Abstract:
:Childhood immunization constitutes one of the great success stories of American public health in the 20th century. This essay provides a historical examination of this topic through 4 particularly important examples: diphtheria, pertussis, polio, and measles. Each case study illustrates how new vaccines have posed unique challenges related to basic science, clinical trial methodology, medical ethics, and public acceptance. A brief comparison of each story to the experience of Great Britain, however, suggests an underlying unity connecting all 4 examples. Whereas the British led the way in introducing formal clinical trial methodology in the field of immunization development, the Americans excelled in the rapid translation of laboratory knowledge into strategies suitable for mass application. Although this distinction appears to have diminished in recent years, it offers insight into the sources of creativity underlying American vaccine development and the corresponding difficulties sometimes created for utilizing vaccines fruits rationally.
journal_name
Am J Public Healthjournal_title
American journal of public healthauthors
Baker JPdoi
10.2105/ajph.90.2.199subject
Has Abstractpub_date
2000-02-01 00:00:00pages
199-207issue
2eissn
0090-0036issn
1541-0048journal_volume
90pub_type
历史文章,杂志文章abstract::Estimates from the National Study of the Incidence and Severity of Child Abuse and Neglect suggest that hospitals recognized over 77,000 cases of child abuse between May 3, 1979, and April 30, 1980. Compared to other agencies in the sample, hospitals identified children who were younger, Black, lived in urban areas, a...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.75.1.56
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVES:This study examined absence rates among US Department of Energy workers who had beryllium sensitization (BeS) or were diagnosed with chronic beryllium disease (CBD) compared with those of other workers. METHODS:We used the lymphocyte proliferation test to determine beryllium sensitivity. In addition, we app...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2014.302132
更新日期:2014-11-01 00:00:00
abstract::National rates of unintended births are a major public health concern. The availability of highly effective long-acting contraceptives has prompted some public officials to promote the coercive use of these methods to reduce such problems as intergenerational poverty and child abuse. Broad-brush public policies that r...
journal_title:American journal of public health
pub_type: 杂志文章,评审
doi:10.2105/ajph.86.6.787
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVES:To review the contribution of the Nurses' Health Studies (NHS and NHS II) in addressing hypotheses regarding risk factors for and consequences of obesity. METHODS:Narrative review of the publications of the NHS and NHS II between 1976 and 2016. RESULTS:Long-term NHS research has shown that weight gain and ...
journal_title:American journal of public health
pub_type: 杂志文章,评审
doi:10.2105/AJPH.2016.303326
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:This study investigated the efficacy of a social-influences tobacco prevention program conducted with adolescents living in a high tobacco production area. METHODS:Students in 10 experimental schools completed the tobacco prevention program and a booster intervention. Control students received health educat...
journal_title:American journal of public health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2105/ajph.88.12.1862
更新日期:1998-12-01 00:00:00
abstract::We use systems thinking to develop a strategic framework for analyzing the tobacco problem and we suggest solutions. Humans are vulnerable to nicotine addiction, and the most marketable form of nicotine delivery is the most harmful. A tobacco use management system has evolved out of governments' attempts to regulate t...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2009.165910
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:We examined correlates of condomless anal intercourse with nonmain sexual partners among African American men who have sex with men (MSM). METHODS:We recruited social networks composed of 445 Black MSM from 2012 to 2014 in Milwaukee, Wisconsin; Cleveland, Ohio; and Miami Beach, Florida. Participants reporte...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2015.302945
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To describe salient epidemiological characteristics of Zika virus outbreaks across the world and to examine the clinical presentations, complications, and atypical manifestations related to their occurrence in recent history. METHODS:We conducted a systematic review of the literature by searching through ME...
journal_title:American journal of public health
pub_type: 历史文章,杂志文章,评审
doi:10.2105/AJPH.2016.303112
更新日期:2016-04-01 00:00:00
abstract::The World Health Organization's determination of the Ebola virus disease outbreak as a public health event of international concern prompted nonaffected countries to implement measures to prevent, detect, and manage the introduction of the virus in their territories. The outbreak provided an opportunity to assess the ...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2015.302969
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:This study evaluated the long-term effectiveness of Draw the Line/Respect the Line, a theoretically based curriculum designed to reduce sexual risk behaviors among middle school adolescents. METHODS:The randomized controlled trial involved 19 schools in northern California. A cohort of 2829 sixth graders wa...
journal_title:American journal of public health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2105/ajph.94.5.843
更新日期:2004-05-01 00:00:00
abstract::In 1985, a measles outbreak involved 14 students and non-student contacts in Michigan. Eight transmissions occurred at university medical facilities; five of these were likely airborne transmissions. Medical students and a medical resident were involved in the outbreak's propagation. Health care providers need to be i...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.77.9.1222
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVES:The effect of a community-based physical activity program in Pawtucket, RI, was evaluated relative to one in a comparison community. METHODS:Cross-sectional surveys of 7529 residents of Pawtucket, RI, and 7732 residents of the comparison city were conducted at 2-year intervals during 7 years of intervention...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.89.11.1741
更新日期:1999-11-01 00:00:00
abstract::Eighteen children, ages 4 to 6 years, with known exposure to polybrominated biphenyls (PBB) in utero and/or through breast milk were administered developmental tests. These same children had exhibited low scores on a partial developmental assessment two years earlier. Current results were compared to normative test da...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.73.3.277
更新日期:1983-03-01 00:00:00
abstract:OBJECTIVES:This analysis was conducted to determine whether atopic disorders were related to social class in a pediatric population of a former socialist country. METHODS:A cross-sectional study of 2471 schoolchildren was carried out in 1992 and 1993 in 3 towns in the former East Germany. Parents completed a standardi...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.88.9.1319
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:In a large heterogeneous sample of adults with mental illnesses, we examined the 6-month prevalence and nature of community violence perpetration and victimization, as well as associations between these outcomes. METHODS:Baseline data were pooled from 5 studies of adults with mental illnesses from across th...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2013.301680
更新日期:2014-12-01 00:00:00
abstract::This study provides the first estimated prevalence of implanted orthopedic fixation devices (e.g., pins or wires) among children in the United States, based on the Medical Device Implant Supplement to the 1988 National Health Interview Survey. The overall prevalence was 27 per 10,000 children younger than 18 years; pr...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.83.7.1028
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:We describe common surgical and medical hospital admission rates for Maryland residents, exploring systematic effects of race and income. METHODS:The data comprise Maryland hospital discharges and population estimates for 1985 to 1987. Patient income is the race-specific median family income of residence zi...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.81.11.1435
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVES:To investigate the effects of precursor chemical regulation aimed at reducing cocaine production on cocaine-related maternal and newborn hospital stays in the United States. METHODS:We analyzed monthly counts of maternal and neonatal stays from January 2002 through December 2013 by using a quasi-experimenta...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2017.303708
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Data from the Western Collaborative Group Study were used to determine the extent to which the inverse association between socioeconomic status (SES) and mortality can be explained by risk factors for major causes of mortality. METHODS:The relation of education and income to subsequent mortality was studied...
journal_title:American journal of public health
pub_type: 杂志文章,多中心研究
doi:10.2105/ajph.85.9.1231
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVES:This study sought to estimate the impact on birthweight of maternal participation in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). METHODS:WIC estimates were based on sibling models incorporating data on children born between 1990 and 1996 to women taking part in the Nat...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.92.5.799
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:We determined factors associated with hearing aid acquisition in older adults. METHODS:We conducted a population-based, prospective study that used information from 3 examinations performed on study participants as part of the Epidemiology of Hearing Loss Study (1993-2005). We included participants (n = 718...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2010.300078
更新日期:2011-08-01 00:00:00
abstract::Objectives. To investigate differences in funding and service delivery between rural and urban local health departments (LHDs) in the United States.Methods. In this repeated cross-sectional study, we examined rural-urban differences in funding and service provision among LHDs over time using 2010 and 2016 National Ass...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2020.305757
更新日期:2020-09-01 00:00:00
abstract::Objectives. To comprehensively assess asthma disparities and identify correlates in youths at the intersections of sex, sexual identity, and race/ethnicity in the United States.Methods. We obtained a diverse sample of youths (n = 307 073) from the Centers for Disease Control and Prevention's Youth Risk Behavior Survey...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2020.305664
更新日期:2020-05-21 00:00:00
abstract:OBJECTIVES:Suffering from waning demand, poor quality, and reform efforts enabling veterans to "vote with their feet" and leave, the Veterans Health Administration (VA) health care system transformed itself through a series of substantive changes. We examined the evolution of primary care changes underlying VA's transf...
journal_title:American journal of public health
pub_type: 杂志文章,多中心研究
doi:10.2105/AJPH.2007.115709
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:We sought to examine trends in hepatitis B virus (HBV) vaccination among high-risk adults and assess the potential effect vaccinated adolescents have on these trends as they age. METHODS:We used data from the National Health Interview Survey 2000, 2002, and 2004 to examine trends in HBV vaccination among hi...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2007.116046
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:We assessed whether living in counties with Title X clinics and increased use of long-acting reversible contraception (LARC) in Colorado are associated with decreased risk of adverse birth outcomes. METHODS:We linked Title X clinic counties to the Colorado birth data set by using the mother's county of resi...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2015.302711
更新日期:2015-09-01 00:00:00
abstract::Mammograms from a statewide screening program were subjected to a blind review by a panel of expert mammographers. Ninety-five percent (173/182) of original normal mammograms and 53% (164/311) of original abnormal mammograms were reread as normal. In comparison with the expert panel community radiologists were more li...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.85.6.837
更新日期:1995-06-01 00:00:00
abstract::Nauru is a small phosphate-rich independent island country situated in the Central Pacific. The population is Micronesian and was estimated to be 4,680 in mid-1981. An analysis of mortality data for the years 1976-81 indicates a high adult male mortality due to accidents, injuries, cardiovascular disease, and diabetes...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.75.2.149
更新日期:1985-02-01 00:00:00
abstract:OBJECTIVES:This study sought to estimate rates of cervical cancer and Papanicolaou testing among Aboriginal and non-Aboriginal women in Manitoba, Canada. METHODS:Data were derived through linking of administrative databases. RESULTS:In comparison with non-Aboriginal women, Aboriginal women had 1.8 and 3.6 times the a...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.90.9.1466
更新日期:2000-09-01 00:00:00
abstract::Decentralized health service delivery responsive to the needs of local populations implies allocating program funds to regions on the basis of predetermined criteria that can facilitate effective planning and budgeting. In 1974, the Manitoba Continuing Care Program attempted to develop a formula for regional allocatio...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.70.1.77
更新日期:1980-01-01 00:00:00