Impact of mutations in hVISA isolates on decreased susceptibility to vancomycin, through population analyses profile - area under curve (PAP-AUC).

Abstract:

:We analyzed sequences of graSR, vraSR, walKR and rpoB genes in hVISA from Brazil. Five isolates showed mutations in at least one gene. rpoB H481N and graS T224I were the most frequent mutations, followed by graR D148Q and walK A468T. Our study reinforces the heterogeneity of genetic patterns among hVISA.

authors

Silveira ACO,Caierão J,Silva CI,Anzai EK,McCulloch JA,d'Azevedo PA,Sincero TCM

doi

10.1016/j.diagmicrobio.2019.06.006

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

114854

issue

3

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(18)30594-7

journal_volume

95

pub_type

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