Abstract:
BACKGROUND:An important component of the multicentre Chronic Effects of Neurotrauma Consortium (CENC) project is the development of improved quantitative magnetic resonance imaging (MRI) methods, including volumetric analysis. Although many studies routinely employ quality assurance (QA) procedures including MR and human phantoms to promote accuracy and monitor site differences, few studies perform rigorous direct comparisons of these data nor report findings that enable inference regarding site-to-site comparability. These gaps in evaluating cross-site differences are concerning, especially given the well-established differences that can occur between data acquired on scanners with different manufacturer, hardware or software. METHODS:This study reports findings on (1) a series of studies utilizing two MR phantoms to interrogate machine-based variability using data collected on the same magnet, (2) a human phantom repeatedly imaged on the same scanner to investigate within-subject, within-site variability and (3) a human phantom imaged on three different scanners to examine within subject, between-site variability. RESULTS:Although variability is relatively minimal for the phantom scanned on the same magnet, significantly more variability is introduced in a human subject, particularly when regions are relatively small or multiple sites used. CONCLUSION:Vigilance when combining data from different sites is suggested and that future efforts address these issues.
journal_name
Brain Injjournal_title
Brain injuryauthors
Wilde EA,Bigler ED,Huff T,Wang H,Black GM,Christensen ZP,Goodrich-Hunsaker N,Petrie JA,Abildskov T,Taylor BA,Stone JR,Tustison NJ,Newsome MR,Levin HS,Chu ZD,York GE,Tate DFdoi
10.1080/02699052.2016.1219063subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1442-1451issue
12eissn
0269-9052issn
1362-301Xjournal_volume
30pub_type
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