Simvastatin Alleviates Intestinal Ischemia/Reperfusion Injury by Modulating Omi/HtrA2 Signaling Pathways.

Abstract:

PURPOSE:The objective of this research was to survey the therapeutic action of simvastatin (Sim) on intestinal ischemia/reperfusion injury (II/RI) by modulating Omi/HtrA2 signaling pathways. METHODS:Sprague Dawley rats were pretreated with 40 mg/kg Sim and then subjected to 1 hour of ischemia and 3 hours of reperfusion. The blood and intestinal tissues were collected, pathologic injury was observed, the contents of serum tumor necrosis factor-α and interleukin-6 (IL-6) were estimated, and superoxide dismutase, methane dicarboxylic aldehyde, and cysteinyl aspartate specific proteinase-3 (caspase-3) levels, as well as the expressions of Omi/HtrA2 and caspase-3, were measured in the intestinal tissues. RESULTS:Sim preconditioning mitigated the damnification of intestinal tissues by decreasing oxidative stress, inflammatory damage, and apoptosis and downregulating the expression of Omi/HtrA2 compared to the ischemia/reperfusion group, while Sim+Ucf-101 significantly augmented this effect. CONCLUSION:These results suggest that Sim may alleviate intestinal ischemia/reperfusion injury by modulating Omi/HtrA2 signaling pathways.

journal_name

Transplant Proc

authors

Yan Y,Lv X,Ma J,Hong G,Li S,Shen J,Chen H,Cao K,Chen S,Cheng T,Dong C,Han J,Ma H,Wu M,Wang X,Xing C,Zhu Y,Shen L,Wang Y,Tong F,Wang Z

doi

10.1016/j.transproceed.2019.04.076

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

2798-2807

issue

8

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(19)30274-X

journal_volume

51

pub_type

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