Abstract:
:Advances in genomics and neuroscience have ushered in unprecedented opportunities to increase our understanding of the biological underpinnings of mental disorders, yet there has been limited progress in translating knowledge on genetic risk factors to reduce the burden of these conditions in the population. We describe the challenges and opportunities afforded by the growth of large-scale population health databases, progress in genomics, and collaborative efforts in epidemiology and neuroscience to develop informed population-wide interventions for mental disorders. Future progress is likely to benefit from the following efforts: expansion of large collaborative studies of mental disorders to include more systematically ascertained multiethnic samples from biobanks and registries, harmonization of phenotypic characterization in registry and population samples to extend clinical diagnosis to transdiagnostic concepts, systematic investigation of the influences of both specific and nonspecific environmental factors that may combine with genetic susceptibility to confer increased risk of specific mental disorders, and implementation of study designs that can inform gene-environment interactions. Such data can ultimately be combined to develop comprehensive models of risks of, interventions for, and outcomes of mental disorders. With its focus on phenotypic characterization, sampling, study designs, and analytic methods, epidemiology will be central to progress in translating genomics to public health.
journal_name
Am J Public Healthjournal_title
American journal of public healthauthors
Merikangas KR,Merikangas AKdoi
10.2105/AJPH.2019.304948subject
Has Abstractpub_date
2019-06-01 00:00:00pages
S171-S175issue
S3eissn
0090-0036issn
1541-0048journal_volume
109pub_type
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journal_title:American journal of public health
pub_type: 历史文章,杂志文章
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journal_title:American journal of public health
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更新日期:2009-01-01 00:00:00
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更新日期:1984-12-01 00:00:00
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journal_title:American journal of public health
pub_type: 杂志文章,随机对照试验
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更新日期:2016-01-01 00:00:00
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pub_type: 历史文章,杂志文章
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