Incidence of dual antiplatelet therapy interruption within 1 year after primary percutaneous coronary intervention in patients with acute ST elevation myocardial infarction.


BACKGROUND:After primary percutaneous coronary intervention (PPCI) in patients with acute ST elevation myocardial infarction (STEMI), dual antiplatelet therapy (DAPT) is recommended to continue for 1 year. Occasionally, DAPT interruption may be required due to bleeding issues or unplanned surgical procedures. OBJECTIVE:To systematically evaluate the incidence of DAPT interruption within 1 year after PPCI. METHODS AND RESULTS:This was a single-centre, retrospective registry study. Consecutive patients with STEMI who underwent PPCI from 2013 to 2017 (N=538) were recruited into the analysis. The primary outcome was the incidence of interruption of DAPT within 1 year from the index PPCI. Secondary outcomes included incidence of bleeding in 1 year and prevalence of high bleeding risk (HBR) criteria at index presentation. Within 1 year, 17.1% (84/490) of post-PPCI survivors needed DAPT interruption and 7.1% (35/490) had major bleeding (Bleeding Academic Research Consortium type 3 or 5). At index presentation, HBR criteria were present in 36.1% (194/538) of patients. On univariate analysis, age, female gender, anaemia, anticoagulation, diabetes, hypertension and being a non-smoker were associated with DAPT interruption. On multivariate analysis, age was the only independent factor to predict DAPT interruption. CONCLUSION:DAPT interruption was not uncommon after PPCI in patients with STEMI particularly in the elderly. This has implication on stent selection during PPCI, and further studies are required to investigate which type of stent may best suit our real-life patients with STEMI.


Postgrad Med J


Tam CC,Lee J,Chan KW,Lam CC,Wong YT,Chan E,Sze M,Lam YM,Chan C,Tse HF,Siu CW




Has Abstract


2020-01-01 00:00:00














  • Myocardial abscess and sternal osteomyelitis following myocardial infarction and resuscitation.

    abstract::A 58 year old man presented with an anterior myocardial infarction requiring repeated resuscitation. He had impaired glucose tolerance. He died five weeks later and post-mortem examination revealed a myocardial abscess and sternal osteomyelitis due to Staphylococcus aureus. These had not been apparent clinically. The ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Smith RE,Martin JE,Mills PG

    更新日期:1989-08-01 00:00:00

  • Biliary peritonitis secondary to perforation of common bile duct: an unusual presentation of chronic calcific pancreatitis.

    abstract::Common bile duct perforation causing biliary peritonitis is an unusual entity and a pancreatic calculus causing this perforation is all the more rare, and to our knowledge has not been reported previously. Such an unusual presentation of chronic calcific pancreatitis is herein reported. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Kumar A,Kataria R,Chattopadhyay TK,Karak PK,Tandon RK

    更新日期:1992-10-01 00:00:00

  • Improving residents' clinical approach to obesity: impact of a multidisciplinary didactic curriculum.

    abstract:BACKGROUND/OBJECTIVES:Obesity has been declared a 21st century pandemic by WHO. Yet surveys reveal physicians-in-training are uncomfortable managing obesity. One major barrier is the lack of residency education on obesity management. This study incorporates an obesity-specific didactic curriculum into an internal medic...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Acosta A,Azzalin A,Emmons CJ,Shuster JJ,Jay M,Lo MC

    更新日期:2014-11-01 00:00:00

  • Communication skills training in postgraduate medicine: the development of a new course.

    abstract::It has long been accepted that communication is of central importance in healthcare, and a core aspect of clinical competence. Many educational institutions and Royal Colleges now reflect this and consider communication skills a priority in postgraduate examination. The new examination "Practical Assessment of Clinica...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Dacre J,Richardson J,Noble L,Stephens K,Parker N

    更新日期:2004-12-01 00:00:00

  • Tuberculous meningitis in the elderly.

    abstract::Six cases of tuberculous meningitis, all occurring in patients over the age of 65, are described. All patients presented with an acute illness, primarily with a confusional state. Headache was a symptom in only two patients and the cases were not confined to ethnic minority groups. The mortality was 50%. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Dixon PE,Hoey C,Cayley AC

    更新日期:1984-09-01 00:00:00

  • Multiple strokes after initiation of steroid therapy in giant cell arteritis.

    abstract::We report the case of a 66 year old woman with clinical manifestations of giant-cell arteritis, positive temporal artery biopsy and excellent response to prednisone, who developed massive cerebral infarcts after 5 days of treatment. Computed tomographic and magnetic resonance imaging scans revealed multiple infarcts i...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Collazos J,García-Moncó C,Martín A,Rodriguez J,Gómez MA

    更新日期:1994-03-01 00:00:00

  • Treatment of non-alcoholic fatty liver disease.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is common and may progress to cirrhosis and its complications. The pathogenesis of steatosis and cellular injury is thought to be related mostly to insulin resistance and oxidative stress. Therefore, management entails identification and treatment of metabolic risk factors, im...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Adams LA,Angulo P

    更新日期:2006-05-01 00:00:00

  • The CREST syndrome--successful reduction of pulmonary hypertension by captopril.

    abstract::A patient with severe pulmonary hypertension due to pulmonary arteriolar obliteration complicating a long standing CREST variant of systemic sclerosis showed improvement in cardiac output and exercise tolerance during treatment with captopril, which was discontinued because of persistent systemic hypotension. It is su...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Prouse PJ,Lahiri A,Gumpel JM

    更新日期:1984-10-01 00:00:00

  • Association between ADAMTS7 TagSNPs and the risk of myocardialinfarction.

    abstract:PURPOSE OF THE STUDY:Genome-wide association studies have revealed an association of ADAMTS7 polymorphisms with the risk of cardiovascular diseases. Nonetheless, the role of ADAMTS7 polymorphisms on myocardial infarction (MI) risk remains poorly understood. Here, we aim to evaluate the effect of ADAMTS7 tag single nucl...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Liang LL,Zhou YL,Cheng J,Xiao YT,Tang ZB,Liu SM,Lian JC,Wang XX,Liu X,Xiong XD

    更新日期:2019-09-01 00:00:00

  • Cryoglobulinaemic vasculitis: classification and clinical and therapeutic aspects.

    abstract::Cryoglobulinaemia may cause cutaneous vasculitis and glomerulonephritis, potentially leading to end stage renal failure. An important proportion of cryoglobulinaemias are secondary to hepatitis C virus infection. Emerging antiviral treatment options offer a chance for causal therapy of these cases of cryoglobulinaemia...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Braun GS,Horster S,Wagner KS,Ihrler S,Schmid H

    更新日期:2007-02-01 00:00:00

  • Digoxin toxicity presenting as encephalopathy.

    abstract::We describe two cases of digoxin toxicity presenting with clinical and electroencephalographic evidence of encephalopathy without other features of digoxin toxicity. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Greenaway JR,Abuaisha B,Bramble MG

    更新日期:1996-06-01 00:00:00

  • Associations of the NOS3 rs1799983 polymorphism with circulating nitric oxide and lipid levels: a systematic review and meta-analysis.

    abstract:BACKGROUND:Circulating nitric oxide (NO) and lipid levels are closely associated with coronary artery disease (CAD). It is unclear whether the rs1799983 polymorphism in endothelial nitric oxide synthase (NOS3) gene is associated with plasma levels of NO and lipids. This systematic review and meta-analysis (Preferred Re...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,meta分析


    authors: Luo Z,Jia A,Lu Z,Muhammad I,Adenrele A,Song Y

    更新日期:2019-07-01 00:00:00

  • Health benefits from devolution in England: international lessons.

    abstract::The Chancellor of the Exchequer's recent announcements to devolve decision making power from Whitehall to 30 English regions provide a challenge to use devolution to deliver more favourable health outcomes. However evaluation of devolved health models internationally is scarce, because it is rarely considered. Evidenc...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Doyle Y,Johnstone P

    更新日期:2016-05-01 00:00:00

  • Bilateral foot drop, weight loss and rectal bleeding as an acute presentation of Crohn's disease.

    abstract::We report a 71 year old lady who presented with weight loss, rectal bleeding and bilateral foot drop having been previously fit and well. Clinical examination, laboratory investigation and postmortem examination confirmed the diagnosis of active Crohn's disease and acute peripheral neuropathy. The clinical course of t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Gariballa SE,Gunasekera NP

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  • Association of adiposity, measured by skinfold thickness, with parental history of diabetes in a South Indian population: data from CURES-114.

    abstract:PURPOSE OF THE STUDY:To look at the association of central and peripheral skinfold thickness with parental history of diabetes in subjects without diabetes. METHODS:Subjects with no parental history of diabetes (n=1132), subjects with one parent with diabetes (n=271) and subjects with both parents with diabetes (n=51)...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Surendar J,Indulekha K,Deepa M,Mohan V,Pradeepa R

    更新日期:2016-07-01 00:00:00

  • Postgraduate medical education quality metrics panels can be enhanced by including learner outcomes.

    abstract::Postgraduate medical education (PME) quality assurance at Health Education England (HEE) currently relies upon survey data. As no one metric can reflect all aspects of training, and each has its limitations, additional metrics should be explored. At HEE (West Midlands), we explored the use of learner outcomes, special...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Pinnell J,Tranter A,Cooper S,Whallett A

    更新日期:2020-11-12 00:00:00

  • Roth's spots: an unusual presentation of HIV.

    abstract::A 46 year old Nigerian man presented with a four week history of progressive bilateral visual loss. He had been unwell, with weight loss, fever, and night sweats for six months. Dilated fundoscopy revealed macular haemorrhages and diffuse Roth's spots. The patient was found to be severely anaemic and a bone marrow asp...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Vose MJ,Charles SJ

    更新日期:2003-02-01 00:00:00

  • A case of myasthenia gravis treated with steroids: some suggestions for the mechanisms underlying their effect.

    abstract::This report deals with a patient with long standing myasthenia gravis treated with a small dose of corticosteroids. The response to treatment was prompt and the post-therapeutic deterioration in function was minimal and cholinergic in nature. It is suggested that the dose of anticholinesterases be reduced concomitantl...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Dandona P,Corkan EJ,Sladen GE

    更新日期:1977-06-01 00:00:00

  • Spinal ganglioneuroblastoma--complete response to chemotherapy alone.

    abstract::Ganglioneuroblastoma in the spinal region is rare, the treatment of choice being surgical excision. We present a 21 year old male who was diagnosed to have this condition in the dorsolumbar spinal region. The tumour was extending intraspinally and was unresectable. Combination chemotherapy with Adriamycin (doxorubicin...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Raina V,Kamble R,Tanwar R,Singh SP,Sharma S

    更新日期:1993-09-01 00:00:00

  • Post-exposure prophylaxis for blood borne viral infections in healthcare workers.

    abstract::Healthcare workers have a high risk of occupational exposure, more so in developing countries, with high incidence of blood borne diseases and prevalence of unsafe practices. Among the various blood borne diseases, the most common and important ones are HIV infection, hepatitis B, and hepatitis C. Most of the occupati...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Varghese GM,Abraham OC,Mathai D

    更新日期:2003-06-01 00:00:00

  • Anabolic steroid induced hypogonadism treated with human chorionic gonadotropin.

    abstract::A case is presented of a young competitive body-builder who abused anabolic steroid drugs and developed profound symptomatic hypogonadotrophic hypogonadism. With the help of prescribed testosterone (Sustanon) he stopped taking anabolic drugs, and later stopped Sustanon also. Hypogonadism returned, but was successfully...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Gill GV

    更新日期:1998-01-01 00:00:00

  • Staphylococcus aureus endocarditis presenting as acute scrotal pain.

    abstract::A previously healthy 17 year old boy had Staphylococcus aureus endocarditis presenting as acute scrotal pain. There was no trauma or evidence of scrotal or epididymal infection. The pain subsided after therapy for endocarditis was started. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Watanakunakorn C

    更新日期:1987-07-01 00:00:00

  • Recurrent glomerulonephritis.

    abstract::A patient with seven attacks of acute glomerulonephritis is described. Following each attack renal function returned to normal. Investigations strongly suggested immune complex disease as the cause of the nephritis but extensive tests failed to define the antigen. The possibility of an exogenous self-administered anti...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Coles GA

    更新日期:1983-01-01 00:00:00

  • A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis.

    abstract::Conventional diagnostic tests for tuberculosis have several limitations and are often unhelpful in establishing the diagnosis of extrapulmonary tuberculosis. Although commercial serological antibody based tests are available, their usefulness in the diagnosis of extrapulmonary tuberculosis is unknown. A systematic rev...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Steingart KR,Henry M,Laal S,Hopewell PC,Ramsay A,Menzies D,Cunningham J,Weldingh K,Pai M

    更新日期:2007-11-01 00:00:00

  • A model for rational introduction of new and expensive medicines.

    abstract::The reported impact of human monoclonal IgM antibody (HA1A) on the mortality rate from Gram-negative bacteraemia aroused considerable interest in its use in Glasgow Royal Infirmary. However, the commercial preparation of HA1A was extremely expensive. With this in mind, the Infirmary's Drugs and Therapeutics Committee ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Bell E,McCartney C

    更新日期:1995-02-01 00:00:00

  • Diurnal rhythms and clinical events in coronary artery disease.

    abstract::Patients with coronary atherosclerosis present with angina, myocardial infarction and sudden death, most often caused by atherosclerotic stenosis complicated by spasm and/or occlusive thrombosis. All of these events have been shown to exhibit similar diurnal rhythms, with a peak incidence in the morning after waking a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Selwyn AP,Raby K,Vita JA,Ganz P,Yeung A

    更新日期:1991-01-01 00:00:00

  • Evaluation of renal function in elderly heart failure patients on ACE inhibitors.

    abstract::A total of 187 heart failure patients aged 65-92 years, with pretreatment serum creatinine levels below 200 mumol/l, were monitored for more than 12 months on angiotensin-converting enzyme (ACE) inhibitor therapy. Optimal ACE inhibitor dosage was found in 27% of patients, while a significant deterioration in renal fun...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Jolobe OM

    更新日期:1999-05-01 00:00:00

  • Coeliac disease and goitre.

    abstract::Two cases of coeliac disease associated with thyroid enlargement are presented. One had a large simple adenomatous goitre which was removed surgically and the other had histological confirmation of lymphadenoma (Hashimoto's disease). ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Robinson TJ

    更新日期:1977-02-01 00:00:00

  • Republished paper: Meta-analysis of the effect of comprehensive smoke-free legislation on acute coronary events.

    abstract:OBJECTIVE:To assess the evidence for a reduced risk of acute coronary events following comprehensive smoke-free legislation. METHODS:Two independent systematic reviews were undertaken using PubMed, Embase and Science Direct with no date restrictions imposed. Meta-analysis was undertaken using a random effects model to...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Mackay DF,Irfan MO,Haw S,Pell JP

    更新日期:2011-04-01 00:00:00

  • Prospective study of acute gastrointestinal bleeding attributable to anti-inflammatory drug ingestion in the Yorkshire region of the United Kingdom.

    abstract:OBJECTIVE:To assess the general use of all non-steroidal anti-inflammatory drugs (NSAID) and their relation to upper gastrointestinal bleeding in view of National Institute for Clinical Excellence guidelines published in July 2001 in the UK. METHODS:Cross sectional study on all patients who were referred for endoscopy...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,多中心研究


    authors: Lim CH,Heatley RV

    更新日期:2005-04-01 00:00:00