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Robot-assisted stereotactic biopsies in 377 consecutive adult patients with supratentorial diffuse gliomas: diagnostic yield, safety and postoperative outcomes.

Abstract：

BACKGROUND:Multiple biopsy samples are warranted for the histomolecular diagnosis of diffuse gliomas in the current molecular era, which possibly increases morbidity. OBJECTIVE:We assessed diagnostic yield, safety, and risk factors of postoperative morbidity after robot-assisted serial stereotactic biopsy sampling along 1 biopsy trajectory for diffuse gliomas. METHODS:Observational retrospective analysis of consecutive magnetic resonance imaging-based robot-assisted stereotactic biopsies performed at a single institution to assess the diagnosis of nonresectable newly diagnosed supratentorial diffuse gliomas in adults (2006-2016). RESULTS:In 377 patients, 4.2 ± 1.9 biopsy samples were obtained at 2.6 ± 1.2 biopsy sites. The histopathologic diagnosis was obtained in 98.7% of cases. Preoperative neurologic deficit (P = 0.030), biopsy site hemorrhage ≥20 mm (P = 0.004), and increased mass effect on postoperative imaging (P = 0.014) were predictors of a new postoperative neurologic deficit (7.7%). Postoperative neurologic deficit (P < 0.001) and increased mass effect on postoperative imaging (P = 0.014) were predictors of a Karnofsky Performance Status decrease ≥20 points postoperatively (4.0%). Increased intracranial pressure preoperatively (P = 0.048) and volume of the contrast-enhanced area ≥13 cm3 (P = 0.048) were predictors of an increased mass effect on postoperative imaging (4.4%). Preoperative Karnofsky Performance Status <70 (P = 0.045) and increased mass effect on postoperative imaging (P < 0.001) were predictors of mortality 1 month postoperatively (2.9%). Preoperative neurologic deficit (P = 0.005), preoperative Karnofsky Performance Status <70 (P < 0.001), subventricular zone contact (P = 0.004), contrast enhancement (P = 0.018), and steroid use (P = 0.003), were predictors of the inability to discharge to home postoperatively (37.0%). CONCLUSIONS:Robot-assisted stereotactic biopsy sampling results in high diagnostic accuracy with low complication rates. Multiple biopsy sites and samples do not increase postoperative complications.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Zanello M,Roux A,Senova S,Peeters S,Edjlali M,Espariat AT,Dezamis E,Parraga E,Zah-Bi G,Harislur M,Oppenheim C,Sauvageon X,Chretien F,Devaux B,Varlet P,Pallud J

doi

10.1016/j.wneu.2020.12.127

subject

Has Abstract

pub_date

2021-01-04 00:00:00

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(20)32694-2

pub_type

杂志文章

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Robot-assisted stereotactic biopsies in 377 consecutive adult patients with supratentorial diffuse gliomas: diagnostic yield, safety and postoperative outcomes.