

  • Isolated human islets contain a distinct population of mesenchymal stem cells.

    abstract::Islet replacement is a promising approach for type-1 diabetes treatment, but the shortage of organ donors demands new sources of β-cells. The use of stem/precursor cells may represent an attractive alternative. Islet-derived stem/precursor cells (hIPC) have been isolated from human islet preparations, but neither thei...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.2.3.11449

    authors: Carlotti F,Zaldumbide A,Loomans CJ,van Rossenberg E,Engelse M,de Koning EJ,Hoeben RC

    更新日期:2010-05-01 00:00:00

  • Identification of genes selectively disallowed in the pancreatic islet.

    abstract::We have previously identified two genes, encoding lactate dehydrogenase (Ldha) and the monocarboxylate carrier, MCT1 (Slc16a1) whose expression is remarkably low in pancreatic β-cells and islets. We sought here to determine whether these may be part of a larger family of genes selectively repressed ("disallowed") in t...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.2.2.11025

    authors: Pullen TJ,Khan AM,Barton G,Butcher SA,Sun G,Rutter GA

    更新日期:2010-03-01 00:00:00

  • Immunocytochemical localization of cleaved caspase-3 in pancreatic islets from type 1 diabetic subjects.

    abstract:UNLABELLED:AIMS/ HYPOTHESIS: Caspase-3 is a main effector caspase of the apoptotic cascade. Involvement of caspase-3 has been implicated in a β cell cloned cell line from type 1 diabetic subjects and in isolated islets from type 2 diabetic subjects. RESULTS:The control islets revealed cleaved caspase-3 positive cells ...

    journal_title:Islets

    pub_type: 杂志文章

    doi:10.4161/isl.2.1.10041

    authors: Tomita T

    更新日期:2010-01-01 00:00:00

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