Abstract：
OBJECTIVE:We aimed to evaluate the combined effect of ellagic acid (EA) and temozolomide (TEM) on the cadherin switch and angiogenesis in the C6 glioma cell line. METHODS:A total of 100 μM EA and 100 μM TEM were applied to rat C6 glioma cells for 24, 48, and 72 hours. Cell proliferation was detected by 5-bromo-2'-deoxyuridine immunohistochemistry. The messenger RNA and protein levels of E-cadherin, N-cadherin, and vascular endothelial growth factor (VEGF) were determined by real-time polymerase chain reaction and their immunohistochemistry, respectively, subsequent to EA treatment combined with TEM. RESULTS:EA in combination with TEM conspicuously reduced the viability of C6 glioma cells at all incubation times (P < 0.001). EA upregulated the expression of E-cadherin at the gene and protein levels in a time-independent manner (P < 0.05 and P < 0.001, respectively). By the presence of TEM, the increase was exaggerated at 24-hour incubation (P < 0.01). Conversely, EA reduced N-cadherin expression and immunoreactivity in a time-independent manner (P < 0.05 and P < 0.001, respectively), and combination with TEM enhanced this effect at the 24th hour (P < 0.001). Combination also downregulated the gene expression (P < 0.001) and immunoreactivity of VEGF only at 72 hours (P < 0.001). CONCLUSIONS:A successful therapeutic efficacy of EA combined with TEM is suggested probably by inhibiting the cadherin switch and angiogenesis.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Çetin A,Biltekin Bdoi
10.1016/j.wneu.2019.08.228subject
Has Abstractpub_date
2019-12-01 00:00:00pages
e178-e184eissn
1878-8750issn
1878-8769pii
S1878-8750(19)32395-2journal_volume
132pub_type
杂志文章abstract：BACKGROUND:Determining the risks of treatment of unruptured intracranial aneurysms is critical in the decision-making process of management. Most studies have reported the results for endovascular or surgical management. Our objective was to better delineate the risk estimates for unruptured intracranial aneurysms trea...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.005
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Preoperative embolization is established as an advantageous adjunct in multimodality treatment of cerebral arteriovenous malformations (AVMs). However, the benefit of preoperative embolization in AVMs with favorable surgical risk profile is debatable, because it has yet to be supported by evidence in compara...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.05.026
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Oblique lateral interbody fusion (OLIF) surgery provides a convenient and minimal access to the lesion disc with few complications; however, the left lumbar sympathetic trunk (LST) lies in the surgical field with a certain incidence of injury. The aim of this study was to describe the anatomic structures of ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.212
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:To examine the occurrence of traumatic intracranial hemorrhage (tICH) and outcome in patients with minor head injury and assess the probable risk factors. METHODS:Patients with minor head injury who visited our hospital from January 2015 to July 2017 were registered consecutively, and enrolled patients were ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.06.044
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:The angioarchitecture and presentation of arteriovenous malformations (AVMs) associated with AVM hemorrhage may vary with patient age. Our aim was to determine the influence of patient age at diagnosis on hemorrhage patterns and outcomes. METHODS:A consecutive case series of 267 cases of ruptured AVMs was r...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.05.020
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:Diffusion tensor imaging (DTI) tractography provides useful information that can be used to optimize surgical planning and help avoid injury during subcortical dissection of eloquent tracts. The objective is to provide a safe, timely, and affordable algorithm for preoperative DTI language reconstruction for i...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.01.163
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:It is well established that inflammation plays a critical role in the progression of intracerebral hemorrhage (ICH). Recently the neutrophil-to-lymphocyte ratio (NLR) was identified as a predictor for the short-term outcome in ICH patients. However, the association of NLR with the long-term outcome in patien...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.01.143
更新日期：2019-05-01 00:00:00
abstract：:Hydatid cyst is an infectious disease caused by Echinococcus granulosus, primarily involving the liver and lungs. The orbit is an extremely rare site for involvement with hydatid cyst. We present a 36-year-old man with unilateral visual loss, proptosis, and papilledema caused by an orbital hydatid cyst. ...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.03.030
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Posterior fossa arachnoid cysts are often asymptomatic, but can rarely cause postural headache, the mechanism of which remains unknown. CASE DESCRIPTION:We present a 40-year-old woman with an asymptomatic supracerebellar arachnoid cyst. Upright computed tomography (CT) showed enlargement of the arachnoid cy...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.09.132
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:The mortality index, or the ratio of observed to expected mortality, is a reported quality metric that has been assumed to directly reflect patient care. However, documentation and coding that does not use knowledge of how a reported mortality index is derived could reflect poorly on a hospital or service li...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.10.022
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:To investigate the changes in the sagittal parameters of the cervical spine and the clinical efficacy of C2∼3 anterior cervical discectomy and fusion (ACDF) combined with internal fixation for unstable hangman's fractures. METHOD:The clinical data of 46 patients with unstable hangman's fractures treated with...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.08.147
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:To explore the feasibility and effectiveness of C1 lateral mass fixation via the posterior arch using pedicle screws of 3.5-mm diameter in patients whose atlas in the vertebral artery groove (C1 pedicle) was ≤3.5 mm in height. METHODS:A total of 14 patients who underwent transposterior arch lateral mass scre...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.175
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:Vasospasm developing after subarachnoid hemorrhage (SAH) is an important cause of mortality and morbidity. Lutein is a carotenoid with antioxidant and anti-inflammatory properties. The aim of present study was to investigate effects of lutein on the basilar artery and nerve tissues. METHODS:Wistar rats were ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.07.186
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Lumbar arthrodesis is a surgical option for treatment of lumbar pathologies. Stability of the spinal construct partly depends on load-bearing support from back muscles. Despite the role of the psoas muscle in upright spinal stabilization, data describing its clinical significance are scarce. We evaluated the...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.11.022
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Surgical treatment of patients with atlantoaxial instability caused by pathologic changes of the skull base and craniovertebral junction combined with anterior compression of the brain stem is still associated with substantial technical difficulties and remains a matter of debate. Currently, anterior stabili...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.09.124
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Although reoperation likely confers survival benefit for glioblastoma, whether the extent of resection (EOR) of the reoperation affects survival outcome has yet to be thoroughly evaluated in the current temozolomide (TMZ) era. The aim of this meta-analysis was to pool the current literature and evaluate the ...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2019.03.250
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Intracranial extraskeletal mesenchymal chondrosarcomas (MCSs) are rare tumors accounting for <0.16% of intracranial tumors. They are usually described as occurring in the age group of 20-30 years and are commonly found in the frontoparietal region arising from the falx and surrounding dura. We describe 3 cas...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.08.049
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:The minimized approach for superficial temporal to middle cerebral artery (STA-MCA) bypass surgery is frequently associated with unfamiliar situations and technical problems. OBJECTIVE:Description of operative nuances and evaluation of problem-solving aspects to facilitate potential limitations related with...
journal_title：World neurosurgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.wneu.2015.12.029
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:This study aims to assess whether the A1 segment hypoplasia is a risk factor for unfavorable radiologic and clinical outcomes of surgical clipping anterior communicating artery (ACoA) aneurysm. METHODS:We retrospectively reviewed 251 patients with ACoA aneurysm who underwent surgical clipping in Beijing Tian...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.07.122
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Cases of nail gun injuries to the head and neck are rare, and treatment approach varies with each case based on location and extent of injury. CASE DESCRIPTION:We present a case of a 52-year-old male who fell off a roof holding a pneumatic nail gun and accidentally shot himself with a nail through the right...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.083
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Spine surgery relies heavily on imaging, with radiography-based devices being the major operating room imaging modality. Radiation exposure is an occupational risk historically recognized shortly after the discovery of radiation itself. Exposure of both patients and operating room staff is of increasing conc...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2016.05.025
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:Spinal metastases represent the most common site of bony metastases and frequently reduce quality of life. A beneficial effect of surgery and radiotherapy versus radiotherapy alone has been demonstrated in symptomatic patients. The goal of our study was to perform a cost-utility analysis of surgery for spinal...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.01.130
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Multiple biopsy samples are warranted for the histomolecular diagnosis of diffuse gliomas in the current molecular era, which possibly increases morbidity. OBJECTIVE:We assessed diagnostic yield, safety, and risk factors of postoperative morbidity after robot-assisted serial stereotactic biopsy sampling alo...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.12.127
更新日期：2021-01-04 00:00:00
abstract：OBJECTIVE:The purpose of this study is to analyze symptomatic middle fossa arachnoid cysts and describe the advantages of the endoscopic technique to manage those cases that should be resolved surgically. METHODS:The physiopathology is described, and the clinical manifestations are analyzed. The diagnostic methodology...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2012.02.012
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Alveolar soft part sarcoma (ASPS) is a rare, malignant soft-tissue neoplasm typically seen in young adults that possesses an unusual tendency to metastasize. Metastases to the intramedullary compartment of the spinal cord, however, are exceptionally rare and have not been described in the literature. CASE D...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.04.100
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Therapeutic hypothermia (TH) offers cerebral protection following ischemic stroke and may improve outcomes in conjunction with decompressive hemicraniectomy (DHC). We aimed to assess the effectiveness of TH in patients with malignant ischemic stroke and DHC. METHODS:We performed a meta-analysis in patients ...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析
doi：10.1016/j.wneu.2020.05.277
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Bipolar coagulation has enhanced the capabilities and safety profile of contemporary neurosurgery and has become indispensable in the neurosurgical armamentarium. Nevertheless, significant heat transfer issues remain to be resolved before it can achieve the status of minimal risk. METHODS:The Codman irrigat...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2014.10.007
更新日期：2015-03-01 00:00:00
abstract：:Meningiomas are mostly benign intradural tumors. Concerning the spine, some of them can extend outside the canal or even develop extradurally but their primary attach is often located in the vertebral canal. Here we present the case of an exceptional purely intraforaminal meningioma mimicking a neurogenic tumor, invol...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.10.006
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Treatment-related chronic neuropathic pain represents a major and increasing cause of discomfort in cancer survivors. Unfortunately, in approximately 10%-15% of cases, pain is scarcely relieved by opioids and common painkillers. Thus, alternative measures to manage pain have recently been adopted in these pa...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.03.104
更新日期：2016-07-01 00:00:00
abstract：:Recent advances in neuroimaging demonstrated many markedly improved images hitherto unavailable, specifically the areas that lie deep in the brain. The anatomic images of the deep brain structure taken in vivo using 7.0 T magnetic resonance imaging (MRI) and the molecular images using high resolution research tomograp...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2012.10.020
更新日期：2014-07-01 00:00:00
