Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer.

Abstract:

Objectives:To evaluate the relationship of D-dimer, CD147 and miR-203, and detect the influence of these biomarkers on the pathological characteristics in patients with gastric cancer. Methods:The patients with gastric cancer treated using radical gastrectomy between May 2013 and October 2017 were reviewed retrospectively. The expression of D-dimer, miR203 and CD147 was measured for all the patients, and the clinical data including age, gender, tumor size, tumor differentiation, invasion depth, lymphatic metastasis, TMN stage, and pathological type were retrieved and analyzed. The study was carried out in affiliated Yidu Central Hospital of Weifang Medical College, Qingzhou, China. Results:Two hundred sixty patients with gastric cancer were included. The patients with tumor metastasis, larger tumor diameter, lower differentiation, lymphatic metastasis, deeper invasion, and higher TMN stage presented with a significantly higher D-dimer and CD 147 expression, but the level of the two biomarkers didn't show a significant difference in patients with different pathological type, gender and age. Compared with CD147 and D-dimer, miR203 presented with different characteristics of expression. In addition, the expression of miR203 was negatively correlated with CD147 and D-dimer, and there was a positive correlation between CD147 and D-dimer in patients with gastric cancer. Conclusion:In this study, a close correlation of D-dimer, miR203 and CD147 was found, and these three biomarkers should be screened in gastric cancer patients.

journal_name

Pak J Med Sci

authors

Wu X,Liu X

doi

10.12669/pjms.35.2.718

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

443-447

issue

2

eissn

1682-024X

issn

1681-715X

pii

PJMS-35-443

journal_volume

35

pub_type

杂志文章
  • Exploring variability of teaching & supervision at clinical clerkship teaching sites.

    abstract:Objective:To explore undergraduate medical students' perception of variation in teaching and supervision at different clinical teaching sites. Methods:This descriptive cross-sectional study was conducted at the College of Medicine & Health Sciences, United Arab Emirates University, UAE during 2017. Four clinical teach...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.342.14656

    authors: Naeem N,Elzubeir M,Al-Houqani M,Ahmed LA

    更新日期:2018-03-01 00:00:00

  • Fetomaternal outcome in patients with placenta previa.

    abstract:Objectives:To assess maternal and fetal morbidity associated with placenta previa and morbidly adherent placenta (MAP). Methods:All patients with placenta previa who delivered in services hospital from April 1, 2017 to March 31, 2019 were included. Maternal and fetal outcomes were compared amongst patients with placen...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.5.1647

    authors: Wasim T,Bushra N,Riaz S,Iqbal HI

    更新日期:2020-07-01 00:00:00

  • Neonatal idiopathic primary hypoparathyroidism: A rare cause of neonatal seizures.

    abstract::Etiology of neonatal seizures (NNS) is diverse and hypocalcemia is one of the treatable causes. Neonatal hypocalcemia (NHC) due to congenital hypoparathyroidism, either permanent or transient, is extremely rare. Its biochemical abnormalities include hypocalcemia, hyperphosphatemia and low levels of intact parathyroid ...

    journal_title:Pakistan journal of medical sciences

    pub_type:

    doi:10.12669/pjms.315.7807

    authors: Hussain S,Sabir MU,Ali M,Shah SA

    更新日期:2015-09-01 00:00:00

  • Students' Feedback about Feedback; Have our PBL tutors started the shift towards a dialogic ask-tell-ask approach?

    abstract:Objective:A paradigm shift towards a PBL bidirectional dialogic feedback can enhance learners' performance. This study aimed to investigate undergraduate medical students' perceptions of their PBL feedback. Methods:We sent e-mail invitations to a web-based survey to year one and two students at College of Medicine, Ki...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.7.1778

    authors: Saeed M,Isnani AC,Khan SA,Khamis N

    更新日期:2020-11-01 00:00:00

  • Seroprevalence of Human Brucellosis in Wadi Al Dawaser region of Saudi Arabia.

    abstract:Background and Objective:Brucellosis is an important zoonotic disease and a major public health problem in the Middle East countries including Saudi Arabia. This study has evaluated the seroprevalence of human brucellosis in Wadi Al Dawaser region of Central Saudi Arabia. Methods:The study was conducted for three year...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.1.55

    authors: Rahamathulla MP

    更新日期:2019-01-01 00:00:00

  • A New Model of Master of Philosophy in Physiological Sciences.

    abstract::The objectives of Master of Philosophy (MPhil) in Physiological Sciences are: 1) to describe the new ways in which anatomy, biochemistry and physiology on one hand, and microbiology, pathology and pharmacology on other hand meet their functional requirements through multidisciplinary integrated concepts; 2) to elucida...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.325.11481

    authors: Ahmad HR,Arain FM,Khan NA

    更新日期:2016-09-01 00:00:00

  • Prevalence of obesity and hypertension among University students' and their knowledge and attitude towards risk factors of Cardiovascular Disease (CVD) in Jeddah, Saudi Arabia.

    abstract:OBJECTIVES:To investigate the prevalence of obesity and hypertension among University students' and their knowledge and attitude towards risk factors of cardiovascular disease (CVD) in Jeddah,: Saudi Arabia. METHODS:A total of 610 male students were selected for present cross sectional study and their blood pressure (...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.314.7953

    authors: Baig M,Gazzaz ZJ,Gari MA,Al-Attallah HG,Al-Jedaani KS,Mesawa AT,Al-Hazmi AA

    更新日期:2015-07-01 00:00:00

  • Ultrasound diagnosis of age-related involutional changes in the lower third of face and neck to determine treatment techniques.

    abstract:Objective:To develop a clinical technique for objective estimation of exact location and degree of participation of face and neck soft tissues in age-related deformations for determine effective mini-invasive treatment techniques. Methods:Ultrasound examination was performed in 2017-2019 at 63 patients with age-relate...

    journal_title:Pakistan journal of medical sciences

    pub_type:

    doi:10.12669/pjms.37.1.3034

    authors: Sharobaro V,Alimova S,Telnova A,Shamanaeva L

    更新日期:2021-01-01 00:00:00

  • Nurses in double trouble: Antecedents of job burnout in nursing profession.

    abstract:Objective:To understand the most prominent factors contributing to job burnout in the nursing profession. Methods:Mixed method design was used in this study. In the qualitative part of the study, a focus group discussion approach was used to determine the major factors contributing in nurses' job burnout. The quantita...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.4.600

    authors: Shahzad MN,Ahmed MA,Akram B

    更新日期:2019-07-01 00:00:00

  • A comparative study of functional outcome of treatment of intra articular fractures of distal radius fixed with percutaneous Kirschner's wires vs T-plate.

    abstract:BACKGROUND & OBJECTIVE:Fractures of the distal radius are common with a variable prognosis in case of intra articular extension. The available options include Plaster, External fixation, Prefabricated Splintage using Ligamentotaxis, K-wire fixation, and open reduction internal fixation with T-plate without an as yet cl...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.333.11421

    authors: Khan JI,Hussain FN,Mehmood T,Adil O

    更新日期:2017-05-01 00:00:00

  • Perception on the severity of unwanted pregnancy among university students.

    abstract:OBJECTIVES:The purpose of this study was to examine the perception of University students regarding the severity of unwanted pregnancy. METHODS:This cross sectional study involved 408 (206 females and 202 males) students residing within the university campus. Simple and systematic sampling methods were used to select ...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.294.3626

    authors: Chima Anyanwu F,Ter Goon D,Tugli A

    更新日期:2013-07-01 00:00:00

  • Association among helicobacter pylori infection, gastrin level and colorectal cancer in patients aged 50 years and over.

    abstract:Objectives:To study the correlations among helicobacter pylori infection, gastrin and colorectal cancer in patients aged over 50 years old. Methods:In this study, the patients diagnosed with colorectal cancer treated in the department of digestion of our hospital together with the healthy subjects undergoing colonosco...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.5.1993

    authors: Luan C,Liu Z,Li Y,Dong T

    更新日期:2020-07-01 00:00:00

  • Agreement between Keratometric readings by VERION image guided System, Galilei G4 and Pentacam.

    abstract:Objective:To study Agreement between Keratometric readings by VERION image guided System, Galilei G4 and Pentacam. Methods:The quasi experimental study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from August 2016 to December 2016. Twenty five patients fulfilling the inclusion criteri...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.343.14577

    authors: Habib A,Khan MS,Ishaq M,Yaqub MA

    更新日期:2018-05-01 00:00:00

  • Subtenon Vs Intravitreal Triamcinolone injection in Diabetic Macular Edema, A prospective study in Chinese population.

    abstract:OBJECTIVE:Purpose of this study was to validate that Subtenon (SB) Triamcinolone (TA) injection is an alternative to Intravitreal (IV) Triamcinolone (TA) injection for the treatment of diabetic macular edema (DME). METHODS:Forty eyes were selected having DME due to type 1 or type 2 diabetes. All the patients were trea...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.304.4810

    authors: Luo D,Zhu B,Zheng Z,Zhou H,Sun X,Xu X

    更新日期:2014-07-01 00:00:00

  • Assessment of Risk Factors of Obesity and Diet on Breast Cancer in Ankara, Turkey.

    abstract:OBJECTIVE:To determine the risk factors of obesity and diet on breast cancer in Ankara, Turkey. METHODS:A case-controlled study was carried out on newly diagnosed 40 breast cancer patients [patient group (PC)] and 40 volunteer individuals [control group (CG)] with no diagnosis of cancer and history of cancer in the fa...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.326.11346

    authors: Alim NE,Kiziltan G

    更新日期:2016-11-01 00:00:00

  • The effectiveness of trendelenburg positioning on the cross-sectional area of the right internal jugular vein in obese patients.

    abstract:OBJECTIVE:Trendelenburg positioning is a common approach used during internal jugular vein (IJV) cannulation. No evidence indicates that Trendelenburg positioning significantly increases the cross-sectional area (CSA) of the IJV in obese patients. The primary aim of this study was to determine the effectiveness of Tren...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.314.7326

    authors: Onal O,Apiliogullari S,Nayman A,Saltali A,Yilmaz H,Celik JB

    更新日期:2015-07-01 00:00:00

  • Intra-Operative Predictors of difficult cholecystectomy and Conversion to Open Cholecystectomy - A New Scoring System.

    abstract:Objective:To evaluate the intra-operative scoring system to predict difficult cholecystectomy and conversion to open surgery. Methods:This descriptive study was conducted from March 2016 to August, 2016 in the Department of Surgery, Shalimar Hospital. The study recruited 120 patients of either gender, age greater than...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.341.13302

    authors: Ahmed N,Hassan MU,Tahira M,Samad A,Rana HN

    更新日期:2018-01-01 00:00:00

  • Comparison of failure loads and compressive stress in Press on metal and Press on Y-TZP copings.

    abstract:Objective:The aim of the study was to assess the failure loads and compressive stresses among bilayered press on Y-TZP (POZ) and press on metal (POM) crowns with different core-veneer thickness. Methods:Thirty metal and Y-TZP copings were fabricated using CAD-CAM technology with specified thickness. All copings were v...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.7.2472

    authors: Vohra F,Shuwaish MB,Deeb MA,Alhamdan R,Alotaibi N,Abduljabbar T

    更新日期:2020-11-01 00:00:00

  • Determination of site-specific carotid-intima media thickness: common -carotid artery and carotid bifurcation in hypercholesterolemia patients.

    abstract:OBJECTIVE:To determine site specific carotid intima-media thickness: common-carotid artery and carotid bifurcation in hypercholesterolemia patients as a marker for atherosclerosis. METHODS:Fifty patients with hypercholesterolemia and twenty controls were selected after getting informed consent regarding the investigat...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.295.3830

    authors: Perwaiz Khan S,Gul P,Khemani S,Yaqub Z

    更新日期:2013-09-01 00:00:00

  • Prognostic markers in Chronic Lymphocytic Leukaemia - A flow cytometric analysis.

    abstract:Objective:To find out the frequency of ZAP-70, CD38 and CD49d in patients diagnosed with CLL in our population. Methods:This is a cross sectional study conducted in Army Medical College in collaboration with Armed Forces Institute of Pathology and Military Hospital Rawalpindi from 1st January 2018 to 30th November 201...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.3.541

    authors: Haq H,Uddin N,Khan SA,Ghaffar S

    更新日期:2020-03-01 00:00:00

  • Prevalence of dental caries and associated social risk factors among preschool children in Riyadh, Saudi Arabia.

    abstract:OBJECTIVES:To determine the prevalence of dental caries, and associated social risk factors among preschool children in Riyadh, Saudi Arabia. METHODS:The study consisted of a random sample of 3 to 5 years- old preschool children who were examined in Riyadh, Saudi Arabia; 388 children (184 boys and 204 girls) were exam...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.322.9439

    authors: Al-Meedani LA,Al-Dlaigan YH

    更新日期:2016-03-01 00:00:00

  • Efficacy of botulinum toxin in benign essential Blepharospasm: Desirable & undesirable effects.

    abstract:OBJECTIVE:To study the efficacy, desirable and undesirable effects of locally injectable preparation of botulinum toxin in patients suffering from Benign Essential Blepharospasm (BEB). METHODS:It was a prospective study carried out from October 2006 till November 2012 at a private set up, "Dr Shakaib's Eye Clinic", in...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.296.3853

    authors: Anwar MS,Zafar H

    更新日期:2013-11-01 00:00:00

  • Evaluation of the Rational Analgesic use in elderly adults: A cross-sectional study.

    abstract:Objectives:To assess inappropriate analgesic use (IAU) by comparison of STOPP/START Version-2 and Beers 2019 criteria. Methods:This is a cross-sectional study of 331 elderly patients admitted to family medicine clinics at a tertiary hospital between February and July 2018. Data were collected from face-to-face surveys...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.5.2331

    authors: Baspınar MM,Basat O

    更新日期:2020-07-01 00:00:00

  • Non Invasive Follicular Thyroid Neoplasm with Papillary like nuclear features (NIFTP), A time for change in Pakistan.

    abstract:Objective:To determine the cases of Noninvasive Follicular thyroid neoplasm with papillary like nuclear features (NIFTP) in Pakistani population retrospectively. Another objective was to determine their clinical and radiological outcomes with respect to local and systemic disease recurrence, reconfirming the benign cou...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.2.1123

    authors: Jabeen S,Fatima S,Sheikh A,Islam N

    更新日期:2020-01-01 00:00:00

  • The learning environment of four undergraduate health professional schools: Lessons learned.

    abstract:Background and Objectives:Learning is an interplay between cognition and environmental factors. Any learning environment, that fulfills the intrinsic and extrinsic needs of the students will probably lead to better and more promising learning outcomes. This study aimed to investigate the student perceptions of Learning...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.3.712

    authors: Irfan F,Faris EA,Maflehi NA,Karim SI,Ponnamperuma G,Saad H,Ahmed AM

    更新日期:2019-01-01 00:00:00

  • Impact of an IEC (Information, Education and Communication) intervention on key family practices of mothers related to child health in Jamshoro, Sindh.

    abstract:OBJECTIVE:To determine change in practice of mothers having children less than five years of age in five key areas related to child health, growth and development including immunization, feeding during illness, appropriate home treatment for infections and care seeking behavior. METHODS:This was a community based inte...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.303.4798

    authors: Shaikh S,Memon S,Ahmed I,Amna,Manzoor R,Shaikh S

    更新日期:2014-05-01 00:00:00

  • Long Term Outcomes of Laparoscopic and Open Modified Lich-Gregoir Reimplantation in Adults: A multicentric comparative study.

    abstract:BACKGROUND & OBJECTIVE:Obstructive ureteral pathologies in adult patients are most commonly due to ureteral strictures and secondary to surgical interventions. In this study, we aimed to compare open and laparoscopic modified Lich-Gregoir ureteral reimplantation with regards to outcomes in benign ureteral pathologies i...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.334.12661

    authors: Atar A,Eksi M,Güler AF,Tuncer M,Akkas F,Tugcu V

    更新日期:2017-07-01 00:00:00

  • Low dose albumin for the prevention of renal impairment following large volume paracentesis in cirrhosis.

    abstract:OBJECTIVES:To evaluate the effect of low dose Albumin i.e. 4 grams per litre of ascitic fluid after large volume paracentesis (LVP) for the prevention of paracentesis induced circulatory dysfunction (PICD) related renal impairment in cirrhosis. METHODS:Case records of all patients with cirrhosis who underwent LVP from...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.313.7281

    authors: Hussain W,Khalid AB,Usmani T,Ghufran A,Shah H

    更新日期:2015-01-01 00:00:00

  • Cardiorespiratory fitness and its association with adiposity indices in young adults.

    abstract:OBJECTIVE:This study investigated the relationship between cardiorespiratory fitness (CRF) and adiposity in young adults. METHODS:Data was collected from 133 students of a medical college of Pakistan. The study was conducted on young adults, aged 17-24 years, recruited from Jinnah Medical & Dental College, Karachi, be...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.333.12294

    authors: Hingorjo MR,Zehra S,Hasan Z,Qureshi MA

    更新日期:2017-05-01 00:00:00

  • Genetic polymorphism of miRNA-196a and its target gene annexin-A1 expression based on ethnicity in Pakistani female breast cancer patients.

    abstract:Objective:To evaluate the association of miR-196a rs11614913 C/T genetic variation and its target gene annexin A1 mRNA expression with breast cancer risk in Pakistani female ethnicities. Methods:This case control study, conducted from March 2017 to November 2018 included 295 breast cancer patients, 295 controls of thr...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.6.1322

    authors: Rahim A,Afzal M,Naveed AK

    更新日期:2019-11-01 00:00:00