Robot-assisted stereotactic biopsies in 377 consecutive adult patients with supratentorial diffuse gliomas: diagnostic yield, safety and postoperative outcomes.


BACKGROUND:Multiple biopsy samples are warranted for the histomolecular diagnosis of diffuse gliomas in the current molecular era, which possibly increases morbidity. OBJECTIVE:We assessed diagnostic yield, safety, and risk factors of postoperative morbidity after robot-assisted serial stereotactic biopsy sampling along 1 biopsy trajectory for diffuse gliomas. METHODS:Observational retrospective analysis of consecutive magnetic resonance imaging-based robot-assisted stereotactic biopsies performed at a single institution to assess the diagnosis of nonresectable newly diagnosed supratentorial diffuse gliomas in adults (2006-2016). RESULTS:In 377 patients, 4.2 ± 1.9 biopsy samples were obtained at 2.6 ± 1.2 biopsy sites. The histopathologic diagnosis was obtained in 98.7% of cases. Preoperative neurologic deficit (P = 0.030), biopsy site hemorrhage ≥20 mm (P = 0.004), and increased mass effect on postoperative imaging (P = 0.014) were predictors of a new postoperative neurologic deficit (7.7%). Postoperative neurologic deficit (P < 0.001) and increased mass effect on postoperative imaging (P = 0.014) were predictors of a Karnofsky Performance Status decrease ≥20 points postoperatively (4.0%). Increased intracranial pressure preoperatively (P = 0.048) and volume of the contrast-enhanced area ≥13 cm3 (P = 0.048) were predictors of an increased mass effect on postoperative imaging (4.4%). Preoperative Karnofsky Performance Status <70 (P = 0.045) and increased mass effect on postoperative imaging (P < 0.001) were predictors of mortality 1 month postoperatively (2.9%). Preoperative neurologic deficit (P = 0.005), preoperative Karnofsky Performance Status <70 (P < 0.001), subventricular zone contact (P = 0.004), contrast enhancement (P = 0.018), and steroid use (P = 0.003), were predictors of the inability to discharge to home postoperatively (37.0%). CONCLUSIONS:Robot-assisted stereotactic biopsy sampling results in high diagnostic accuracy with low complication rates. Multiple biopsy sites and samples do not increase postoperative complications.


World Neurosurg


World neurosurgery


Zanello M,Roux A,Senova S,Peeters S,Edjlali M,Espariat AT,Dezamis E,Parraga E,Zah-Bi G,Harislur M,Oppenheim C,Sauvageon X,Chretien F,Devaux B,Varlet P,Pallud J




Has Abstract


2021-01-04 00:00:00








  • Angiographic "Blush" After Stereotactic Radiosurgery Ablation of Residual Arteriovenous Malformation in Pediatric Patient: Case Report and Review of Literature.

    abstract:INTRODUCTION:While surgical resection remains a primary treatment for accessible arteriovenous malformations (AVMs), stereotactic radiosurgery (SRS) has become thoroughly integrated into the AVM armamentarium; however, delayed sequelae of this treatment have become evident with increased long-term follow-up. To our kno...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审


    authors: Szujewski CC,Heiferman DM,Rosenbaum MD,Reynolds MR,Anderson DE,Serrone JC

    更新日期:2018-03-01 00:00:00

  • Machine Learning and Neurosurgical Outcome Prediction: A Systematic Review.

    abstract:OBJECTIVE:Accurate measurement of surgical outcomes is highly desirable to optimize surgical decision-making. An important element of surgical decision making is identification of the patient cohort that will benefit from surgery before the intervention. Machine learning (ML) enables computers to learn from previous da...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审


    authors: Senders JT,Staples PC,Karhade AV,Zaki MM,Gormley WB,Broekman MLD,Smith TR,Arnaout O

    更新日期:2018-01-01 00:00:00

  • Flow Diverter for the Treatment of Pseudoaneurysms of the Extracraneal Vertebral Artery: Report of Two Cases and Review of the Literature.

    abstract:BACKGROUND:Pseudoaneurysms (PAs) of the extracranial vertebral artery (VA) are rare lesions, representing less than 1% of all aneurysms. Although these lesions may resolve spontaneously, they present a high rupture rate, so early preventive treatment is advised. CASE DESCRIPTION:Case 1: A 48-year-old woman presented w...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Plou P,Landriel F,Beltrame S,Hem S,Peralta O,García-Mónaco R,Yampolsky C

    更新日期:2019-07-01 00:00:00

  • Intraoperative fluorescence-guided resection of high-grade gliomas: a comparison of the present techniques and evolution of future strategies.

    abstract:OBJECTIVE:Fluorescence guidance has a demonstrated potential in maximizing the extent of high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5-aminolevulinic acid (5-ALA) and fluorescein, have been examined with the use of several imaging techniques. Our goal was to review the state ...

    journal_title:World neurosurgery

    pub_type: 杂志文章,meta分析,评审


    authors: Li Y,Rey-Dios R,Roberts DW,Valdés PA,Cohen-Gadol AA

    更新日期:2014-07-01 00:00:00

  • Virtual Cerebral Aneurysm Clipping with Real-Time Haptic Force Feedback in Neurosurgical Education.

    abstract:OBJECTIVE:Realistic, safe, and efficient modalities for simulation-based training are highly warranted to enhance the quality of surgical education, and they should be incorporated in resident training. The aim of this study was to develop a patient-specific virtual cerebral aneurysm-clipping simulator with haptic forc...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Gmeiner M,Dirnberger J,Fenz W,Gollwitzer M,Wurm G,Trenkler J,Gruber A

    更新日期:2018-04-01 00:00:00

  • The Evolution of Cerebral Language Localization: Historical Analysis and Current Trends.

    abstract::Language localization has been an evolving concept over the past 150 years, with the emergence of several important yet conflicting ideologies. The classical theory, starting from the phrenologic work of Gall to the identification of specific regions of language function by Broca, Wernicke, and others, proposed that d...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审


    authors: Monroy-Sosa A,Chakravarthi SS,Cortes-Contreras AP,Hernandez-Varela M,Andres-Arrieta V,Epping A,Rovin RA

    更新日期:2021-01-01 00:00:00

  • Two-Stage Approach for Unstable Pediatric Craniocervical Junction Anomalies with a Halo Vest and Delayed Occipitocervical Fusion: Technical Note, Case Series, and Literature Review.

    abstract:OBJECTIVE:Malformations in the craniocervical junction (CCJ) are rare in the pediatric population but often need surgical treatment. We present a pediatric case series of patients treated with a 2-stage surgical approach with a halo vest and occipitocervical fusion and review complications and outcomes. METHODS:A retr...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Tirado-Caballero J,Moreno-Madueño G,Rivero-Garvia M,Mayorga-Buiza MJ,Valencia-Anguita J,Márquez-Rivas J

    更新日期:2020-11-20 00:00:00

  • Endoscopic Endonasal Versus Transorbital Surgery for Middle Cranial Fossa Tumors: Comparison of Clinical Outcomes Based on Surgical Corridors.

    abstract:BACKGROUND:Based on our experience with the endoscopic endonasal approach (EEA) and transorbital approach (TOA) for middle cranial fossa tumors, we evaluated the efficacy and limitations of visualization and the clinical outcomes associated with the approaches depending on the surgical corridors. In addition, we determ...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Lee MH,Hong SD,Woo KI,Kim YD,Choi JW,Seol HJ,Lee JI,Shin HJ,Nam DH,Kong DS

    更新日期:2019-02-01 00:00:00

  • The Assassination of Abraham Lincoln and the Evolution of Neuro-Trauma Care: Would the 16th President Have Survived in the Modern Era?

    abstract::Abraham Lincoln was the 16(th) President of the United States of America. On April 14, 1865, shortly after his re-election and the conclusion of the Civil War, Lincoln was shot and killed by John Wilkes Booth. Although numerous physicians tended to the President shortly after his injury, he passed away the next mornin...

    journal_title:World neurosurgery

    pub_type: 传,历史文章,杂志文章,评审


    authors: Yan SC,Smith TR,Bi WL,Brewster R,Gormley WB,Dunn IF,Laws ER Jr

    更新日期:2015-11-01 00:00:00

  • Intracranial Meningioma in Patients Age

    abstract:BACKGROUND:Intracranial meningiomas are most common among patients in their fifth to seventh decade of life and rare in children and young adults. They constitute 1.5% of all neoplasms in patients age <20 years, but account for 13.5% of all neoplasms in patients age 20-34 years. They are often associated with hereditar...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Motebejane MS,Kaminsky I,Choi IS

    更新日期:2018-01-01 00:00:00

  • Volume of Brain Herniation in Patients with Ischemic Stroke After Decompressive Craniectomy.

    abstract:BACKGROUND:Decompressive craniectomy procedures are performed in patients with malignant intracranial hypertension. A bone flap is removed to relieve pressure. Later, a second operation is performed to reconstruct the skull after brain swelling has resolved. This surgical treatment would be improved if it were possible...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Stoner KE,Abode-Iyamah KO,Grosland NM,Howard MA 3rd

    更新日期:2016-12-01 00:00:00

  • Endodermal Cyst Arising from the Oculomotor Nerve: A Case Report Outlining the Novel Insertion of Cysto-subarachnoid Shunt for Refractory Disease.

    abstract:BACKGROUND:Endodermal cysts of the oculomotor nerve are rare presentations. Only case reports are available to help guide clinicians with managing this rare entity. CASE DESCRIPTION:A 3-year-old boy presented with an acute on chronic left oculomotor nerve palsy due to a left interpeduncular cistern cyst found on magne...

    journal_title:World neurosurgery



    authors: Cox AAJ,Siedler DG,Asaid M,Thani NB

    更新日期:2020-08-01 00:00:00

  • Effect of Fetal Posterior Circulation on Efficacy of Flow Diversion for Treatment of Posterior Communicating Artery Aneurysms: A Multi-Institutional Study.

    abstract:BACKGROUND:Flow diversion (FD) has emerged as an effective treatment modality for aneurysms of the posterior communicating artery (PCOM). Whether or not a fetal posterior circulation (FPC) affects PCOM aneurysm occlusion rates after FD remains undetermined. METHODS:We performed a retrospective cohort study in which tr...

    journal_title:World neurosurgery

    pub_type: 杂志文章,多中心研究


    authors: Rinaldo L,Brinjikji W,Cloft H,Lanzino G,Gonzalez LF,Kan P,Castilla LR

    更新日期:2019-07-01 00:00:00

  • Hippocampal Transection Plus Tumor Resection as a Novel Surgical Treatment for Temporal Lobe Epilepsy Associated with Cerebral Cavernous Malformations.

    abstract:OBJECTIVE:The optimal surgical treatment for cavernous malformation-related temporal lobe epilepsy (CRTLE) is still controversial because it frequently involves the hippocampus as an epileptogenic zone. Here we describe our unique surgical strategy of performing hippocampal transection (HT) plus tumor resection for CRT...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Ishida W,Morino M,Matsumoto T,Casaos J,Ramhmdani S,Lo SL

    更新日期:2018-11-01 00:00:00

  • Use of Intramedullary K-Wire to Enhance Fibular Graft Placement in 4-Level Thoracolumbar Corpectomy for Pott Disease: Case Report and Review of Literature.

    abstract:BACKGROUND:Reports of tuberculosis involving ≥4 contiguous spinal levels are rare. Surgery is often required in this population for neurological decompression and stabilization. These patients appear to be particularly predisposed to complications that include incomplete recovery of neurological function after decompre...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审


    authors: Forbes JA,Williams J,Awad AJ,Tiger M,Anderson B,Finnan R

    更新日期:2016-05-01 00:00:00

  • Measurement of Cervical Sagittal Alignment Parameters on X-Ray Films of Adults without Severe Spinal Deformity Whose Shoulder Hides the Lower Cervical Column.

    abstract:OBJECTIVE:The Cobb angle between the lower endplate of C2 and C7 (C2L-C7L angle) is a traditional parameter used for the assessment of the cervical alignment. However, when the lower cervical column is masked by the shoulder, measurements are difficult. In the present study, we inspected 191 X-ray films, measured the C...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Yamahata H,Sugata J,Mori M,Niiro T,Yonenaga M,Yamaguchi S,Hiwatari T,Okada T,Arita K,Yoshimoto K

    更新日期:2019-01-01 00:00:00

  • Bilateral Dysplastic Gangliocytoma with Concurrent Polyostotic Fibrous Dysplasia: A Case Report and Literature Review.

    abstract:BACKGROUND:Dysplastic gangliocytoma is a sporadic cerebellar benign tumor with the characteristics of hamartoma and true tumor, also known as Lhermitte-Duclos disease (LDD). Bone fibrous dysplasia (FD) is a slowly progressive self-limited benign bone tissue disease. Cowden syndrome, an autosomal dominant genetic disord...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审


    authors: Jiang C,Lu WX,Yan GZ,Bai RB,Wang ZN,Chen Y,Hou B,Ren HJ

    更新日期:2020-09-01 00:00:00

  • History of Hemostasis in Neurosurgery.

    abstract::Control of bleeding in the confined area of the skull is imperative for successful neurosurgery and the prevention of devastating complications such as postoperative hemorrhage. This paper reviews the historical evolution of methods to achieve successful hemostasis in neurosurgery from the early1800s to today. The maj...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审


    authors: Paulo D,Semonche A,Choudhry O,Al-Mufti F,Prestigiacomo CJ,Roychowdhury S,Nanda A,Gupta G

    更新日期:2018-12-19 00:00:00

  • Successful Novel Treatment of a Paraspinal Primitive Neuroectodermal Tumor with Predominantly Glial Differentiation: A 3-Year Follow-Up After Surgery, Intensity-Modulated Radiation Therapy and Oral Temozolomide.

    abstract:BACKGROUND:Paraspinal masses are a relatively uncommon but diverse group of lesions that can be neoplastic or non-neoplastic. Peripheral primitive neuroectodermal tumors of the lumbar paraspinal region with diffuse and strong glial differentiation have never been reported before. CASE DESCRIPTION:We report a primary p...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: El Ahmadieh TY,Raisanen JM,Botros J,Kabangu JL,Pan E,Gluf W

    更新日期:2018-11-01 00:00:00

  • Preoperative Intracranial Dissemination of Spinal Myxopapillary Ependymoma Attributed to Tumor Hemorrhage.

    abstract:BACKGROUND:Spinal myxopapillary ependymoma (SME), generally considered a benign entity, can exhibit brain and whole-spine metastases as well as local recurrence after surgery. However, the presence of preoperative retrograde intracranial dissemination at the time of diagnosis is very rare. CASE DESCRIPTION:We report a...

    journal_title:World neurosurgery



    authors: Awaya T,Nishimura Y,Eguchi K,Nagashima Y,Ando R,Akahori S,Yoshikawa S,Haimoto S,Hara M,Natsume A

    更新日期:2021-01-01 00:00:00

  • Initial Results of Bilateral Subthalamic Nucleus Stimulation for Parkinson Disease in a Newly Established Center in a Developing Country: Shiraz, Southern Iran.

    abstract:OBJECTIVE:To report the establishment of a new center for deep brain stimulation (DBS) as a surgical treatment for Parkinson disease and the surgical outcomes, from 2014 to 2017 in Shiraz, Southern Iran. METHODS:A new treatment program was established in Shiraz through a multidisciplinary team in 2014. Thirty-four pat...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Razmkon A,Yousefi O,Rezaei R,Salehi S,Petramfar P,Mani A,Rahmati H,Vaidyanathan J,Ilami G,Amirmoezzi Y

    更新日期:2019-01-01 00:00:00

  • Treatment of Extracranial Vertebral Artery Aneurysm with Flow Diversion.

    abstract:BACKGROUND:Aneurysms of the extracranial vertebral artery are rare, and the treatment options are not standardized. We present a case of an extracranial vertebral artery aneurysm treated with flow diversion. CASE DESCRIPTION:In a 72-year-old woman, computed tomography angiography demonstrated a right extracranial vert...

    journal_title:World neurosurgery



    authors: Wu H,Wang M,Li K,Wang F

    更新日期:2020-06-01 00:00:00

  • Solitary Cysticercal Cyst Inside the Blake's Pouch Remnant of Mega Cisterna Magna with Associated Aqueductal Stenosis: Clinical and Management Implications.

    abstract:BACKGROUND:Intraventricular and subarachnoid forms represent the relatively complex, albeit uncommon, manifestations of central nervous system involvement by cysticercal cysts. Cysticercal encystation inside the Blake's pouch remnant of mega cisterna magna (MCM) remains an extremely rare clinical scenario that, to the ...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Das KK,Gosal JS,Singh S,Mehrotra A,Jaiswal A,Jaiswal S,Kumar R

    更新日期:2017-06-01 00:00:00

  • Comparison of Proximal Junctional Failure and Functional Outcomes Across Varying Definitions of Proximal Junctional Kyphosis.

    abstract:BACKGROUND:Proximal junctional kyphosis (PJK) is a well-recognized complication following surgery for adult spinal deformity (ASD); however, definitions for PJK and its clinical implications can significantly vary by study. This study compares multiple definitions of PJK and describes incidence and clinical significanc...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Ton A,Alluri RK,Kang HP,Kim A,Hah RJ

    更新日期:2020-10-20 00:00:00

  • A Poorly Known Cerebrospinal Fluid Shunt Complication: Miyazaki Syndrome.

    abstract::We studied a poorly known form of cerebrospinal fluid hypotension characterized by cervical myelopathy, a considerable growth in volume of the venous plexus of the cervical spine, and absence of headache. This form was first described by Miyazaki. We reported a case brought to our attention, reviewed the literature, a...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Caruso R,Wierzbicki V,Marrocco L,Pesce A,Piccione E

    更新日期:2015-09-01 00:00:00

  • Microsurgical Trapping and Excision of Ruptured Mycotic Aneurysms in a Patient with Mitral Valve Endocarditis: A Surgical Technique.

    abstract::This case Video 1 demonstrates a microsurgical technique for trapping and excision of 2 ruptured mycotic aneurysms. The patient was a 64-year-old man with severe mitral regurgitation and valvular vegetations suggestive of endocarditis. On examination, the patient presented with speech difficulty. Preoperative imaging ...

    journal_title:World neurosurgery



    authors: Dimentberg R,Cox M,Kolster R,Choudhri OA

    更新日期:2020-05-01 00:00:00

  • A method of untethering by skipping the area of positive responses on electrical stimulation during surgery of lumbosacral lipomatous malformation: 'hopping on a stepping stone'.

    abstract:OBJECTIVES:In complex lumbosacral lipomatous malformation or retethering, 'crotch' dissection, an incision on the dura or lipoma at the site lateral to the lipoma-cord fusion line saving underlying roots, is often not easy. Attempts of this dissection in complex and obscured conditions may cause damage to the spinal co...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Kim KH,Chong S,Lee JY,Kim SK,Cho BK,Wang KC

    更新日期:2019-01-04 00:00:00

  • Infratentorial Glioblastoma Metastasis to Bone.

    abstract:BACKGROUND:Glioblastoma multiforme (GBM) is a rapid-growing central nervous system neoplasm. We report a case of GBM with extensive intramedullary lumbar drop metastasis and highly unusual osseous spine metastasis from a primary infratentorial GBM occurring 10 years after the initial diagnosis, which to our knowledge h...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Ricard JA,Cramer SW,Charles R,Gil Tommee C,Le A,Bell WR,Chen CC,Flanagan ME

    更新日期:2019-11-01 00:00:00

  • Quo vadis, academia? Can academic neurosurgery be resurrected?

    abstract::Clinical neurosurgery is an endangered academic discipline. Neurosurgeons have competition from many directions: orthopedists, ear, nose and throat surgeons, plastic surgeons, radio-oncologists, and interventional radiologists, among others. Academic centers are no longer the only sites of neurosurgical education at t...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Kasper EM,Fischer EG,Ostertag CB

    更新日期:2012-07-01 00:00:00

  • Cost-Utility Analysis of Surgery and Radiotherapy for Symptomatic Spinal Metastases in a Belgian Specialist Center.

    abstract:OBJECTIVE:Spinal metastases represent the most common site of bony metastases and frequently reduce quality of life. A beneficial effect of surgery and radiotherapy versus radiotherapy alone has been demonstrated in symptomatic patients. The goal of our study was to perform a cost-utility analysis of surgery for spinal...

    journal_title:World neurosurgery

    pub_type: 杂志文章


    authors: Depreitere B,Turner I,Vandoren C,Choi D

    更新日期:2019-05-01 00:00:00