Inflammation, Bone Healing, and Anti-Inflammatory Drugs: An Update.

Abstract:

:Fracture healing is a unique multifaceted process requiring the presence of cells, molecular mediators, and angiogenic factors. The state of inflammation dominates the initial phase, but the ideal magnitude and duration of the process for an optimal outcome remains obscure. Biological response modifiers, such as platelet-rich plasma (PRP) preparations, have been used to reconstitute the desirable early inflammatory state, but the results obtained remain inconclusive. Ongoing research to characterize and quantify the inflammatory response after bone fracture is essential in order to better understand the molecular insights of this localized reaction and to expand our armamentarium in the management of patients with an impaired fracture healing response. Non-steroidal anti-inflammatory drugs frequently administered for analgesia after trauma procedures continue to be a cause of concern for a successful bone repair response.

journal_name

J Orthop Trauma

authors

Giannoudis PV,Hak D,Sanders D,Donohoe E,Tosounidis T,Bahney C

doi

10.1097/BOT.0000000000000465

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

S6-9

eissn

0890-5339

issn

1531-2291

pii

00005131-201512001-00002

journal_volume

29 Suppl 12

pub_type

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