Dual effects of heme oxygenase-1 on astrocyte injury induced by hemin in vitro.

Abstract:

PRIMARY OBJECTIVE:The purpose of this study was to investigate the effects of heme oxygenase-1 (HO-1) on astrocyte injury induced by hemin. RESEARCH DESIGN:Primary astrocytes were isolated from Sprague Dawley rat pups and cultured in vitro. The expression of HO-1 was induced by hemin in a quantitative fashion and the effects of HO-1 on hemin-induced astrocyte injury were estimated by cell viability, cell membrane permeability and apoptosis. METHODS AND PROCEDURES:Astrocytes were divided into control group, hemin 5 μM group, hemin 5 μM + Zn-PPIX group, hemin 30 μM group and hemin 30 μM + Zn-PPIX group. Survival quality of astrocyte was measured by WST-8 assay, LDH assay, Hoechst 33258 Staining and annexin V-FITC/PI assay and apoptotic-related proteins were measured using Western blotting. MAIN OUTCOME AND RESULTS:Hemin could dose-dependently up-regulate the expression of HO-1. HO-1 exerted a protective role on astrocyte damage induced by 5 μM hemin, including increased cell survival rate and anti-apoptotic proteins expression (Bcl-2 and p-AKT), as well as decreased LDH release, apoptosis ratio and apoptotic protein expression (Bax, p-ERK and cleaved-caspase3). However, the effect of HO-1 on astrocyte injury between 30 μM hemin-treated groups was opposite of the protective role in 5 μM hemin-treated groups. CONCLUSIONS:There were dual effects of HO-1 in 5 μM and 30 μM hemin-induced astrocyte injuries.

journal_name

Brain Inj

journal_title

Brain injury

authors

Chen H,Wang X,Zhao Q,Zhang Z,Ye X,Hua F,Cui G

doi

10.3109/02699052.2015.1084648

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

36-42

issue

1

eissn

0269-9052

issn

1362-301X

journal_volume

30

pub_type

杂志文章
  • Neurophysiological and cognitive impairment following repeated sports concussion injuries in retired professional rugby league players.

    abstract:BACKGROUND:Concussion is regarded as a common injury in rugby league, however no studies have explored the long-term neurophysiological and cognitive effects of repeated concussion injuries in this sport. METHODS:Former professional rugby athletes (n = 25) were compared to 25 age-matched participants with no history o...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2018.1430376

    authors: Pearce AJ,Rist B,Fraser CL,Cohen A,Maller JJ

    更新日期:2018-01-01 00:00:00

  • Music as a diagnostic tool in low awareness states: considering limbic responses.

    abstract:PRIMARY OBJECTIVE:Examining the evidence from contrasting epistemological sources a case is made for the use of music as an assessment medium with patients in low awareness states. Profound brain damage can result in long-term states of altered consciousness such as vegetative and minimally conscious states. Differenti...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.1080/02699050701426907

    authors: Magee WL

    更新日期:2007-06-01 00:00:00

  • EMA analysis of tongue function in children with dysarthria following traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:To investigate the speed and accuracy of tongue movements exhibited by a sample of children with dysarthria following severe traumatic brain injury (TBI) during speech using electromagnetic articulography (EMA). METHODS AND PROCEDURES:Four children, aged between 12.75-17.17 years with dysarthria foll...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/0269905021000010203

    authors: Murdoch BE,Goozée JV

    更新日期:2003-01-01 00:00:00

  • Sinemet and brain injury: functional versus statistical change and suggestions for future research designs.

    abstract::During the past decade the usage of dopaminergic agonists for the brain-injured population has become a more common treatment option during both the acute and subacute phases of recovery. We attempted to use Sinemet to address the functional limitations of a 74-year-old woman who was 7 months status post-traumatic bra...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059509008208

    authors: Wolf AP,Gleckman AD

    更新日期:1995-07-01 00:00:00

  • Health-related quality-of-life and behavioural outcome in survivors of childhood meningitis.

    abstract:OBJECTIVE:To describe behavioural and health-related quality-of-life (HRQoL) outcomes in survivors of childhood meningitis and identify variables predictive of psychosocial outcome. METHODS:Psychosocial outcomes were measured via parent and teacher report using the Strengths and Difficulties Questionnaire (SDQ) and th...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2011.613090

    authors: Sumpter R,Brunklaus A,McWilliam R,Dorris L

    更新日期:2011-01-01 00:00:00

  • The personal and workplace factors relevant to work readiness evaluation following acquired brain injury: occupational therapists' perceptions.

    abstract:OBJECTIVE:This study examined the personal and workplace/environmental factors perceived most relevant to work readiness evaluations following acquired brain injury. RESEARCH DESIGN:Using a qualitative secondary analysis design 'indicators of success' and 'risks of failure', identified as relevant in a primary study o...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2010.491495

    authors: Stergiou-Kita M,Yantzi A,Wan J

    更新日期:2010-01-01 00:00:00

  • Characteristics and outcomes of a home and community-based neurorehabilitation programme.

    abstract::The potential clinical and financial advantages of providing neurorehabilitation directly in patients' homes and communities have recently been discussed. However, the specific characteristics and outcomes of a coordinated, interdisciplinary, home-based programme does not currently exist in the rehabilitation literatu...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990599121430

    authors: Pace GM,Schlund MW,Hazard-Haupt T,Christensen JR,Lashno M,McIver J,Peterson K,Morgan KA

    更新日期:1999-07-01 00:00:00

  • Semantic memory impairments following non-progressive brain injury: a study of four cases.

    abstract::Four brain-injured subjects with semantic memory impairments are described. Two had sustained traumatic head injury and two had herpes simplex virus encephalitis. The study seeks to determine (a) whether subjects with non-progressive brain injury and impaired semantic memory perform similarly to patients with progress...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123566

    authors: Wilson BA

    更新日期:1997-04-01 00:00:00

  • Indicators of complicated mild TBI predict MMPI-2 scores after 23 years.

    abstract:PRIMARY OBJECTIVE:Research suggests that post-concussive syndrome may become persistent after mild traumatic brain injury (mTBI). The aim of this study was to investigate determinants of subjective complaints, characteristic for post-concussive syndrome, 23 years after mTBI. RESEARCH DESIGN:The study was a follow-up a...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050902748349

    authors: Hessen E,Nestvold K

    更新日期:2009-03-01 00:00:00

  • A systematic review of treatments for mild traumatic brain injury.

    abstract:OBJECTIVES:To assess the effectiveness of interventions for mild traumatic brain injury (MTBI) in adults as found in the literature. RESEARCH DESIGN:Systematic review of the literature. METHODS:Six electronic databases and 18 journals within the brain injury field were manually searched between the years 1980-2003. R...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.1080/02699050400025042

    authors: Comper P,Bisschop SM,Carnide N,Tricco A

    更新日期:2005-10-01 00:00:00

  • Quantitative structural neuroimaging of mild traumatic brain injury in the Chronic Effects of Neurotrauma Consortium (CENC): Comparison of volumetric data within and across scanners.

    abstract:BACKGROUND:An important component of the multicentre Chronic Effects of Neurotrauma Consortium (CENC) project is the development of improved quantitative magnetic resonance imaging (MRI) methods, including volumetric analysis. Although many studies routinely employ quality assurance (QA) procedures including MR and hum...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2016.1219063

    authors: Wilde EA,Bigler ED,Huff T,Wang H,Black GM,Christensen ZP,Goodrich-Hunsaker N,Petrie JA,Abildskov T,Taylor BA,Stone JR,Tustison NJ,Newsome MR,Levin HS,Chu ZD,York GE,Tate DF

    更新日期:2016-01-01 00:00:00

  • Participation after traumatic brain injury: the surplus value of social cognition tests beyond measures for executive functioning and dysexecutive behavior in a statistical prediction model.

    abstract::Objective: This study evaluates the contribution of measures for social cognition (SC), executive functioning (EF) and dysexecutive behavior to the statistical prediction of social and vocational participation in patients with traumatic brain injury (TBI), taking into account age and injury severity.Method: A total of...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2018.1531303

    authors: Westerhof-Evers HJ,Fasotti L,van der Naalt J,Spikman JM

    更新日期:2019-01-01 00:00:00

  • The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis.

    abstract::Traumatic brain injury (TBI) is a major health concern. The purpose of this study is to identify the diagnostic accuracy of ubiquitin C-terminal hydrolase-L1 (UCH-L1)-a protein biomarker-in comparison with CT-scan findings post-TBI. Accordingly, we conducted a systematic review of eligible studies and assessed the ris...

    journal_title:Brain injury

    pub_type: 杂志文章,meta分析

    doi:10.1080/02699052.2017.1382717

    authors: Shahjouei S,Sadeghi-Naini M,Yang Z,Kobeissy F,Rathore D,Shokraneh F,Blackburn S,Manley GT,Wang KKW

    更新日期:2018-01-01 00:00:00

  • Reading assessment post head injury: how valid is it?

    abstract::The purpose of this study was to identify the passage dependency for three reading tests applied to the closed head injured (CHI) population and to determine whether reading the passage resulted in improved accuracy in responding to passage-related questions. Based on the performance of 10 CHI adults, passage dependen...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059009026160

    authors: Rand MB,Trudeau MD,Nelson LK

    更新日期:1990-04-01 00:00:00

  • Characterizing computer-mediated communication, friendship, and social participation in adults with traumatic brain injury.

    abstract:BACKGROUND:Adults with traumatic brain injury (TBI) report loss of friendship and reduced social participation after injury, but there is limited information regarding quantity of friends and methods of communication. Our objective was to characterize friendship networks, social participation, and methods of communicat...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2019.1616112

    authors: Flynn MA,Rigon A,Kornfield R,Mutlu B,Duff MC,Turkstra LS

    更新日期:2019-01-01 00:00:00

  • Fixation stability as a biomarker for differentiating mild traumatic brain injury from age matched controls in pediatrics.

    abstract:OBJECTIVES:Traumatic brain injury (TBI) is an increasingly significant health concern worldwide, compounded by the difficultly in detection and diagnosis. Fortunately, a growing body of research has identified oculomotor behavior, specifically fixations, saccades and smooth pursuit eye movements as a promising endophen...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1865566

    authors: Hunfalvay M,Murray NP,Carrick FR

    更新日期:2020-12-24 00:00:00

  • Preliminary study of the reliability and validity of the Johns Hopkins Adapted Cognitive Exam (Chinese version) in neurological intensive care unit patients.

    abstract:OBJECTIVE:To evaluate the reliability and validity of the Chinese version of the Johns Hopkins Adapted Cognitive Exam (ACE) in neurological intensive care unit patients. DESIGN:The English version of the ACE was translated and adapted into Chinese. The cognitive function of 40 critically ill NICU patients was assessed...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2018.1537511

    authors: Wu YH,Yao QJ,Zhang Y,Wang Y,Wang H,Zhang Y

    更新日期:2019-01-01 00:00:00

  • Transcranial magnetic stimulation: A potential new treatment for depression associated with traumatic brain injury.

    abstract:BACKGROUND:Each year, more than 1.7 million Americans suffer a traumatic brain injury (TBI) and the lifetime prevalence of major depressive disorder following TBI is between 25-50%. There are no validated established strategies to treat TBI depression. Repetitive transcranial magnetic stimulation (rTMS) is a novel puta...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2015.1009168

    authors: Reti IM,Schwarz N,Bower A,Tibbs M,Rao V

    更新日期:2015-01-01 00:00:00

  • Is high PEEP ventilation strategy safe for acute respiratory distress syndrome after severe traumatic brain injury?

    abstract:PRIMARY OBJECTIVE:To investigate the safety and efficacy of high positive end-expiratory pressure (PEEP) ventilation strategy for acute respiratory distress syndrome (ARDS) after traumatic brain injury. RESEARCH DESIGN:A case report and discussion based on literature review. METHODS AND PROCEDURES:This article report...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2012.660514

    authors: Lou M,Xue F,Chen L,Xue Y,Wang K

    更新日期:2012-01-01 00:00:00

  • Knowledge, attitudes, and behavior toward concussion in adult cyclists.

    abstract:OBJECTIVE:To determine knowledge, attitudes, and behavior toward concussion in cyclists and to identify predictors of concussion knowledge. METHODS:Cycling organizations sent members a web link to online information about the study and a questionnaire. Anyone aged >16 years, living in New Zealand and engaged in a cycl...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1793386

    authors: O'Reilly M,Mahon S,Reid D,Hume P,Hardaker N,Theadom A

    更新日期:2020-07-28 00:00:00

  • The ethics of using placebo medication in a non-capacitous patient.

    abstract:BACKGROUND:The use of placebo has long been controversial. Whilst evidence accumulates regarding it's beneficial and safe effects, ethical issues around the eroding of patient autonomy and accusations of deception stop most doctors prescribing inert placebo substances. CASE STUDY:This paper presents a case of a non-ca...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2012.694560

    authors: Bolton P,Shotton L,Young A,Grace J

    更新日期:2012-01-01 00:00:00

  • The use of cranial electrotherapy stimulation in the treatment of closed-head-injured patients.

    abstract::This double-blind study sought to discover if cranial electrotherapy stimulation (CES), which is a known treatment of depression, anxiety and insomnia in non-head-injured patients, could be an effective, drug-free treatment of stress-related symptoms in the closed-head-injured (CHI) patient. In this study 10 CHI patie...

    journal_title:Brain injury

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/02699059409150986

    authors: Smith RB,Tiberi A,Marshall J

    更新日期:1994-05-01 00:00:00

  • The 'dice' game: a new test of pragmatic language skills after closed-head injury.

    abstract::There are few clinical tools available to assess communication skills following closed-head injury. This paper describes one such task in which the subject is required to explain a board game to a naive listener. The explanation is taped, transcribed and the content is quantified. Reliability studies demonstrated that...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059509008197

    authors: McDonald S,Pearce S

    更新日期:1995-04-01 00:00:00

  • In search of evidence-based treatment for concussion: characteristics of current clinical trials.

    abstract:UNLABELLED:Abstract Objective: To assess the characteristics of current clinical trials investigating the treatment of concussion. BACKGROUND:Recent systematic literature reviews have concluded that there is minimal evidence to support any specific treatment for concussion, including the principles of return-to-activi...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2014.974673

    authors: Burke MJ,Fralick M,Nejatbakhsh N,Tartaglia MC,Tator CH

    更新日期:2015-01-01 00:00:00

  • Impact of divided attention during verbal learning in young adults following mild traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:The goal of the present study was to assess the impact of mild traumatic brain injury (MTBI) on episodic memory performance in relation to attentional and executive control processes in young adults. RESEARCH DESIGN/METHODS:A verbal memory paradigm manipulating attentional load (full attention or div...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050802649688

    authors: Blanchet S,Paradis-Giroux AA,Pépin M,McKerral M

    更新日期:2009-02-01 00:00:00

  • Golf cart associated traumatic brain injury.

    abstract::Object: Although contact sport-related head injuries are frequently reported, golf cart accidents may have significant consequences including severe traumatic brain injury (TBI) or head injury. As no standardized regulations exist, this mechanism may be underreported. Methods: A retrospective review of TBI or cranial ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2019.1642516

    authors: Simpson B,Shepard S,Kitagawa R

    更新日期:2019-01-01 00:00:00

  • Effectiveness of valproic acid on destructive and aggressive behaviours in patients with acquired brain injury.

    abstract::Valproic acid, a primary anticonvulsant drug, has recently been studied for purported effectiveness in disparate disorders of mood and behaviour. The psychopharmacological treatment of patients with acquired brain injury frequently includes numerous trials of psychotherapeutic drugs such as antipsychotics, benzodiazep...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123791

    authors: Wroblewski BA,Joseph AB,Kupfer J,Kalliel K

    更新日期:1997-01-01 00:00:00

  • Models of brain injury rehabilitation.

    abstract::Rehabilitation services for patients with brain injury have been slower to develop than those with other disabilities, but have rapidly improved over the past 10-15 years. A range of different, specialized brain injury programmes has evolved. The literature is reviewed and the author describes and discusses the relati...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699059509008229

    authors: Burke DC

    更新日期:1995-10-01 00:00:00

  • Predictors of performance on three developmentally sensitive neuropsychological tests in children with and without traumatic brain injury.

    abstract:OBJECTIVE:To determine the effect of age and vocabulary as predictors of performance on neuropsychological tests in children with and without traumatic brain injury (TBI). SETTING AND PARTICIPANTS:In the first study, 213 school-age children were evaluated in their public school environment. In the second study, 65 chi...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050802084902

    authors: Prigatano GP,Gray JA

    更新日期:2008-06-01 00:00:00

  • Validity of the modified 20-metre shuttle test: assessment of cardiorespiratory fitness in people who have sustained a traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:To validate the modified 20-metre shuttle test in adults who have sustained a traumatic brain injury (TBI). DESIGN:Single-sample validity study. SETTING:Brain injury rehabilitation unit. PARTICIPANTS:Twenty-four adults with severe TBI, discharged from hospital for at least 6-months. PROTOCOL:Parti...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050701630375

    authors: Hassett LM,Harmer AR,Moseley AM,Mackey MG

    更新日期:2007-09-01 00:00:00