Abstract:
:Astrocytic subtypes in different cortical regions of injured human cerebral cortex of 22 patients with brain trauma, vascular anomalies and brain tumours have been examined by means of light microscopy and conventional transmission electron microscopy. The cortical biopsies of frontal, parietal and temporal cortex were examined to analyse the heterogeneous astrocytic response and characterize astrocytic population subtypes. Swollen clear and dense astrocytes, glycogen rich- and glycogen-depleted astrocytes, aged or lipofucsin rich-astrocytes and reactive, dark, hypertrophic astrocytes were identified. Clear and dense astrocytes displayed bundles of glial filaments and dense inclusion bodies. Glycogen-rich astrocytes exhibited an accumulation of beta type of monogranular glycogen granules, which disappear in the glycogen-depleted astrocytes, suggesting anoxic mobilization of glycogen stores during ischemia or anoxia. Lipofucsin rich astrocytes were mainly related with ageing processes, although their presence in young patients suggests also an injured related process. Dark astrocytes with phagocytic properties were found. They exhibited bundles of glial filaments. The astrocytic response depended upon the nature of cortical insult, extent of damage, time course of pathological lesion and affected cortical region.
journal_name
Brain Injjournal_title
Brain injuryauthors
Castejón OJdoi
10.1080/026990599121665subject
Has Abstractpub_date
1999-04-01 00:00:00pages
291-304issue
4eissn
0269-9052issn
1362-301Xjournal_volume
13pub_type
杂志文章相关文献
BRAIN INJURY文献大全abstract:PRIMARY OBJECTIVE:This study was designed to determine whether electro-acupuncture (EA) could alleviate cerebral oedema after cerebral ischemia. RESEARCH DESIGN:EA has been widely used for cerebrovascular disease in East Asian countries. However, whether EA might reduce cerebral oedema after stroke remains unclear. In...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2011.581639
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:To conduct a nationwide telephone survey in order to gather data on some of the quantifiable characteristics of home-based community integration programmes available in the US to adults with brain injury. DESIGN:Survey. METHODS:The Community Integration Programme Questionnaire (CIPQ) was used to interview ...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050500309460
更新日期:2005-12-20 00:00:00
abstract::The neuropsychological functioning of a group of 65 adults with severe traumatic brain injury was assessed at 6 months and 1 year post-injury. The cognitive domains assessed were pre-morbid intellectual level, current level of general intellectual functioning, simple and complex attention, verbal memory, executive fun...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050010005887
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between working alliance, compliance, awareness and subjective outcome of brain injury rehabilitation. Subjects were 86 patients who were clients in an holistic neuropsychological outpatient rehabilitation programme. They had suffered a traumatic brain injury (n = 27), a cerebr...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050601049395
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the prognostic value of admission immune cell levels in the peripheral blood in determining outcomes in patients with TBI. METHOD:We studied 141 adult patients with mild-to-severe TBI (Glasgow Coma Scale (GCS) 3-15). Patient outcome was assessed using the Extended Glasgow ...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2018.1429023
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To explore the cognitive long-term outcome of two cohorts of patients neurosurgically treated for childhood traumatic brain injury (CTBI), either in 1987-1991 according to an older concept or 1997-2001 with a stronger emphasis on volume targeted interventions. RESEARCH DESIGN AND METHODS:Participants in the ...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699050903379354
更新日期:2009-12-01 00:00:00
abstract::Traumatic brain injury is followed by many changes in cognition, emotion, social interaction and functioning, and communication. These changes may range from severe to subtle. They create complex difficulties for the individual and his or her network of support. Presented here is a review of the literature on the chan...
journal_title:Brain injury
pub_type: 杂志文章,评审
doi:10.3109/02699059409151016
更新日期:1994-10-01 00:00:00
abstract:PRIMARY OBJECTIVE:to investigate the road traffic accident rate in patients who have resumed driving after severe brain injury. RESEARCH DESIGN:a retrospective study conducted by means of telephone interviews. METHODS AND PROCEDURES:The caregivers of 90 patients suffering from severe brain injury were included. All o...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050400017163
更新日期:2005-03-01 00:00:00
abstract:PRIMARY OBJECTIVE:Patients with traumatic brain injury (TBI) have difficulty dealing with the social world and may display inappropriate social behavior that negatively affects their social and occupational rehabilitation. This difficulty may be explained by a social problem-solving (SPS) impairment, but little is yet ...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2018.1531306
更新日期:2019-01-01 00:00:00
abstract::An explanatory analysis of data from serial assessments of 30 patients with a diagnosis of vegetative state (persistent vegetative state) was carried out. The data were gathered using the Sensory Modality Assessment and Rehabilitation Technique (SMART) and the Western Neuro Sensory Stimulation Profile (WNSSP) on the s...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/026990500120619
更新日期:2000-04-01 00:00:00
abstract::Opinions about persisting post-concussional symptoms after minor traumatic brain injury still reflect a polarization of views around the sterile debate concerning the psychological vs organic origins of symptoms. Reviews of the experimental literature do not always integrate the often diverse perspectives that explain...
journal_title:Brain injury
pub_type: 杂志文章,评审
doi:10.1080/02699050410001675906
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To examine the prognostic ability of protein S100B, neuron-specific enolase (NSE) and glial fibrillary acid protein (GFAP) for prediction of 1-year mortality in patients with traumatic brain injury (TBI) in relation to clinical and radiological characteristics of TBI. METHODS:Brain injury was quantified in 8...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2012.694567
更新日期:2012-01-01 00:00:00
abstract:PRIMARY OBJECTIVE:To validate the modified 20-metre shuttle test in adults who have sustained a traumatic brain injury (TBI). DESIGN:Single-sample validity study. SETTING:Brain injury rehabilitation unit. PARTICIPANTS:Twenty-four adults with severe TBI, discharged from hospital for at least 6-months. PROTOCOL:Parti...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050701630375
更新日期:2007-09-01 00:00:00
abstract::This paper describes a conceptual model for treatment of the externalizing behavioural sequelae to an acquired brain injury and discusses relevant research. Use of the model by practitioners should lead to sophisticated and minimally intrusive intervention. In the model, there are two different categories of approache...
journal_title:Brain injury
pub_type: 杂志文章,评审
doi:10.1080/026990599121232
更新日期:1999-09-01 00:00:00
abstract::A case is described of repetitive familiar activities apparently accompanied by a hallucinated physical environment in an older brain-injured man with an amputation of the left temporal lobe. A parallel is drawn to the 'experiential hallucinations' described in psychomotor seizures and direct stimulation of the cortex...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699059509004576
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:To assess the effectiveness of interventions for mild traumatic brain injury (MTBI) in adults as found in the literature. RESEARCH DESIGN:Systematic review of the literature. METHODS:Six electronic databases and 18 journals within the brain injury field were manually searched between the years 1980-2003. R...
journal_title:Brain injury
pub_type: 杂志文章,评审
doi:10.1080/02699050400025042
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:The influence of oestrogen and testosterone replacement on stroke risk has been examined, as well as mechanisms by which oestrogen may protect from post-stroke damage. However, whether testosterone levels in the early time period after haemorrhagic stroke influence long-term mortality has not previously been ...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2016.1265668
更新日期:2017-01-01 00:00:00
abstract:PRIMARY OBJECTIVE:The aim was to assess the visual exploration of a person suffering from traumatic brain injury (TBI). It was hypothesized that visual exploration could be modified as a result of attentional or executive function deficits that are often observed following brain injury. RESEARCH DESIGN:This study comp...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699051003692159
更新日期:2010-01-01 00:00:00
abstract::Objective: To examine the impact of bright white light (BWL) exposure on sleep quality in persons with recent traumatic brain injury (TBI). Design: Randomized, controlled device-sham study Setting: 3 TBI Model System inpatient rehabilitation units Participants: 131 participants (mean 40.9 years, 68% male) Intervention...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2021.1871952
更新日期:2021-01-17 00:00:00
abstract:OBJECTIVE:Remote limb ischemic post-conditioning (RLIPostC) has been shown to be neuroprotective in cerebral ischemia, whereas the effect of RLIPostC on synaptogenesis remains elusive. In the present study, we investigated the effects of RLIPostC on synaptogenesis in an experimental stroke rat model. METHODS:Sprague-D...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2018.1483029
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Zolpidem is a non-benzodiazepine drug used for the therapy of insomnia, which has selectivity for stimulating the effect of GABA-A receptors. Recently, a paradoxical arousing effect of zolpidem in patients with severe brain damage has been repeatedly reported. METHODS:A placebo-controlled magnetic resonan...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2013.794961
更新日期:2013-01-01 00:00:00
abstract:PRIMARY OBJECTIVE:The purpose of this study was to investigate the effects of heme oxygenase-1 (HO-1) on astrocyte injury induced by hemin. RESEARCH DESIGN:Primary astrocytes were isolated from Sprague Dawley rat pups and cultured in vitro. The expression of HO-1 was induced by hemin in a quantitative fashion and the ...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2015.1084648
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To estimate the magnitude and relative importance of hospital treatment costs and productivity losses caused by traumatic brain injuries (TBIs). PATIENTS:A total of 155 patients with new TBI diagnoses admitted to Turku University Hospital were systematically sampled. METHODS:Hospital costs were determined b...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2012.722256
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To assess cerebral blood flow (CBF) changes in patients with mild traumatic brain injury (MTBI) using an arterial spin labelling (ASL) perfusion MRI and to investigate the severity of neuropsychological functional impairment with respect to haemodynamic changes. MATERIALS AND METHODS:Twenty-one patients with...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050903014899
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:This study presents a patient with a stroke who had total paralysis of his left-side limbs after intracranial haemorrhaging, who later experienced partial weakness of the right-side limbs after a subdural hygroma. Both conditions occurred without major trauma. He received two separate operations, a craniotom...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.3109/02699052.2011.571228
更新日期:2011-01-01 00:00:00
abstract:PRIMARY OBJECTIVE:To examine the relationship between cortical lesion location and brain injury outcome. It was hypothesized that focal frontal lesions after traumatic brain injury (TBI) would result in decreased executive and memory functioning and poor community participation outcome. RESEARCH DESIGN:Three quasi-exp...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/0269905040004310
更新日期:2005-04-01 00:00:00
abstract::Background: Volunteering has been found to improve life satisfaction and participation in the general population, but its impact has not been thoroughly studied among those with traumatic brain injury (TBI). It is important to investigate whether volunteering is helpful in addressing participation and life satisfactio...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2019.1679886
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The number of electrical injuries are rising in proportion to the increased use of electricity in both domestic and industrial sectors. There are multiple ways in which electricity can cause tissue damage, which can be due to direct effects, electroporation and thermal effects. However, these mechanisms fail...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050801978955
更新日期:2008-04-01 00:00:00
abstract::Narcolepsy arising from trauma can present particular problems of differential diagnosis. In this case study presentation the patient suffered a head trauma, without unconsciousness, and began to experience unusual episodic behaviours. Symptom presentation differed from the typical clinical manifestations of idiopathi...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699050310001617433
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:To determine what is the use of time and physical activity in people undertaking inpatient rehabilitation in a specialised brain injury unit. To determine participants' level of independence related to the use of time and physical activity. METHODS:Design: Cross-sectional observation study. PARTICIPANTS:Fo...
journal_title:Brain injury
pub_type: 杂志文章
doi:10.1080/02699052.2018.1463454
更新日期:2018-01-01 00:00:00